ENSG00000143515

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000368489 ENSG00000143515 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATP8B2 protein_coding protein_coding 31.94253 34.78784 34.06749 1.162173 1.69746 -0.0301785 13.651880 8.522792 17.5646680 3.951027 1.4926861 1.0424076 0.42749167 0.2381667 0.520333333 0.2821667 0.20465363 0.02608125 FALSE TRUE
ENST00000505882 ENSG00000143515 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATP8B2 protein_coding retained_intron 31.94253 34.78784 34.06749 1.162173 1.69746 -0.0301785 1.725276 4.309351 0.3052769 0.480334 0.3052769 -3.7761233 0.05295833 0.1248000 0.008266667 -0.1165333 0.02608125 0.02608125 FALSE TRUE
ENST00000672630 ENSG00000143515 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATP8B2 protein_coding protein_coding 31.94253 34.78784 34.06749 1.162173 1.69746 -0.0301785 13.119346 18.621915 13.1506038 2.025997 2.2987073 -0.5015503 0.41142917 0.5402667 0.381500000 -0.1587667 0.33224794 0.02608125 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000143515 E001 0.8030446 0.2315260512 0.1784200468   1 154325525 154325534 10 + 0.396 0.121 -2.209
ENSG00000143515 E002 3.9037705 0.0454784400 0.8216270594 0.95494300 1 154325535 154325542 8 + 0.701 0.687 -0.058
ENSG00000143515 E003 11.9821121 0.0257545367 0.2777498897 0.68115047 1 154325543 154325552 10 + 1.160 1.055 -0.379
ENSG00000143515 E004 24.6643127 0.0296594273 0.2254649210 0.63045859 1 154325553 154325604 52 + 1.450 1.357 -0.323
ENSG00000143515 E005 50.9599893 0.0337164716 0.0374987771 0.30559088 1 154325605 154325702 98 + 1.792 1.624 -0.570
ENSG00000143515 E006 0.1544607 0.0375954758 0.4882288813   1 154327800 154327861 62 + 0.000 0.121 9.765
ENSG00000143515 E007 70.8096154 0.0022580529 0.0028463809 0.09563482 1 154328105 154328172 68 + 1.906 1.780 -0.425
ENSG00000143515 E008 0.1717682 0.0321776458 0.4897095405   1 154328799 154328799 1 + 0.000 0.121 9.863
ENSG00000143515 E009 0.7872842 0.0169993849 0.6612555223   1 154328800 154329075 276 + 0.211 0.293 0.629
ENSG00000143515 E010 3.9370085 0.0056505069 0.6781327189 0.90743183 1 154330325 154330395 71 + 0.705 0.657 -0.199
ENSG00000143515 E011 91.3287188 0.0015978935 0.0059513349 0.13698983 1 154330396 154330454 59 + 2.004 1.904 -0.337
ENSG00000143515 E012 3.2225943 0.0364986119 0.1525549240 0.54280866 1 154330455 154330702 248 + 0.461 0.715 1.150
ENSG00000143515 E013 134.4023442 0.0008518537 0.2633227023 0.66824288 1 154330815 154330880 66 + 2.133 2.110 -0.079
ENSG00000143515 E014 147.9057796 0.0003430244 0.8669742573 0.96735921 1 154330881 154330928 48 + 2.157 2.167 0.031
ENSG00000143515 E015 223.0072614 0.0001911065 0.8899221978 0.97358742 1 154331048 154331146 99 + 2.334 2.345 0.037
ENSG00000143515 E016 162.0589673 0.0002040705 0.5433568190 0.85153394 1 154331444 154331486 43 + 2.186 2.218 0.106
ENSG00000143515 E017 123.3631792 0.0003198438 0.9558586816 0.98989492 1 154331487 154331505 19 + 2.081 2.093 0.043
ENSG00000143515 E018 5.3582004 0.1047219563 0.2282760533 0.63349740 1 154331506 154331605 100 + 0.673 0.904 0.918
ENSG00000143515 E019 170.9310715 0.0002136873 0.1759050526 0.57410534 1 154331606 154331678 73 + 2.239 2.216 -0.075
ENSG00000143515 E020 186.2452261 0.0001837830 0.3341519157 0.72771940 1 154331954 154332024 71 + 2.269 2.258 -0.036
ENSG00000143515 E021 192.9359518 0.0008064761 0.5893416346 0.87105178 1 154332618 154332697 80 + 2.281 2.279 -0.007
ENSG00000143515 E022 247.3226061 0.0002072053 0.1084601058 0.47281569 1 154334107 154334265 159 + 2.399 2.376 -0.075
ENSG00000143515 E023 221.1185843 0.0002494136 0.0058760588 0.13635567 1 154334503 154334591 89 + 2.366 2.313 -0.176
ENSG00000143515 E024 303.1491321 0.0028821920 0.4185277939 0.78542213 1 154337348 154337544 197 + 2.489 2.472 -0.058
ENSG00000143515 E025 6.0538108 0.6108846679 0.1238474646 0.50025948 1 154337545 154337846 302 + 0.657 0.965 1.220
ENSG00000143515 E026 1.9560240 0.0104569797 0.5754535075 0.86459800 1 154340537 154340543 7 + 0.408 0.512 0.529
ENSG00000143515 E027 326.7766460 0.0013395656 0.1914869542 0.59361934 1 154340854 154341062 209 + 2.522 2.500 -0.073
ENSG00000143515 E028 8.9724910 0.1663245156 0.1274182704 0.50630300 1 154341167 154341788 622 + 0.802 1.113 1.165
ENSG00000143515 E029 172.3278574 0.0034033995 0.3141730193 0.71155146 1 154342480 154342523 44 + 2.245 2.222 -0.078
ENSG00000143515 E030 265.9380303 0.0001477012 0.3668323214 0.75140378 1 154342796 154342961 166 + 2.420 2.415 -0.018
ENSG00000143515 E031 318.3418602 0.0001866429 0.4430675752 0.79944393 1 154343113 154343301 189 + 2.494 2.492 -0.006
ENSG00000143515 E032 315.4783793 0.0015772615 0.7022550891 0.91590247 1 154343453 154343568 116 + 2.493 2.494 0.004
ENSG00000143515 E033 355.5372252 0.0001578393 0.4233392447 0.78818830 1 154343893 154344039 147 + 2.545 2.544 -0.004
ENSG00000143515 E034 168.4692652 0.0002211439 0.0276486920 0.26963495 1 154344040 154344057 18 + 2.243 2.196 -0.155
ENSG00000143515 E035 12.6940835 0.0161059992 0.7487074834 0.93222545 1 154344122 154344142 21 + 1.105 1.142 0.132
ENSG00000143515 E036 345.2035182 0.0001311062 0.5928772646 0.87257278 1 154344143 154344254 112 + 2.527 2.531 0.013
ENSG00000143515 E037 340.8527388 0.0004416069 0.2694670359 0.67394133 1 154344395 154344500 106 + 2.530 2.519 -0.037
ENSG00000143515 E038 409.5625302 0.0003431371 0.2628122989 0.66790129 1 154344641 154344785 145 + 2.609 2.600 -0.029
ENSG00000143515 E039 448.8744614 0.0001053703 0.0216491033 0.24367913 1 154344971 154345154 184 + 2.656 2.631 -0.082
ENSG00000143515 E040 438.1562392 0.0001469419 0.0853352313 0.42888647 1 154345322 154345545 224 + 2.640 2.624 -0.052
ENSG00000143515 E041 294.3715968 0.0011307622 0.1814495929 0.58118108 1 154345800 154345883 84 + 2.436 2.482 0.155
ENSG00000143515 E042 559.2733487 0.0001481670 0.0666746385 0.38819084 1 154346231 154346476 246 + 2.715 2.757 0.141
ENSG00000143515 E043 1.7213973 0.1358878307 0.9742999318 0.99394246 1 154346615 154346619 5 + 0.419 0.416 -0.020
ENSG00000143515 E044 441.0753054 0.0001738803 0.4050732527 0.77693105 1 154346620 154346758 139 + 2.636 2.636 0.000
ENSG00000143515 E045 387.9348373 0.0006752422 0.4124698592 0.78203837 1 154348408 154348538 131 + 2.565 2.597 0.106
ENSG00000143515 E046 2463.8299062 0.0016091676 0.0001195789 0.01485405 1 154348840 154351304 2465 + 3.354 3.420 0.219