ENSG00000143198

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000367888 ENSG00000143198 HEK293_DMSO_6hA HEK293_OSMI2_6hA MGST3 protein_coding protein_coding 119.2924 119.9565 149.5713 10.65684 17.85148 0.3182983 25.92263 21.66108 38.07846 2.283756 4.907309 0.8135830 0.2225792 0.1800 0.2555333 0.07553333 0.02006224 0.02006224 FALSE  
ENST00000367889 ENSG00000143198 HEK293_DMSO_6hA HEK293_OSMI2_6hA MGST3 protein_coding protein_coding 119.2924 119.9565 149.5713 10.65684 17.85148 0.3182983 88.53275 92.24936 107.07808 9.391775 14.384193 0.2150306 0.7310208 0.7671 0.7135333 -0.05356667 0.28389062 0.02006224 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000143198 E001 76.780344 9.462436e-03 1.272247e-02 0.1945218286 1 165631213 165631225 13 + 1.964 1.805 -0.535
ENSG00000143198 E002 122.394409 7.302664e-03 2.327107e-03 0.0861341628 1 165631226 165631233 8 + 2.165 2.004 -0.537
ENSG00000143198 E003 168.162694 2.721722e-03 7.899123e-05 0.0118611702 1 165631234 165631236 3 + 2.296 2.148 -0.494
ENSG00000143198 E004 187.725744 2.316344e-03 6.245020e-04 0.0414938285 1 165631237 165631238 2 + 2.332 2.211 -0.401
ENSG00000143198 E005 195.019013 1.599982e-03 4.212131e-04 0.0325705999 1 165631239 165631239 1 + 2.345 2.231 -0.378
ENSG00000143198 E006 396.031339 1.077444e-03 1.546609e-04 0.0174939995 1 165631240 165631254 15 + 2.639 2.549 -0.301
ENSG00000143198 E007 426.675938 4.952721e-04 2.507619e-05 0.0056077603 1 165631255 165631257 3 + 2.668 2.583 -0.281
ENSG00000143198 E008 968.477724 1.179107e-04 1.715099e-02 0.2214832752 1 165631258 165631292 35 + 2.996 2.968 -0.096
ENSG00000143198 E009 957.398506 1.773901e-04 1.990341e-02 0.2351795437 1 165631293 165631293 1 + 2.992 2.963 -0.098
ENSG00000143198 E010 1.376285 2.357724e-01 5.648219e-01   1 165632063 165632142 80 + 0.284 0.432 0.881
ENSG00000143198 E011 4.426758 4.910469e-03 9.985392e-01 0.9995887960 1 165632231 165632239 9 + 0.735 0.734 -0.005
ENSG00000143198 E012 5.201174 4.660405e-03 8.122949e-01 0.9522341688 1 165632240 165632274 35 + 0.780 0.809 0.114
ENSG00000143198 E013 1.316500 9.787059e-02 1.488993e-01   1 165635376 165635436 61 + 0.201 0.484 1.793
ENSG00000143198 E014 1.266751 1.270835e-02 3.697218e-01   1 165635727 165635822 96 + 0.275 0.431 0.941
ENSG00000143198 E015 2.518214 1.904402e-02 3.193989e-01 0.7161624658 1 165636775 165637149 375 + 0.444 0.608 0.779
ENSG00000143198 E016 10.188121 1.964864e-01 6.726848e-02 0.3896868485 1 165645661 165647895 2235 + 0.835 1.184 1.287
ENSG00000143198 E017 1.899333 1.112979e-02 2.652232e-01 0.6701567053 1 165648450 165648670 221 + 0.340 0.529 1.004
ENSG00000143198 E018 10.072323 1.655482e-01 1.502069e-01 0.5396344569 1 165648792 165649754 963 + 0.899 1.145 0.906
ENSG00000143198 E019 12.154511 4.293181e-02 3.944623e-01 0.7696973841 1 165649755 165649837 83 + 1.061 1.164 0.371
ENSG00000143198 E020 11.608334 3.900365e-02 7.627620e-02 0.4098194076 1 165649838 165649840 3 + 0.979 1.202 0.807
ENSG00000143198 E021 1777.095445 6.655067e-05 1.795502e-01 0.5787386786 1 165649841 165649964 124 + 3.241 3.251 0.036
ENSG00000143198 E022 27.702403 5.742739e-02 1.299001e-03 0.0628068571 1 165649965 165651013 1049 + 1.199 1.616 1.446
ENSG00000143198 E023 1872.383253 3.518704e-04 3.722049e-01 0.7548532349 1 165651014 165651087 74 + 3.264 3.275 0.038
ENSG00000143198 E024 24.915536 8.027625e-02 7.845991e-02 0.4145626104 1 165651088 165651892 805 + 1.274 1.511 0.823
ENSG00000143198 E025 1478.172760 1.255177e-04 3.994590e-02 0.3138641430 1 165651978 165652035 58 + 3.156 3.176 0.066
ENSG00000143198 E026 7.357751 1.129159e-01 1.642064e-02 0.2170933137 1 165653697 165653801 105 + 0.636 1.094 1.779
ENSG00000143198 E027 24.013212 1.263911e-01 1.459511e-02 0.2062370402 1 165653833 165654278 446 + 1.129 1.563 1.513
ENSG00000143198 E028 1593.528213 8.236846e-05 9.683062e-03 0.1711510244 1 165654279 165654351 73 + 3.187 3.210 0.077
ENSG00000143198 E029 1541.859389 1.198285e-04 1.515395e-07 0.0001372211 1 165655368 165656136 769 + 3.159 3.209 0.167
ENSG00000143198 E030 0.000000       1 165661429 165661796 368 +