ENSG00000142751

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374133 ENSG00000142751 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPN2 protein_coding protein_coding 37.23536 33.95728 54.58413 3.905914 9.185386 0.6845999 13.328583 9.907557 19.071952 1.7775729 5.667943 0.9441521 0.33961250 0.29140000 0.3312333 0.03983333 0.804940390 0.008152443 FALSE TRUE
ENST00000374135 ENSG00000142751 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPN2 protein_coding protein_coding 37.23536 33.95728 54.58413 3.905914 9.185386 0.6845999 9.443649 12.548085 9.171580 0.1410712 1.412247 -0.4518021 0.27747917 0.37926667 0.1901000 -0.18916667 0.175440038 0.008152443 FALSE TRUE
MSTRG.627.2 ENSG00000142751 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPN2 protein_coding   37.23536 33.95728 54.58413 3.905914 9.185386 0.6845999 8.717517 6.393590 16.817336 1.0186000 3.843247 1.3938540 0.22897917 0.18623333 0.3009333 0.11470000 0.008152443 0.008152443 FALSE TRUE
MSTRG.627.6 ENSG00000142751 HEK293_DMSO_6hA HEK293_OSMI2_6hA GPN2 protein_coding   37.23536 33.95728 54.58413 3.905914 9.185386 0.6845999 3.732302 2.792086 7.437898 1.4091719 2.931923 1.4103321 0.08665833 0.07483333 0.1301667 0.05533333 0.761615898 0.008152443 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000142751 E001 0.520307 0.175156595 5.799266e-01   1 26876132 26876147 16 - 0.111 0.230 1.251
ENSG00000142751 E002 10.206769 0.019067344 1.857408e-01 0.58647069 1 26876148 26876173 26 - 0.934 1.131 0.724
ENSG00000142751 E003 26.051460 0.001457396 2.320774e-02 0.25097768 1 26876174 26876208 35 - 1.316 1.514 0.684
ENSG00000142751 E004 90.639735 0.014616832 1.255772e-02 0.19335875 1 26876209 26876346 138 - 1.844 2.054 0.703
ENSG00000142751 E005 762.279862 0.044383924 7.113669e-03 0.14841580 1 26876347 26878415 2069 - 2.742 2.994 0.838
ENSG00000142751 E006 18.968757 0.011531927 2.829184e-01 0.68576205 1 26878416 26878511 96 - 1.211 1.354 0.504
ENSG00000142751 E007 103.676399 0.023735807 3.779630e-02 0.30645288 1 26878512 26878828 317 - 1.912 2.106 0.652
ENSG00000142751 E008 186.127789 0.041791977 3.623401e-02 0.30131350 1 26878829 26879375 547 - 2.150 2.370 0.734
ENSG00000142751 E009 194.408320 0.001116489 1.089775e-01 0.47369158 1 26879376 26879500 125 - 2.242 2.332 0.300
ENSG00000142751 E010 442.210380 0.003054054 3.493104e-01 0.73877659 1 26879501 26879749 249 - 2.636 2.654 0.062
ENSG00000142751 E011 32.276482 0.017743721 6.842076e-01 0.90972330 1 26884125 26884159 35 - 1.481 1.551 0.238
ENSG00000142751 E012 289.344161 0.003997185 6.269633e-02 0.37896578 1 26884160 26884232 73 - 2.471 2.451 -0.066
ENSG00000142751 E013 267.522456 0.003741743 8.952882e-02 0.43774839 1 26884233 26884290 58 - 2.433 2.420 -0.044
ENSG00000142751 E014 326.342175 0.001231603 6.862587e-02 0.39279904 1 26885973 26886041 69 - 2.513 2.512 -0.003
ENSG00000142751 E015 351.887893 0.003703795 7.625920e-03 0.15363934 1 26886042 26886133 92 - 2.566 2.525 -0.139
ENSG00000142751 E016 4.958653 0.036900247 7.995736e-03 0.15624592 1 26886134 26886341 208 - 0.485 0.937 1.895
ENSG00000142751 E017 1.672338 0.262553367 3.350125e-01 0.72827809 1 26886477 26886525 49 - 0.281 0.531 1.402
ENSG00000142751 E018 4.113993 0.088035781 3.593352e-01 0.74643784 1 26888897 26888968 72 - 0.599 0.791 0.802
ENSG00000142751 E019 383.489304 0.003440924 9.302958e-04 0.05187025 1 26888969 26889125 157 - 2.612 2.553 -0.196
ENSG00000142751 E020 3.034172 0.007215329 6.222640e-01 0.88511271 1 26889126 26889155 30 - 0.621 0.577 -0.195
ENSG00000142751 E021 193.645779 0.001812548 2.595379e-06 0.00114994 1 26889686 26889732 47 - 2.335 2.229 -0.354
ENSG00000142751 E022 146.770997 0.001269262 6.833734e-04 0.04380982 1 26889733 26889754 22 - 2.199 2.131 -0.229
ENSG00000142751 E023 296.023250 0.007195911 1.135408e-02 0.18436523 1 26889755 26889944 190 - 2.500 2.439 -0.202
ENSG00000142751 E024 424.080873 0.006166485 1.457022e-02 0.20613136 1 26889945 26890444 500 - 2.650 2.603 -0.158