ENSG00000141867

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000263377 ENSG00000141867 HEK293_DMSO_6hA HEK293_OSMI2_6hA BRD4 protein_coding protein_coding 28.49727 22.34329 38.25755 1.729767 6.09843 0.7756344 3.745712 6.4994320 6.4717678 1.1518164 2.3608870 -0.006144319 0.1196958 0.28643333 0.1626667 -0.12376667 0.2390927 0.0395935 FALSE TRUE
ENST00000371835 ENSG00000141867 HEK293_DMSO_6hA HEK293_OSMI2_6hA BRD4 protein_coding protein_coding 28.49727 22.34329 38.25755 1.729767 6.09843 0.7756344 9.382898 8.4628732 16.2282147 0.5140642 3.0427228 0.938469848 0.3158917 0.38226667 0.4196333 0.03736667 0.7489722 0.0395935 FALSE TRUE
ENST00000679869 ENSG00000141867 HEK293_DMSO_6hA HEK293_OSMI2_6hA BRD4 protein_coding protein_coding 28.49727 22.34329 38.25755 1.729767 6.09843 0.7756344 6.562158 2.5458038 9.7194846 0.3168945 2.0212089 1.928586280 0.2293042 0.11733333 0.2523667 0.13503333 0.0395935 0.0395935 FALSE TRUE
MSTRG.16611.10 ENSG00000141867 HEK293_DMSO_6hA HEK293_OSMI2_6hA BRD4 protein_coding   28.49727 22.34329 38.25755 1.729767 6.09843 0.7756344 1.943440 0.4758571 0.0000000 0.4758571 0.0000000 -5.602460194 0.0767000 0.01873333 0.0000000 -0.01873333 0.7463153 0.0395935 FALSE TRUE
MSTRG.16611.7 ENSG00000141867 HEK293_DMSO_6hA HEK293_OSMI2_6hA BRD4 protein_coding   28.49727 22.34329 38.25755 1.729767 6.09843 0.7756344 2.479661 0.0000000 0.8937341 0.0000000 0.8937341 6.497826440 0.0969125 0.00000000 0.0338000 0.03380000 0.8215774 0.0395935 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000141867 E001 470.2098382 0.0032947929 0.098744953 0.45486691 19 15235519 15237081 1563 - 2.641 2.701 0.201
ENSG00000141867 E002 188.6597014 0.0115950372 0.978056633 0.99484557 19 15237082 15237284 203 - 2.265 2.278 0.046
ENSG00000141867 E003 117.6978483 0.0084944989 0.916262694 0.97991012 19 15237285 15237350 66 - 2.064 2.073 0.031
ENSG00000141867 E004 138.5059465 0.0040917469 0.737318777 0.92811186 19 15237351 15237389 39 - 2.135 2.148 0.042
ENSG00000141867 E005 275.2910251 0.0013350872 0.158811474 0.55246123 19 15237390 15237566 177 - 2.419 2.459 0.130
ENSG00000141867 E006 200.1080557 0.0021771757 0.609686849 0.87980457 19 15237567 15237674 108 - 2.287 2.310 0.076
ENSG00000141867 E007 258.9891607 0.0065300039 0.679129536 0.90776850 19 15237675 15237890 216 - 2.411 2.405 -0.019
ENSG00000141867 E008 493.1861349 0.0017356666 0.583584186 0.86835770 19 15237891 15238445 555 - 2.689 2.684 -0.015
ENSG00000141867 E009 255.1903048 0.0001584582 0.555837430 0.85634177 19 15238743 15238980 238 - 2.407 2.394 -0.044
ENSG00000141867 E010 319.1932121 0.0001188690 0.322143567 0.71851522 19 15239059 15239264 206 - 2.507 2.487 -0.066
ENSG00000141867 E011 259.0193147 0.0001863173 0.129772488 0.50995294 19 15239392 15239522 131 - 2.420 2.386 -0.113
ENSG00000141867 E012 194.4905018 0.0003565914 0.499900351 0.82955371 19 15239659 15239821 163 - 2.292 2.275 -0.057
ENSG00000141867 E013 120.7519669 0.0021041491 0.696200438 0.91375801 19 15239910 15240022 113 - 2.074 2.092 0.058
ENSG00000141867 E014 71.5025540 0.0004495612 0.126232824 0.50458112 19 15242900 15243038 139 - 1.830 1.893 0.216
ENSG00000141867 E015 4.1518885 0.0963033991 0.562440514 0.85900192 19 15243039 15243107 69 - 0.645 0.775 0.538
ENSG00000141867 E016 5.3953163 0.0264405308 0.062038349 0.37699946 19 15243108 15243221 114 - 0.668 0.945 1.095
ENSG00000141867 E017 76.1084037 0.0137657903 0.700084045 0.91507314 19 15243222 15243487 266 - 1.870 1.902 0.108
ENSG00000141867 E018 91.4175201 0.0134487031 0.427884111 0.79081912 19 15244231 15244522 292 - 1.981 1.930 -0.172
ENSG00000141867 E019 43.1578653 0.0011692857 0.014447389 0.20532267 19 15244523 15244600 78 - 1.691 1.553 -0.471
ENSG00000141867 E020 3.6779842 0.1470919591 0.451709183 0.80443631 19 15244601 15244709 109 - 0.582 0.740 0.674
ENSG00000141867 E021 59.3703067 0.0018868547 0.940834553 0.98615409 19 15244710 15244762 53 - 1.776 1.780 0.013
ENSG00000141867 E022 10.0244304 0.1141514208 0.010488589 0.17724367 19 15244763 15244998 236 - 0.770 1.250 1.781
ENSG00000141867 E023 7.0569228 0.0375303760 0.016381289 0.21685752 19 15246508 15246618 111 - 0.719 1.065 1.327
ENSG00000141867 E024 83.8317996 0.0019885115 0.600148958 0.87551766 19 15247047 15247276 230 - 1.929 1.907 -0.072
ENSG00000141867 E025 777.3877106 0.0005616392 0.028687167 0.27448535 19 15247277 15248793 1517 - 2.867 2.906 0.130
ENSG00000141867 E026 96.8693038 0.0014880579 0.002000158 0.07965493 19 15248794 15248823 30 - 1.925 2.050 0.421
ENSG00000141867 E027 177.5502372 0.0030785608 0.284379280 0.68712208 19 15248824 15249004 181 - 2.221 2.269 0.158
ENSG00000141867 E028 92.6319795 0.0052723002 0.780481508 0.94233615 19 15249005 15249061 57 - 1.957 1.971 0.047
ENSG00000141867 E029 180.3854413 0.0020636862 0.517442325 0.83887054 19 15249062 15249290 229 - 2.255 2.239 -0.056
ENSG00000141867 E030 27.6665091 0.0238409572 0.006389069 0.14119091 19 15252992 15253750 759 - 1.314 1.588 0.947
ENSG00000141867 E031 4.8121117 0.0049850239 0.797135278 0.94738648 19 15253751 15253783 33 - 0.735 0.771 0.147
ENSG00000141867 E032 14.8720199 0.0025050988 0.066665569 0.38817544 19 15253784 15254151 368 - 1.116 1.278 0.577
ENSG00000141867 E033 221.0249322 0.0001701738 0.372762798 0.75521017 19 15254152 15254262 111 - 2.350 2.328 -0.073
ENSG00000141867 E034 376.0293721 0.0001845621 0.143961430 0.53082300 19 15255297 15255592 296 - 2.583 2.555 -0.094
ENSG00000141867 E035 121.2346938 0.0036962425 0.406850773 0.77812555 19 15256064 15256098 35 - 2.095 2.060 -0.118
ENSG00000141867 E036 111.9021997 0.0002960421 0.283173662 0.68603963 19 15256099 15256134 36 - 2.062 2.025 -0.124
ENSG00000141867 E037 131.4154598 0.0037612926 0.702469253 0.91602318 19 15256135 15256207 73 - 2.121 2.107 -0.048
ENSG00000141867 E038 121.1036301 0.0068872287 0.576997925 0.86536269 19 15256208 15256263 56 - 2.094 2.063 -0.104
ENSG00000141867 E039 267.1768943 0.0002963364 0.457183438 0.80717883 19 15256964 15257173 210 - 2.432 2.415 -0.058
ENSG00000141867 E040 4.4860066 0.0902800179 0.052516614 0.35141224 19 15257174 15258201 1028 - 0.547 0.899 1.457
ENSG00000141867 E041 4.1315422 0.0146955780 0.050075319 0.34429820 19 15258889 15259793 905 - 0.569 0.853 1.180
ENSG00000141867 E042 259.8077091 0.0001467220 0.305016806 0.70390683 19 15263420 15263548 129 - 2.419 2.396 -0.077
ENSG00000141867 E043 0.7308349 0.0168516942 0.312132813   19 15264118 15264403 286 - 0.173 0.347 1.322
ENSG00000141867 E044 350.3532877 0.0003165867 0.603485711 0.87721942 19 15264404 15264766 363 - 2.533 2.545 0.041
ENSG00000141867 E045 192.0293194 0.0009409869 0.675543431 0.90633832 19 15265354 15265626 273 - 2.283 2.271 -0.038
ENSG00000141867 E046 96.9664079 0.0026511942 0.788743107 0.94475623 19 15265627 15265643 17 - 1.988 1.976 -0.040
ENSG00000141867 E047 178.3696094 0.0007742466 0.422120119 0.78742317 19 15267416 15267513 98 - 2.254 2.231 -0.074
ENSG00000141867 E048 144.2239679 0.0039667566 0.319845038 0.71642391 19 15267514 15267551 38 - 2.164 2.130 -0.116
ENSG00000141867 E049 13.4399065 0.0164420849 0.363078031 0.74911453 19 15268154 15268240 87 - 1.108 1.207 0.353
ENSG00000141867 E050 7.8393775 0.1449421244 0.334619078 0.72806451 19 15268241 15268281 41 - 0.844 1.048 0.764
ENSG00000141867 E051 199.7058130 0.0020805090 0.112961958 0.48080790 19 15268905 15269012 108 - 2.312 2.264 -0.162
ENSG00000141867 E052 119.3841603 0.0034099533 0.158162137 0.55146390 19 15269013 15269042 30 - 2.094 2.038 -0.187
ENSG00000141867 E053 2.5228046 0.0081925412 0.620795865 0.88444410 19 15271322 15271392 71 - 0.507 0.587 0.370
ENSG00000141867 E054 217.9476404 0.0015529073 0.443808067 0.79984089 19 15272815 15273133 319 - 2.339 2.320 -0.065
ENSG00000141867 E055 0.1125166 0.0320534205 0.757669939   19 15275657 15275839 183 - 0.095 0.000 -8.636
ENSG00000141867 E056 0.1767706 0.0492532117 0.755054874   19 15280264 15280451 188 - 0.096 0.000 -8.397
ENSG00000141867 E057 2.7623648 0.0997272039 0.926574447 0.98259484 19 15331836 15331907 72 - 0.552 0.539 -0.058
ENSG00000141867 E058 21.8756970 0.0013539543 0.257864094 0.66358767 19 15332290 15332579 290 - 1.382 1.297 -0.298