ENSG00000141655

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000586569 ENSG00000141655 HEK293_DMSO_6hA HEK293_OSMI2_6hA TNFRSF11A protein_coding protein_coding 2.732314 2.396905 1.898495 0.1347469 0.5198206 -0.3347437 1.2432035 1.0025729 1.2987756 0.10582824 0.1280547 0.3701921 0.5339208 0.4189667 0.7671000 0.3481333 0.342296872 0.006884645 FALSE TRUE
ENST00000587697 ENSG00000141655 HEK293_DMSO_6hA HEK293_OSMI2_6hA TNFRSF11A protein_coding retained_intron 2.732314 2.396905 1.898495 0.1347469 0.5198206 -0.3347437 0.1518828 0.2986155 0.0000000 0.05542455 0.0000000 -4.9477385 0.0569750 0.1277333 0.0000000 -0.1277333 0.006884645 0.006884645   FALSE
ENST00000639222 ENSG00000141655 HEK293_DMSO_6hA HEK293_OSMI2_6hA TNFRSF11A protein_coding protein_coding 2.732314 2.396905 1.898495 0.1347469 0.5198206 -0.3347437 0.9009424 0.8319585 0.4767173 0.09748382 0.4767173 -0.7906650 0.2706583 0.3446333 0.1628333 -0.1818000 0.424173436 0.006884645 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000141655 E001 0.0000000       18 62325287 62325308 22 +      
ENSG00000141655 E002 0.0000000       18 62325309 62325309 1 +      
ENSG00000141655 E003 0.4046060 0.062175580 6.057766e-01   18 62325310 62325325 16 + 0.210 0.121 -0.954
ENSG00000141655 E004 1.2797092 0.084457408 1.500697e-01   18 62325326 62325351 26 + 0.498 0.215 -1.743
ENSG00000141655 E005 3.5450691 0.061734075 4.411455e-01 0.798350678 18 62325352 62325427 76 + 0.727 0.591 -0.579
ENSG00000141655 E006 0.3591457 0.441876641 3.038137e-01   18 62336314 62336387 74 + 0.000 0.218 11.605
ENSG00000141655 E007 1.0746347 0.887788795 5.818314e-01   18 62336388 62336786 399 + 0.123 0.426 2.342
ENSG00000141655 E008 0.2250332 0.092134304 2.273793e-01   18 62348113 62348167 55 + 0.209 0.000 -12.760
ENSG00000141655 E009 8.0238732 0.003429472 2.274639e-01 0.632472232 18 62348168 62348249 82 + 0.880 1.012 0.495
ENSG00000141655 E010 13.6879491 0.001990117 3.311173e-01 0.725465204 18 62349812 62349937 126 + 1.122 1.205 0.298
ENSG00000141655 E011 15.7411077 0.029255243 6.054212e-01 0.877815127 18 62354391 62354534 144 + 1.210 1.255 0.157
ENSG00000141655 E012 2.4787842 0.008325136 1.020009e-05 0.003101369 18 62357903 62358247 345 + 0.000 0.763 15.239
ENSG00000141655 E013 7.8358765 0.009176668 6.120418e-01 0.880962729 18 62358248 62358252 5 + 0.929 0.984 0.203
ENSG00000141655 E014 18.3416018 0.006247194 6.542183e-01 0.898268795 18 62358253 62358341 89 + 1.280 1.312 0.111
ENSG00000141655 E015 22.3246448 0.003664558 2.289698e-01 0.634158809 18 62359955 62360049 95 + 1.329 1.414 0.295
ENSG00000141655 E016 27.3604331 0.001026665 5.283103e-01 0.844196378 18 62361680 62361793 114 + 1.432 1.470 0.129
ENSG00000141655 E017 20.9403028 0.016876656 9.854245e-01 0.996465045 18 62366708 62366760 53 + 1.340 1.333 -0.024
ENSG00000141655 E018 0.1544607 0.033333307 4.829676e-01   18 62367430 62367435 6 + 0.000 0.120 11.443
ENSG00000141655 E019 83.5315783 0.009647452 7.659403e-01 0.938073315 18 62368701 62369484 784 + 1.931 1.915 -0.054
ENSG00000141655 E020 195.5358086 0.003424326 7.568330e-02 0.408302015 18 62384751 62391288 6538 + 2.315 2.272 -0.146