ENSG00000141504

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380466 ENSG00000141504 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAT2 protein_coding processed_transcript 84.89185 75.11673 113.5983 8.140397 20.68336 0.5966702 7.771454 5.237647 8.455534 0.9671237 1.6748580 0.6899304 0.09895000 0.07336667 0.07676667 0.00340000 0.93535145 0.04173983 FALSE  
ENST00000570914 ENSG00000141504 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAT2 protein_coding retained_intron 84.89185 75.11673 113.5983 8.140397 20.68336 0.5966702 4.299506 7.797358 2.670597 1.3846629 0.8547111 -1.5422800 0.06601250 0.10450000 0.02920000 -0.07530000 0.04173983 0.04173983    
ENST00000573566 ENSG00000141504 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAT2 protein_coding protein_coding 84.89185 75.11673 113.5983 8.140397 20.68336 0.5966702 11.075401 8.233149 15.623788 0.3493860 3.2215075 0.9233998 0.12245417 0.11126667 0.13593333 0.02466667 0.41889991 0.04173983 FALSE  
ENST00000576686 ENSG00000141504 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAT2 protein_coding processed_transcript 84.89185 75.11673 113.5983 8.140397 20.68336 0.5966702 13.730481 10.199169 20.369507 2.0302526 4.3781615 0.9972537 0.15514167 0.13336667 0.17723333 0.04386667 0.40009727 0.04173983 FALSE  
ENST00000576846 ENSG00000141504 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAT2 protein_coding retained_intron 84.89185 75.11673 113.5983 8.140397 20.68336 0.5966702 5.384852 8.288657 5.994747 0.2066607 1.0496314 -0.4667746 0.07867500 0.11326667 0.06130000 -0.05196667 0.30599236 0.04173983 FALSE  
MSTRG.13591.3 ENSG00000141504 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAT2 protein_coding   84.89185 75.11673 113.5983 8.140397 20.68336 0.5966702 14.045112 10.125025 21.977855 1.4906882 4.8998914 1.1173572 0.15965833 0.13516667 0.18973333 0.05456667 0.25062116 0.04173983 FALSE  
MSTRG.13591.7 ENSG00000141504 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAT2 protein_coding   84.89185 75.11673 113.5983 8.140397 20.68336 0.5966702 6.104767 3.471563 7.209386 0.7533761 2.4411783 1.0521409 0.06410417 0.04606667 0.06276667 0.01670000 0.74305443 0.04173983 FALSE  
MSTRG.13591.8 ENSG00000141504 HEK293_DMSO_6hA HEK293_OSMI2_6hA SAT2 protein_coding   84.89185 75.11673 113.5983 8.140397 20.68336 0.5966702 14.970108 16.727732 22.040436 3.9215901 5.2640328 0.3977031 0.17567917 0.21863333 0.18896667 -0.02966667 0.75116649 0.04173983 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000141504 E001 6.2893934 0.0147318308 3.373629e-01 0.7300182517 17 7626234 7626236 3 - 0.917 0.804 -0.437
ENSG00000141504 E002 9.3023294 0.0027943394 4.655381e-01 0.8114767244 17 7626237 7626237 1 - 1.046 0.981 -0.240
ENSG00000141504 E003 11.0290610 0.0024383093 9.192872e-02 0.4419326048 17 7626238 7626241 4 - 1.153 0.997 -0.566
ENSG00000141504 E004 17.9043645 0.0132594719 5.146124e-01 0.8374476578 17 7626242 7626245 4 - 1.306 1.251 -0.194
ENSG00000141504 E005 331.4259270 0.0012361774 6.957941e-01 0.9136735928 17 7626246 7626336 91 - 2.507 2.535 0.091
ENSG00000141504 E006 309.7855944 0.0009661608 6.706287e-01 0.9044513884 17 7626337 7626341 5 - 2.477 2.505 0.092
ENSG00000141504 E007 393.3809860 0.0014878622 5.827007e-01 0.8680100540 17 7626342 7626365 24 - 2.579 2.611 0.109
ENSG00000141504 E008 415.6413742 0.0021200868 3.965208e-01 0.7708185565 17 7626366 7626387 22 - 2.597 2.642 0.148
ENSG00000141504 E009 408.5639124 0.0006035300 3.334146e-01 0.7272197856 17 7626388 7626402 15 - 2.594 2.630 0.122
ENSG00000141504 E010 848.6629366 0.0005268422 6.270611e-01 0.8867932545 17 7626403 7626533 131 - 2.917 2.942 0.083
ENSG00000141504 E011 626.0484982 0.0004406051 2.540936e-01 0.6598017623 17 7626534 7626614 81 - 2.799 2.796 -0.011
ENSG00000141504 E012 39.8012834 0.0978120468 2.562080e-02 0.2607351487 17 7626615 7626706 92 - 1.409 1.759 1.195
ENSG00000141504 E013 29.3828292 0.0787662473 3.502762e-02 0.2975101735 17 7626707 7626752 46 - 1.303 1.619 1.089
ENSG00000141504 E014 359.9504619 0.0005733507 9.218226e-02 0.4424856557 17 7626753 7626781 29 - 2.568 2.547 -0.070
ENSG00000141504 E015 313.8495277 0.0003233079 2.511688e-02 0.2591426173 17 7626782 7626793 12 - 2.514 2.481 -0.111
ENSG00000141504 E016 86.0730627 0.0763853051 7.515278e-03 0.1524668560 17 7626794 7626942 149 - 1.725 2.095 1.245
ENSG00000141504 E017 55.5918186 0.0133283655 5.073948e-03 0.1277459577 17 7626943 7626945 3 - 1.628 1.854 0.765
ENSG00000141504 E018 57.5870745 0.0139575145 1.023405e-02 0.1753706103 17 7626946 7626958 13 - 1.653 1.862 0.707
ENSG00000141504 E019 91.2310611 0.0271270414 1.486816e-01 0.5373349542 17 7626959 7627044 86 - 1.891 2.032 0.474
ENSG00000141504 E020 59.7778371 0.0796078106 8.938666e-02 0.4374017838 17 7627045 7627142 98 - 1.655 1.892 0.802
ENSG00000141504 E021 531.5127602 0.0001284857 2.631698e-07 0.0002148257 17 7627143 7627226 84 - 2.756 2.690 -0.218
ENSG00000141504 E022 117.9541933 0.0368353294 1.384574e-01 0.5229966783 17 7627227 7627362 136 - 1.993 2.150 0.524
ENSG00000141504 E023 416.0925732 0.0001371580 2.908838e-03 0.0967842996 17 7627363 7627414 52 - 2.637 2.599 -0.126
ENSG00000141504 E024 84.2879333 0.0354438139 2.069518e-02 0.2389669674 17 7627415 7627541 127 - 1.799 2.040 0.813
ENSG00000141504 E025 43.0748804 0.0520056624 4.513966e-02 0.3303615994 17 7627542 7627552 11 - 1.505 1.757 0.857
ENSG00000141504 E026 207.4349113 0.0004312009 1.589704e-01 0.5527124192 17 7627553 7627556 4 - 2.326 2.305 -0.071
ENSG00000141504 E027 248.9037411 0.0004922257 9.079167e-02 0.4399444238 17 7627557 7627569 13 - 2.407 2.381 -0.086
ENSG00000141504 E028 627.4951412 0.0016558256 1.075553e-04 0.0140840614 17 7627570 7627874 305 - 2.828 2.759 -0.230
ENSG00000141504 E029 0.6860885 0.0250805659 2.585700e-01   17 7627875 7627876 2 - 0.326 0.133 -1.649
ENSG00000141504 E030 0.0000000       17 7630747 7630869 123 -