ENSG00000141401

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000269159 ENSG00000141401 HEK293_DMSO_6hA HEK293_OSMI2_6hA IMPA2 protein_coding protein_coding 20.39454 18.92963 25.55334 1.968092 3.763182 0.4326682 6.587641 3.954370 10.687185 0.41806891 1.79877626 1.4320675 0.31759583 0.21040000 0.41506667 0.204666667 9.495220e-08 9.49522e-08 FALSE TRUE
ENST00000588167 ENSG00000141401 HEK293_DMSO_6hA HEK293_OSMI2_6hA IMPA2 protein_coding retained_intron 20.39454 18.92963 25.55334 1.968092 3.763182 0.4326682 1.159722 1.875729 1.313328 0.04427574 0.23356737 -0.5109519 0.06145417 0.10180000 0.05293333 -0.048866667 2.657642e-01 9.49522e-08 FALSE FALSE
ENST00000588927 ENSG00000141401 HEK293_DMSO_6hA HEK293_OSMI2_6hA IMPA2 protein_coding protein_coding 20.39454 18.92963 25.55334 1.968092 3.763182 0.4326682 8.493711 7.793904 9.001027 1.33758430 1.83486676 0.2074955 0.40315833 0.40606667 0.34510000 -0.060966667 6.798412e-01 9.49522e-08 FALSE TRUE
ENST00000589374 ENSG00000141401 HEK293_DMSO_6hA HEK293_OSMI2_6hA IMPA2 protein_coding retained_intron 20.39454 18.92963 25.55334 1.968092 3.763182 0.4326682 1.368720 1.706505 1.901834 0.46994965 0.05734485 0.1554831 0.06985000 0.08703333 0.07766667 -0.009366667 9.094735e-01 9.49522e-08 FALSE FALSE
ENST00000590107 ENSG00000141401 HEK293_DMSO_6hA HEK293_OSMI2_6hA IMPA2 protein_coding nonsense_mediated_decay 20.39454 18.92963 25.55334 1.968092 3.763182 0.4326682 1.219694 1.665854 1.339130 0.10635774 0.43143899 -0.3128670 0.06755833 0.08890000 0.05413333 -0.034766667 5.517827e-01 9.49522e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000141401 E001 0.5375535 0.0244055205 0.741151344   18 11981025 11981036 12 + 0.190 0.136 -0.571
ENSG00000141401 E002 0.5375535 0.0244055205 0.741151344   18 11981037 11981130 94 + 0.190 0.136 -0.571
ENSG00000141401 E003 0.1795728 0.0332227197 0.375236807   18 11981131 11981205 75 + 0.000 0.136 10.425
ENSG00000141401 E004 0.8145965 0.2316386111 0.352411958   18 11981428 11981464 37 + 0.325 0.136 -1.593
ENSG00000141401 E005 2.6276073 0.0097364649 0.420266697 0.78629817 18 11981465 11981476 12 + 0.502 0.635 0.607
ENSG00000141401 E006 13.2149551 0.0156196628 0.159632583 0.55379824 18 11981477 11981506 30 + 1.081 1.237 0.556
ENSG00000141401 E007 17.6268175 0.0213004222 0.438643645 0.79690480 18 11981507 11981515 9 + 1.232 1.321 0.311
ENSG00000141401 E008 25.8858136 0.0222132470 0.939936997 0.98594568 18 11981516 11981526 11 + 1.430 1.435 0.018
ENSG00000141401 E009 41.7690986 0.0161368287 0.351328019 0.74048397 18 11981527 11981610 84 + 1.654 1.601 -0.181
ENSG00000141401 E010 48.6010419 0.0066387361 0.230423503 0.63537088 18 11981611 11981669 59 + 1.722 1.660 -0.212
ENSG00000141401 E011 46.7370352 0.0009707287 0.187761512 0.58887023 18 11981670 11981693 24 + 1.704 1.645 -0.202
ENSG00000141401 E012 49.7575565 0.0005696424 0.017563824 0.22391782 18 11981694 11981765 72 + 1.751 1.641 -0.373
ENSG00000141401 E013 29.4370361 0.0020554583 0.073574738 0.40330455 18 11999054 11999061 8 + 1.534 1.422 -0.386
ENSG00000141401 E014 69.5385545 0.0004523159 0.132369999 0.51397855 18 11999062 11999135 74 + 1.871 1.816 -0.186
ENSG00000141401 E015 82.7889792 0.0003550170 0.584744620 0.86889456 18 11999136 11999187 52 + 1.923 1.910 -0.042
ENSG00000141401 E016 3.9342454 0.0079608094 0.146942986 0.53501879 18 12008333 12008591 259 + 0.572 0.790 0.919
ENSG00000141401 E017 72.5172702 0.0005003642 0.784890808 0.94370201 18 12009883 12009899 17 + 1.849 1.869 0.068
ENSG00000141401 E018 91.8746160 0.0003384644 0.292196288 0.69316654 18 12009900 12009930 31 + 1.976 1.946 -0.100
ENSG00000141401 E019 107.2591840 0.0003288976 0.140263539 0.52562032 18 12009931 12009987 57 + 2.046 2.005 -0.137
ENSG00000141401 E020 4.1543031 0.0552938851 0.005035835 0.12725927 18 12009988 12010221 234 + 0.422 0.904 2.093
ENSG00000141401 E021 101.5777145 0.0003541871 0.088051491 0.43430418 18 12012170 12012215 46 + 2.027 1.976 -0.170
ENSG00000141401 E022 9.6899470 0.0332327098 0.204728097 0.60849261 18 12012216 12012349 134 + 0.938 1.108 0.622
ENSG00000141401 E023 127.1833721 0.0003342902 0.968776759 0.99272435 18 12014265 12014373 109 + 2.099 2.106 0.024
ENSG00000141401 E024 3.1578939 0.0869216836 0.585112209 0.86911366 18 12017614 12018285 672 + 0.573 0.668 0.416
ENSG00000141401 E025 0.4806895 0.1327202936 0.060288833   18 12021702 12021822 121 + 0.000 0.322 11.402
ENSG00000141401 E026 121.6898249 0.0003348580 0.398332155 0.77217571 18 12028043 12028151 109 + 2.065 2.100 0.117
ENSG00000141401 E027 36.4971842 0.0355749351 0.001684771 0.07283636 18 12028152 12028607 456 + 1.384 1.716 1.136
ENSG00000141401 E028 19.9435306 0.0415518932 0.214560571 0.61910958 18 12028608 12028841 234 + 1.229 1.388 0.553
ENSG00000141401 E029 192.6740958 0.0002997320 0.971198111 0.99327255 18 12028842 12028993 152 + 2.278 2.286 0.027
ENSG00000141401 E030 344.6274918 0.0026040458 0.144777278 0.53187509 18 12030343 12030877 535 + 2.514 2.561 0.158