ENSG00000140391

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000346495 ENSG00000140391 HEK293_DMSO_6hA HEK293_OSMI2_6hA TSPAN3 protein_coding protein_coding 323.1653 310.9981 223.1026 30.47523 8.344842 -0.4791799 72.54363 84.06533 54.30904 6.6446639 4.187050 -0.6302246 0.23065417 0.27146667 0.2442000 -0.02726667 0.71721095 0.02075337 FALSE TRUE
ENST00000558394 ENSG00000140391 HEK293_DMSO_6hA HEK293_OSMI2_6hA TSPAN3 protein_coding processed_transcript 323.1653 310.9981 223.1026 30.47523 8.344842 -0.4791799 32.51911 13.99692 24.17643 0.8823037 4.915608 0.7880580 0.09418333 0.04613333 0.1076333 0.06150000 0.02075337 0.02075337 FALSE FALSE
ENST00000561277 ENSG00000140391 HEK293_DMSO_6hA HEK293_OSMI2_6hA TSPAN3 protein_coding protein_coding 323.1653 310.9981 223.1026 30.47523 8.344842 -0.4791799 205.43603 203.42682 135.41238 23.4558106 6.034278 -0.5871147 0.63571667 0.65156667 0.6066333 -0.04493333 0.25700792 0.02075337   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000140391 E001 394.972349 5.919988e-03 0.0273353163 0.26838121 15 77041404 77046029 4626 - 2.636 2.542 -0.312
ENSG00000140391 E002 182.659155 1.903073e-03 0.4381306472 0.79667941 15 77046030 77046059 30 - 2.219 2.253 0.116
ENSG00000140391 E003 336.380105 4.377121e-03 0.3467512404 0.73667746 15 77046060 77046083 24 - 2.482 2.524 0.139
ENSG00000140391 E004 2519.807693 1.779670e-03 0.0082382469 0.15860030 15 77046084 77046331 248 - 3.349 3.403 0.179
ENSG00000140391 E005 5977.008524 2.163087e-04 0.0003303181 0.02822934 15 77046332 77046927 596 - 3.740 3.767 0.088
ENSG00000140391 E006 1647.319970 5.546283e-04 0.5063323384 0.83290359 15 77052385 77052468 84 - 3.202 3.195 -0.023
ENSG00000140391 E007 2175.775173 3.765347e-05 0.2177707413 0.62243862 15 77052777 77052929 153 - 3.317 3.314 -0.010
ENSG00000140391 E008 955.916533 9.248007e-05 0.5867466235 0.86990920 15 77054178 77054180 3 - 2.958 2.959 0.000
ENSG00000140391 E009 2055.381783 4.987351e-05 0.2064187834 0.61037563 15 77054181 77054279 99 - 3.293 3.289 -0.013
ENSG00000140391 E010 28.153986 9.408802e-02 0.0983432550 0.45429842 15 77054280 77055788 1509 - 1.234 1.536 1.048
ENSG00000140391 E011 1509.641092 2.288771e-04 0.3892997307 0.76653096 15 77055789 77055829 41 - 3.160 3.155 -0.016
ENSG00000140391 E012 1159.490527 2.789572e-04 0.4183657355 0.78535537 15 77055830 77055835 6 - 3.046 3.040 -0.019
ENSG00000140391 E013 1442.081294 3.234916e-04 0.6160581027 0.88256816 15 77055836 77055863 28 - 3.139 3.137 -0.005
ENSG00000140391 E014 6.852992 4.538093e-03 0.0905696583 0.43968499 15 77055864 77056063 200 - 0.727 0.949 0.865
ENSG00000140391 E015 2451.766721 3.385687e-04 0.0410270697 0.31750166 15 77056064 77056255 192 - 3.382 3.362 -0.067
ENSG00000140391 E016 4.989428 3.073236e-02 0.0306084694 0.28184328 15 77069867 77070058 192 - 0.945 0.634 -1.242
ENSG00000140391 E017 982.424011 2.086825e-03 0.0108336455 0.18013572 15 77070892 77071004 113 - 3.013 2.950 -0.208
ENSG00000140391 E018 460.097490 4.551520e-03 0.0018789092 0.07712464 15 77071005 77071122 118 - 2.714 2.599 -0.383
ENSG00000140391 E019 1.338485 3.483896e-02 0.3341571677   15 77083847 77083984 138 - 0.472 0.305 -0.949