ENSG00000140374

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267950 ENSG00000140374 HEK293_DMSO_6hA HEK293_OSMI2_6hA ETFA protein_coding nonsense_mediated_decay 115.0304 54.84509 47.09135 12.61887 5.752495 -0.219857 8.370865 3.3329162 5.143553 1.6868693 0.6431669 0.62446017 0.08057500 0.05203333 0.10946667 0.05743333 0.74796145 0.03686534   FALSE
ENST00000433983 ENSG00000140374 HEK293_DMSO_6hA HEK293_OSMI2_6hA ETFA protein_coding protein_coding 115.0304 54.84509 47.09135 12.61887 5.752495 -0.219857 22.804756 9.9737388 10.653874 1.7346047 3.1145622 0.09507953 0.20500833 0.19186667 0.22186667 0.03000000 0.87246392 0.03686534 FALSE TRUE
ENST00000559973 ENSG00000140374 HEK293_DMSO_6hA HEK293_OSMI2_6hA ETFA protein_coding processed_transcript 115.0304 54.84509 47.09135 12.61887 5.752495 -0.219857 38.228400 19.4946589 13.350666 4.5993674 3.7418567 -0.54582683 0.32253333 0.35316667 0.28230000 -0.07086667 0.71366608 0.03686534 FALSE FALSE
ENST00000560595 ENSG00000140374 HEK293_DMSO_6hA HEK293_OSMI2_6hA ETFA protein_coding protein_coding 115.0304 54.84509 47.09135 12.61887 5.752495 -0.219857 12.236201 5.9915274 5.075652 1.5292538 1.3322368 -0.23889698 0.10908750 0.10946667 0.10436667 -0.00510000 0.92318468 0.03686534 FALSE TRUE
ENST00000685548 ENSG00000140374 HEK293_DMSO_6hA HEK293_OSMI2_6hA ETFA protein_coding nonsense_mediated_decay 115.0304 54.84509 47.09135 12.61887 5.752495 -0.219857 18.846318 10.3988367 4.523450 2.1744020 1.1547248 -1.19912765 0.15851250 0.19120000 0.09563333 -0.09556667 0.03686534 0.03686534 TRUE TRUE
ENST00000688637 ENSG00000140374 HEK293_DMSO_6hA HEK293_OSMI2_6hA ETFA protein_coding processed_transcript 115.0304 54.84509 47.09135 12.61887 5.752495 -0.219857 8.247325 0.8036933 5.830829 0.8036933 0.4352162 2.84361618 0.06472083 0.01036667 0.12886667 0.11850000 0.19078243 0.03686534 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000140374 E001 4.8786347 0.0335234826 5.930053e-01 0.8726483 15 76188555 76188598 44 - 0.802 0.722 -0.321
ENSG00000140374 E002 5.7391102 0.1326448544 4.356967e-01 0.7948003 15 76205902 76206041 140 - 0.736 0.862 0.497
ENSG00000140374 E003 6.0488065 0.1853396123 6.956402e-01 0.9136346 15 76214525 76214697 173 - 0.808 0.861 0.203
ENSG00000140374 E004 0.6205184 0.0339737421 2.240805e-01   15 76215353 76215356 4 - 0.315 0.108 -1.912
ENSG00000140374 E005 0.6205184 0.0339737421 2.240805e-01   15 76215357 76215378 22 - 0.315 0.108 -1.912
ENSG00000140374 E006 6.5028413 0.0038093556 4.965064e-01 0.8275577 15 76215379 76215573 195 - 0.824 0.907 0.320
ENSG00000140374 E007 13.3568775 0.0172922457 9.335011e-02 0.4446783 15 76215574 76216083 510 - 1.039 1.219 0.646
ENSG00000140374 E008 3.5071221 0.0094080955 4.667340e-01 0.8122016 15 76216084 76216129 46 - 0.584 0.696 0.481
ENSG00000140374 E009 3.9329995 0.0515071086 5.412906e-01 0.8504719 15 76216130 76216249 120 - 0.622 0.740 0.494
ENSG00000140374 E010 4.4053757 0.0224080647 6.964844e-01 0.9137775 15 76216250 76216286 37 - 0.773 0.719 -0.221
ENSG00000140374 E011 5.0421301 0.0074381734 5.505847e-02 0.3585790 15 76216287 76216294 8 - 0.925 0.670 -1.010
ENSG00000140374 E012 6.6806604 0.0576553892 6.146387e-02 0.3754743 15 76216295 76216313 19 - 1.051 0.741 -1.182
ENSG00000140374 E013 6.5261998 0.0519261170 4.058884e-02 0.3161427 15 76216314 76216314 1 - 1.052 0.719 -1.277
ENSG00000140374 E014 277.8113302 0.0023244373 9.133818e-01 0.9792992 15 76216315 76216467 153 - 2.440 2.441 0.006
ENSG00000140374 E015 251.7951976 0.0001859237 2.962955e-01 0.6967279 15 76216468 76216482 15 - 2.385 2.407 0.073
ENSG00000140374 E016 273.8850767 0.0001683617 1.337612e-01 0.5158710 15 76216483 76216538 56 - 2.417 2.448 0.102
ENSG00000140374 E017 215.2007520 0.0001873321 3.776604e-02 0.3063604 15 76216539 76216558 20 - 2.301 2.351 0.164
ENSG00000140374 E018 254.2802868 0.0005583692 9.631670e-02 0.4504785 15 76216559 76216597 39 - 2.378 2.417 0.132
ENSG00000140374 E019 1.9628512 0.1650358059 1.051578e-01 0.4669844 15 76217586 76217677 92 - 0.232 0.583 2.002
ENSG00000140374 E020 186.6077907 0.0005733130 5.410569e-02 0.3561673 15 76225849 76225856 8 - 2.236 2.288 0.173
ENSG00000140374 E021 308.7148985 0.0001665496 8.242243e-01 0.9555089 15 76225857 76225904 48 - 2.485 2.488 0.010
ENSG00000140374 E022 215.2133396 0.0001967521 4.090650e-01 0.7797335 15 76225905 76225909 5 - 2.344 2.322 -0.072
ENSG00000140374 E023 256.7752653 0.0001538261 8.987091e-01 0.9758467 15 76225910 76225929 20 - 2.410 2.406 -0.015
ENSG00000140374 E024 15.7836524 0.0113201382 8.830013e-05 0.0126139 15 76225930 76227137 1208 - 0.944 1.347 1.445
ENSG00000140374 E025 2.5782452 0.0078520592 5.865447e-01 0.8697964 15 76227138 76227230 93 - 0.495 0.583 0.412
ENSG00000140374 E026 8.7311695 0.0068694097 4.393923e-01 0.7972938 15 76227231 76227712 482 - 0.927 1.015 0.327
ENSG00000140374 E027 2.4807095 0.0085156863 8.703605e-01 0.9682124 15 76227713 76227720 8 - 0.542 0.514 -0.132
ENSG00000140374 E028 7.6027068 0.0039147076 2.624924e-01 0.6676425 15 76227721 76227866 146 - 0.847 0.978 0.494
ENSG00000140374 E029 5.5068791 0.0676253362 1.544442e-01 0.5456852 15 76227867 76227897 31 - 0.658 0.891 0.932
ENSG00000140374 E030 3.8567603 0.0385700533 7.848407e-01 0.9437020 15 76227898 76227918 21 - 0.658 0.696 0.159
ENSG00000140374 E031 10.0767157 0.0026224824 2.519869e-01 0.6577657 15 76227919 76228249 331 - 0.962 1.081 0.437
ENSG00000140374 E032 0.1125166 0.0326514152 3.994890e-01   15 76230504 76230715 212 - 0.131 0.000 -9.999
ENSG00000140374 E033 0.0000000       15 76230716 76230730 15 -      
ENSG00000140374 E034 13.6221756 0.1194112287 2.763381e-01 0.6800627 15 76230731 76231332 602 - 1.049 1.222 0.621
ENSG00000140374 E035 345.4347929 0.0001204767 9.287282e-01 0.9830260 15 76231333 76231398 66 - 2.538 2.534 -0.010
ENSG00000140374 E036 1.3370818 0.0121989077 7.579531e-01   15 76243170 76243267 98 - 0.384 0.329 -0.325
ENSG00000140374 E037 0.3262289 0.0254413184 2.694459e-01   15 76245212 76245248 37 - 0.000 0.195 9.819
ENSG00000140374 E038 0.0000000       15 76274133 76274175 43 -      
ENSG00000140374 E039 0.4901314 0.1018390081 7.455545e-01   15 76274176 76274411 236 - 0.133 0.194 0.658
ENSG00000140374 E040 198.8040797 0.0001653059 8.973915e-01 0.9755038 15 76274412 76274418 7 - 2.299 2.295 -0.015
ENSG00000140374 E041 324.6578167 0.0001289705 3.219724e-01 0.7183594 15 76274419 76274494 76 - 2.521 2.500 -0.070
ENSG00000140374 E042 0.9523518 0.0150470054 1.529178e-01   15 76281936 76283756 1821 - 0.132 0.383 2.001
ENSG00000140374 E043 392.3287591 0.0060716571 7.307689e-01 0.9259605 15 76283757 76283825 69 - 2.597 2.584 -0.043
ENSG00000140374 E044 1.2220048 0.0353234501 3.414014e-01   15 76283826 76283841 16 - 0.442 0.268 -1.051
ENSG00000140374 E045 2.0240936 0.0107502298 8.476512e-01 0.9622622 15 76284365 76284460 96 - 0.443 0.475 0.160
ENSG00000140374 E046 2.9582146 0.0067904121 8.103740e-01 0.9515786 15 76284805 76284852 48 - 0.622 0.584 -0.169
ENSG00000140374 E047 5.0404028 0.0047568271 6.654208e-01 0.9025023 15 76284853 76284927 75 - 0.823 0.765 -0.233
ENSG00000140374 E048 460.1003988 0.0017575704 5.877283e-01 0.8703206 15 76285637 76285738 102 - 2.667 2.654 -0.042
ENSG00000140374 E049 324.1817852 0.0001267476 3.314807e-01 0.7256761 15 76286371 76286405 35 - 2.520 2.500 -0.068
ENSG00000140374 E050 374.1375352 0.0001796193 5.709569e-01 0.8626908 15 76286406 76286463 58 - 2.567 2.576 0.028
ENSG00000140374 E051 259.8372893 0.0002944754 4.179936e-01 0.7852338 15 76286464 76286481 18 - 2.404 2.420 0.053
ENSG00000140374 E052 2.0061377 0.0597161483 1.634387e-01 0.5583549 15 76286482 76287016 535 - 0.313 0.581 1.412
ENSG00000140374 E053 0.6233207 0.0193874923 8.266145e-01   15 76287768 76287845 78 - 0.233 0.195 -0.323
ENSG00000140374 E054 484.7426327 0.0001020756 7.404211e-01 0.9292147 15 76287846 76287945 100 - 2.686 2.679 -0.023
ENSG00000140374 E055 411.2498679 0.0001621821 2.647602e-01 0.6696862 15 76292431 76292513 83 - 2.624 2.602 -0.072
ENSG00000140374 E056 1.2556687 0.1387872555 8.018174e-01   15 76292514 76292618 105 - 0.316 0.380 0.389
ENSG00000140374 E057 364.5271320 0.0010239055 3.318331e-01 0.7259427 15 76292619 76292700 82 - 2.571 2.547 -0.083
ENSG00000140374 E058 0.0000000       15 76293012 76293133 122 -      
ENSG00000140374 E059 296.7138148 0.0012793792 2.824814e-01 0.6854005 15 76295591 76295737 147 - 2.486 2.458 -0.093
ENSG00000140374 E060 2.0903749 0.1126714803 9.469378e-01 0.9875584 15 76309932 76310062 131 - 0.498 0.474 -0.117
ENSG00000140374 E061 0.9668570 0.0151303165 5.781803e-01   15 76310063 76310064 2 - 0.233 0.329 0.678
ENSG00000140374 E062 179.8185940 0.0030812476 8.105347e-02 0.4197868 15 76311350 76311730 381 - 2.294 2.222 -0.239