ENSG00000140105

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000355338 ENSG00000140105 HEK293_DMSO_6hA HEK293_OSMI2_6hA WARS1 protein_coding protein_coding 93.53548 60.52483 69.73053 4.604375 11.92956 0.2042318 17.815066 9.8498672 15.551374 0.7949563 3.1202068 0.65832936 0.18942917 0.162733333 0.22063333 0.05790000 0.0315546 0.01544652 FALSE TRUE
ENST00000392882 ENSG00000140105 HEK293_DMSO_6hA HEK293_OSMI2_6hA WARS1 protein_coding protein_coding 93.53548 60.52483 69.73053 4.604375 11.92956 0.2042318 46.473661 37.7388665 40.023182 4.0372250 8.2161298 0.08476298 0.51579583 0.620800000 0.56646667 -0.05433333 0.6218537 0.01544652 FALSE TRUE
ENST00000557135 ENSG00000140105 HEK293_DMSO_6hA HEK293_OSMI2_6hA WARS1 protein_coding protein_coding 93.53548 60.52483 69.73053 4.604375 11.92956 0.2042318 6.511905 3.3374746 2.893152 0.1208750 0.2946770 -0.20545291 0.06399583 0.055933333 0.04436667 -0.01156667 0.7428753 0.01544652 FALSE TRUE
MSTRG.10185.16 ENSG00000140105 HEK293_DMSO_6hA HEK293_OSMI2_6hA WARS1 protein_coding   93.53548 60.52483 69.73053 4.604375 11.92956 0.2042318 8.387807 0.1127883 1.439463 0.1127883 0.7290639 3.56127334 0.08097500 0.001833333 0.02153333 0.01970000 0.5497633 0.01544652 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000140105 E001 16.7070717 0.0031602461 9.795599e-01 0.9951006176 14 100333790 100333801 12 - 1.240 1.238 -0.007
ENSG00000140105 E002 26.4066474 0.0065908669 4.707797e-01 0.8141919752 14 100333802 100333817 16 - 1.402 1.453 0.179
ENSG00000140105 E003 52.5908928 0.0005448722 1.661931e-01 0.5621465034 14 100333818 100333827 10 - 1.755 1.689 -0.222
ENSG00000140105 E004 254.4898027 0.0037316155 7.158376e-01 0.9206121652 14 100333828 100333930 103 - 2.397 2.414 0.057
ENSG00000140105 E005 1069.5354144 0.0004662392 3.864349e-01 0.7647323472 14 100333931 100334478 548 - 3.019 3.032 0.044
ENSG00000140105 E006 188.9703648 0.0093125677 9.743380e-01 0.9939424623 14 100334479 100334492 14 - 2.277 2.277 0.001
ENSG00000140105 E007 333.1741750 0.0059966574 8.437582e-01 0.9612272667 14 100334493 100334557 65 - 2.521 2.524 0.009
ENSG00000140105 E008 916.4078162 0.0005649131 3.592006e-01 0.7463054646 14 100334558 100334926 369 - 2.952 2.965 0.045
ENSG00000140105 E009 620.2335740 0.0001246797 5.301542e-01 0.8450404107 14 100334927 100335036 110 - 2.791 2.783 -0.026
ENSG00000140105 E010 3.0774318 0.0075890791 7.480775e-01 0.9320385200 14 100336841 100337061 221 - 0.642 0.595 -0.208
ENSG00000140105 E011 814.3304584 0.0001003801 9.789573e-01 0.9949122269 14 100337062 100337202 141 - 2.904 2.906 0.007
ENSG00000140105 E012 14.3379606 0.0364947573 4.588534e-01 0.8078985722 14 100342050 100342397 348 - 1.218 1.129 -0.317
ENSG00000140105 E013 798.5470950 0.0007182900 5.661371e-01 0.8604801282 14 100342398 100342571 174 - 2.892 2.904 0.040
ENSG00000140105 E014 587.1241082 0.0001327579 1.152719e-01 0.4850246538 14 100343275 100343387 113 - 2.750 2.776 0.085
ENSG00000140105 E015 364.3384407 0.0002331171 3.611803e-01 0.7475856214 14 100346746 100346768 23 - 2.547 2.567 0.066
ENSG00000140105 E016 300.4416774 0.0001659508 7.973114e-01 0.9474273385 14 100346769 100346777 9 - 2.471 2.478 0.023
ENSG00000140105 E017 510.7963803 0.0001031050 5.577328e-01 0.8571867192 14 100346778 100346846 69 - 2.697 2.708 0.036
ENSG00000140105 E018 0.9881285 0.1163216191 1.097575e-01   14 100352883 100353120 238 - 0.118 0.418 2.379
ENSG00000140105 E019 545.7810467 0.0001090434 9.822475e-01 0.9957254181 14 100353687 100353773 87 - 2.729 2.731 0.004
ENSG00000140105 E020 439.2604348 0.0017757605 9.773811e-01 0.9946819165 14 100353774 100353825 52 - 2.639 2.637 -0.009
ENSG00000140105 E021 261.6847637 0.0052768308 9.581534e-01 0.9904925305 14 100353826 100353827 2 - 2.418 2.411 -0.026
ENSG00000140105 E022 368.8575509 0.0048726165 6.809537e-01 0.9085010182 14 100353828 100353869 42 - 2.576 2.552 -0.079
ENSG00000140105 E023 13.4993812 0.1637896322 7.948588e-02 0.4165959021 14 100353870 100354192 323 - 0.947 1.293 1.248
ENSG00000140105 E024 6.6016203 0.0552532165 4.070237e-02 0.3165158054 14 100354193 100354301 109 - 0.678 1.004 1.274
ENSG00000140105 E025 6.7345677 0.1347041202 9.397569e-02 0.4460534315 14 100354302 100354400 99 - 0.692 1.003 1.210
ENSG00000140105 E026 4.2564466 0.0373892405 9.537717e-02 0.4489377827 14 100354401 100354444 44 - 0.544 0.816 1.151
ENSG00000140105 E027 3.9239894 0.0132074417 4.875473e-01 0.8231738171 14 100354445 100354446 2 - 0.613 0.719 0.448
ENSG00000140105 E028 422.8356393 0.0015764378 4.731001e-01 0.8155503452 14 100354447 100354530 84 - 2.631 2.611 -0.067
ENSG00000140105 E029 231.5095646 0.0001572890 6.068527e-01 0.8783859758 14 100354531 100354538 8 - 2.364 2.353 -0.035
ENSG00000140105 E030 268.1154979 0.0004396902 5.799627e-01 0.8668188019 14 100354539 100354559 21 - 2.427 2.415 -0.039
ENSG00000140105 E031 223.3498819 0.0001775769 7.627835e-01 0.9367719904 14 100354560 100354566 7 - 2.345 2.340 -0.018
ENSG00000140105 E032 0.1767706 0.0370614432 5.059608e-01   14 100360524 100360553 30 - 0.117 0.000 -11.142
ENSG00000140105 E033 320.5882268 0.0001152320 5.176478e-01 0.8389201159 14 100360554 100360602 49 - 2.493 2.508 0.048
ENSG00000140105 E034 242.7579502 0.0001582567 4.342088e-01 0.7939765667 14 100360603 100360631 29 - 2.370 2.389 0.065
ENSG00000140105 E035 189.2431526 0.0003970935 2.421350e-01 0.6471891626 14 100360632 100360641 10 - 2.258 2.290 0.107
ENSG00000140105 E036 177.0448968 0.0002415211 3.769039e-01 0.7579748698 14 100360642 100360653 12 - 2.232 2.257 0.083
ENSG00000140105 E037 160.7202251 0.0002071836 3.966726e-01 0.7708979846 14 100360654 100360662 9 - 2.189 2.215 0.084
ENSG00000140105 E038 0.1767706 0.0370614432 5.059608e-01   14 100361703 100361707 5 - 0.117 0.000 -11.142
ENSG00000140105 E039 233.1161639 0.0011901817 3.599329e-01 0.7468075347 14 100361708 100361729 22 - 2.354 2.378 0.081
ENSG00000140105 E040 271.6523117 0.0034637343 8.861280e-01 0.9727778580 14 100361730 100361762 33 - 2.432 2.433 0.003
ENSG00000140105 E041 283.0236494 0.0019067772 8.525958e-01 0.9635307523 14 100361763 100361801 39 - 2.454 2.445 -0.032
ENSG00000140105 E042 206.9855586 0.0013617746 7.879041e-01 0.9445143728 14 100361802 100361806 5 - 2.317 2.307 -0.034
ENSG00000140105 E043 196.5565255 0.0002890700 6.053682e-01 0.8778075055 14 100361807 100361809 3 - 2.295 2.282 -0.041
ENSG00000140105 E044 219.3514708 0.0002784908 8.529586e-01 0.9635632723 14 100361810 100361816 7 - 2.338 2.335 -0.012
ENSG00000140105 E045 243.1223340 0.0001600455 8.149365e-01 0.9529872900 14 100361817 100361830 14 - 2.384 2.380 -0.013
ENSG00000140105 E046 246.9593838 0.0001577585 9.559845e-01 0.9898982280 14 100361831 100361844 14 - 2.388 2.390 0.009
ENSG00000140105 E047 213.4452532 0.0009336611 9.252997e-01 0.9822711914 14 100361845 100361846 2 - 2.330 2.327 -0.010
ENSG00000140105 E048 227.3103768 0.0015231368 5.992162e-01 0.8752552578 14 100361847 100361855 9 - 2.365 2.348 -0.056
ENSG00000140105 E049 316.6728195 0.0019750107 6.884180e-01 0.9113362660 14 100361856 100361902 47 - 2.507 2.493 -0.047
ENSG00000140105 E050 249.8956669 0.0018332468 3.129199e-01 0.7104713953 14 100361903 100361921 19 - 2.413 2.381 -0.109
ENSG00000140105 E051 1.9769743 0.2117656833 2.170164e-01 0.6217092558 14 100361922 100361946 25 - 0.335 0.596 1.339
ENSG00000140105 E052 2.5954262 0.0107831987 3.737757e-01 0.7556993095 14 100365475 100365576 102 - 0.612 0.470 -0.661
ENSG00000140105 E053 0.8927319 0.2217838905 3.958253e-02   14 100365954 100366067 114 - 0.420 0.000 -12.475
ENSG00000140105 E054 0.3563434 0.0286586389 9.752841e-01   14 100368374 100368441 68 - 0.117 0.123 0.077
ENSG00000140105 E055 0.3563434 0.0286586389 9.752841e-01   14 100368442 100368465 24 - 0.117 0.123 0.077
ENSG00000140105 E056 270.1927120 0.0001998733 1.455144e-01 0.5331265790 14 100369087 100369108 22 - 2.443 2.412 -0.102
ENSG00000140105 E057 438.8741961 0.0002167628 2.334563e-02 0.2516676622 14 100369109 100369258 150 - 2.657 2.618 -0.131
ENSG00000140105 E058 3.8008475 0.2991067893 6.520020e-01 0.8973767261 14 100370379 100370527 149 - 0.598 0.751 0.646
ENSG00000140105 E059 2.3872887 0.3124878621 3.138992e-01 0.7113484069 14 100373980 100374064 85 - 0.615 0.422 -0.925
ENSG00000140105 E060 21.7594016 0.0454241622 3.193243e-01 0.7161077681 14 100374136 100374149 14 - 1.408 1.281 -0.442
ENSG00000140105 E061 22.9986205 0.0597743817 4.470554e-01 0.8019518031 14 100374150 100374179 30 - 1.429 1.310 -0.414
ENSG00000140105 E062 23.2477824 0.0155621405 6.392898e-01 0.8920011920 14 100374180 100374220 41 - 1.397 1.360 -0.129
ENSG00000140105 E063 17.1023138 0.0015944404 6.091215e-01 0.8795913116 14 100374221 100374244 24 - 1.269 1.230 -0.140
ENSG00000140105 E064 5.4547394 0.1378933366 8.221974e-01 0.9550030456 14 100374245 100374265 21 - 0.782 0.832 0.194
ENSG00000140105 E065 1.8038900 0.0105608469 1.126533e-01 0.4802819958 14 100374776 100374949 174 - 0.285 0.557 1.493
ENSG00000140105 E066 46.0543029 0.0012070515 6.407873e-01 0.8926232331 14 100375283 100375350 68 - 1.657 1.683 0.089
ENSG00000140105 E067 35.7603928 0.0261750911 4.740584e-01 0.8161964472 14 100375351 100375403 53 - 1.535 1.599 0.218
ENSG00000140105 E068 23.7435266 0.0290659107 4.819010e-01 0.8203553645 14 100375404 100375406 3 - 1.360 1.431 0.245
ENSG00000140105 E069 14.4756884 0.0446891372 5.809132e-01 0.8673285490 14 100375407 100375510 104 - 1.157 1.227 0.249
ENSG00000140105 E070 7.4288504 0.0839590886 7.281429e-01 0.9250642949 14 100375511 100375546 36 - 0.893 0.957 0.242
ENSG00000140105 E071 10.8510835 0.1152199297 4.657548e-01 0.8116240222 14 100375547 100376161 615 - 1.004 1.118 0.412
ENSG00000140105 E072 3.3612582 0.3094585854 7.478523e-01 0.9319846756 14 100376162 100376251 90 - 0.663 0.597 -0.287
ENSG00000140105 E073 238.2735111 0.0001744321 8.706761e-07 0.0005098193 14 100376260 100376805 546 - 2.428 2.314 -0.378