ENSG00000139746

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000267229 ENSG00000139746 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBM26 protein_coding protein_coding 34.38694 12.32949 23.16919 3.044797 6.146342 0.909548 7.3105526 1.5254376 7.0870105 0.009029197 2.3383254 2.2085616 0.20188750 0.13790000 0.29083333 0.152933333 7.333066e-02 4.996702e-08 FALSE TRUE
ENST00000438724 ENSG00000139746 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBM26 protein_coding protein_coding 34.38694 12.32949 23.16919 3.044797 6.146342 0.909548 3.2178680 1.1150282 2.0772088 0.467238336 0.5048134 0.8916138 0.09276667 0.08343333 0.09286667 0.009433333 9.156796e-01 4.996702e-08 FALSE TRUE
ENST00000449987 ENSG00000139746 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBM26 protein_coding protein_coding 34.38694 12.32949 23.16919 3.044797 6.146342 0.909548 3.9930070 4.9015288 4.4860951 1.337943102 0.9409927 -0.1274996 0.17932917 0.39250000 0.20286667 -0.189633333 2.403416e-04 4.996702e-08 FALSE TRUE
MSTRG.8946.1 ENSG00000139746 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBM26 protein_coding   34.38694 12.32949 23.16919 3.044797 6.146342 0.909548 4.1781336 0.0000000 0.0000000 0.000000000 0.0000000 0.0000000 0.08060833 0.00000000 0.00000000 0.000000000   4.996702e-08 FALSE TRUE
MSTRG.8946.20 ENSG00000139746 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBM26 protein_coding   34.38694 12.32949 23.16919 3.044797 6.146342 0.909548 0.9905046 0.1695377 2.1853862 0.169537663 0.6655260 3.6121163 0.02847917 0.01986667 0.09810000 0.078233333 2.285456e-01 4.996702e-08 FALSE TRUE
MSTRG.8946.21 ENSG00000139746 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBM26 protein_coding   34.38694 12.32949 23.16919 3.044797 6.146342 0.909548 0.8359596 0.8737822 0.3309458 0.211555005 0.3309458 -1.3741485 0.03361250 0.07106667 0.01036667 -0.060700000 2.064522e-01 4.996702e-08 TRUE TRUE
MSTRG.8946.22 ENSG00000139746 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBM26 protein_coding   34.38694 12.32949 23.16919 3.044797 6.146342 0.909548 2.8545579 1.2799234 1.5981248 0.377047002 0.5053436 0.3180939 0.08995833 0.10386667 0.06853333 -0.035333333 6.187892e-01 4.996702e-08 TRUE TRUE
MSTRG.8946.3 ENSG00000139746 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBM26 protein_coding   34.38694 12.32949 23.16919 3.044797 6.146342 0.909548 2.5557117 0.2441441 0.5752359 0.244144093 0.3474158 1.2033715 0.05317083 0.01330000 0.02800000 0.014700000 7.462956e-01 4.996702e-08 TRUE TRUE
MSTRG.8946.32 ENSG00000139746 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBM26 protein_coding   34.38694 12.32949 23.16919 3.044797 6.146342 0.909548 1.3906941 0.0000000 1.3461575 0.000000000 0.4090983 7.0833810 0.03340417 0.00000000 0.06030000 0.060300000 4.996702e-08 4.996702e-08 TRUE TRUE
MSTRG.8946.37 ENSG00000139746 HEK293_DMSO_6hA HEK293_OSMI2_6hA RBM26 protein_coding   34.38694 12.32949 23.16919 3.044797 6.146342 0.909548 2.6710450 0.5765733 1.1278363 0.245759758 0.3326102 0.9559096 0.06113750 0.04400000 0.05120000 0.007200000 8.756789e-01 4.996702e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000139746 E001 75.5643726 0.0004497393 2.488643e-15 4.123906e-11 13 79311824 79312197 374 - 1.725 2.049 1.088
ENSG00000139746 E002 82.2200638 0.0050381309 3.756962e-07 2.754701e-04 13 79312198 79312319 122 - 1.786 2.064 0.934
ENSG00000139746 E003 154.5361531 0.0046716270 2.174009e-10 8.187565e-07 13 79312320 79312799 480 - 2.047 2.341 0.984
ENSG00000139746 E004 85.2684628 0.0011508145 7.679560e-20 6.362861e-15 13 79312800 79313233 434 - 1.744 2.122 1.269
ENSG00000139746 E005 89.8361438 0.0115270780 2.073617e-06 9.959915e-04 13 79313234 79313606 373 - 1.796 2.119 1.084
ENSG00000139746 E006 51.5138171 0.0072615433 7.939691e-05 1.189856e-02 13 79313607 79313789 183 - 1.589 1.859 0.914
ENSG00000139746 E007 72.4090763 0.0044743807 4.295104e-05 8.060498e-03 13 79313790 79314177 388 - 1.757 1.987 0.775
ENSG00000139746 E008 63.7641366 0.0138613286 1.417825e-02 2.039276e-01 13 79314178 79314551 374 - 1.711 1.913 0.683
ENSG00000139746 E009 20.8470913 0.0335826904 4.714155e-01 8.145067e-01 13 79314552 79314552 1 - 1.280 1.388 0.378
ENSG00000139746 E010 29.3643095 0.0295902515 1.945791e-01 5.972811e-01 13 79314553 79314606 54 - 1.400 1.559 0.548
ENSG00000139746 E011 22.9679062 0.0020532570 6.495910e-04 4.249628e-02 13 79314607 79314613 7 - 1.253 1.508 0.882
ENSG00000139746 E012 63.0656606 0.0030627388 2.261810e-06 1.052815e-03 13 79314614 79314735 122 - 1.687 1.937 0.841
ENSG00000139746 E013 31.1707921 0.0024979686 1.524472e-04 1.736156e-02 13 79314736 79314737 2 - 1.401 1.647 0.844
ENSG00000139746 E014 103.7950829 0.0002874965 1.126377e-06 6.201025e-04 13 79314738 79314990 253 - 1.946 2.117 0.572
ENSG00000139746 E015 28.0805169 0.0151622327 2.133283e-02 2.420571e-01 13 79314991 79314993 3 - 1.366 1.586 0.758
ENSG00000139746 E016 26.8928090 0.0011302721 1.853992e-03 7.667163e-02 13 79318821 79318867 47 - 1.351 1.561 0.724
ENSG00000139746 E017 16.4857203 0.0015632149 1.551926e-02 2.119400e-01 13 79318868 79318876 9 - 1.149 1.352 0.715
ENSG00000139746 E018 13.9665392 0.0019541434 3.607689e-01 7.472122e-01 13 79318877 79318879 3 - 1.134 1.220 0.305
ENSG00000139746 E019 35.9947529 0.0173927903 8.276570e-03 1.588122e-01 13 79318880 79319534 655 - 1.443 1.689 0.839
ENSG00000139746 E020 96.2267971 0.0003309367 1.357361e-02 2.004160e-01 13 79319535 79319953 419 - 1.950 2.042 0.310
ENSG00000139746 E021 258.0203193 0.0083721568 8.420979e-01 9.609122e-01 13 79319954 79320710 757 - 2.407 2.400 -0.022
ENSG00000139746 E022 23.8765771 0.0409145458 6.818716e-01 9.088118e-01 13 79321234 79321301 68 - 1.350 1.444 0.324
ENSG00000139746 E023 14.7610671 0.0022371176 1.044487e-01 4.657719e-01 13 79322208 79322348 141 - 1.134 1.281 0.522
ENSG00000139746 E024 167.9883871 0.0022669321 6.571863e-02 3.861991e-01 13 79322349 79322462 114 - 2.250 2.190 -0.200
ENSG00000139746 E025 132.1267177 0.0003879854 5.806238e-01 8.671810e-01 13 79334344 79334430 87 - 2.132 2.118 -0.046
ENSG00000139746 E026 0.6903769 0.0605520406 1.377110e-01   13 79334431 79334488 58 - 0.093 0.355 2.403
ENSG00000139746 E027 1.2057716 0.0132806827 9.365289e-01   13 79336456 79336535 80 - 0.340 0.355 0.088
ENSG00000139746 E028 188.9340045 0.0002290026 1.536000e-01 5.442965e-01 13 79337102 79337302 201 - 2.291 2.257 -0.112
ENSG00000139746 E029 136.0886632 0.0002527605 4.445925e-02 3.281939e-01 13 79341123 79341227 105 - 2.162 2.104 -0.196
ENSG00000139746 E030 159.5776287 0.0016196567 1.560484e-03 6.958728e-02 13 79342664 79342831 168 - 2.242 2.139 -0.345
ENSG00000139746 E031 112.5249396 0.0017941269 1.882922e-03 7.715555e-02 13 79344248 79344322 75 - 2.102 1.981 -0.405
ENSG00000139746 E032 137.9461893 0.0011704203 3.419365e-05 6.884806e-03 13 79344669 79344794 126 - 2.195 2.055 -0.471
ENSG00000139746 E033 13.7111782 0.0361237823 5.222935e-01 8.411956e-01 13 79353153 79353224 72 - 1.185 1.118 -0.238
ENSG00000139746 E034 121.9505493 0.0017935841 1.731566e-05 4.462994e-03 13 79354439 79354561 123 - 2.149 1.983 -0.558
ENSG00000139746 E035 42.6328361 0.0071663623 5.590603e-03 1.331603e-01 13 79354562 79354570 9 - 1.698 1.508 -0.646
ENSG00000139746 E036 124.1921726 0.0022942799 4.891578e-03 1.254793e-01 13 79355220 79355384 165 - 2.138 2.026 -0.374
ENSG00000139746 E037 106.3078200 0.0033313683 1.395347e-02 2.026126e-01 13 79358274 79358433 160 - 2.069 1.961 -0.361
ENSG00000139746 E038 102.1174558 0.0153337802 3.025967e-02 2.805987e-01 13 79359575 79359686 112 - 2.055 1.921 -0.452
ENSG00000139746 E039 120.1457757 0.0004353187 2.514458e-03 8.975231e-02 13 79365578 79365718 141 - 2.121 2.023 -0.327
ENSG00000139746 E040 7.9235637 0.0036715398 6.707416e-01 9.044651e-01 13 79365719 79365733 15 - 0.959 0.912 -0.176
ENSG00000139746 E041 0.2937266 0.0274424043 4.060819e-01   13 79365760 79366054 295 - 0.169 0.000 -9.615
ENSG00000139746 E042 99.3787257 0.0005117549 2.735755e-03 9.375630e-02 13 79366055 79366195 141 - 2.044 1.935 -0.365
ENSG00000139746 E043 12.0946400 0.0022799450 3.619897e-01 7.482312e-01 13 79366196 79366225 30 - 1.149 1.062 -0.312
ENSG00000139746 E044 116.1433842 0.0058088732 1.692056e-01 5.662105e-01 13 79366633 79366872 240 - 2.095 2.022 -0.244
ENSG00000139746 E045 140.0635240 0.0002623664 2.139692e-05 5.122607e-03 13 79368730 79368990 261 - 2.196 2.068 -0.430
ENSG00000139746 E046 134.0688982 0.0002608235 2.666490e-07 2.165988e-04 13 79370945 79371159 215 - 2.186 2.025 -0.539
ENSG00000139746 E047 43.5821839 0.0026281104 4.375830e-02 3.259088e-01 13 79371160 79371162 3 - 1.686 1.571 -0.391
ENSG00000139746 E048 79.1042934 0.0108115666 3.904404e-02 3.107737e-01 13 79371842 79371930 89 - 1.943 1.815 -0.433
ENSG00000139746 E049 0.8106075 0.1363026776 4.645345e-01   13 79376217 79377378 1162 - 0.294 0.152 -1.205
ENSG00000139746 E050 76.7533479 0.0076978423 7.594648e-02 4.089421e-01 13 79377379 79377515 137 - 1.926 1.820 -0.356
ENSG00000139746 E051 70.2197179 0.0004129704 1.031768e-04 1.381044e-02 13 79378789 79378907 119 - 1.913 1.746 -0.562
ENSG00000139746 E052 42.2822515 0.0006713330 1.356361e-04 1.622824e-02 13 79405704 79405741 38 - 1.709 1.496 -0.726
ENSG00000139746 E053 57.3328880 0.0005659435 7.219022e-06 2.436368e-03 13 79405742 79406061 320 - 1.839 1.622 -0.735
ENSG00000139746 E054 46.7492388 0.0328824246 4.260421e-02 3.223110e-01 13 79406062 79406477 416 - 1.736 1.555 -0.615