ENSG00000139651

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000416904 ENSG00000139651 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF740 protein_coding protein_coding 26.99933 33.13854 28.16698 0.3634597 2.887066 -0.2344283 4.881603 5.660845 5.038192 0.09746447 0.5123137 -0.16779693 0.18275000 0.17080000 0.17916667 0.008366667 0.86269771 0.01808087 FALSE TRUE
ENST00000549739 ENSG00000139651 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF740 protein_coding retained_intron 26.99933 33.13854 28.16698 0.3634597 2.887066 -0.2344283 1.962555 4.440919 1.564185 0.80863243 0.8161099 -1.49949806 0.06947917 0.13456667 0.05466667 -0.079900000 0.30931444 0.01808087 FALSE FALSE
ENST00000551514 ENSG00000139651 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF740 protein_coding processed_transcript 26.99933 33.13854 28.16698 0.3634597 2.887066 -0.2344283 3.893592 7.328315 4.824185 0.42956428 1.4101758 -0.60217607 0.13260417 0.22093333 0.16620000 -0.054733333 0.60734770 0.01808087   FALSE
ENST00000552593 ENSG00000139651 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF740 protein_coding retained_intron 26.99933 33.13854 28.16698 0.3634597 2.887066 -0.2344283 5.112393 4.659996 5.146119 0.45383622 0.7298394 0.14286432 0.19370833 0.14056667 0.18103333 0.040466667 0.44597349 0.01808087 FALSE FALSE
MSTRG.7349.4 ENSG00000139651 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF740 protein_coding   26.99933 33.13854 28.16698 0.3634597 2.887066 -0.2344283 7.696522 6.916341 9.102307 0.59453968 0.4941240 0.39572299 0.28929583 0.20836667 0.32683333 0.118466667 0.01808087 0.01808087 TRUE TRUE
MSTRG.7349.6 ENSG00000139651 HEK293_DMSO_6hA HEK293_OSMI2_6hA ZNF740 protein_coding   26.99933 33.13854 28.16698 0.3634597 2.887066 -0.2344283 3.031083 2.472751 2.431093 0.46546314 0.2437850 -0.02441244 0.11756667 0.07463333 0.08983333 0.015200000 0.79624455 0.01808087 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000139651 E001 0.000000       12 53178891 53179062 172 +      
ENSG00000139651 E002 3.753213 0.0350459723 0.4337707502 0.79378615 12 53179063 53180703 1641 + 0.738 0.624 -0.476
ENSG00000139651 E003 7.461333 0.0488514160 0.1188376677 0.49148733 12 53180704 53180717 14 + 1.035 0.796 -0.905
ENSG00000139651 E004 9.715048 0.0476001259 0.2142129466 0.61866276 12 53180718 53180721 4 + 1.113 0.933 -0.660
ENSG00000139651 E005 10.696410 0.0752718634 0.2772445873 0.68076228 12 53180722 53180726 5 + 1.150 0.975 -0.635
ENSG00000139651 E006 17.778643 0.0123307516 0.0451303016 0.33032231 12 53180727 53180738 12 + 1.355 1.169 -0.654
ENSG00000139651 E007 47.778528 0.0029740486 0.0009120975 0.05118438 12 53180739 53180795 57 + 1.765 1.588 -0.600
ENSG00000139651 E008 61.437271 0.0081619733 0.0565331149 0.36245365 12 53180796 53180837 42 + 1.844 1.738 -0.357
ENSG00000139651 E009 100.632944 0.0002792905 0.0851796256 0.42842588 12 53181677 53181733 57 + 2.018 1.969 -0.166
ENSG00000139651 E010 91.229623 0.0003419012 0.0425865799 0.32225856 12 53181734 53181754 21 + 1.983 1.918 -0.216
ENSG00000139651 E011 165.517975 0.0002508687 0.0057323998 0.13504553 12 53181755 53181858 104 + 2.243 2.178 -0.216
ENSG00000139651 E012 209.488276 0.0002753597 0.0083235481 0.15917471 12 53181859 53181992 134 + 2.339 2.284 -0.181
ENSG00000139651 E013 42.383494 0.0007374961 0.7795648917 0.94220429 12 53181993 53182190 198 + 1.605 1.631 0.090
ENSG00000139651 E014 209.965383 0.0017670912 0.2423660552 0.64733949 12 53184891 53185040 150 + 2.327 2.299 -0.093
ENSG00000139651 E015 3.860359 0.0058617164 0.8640325917 0.96693568 12 53185385 53185386 2 + 0.648 0.681 0.142
ENSG00000139651 E016 179.777687 0.0009207255 0.5337960849 0.84703224 12 53185387 53185476 90 + 2.227 2.256 0.097
ENSG00000139651 E017 169.829413 0.0002413706 0.0646379851 0.38334690 12 53185954 53186077 124 + 2.182 2.245 0.210
ENSG00000139651 E018 193.475658 0.0003942240 0.5308693694 0.84544918 12 53186391 53186509 119 + 2.261 2.288 0.093
ENSG00000139651 E019 38.237470 0.1164146036 0.0498545253 0.34389574 12 53186510 53186794 285 + 1.432 1.676 0.836
ENSG00000139651 E020 197.838536 0.0030323849 0.1138120830 0.48212297 12 53187501 53187606 106 + 2.318 2.265 -0.179
ENSG00000139651 E021 235.033616 0.0002390172 0.0266017580 0.26513597 12 53187607 53187763 157 + 2.382 2.341 -0.137
ENSG00000139651 E022 740.276273 0.0001041340 0.6137171327 0.88168078 12 53187764 53188536 773 + 2.845 2.862 0.057
ENSG00000139651 E023 283.011229 0.0001441504 0.1776992938 0.57642661 12 53188537 53188664 128 + 2.414 2.454 0.133
ENSG00000139651 E024 1737.483661 0.0010564139 0.0590969630 0.36925073 12 53188665 53190988 2324 + 3.216 3.243 0.090
ENSG00000139651 E025 12.022851 0.1009941042 0.1231045962 0.49905419 12 53190989 53191936 948 + 0.948 1.198 0.907
ENSG00000139651 E026 24.181312 0.0418238516 0.0004597692 0.03436531 12 53191937 53194262 2326 + 1.101 1.528 1.495
ENSG00000139651 E027 12.207069 0.0201134681 0.0072249906 0.14963208 12 53194263 53195142 880 + 0.901 1.217 1.153