ENSG00000139219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380518 ENSG00000139219 HEK293_DMSO_6hA HEK293_OSMI2_6hA COL2A1 protein_coding protein_coding 11.52659 12.56719 15.26427 1.505067 0.5061852 0.2802943 10.6952660 11.09409 14.29763 1.403119 0.6688852 0.3656932 0.932462500 0.88110000 0.9358 0.05470000 0.172135618 0.002200897 TRUE  
ENST00000493991 ENSG00000139219 HEK293_DMSO_6hA HEK293_OSMI2_6hA COL2A1 protein_coding processed_transcript 11.52659 12.56719 15.26427 1.505067 0.5061852 0.2802943 0.1018807 0.57796 0.00000 0.220065 0.0000000 -5.8776461 0.008641667 0.05036667 0.0000 -0.05036667 0.002200897 0.002200897 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000139219 E001 90.3354241 0.0005341517 0.700078530 0.91507314 12 47972967 47973200 234 - 1.948 1.963 0.050
ENSG00000139219 E002 233.5647505 0.0008177803 0.140588236 0.52612914 12 47973201 47973406 206 - 2.347 2.385 0.126
ENSG00000139219 E003 213.5484421 0.0014228671 0.975594759 0.99424417 12 47973407 47973553 147 - 2.326 2.324 -0.005
ENSG00000139219 E004 248.8868249 0.0001556102 0.234197816 0.63910104 12 47974089 47974331 243 - 2.378 2.405 0.088
ENSG00000139219 E005 206.4903802 0.0001668584 0.021643270 0.24365416 12 47974675 47974862 188 - 2.284 2.340 0.186
ENSG00000139219 E006 93.4827569 0.0003404370 0.078861993 0.41511203 12 47975317 47975352 36 - 1.939 2.003 0.213
ENSG00000139219 E007 198.4355026 0.0001952880 0.552789759 0.85509611 12 47975353 47975605 253 - 2.288 2.303 0.048
ENSG00000139219 E008 123.5314113 0.0003149626 0.880865838 0.97144229 12 47975963 47976070 108 - 2.089 2.094 0.016
ENSG00000139219 E009 76.9300680 0.0043623954 0.845430311 0.96172718 12 47976514 47976567 54 - 1.880 1.897 0.056
ENSG00000139219 E010 126.9836287 0.0009217435 0.087269944 0.43262677 12 47976812 47976919 108 - 2.074 2.133 0.198
ENSG00000139219 E011 105.4273820 0.0002879736 0.327566790 0.72282011 12 47977102 47977155 54 - 2.005 2.038 0.112
ENSG00000139219 E012 142.6089294 0.0002104910 0.620543833 0.88437166 12 47977320 47977427 108 - 2.145 2.159 0.048
ENSG00000139219 E013 0.2920894 0.0273345606 0.911220903   12 47977428 47977445 18 - 0.112 0.128 0.217
ENSG00000139219 E014 104.7373647 0.0003010732 0.850214679 0.96311192 12 47977600 47977653 54 - 2.021 2.015 -0.022
ENSG00000139219 E015 119.2120489 0.0002969483 0.472697705 0.81538817 12 47978010 47978117 108 - 2.086 2.062 -0.079
ENSG00000139219 E016 125.2004181 0.0002475205 0.493225272 0.82597819 12 47978291 47978398 108 - 2.083 2.105 0.072
ENSG00000139219 E017 136.1926878 0.0002642875 0.559375590 0.85775967 12 47978597 47978758 162 - 2.122 2.140 0.059
ENSG00000139219 E018 69.2365472 0.0005535511 0.025484536 0.26033015 12 47979511 47979564 54 - 1.882 1.786 -0.323
ENSG00000139219 E019 70.5163653 0.0009777256 0.242276797 0.64733063 12 47980009 47980062 54 - 1.872 1.821 -0.171
ENSG00000139219 E020 98.7992384 0.0023716410 0.302276452 0.70160281 12 47980554 47980661 108 - 2.016 1.973 -0.142
ENSG00000139219 E021 82.2928917 0.0004089446 0.725807307 0.92428594 12 47980915 47980968 54 - 1.922 1.908 -0.046
ENSG00000139219 E022 81.8076285 0.0005378841 0.383641821 0.76271154 12 47981343 47981396 54 - 1.892 1.926 0.114
ENSG00000139219 E023 89.9458893 0.0004115859 0.530144200 0.84503600 12 47981776 47981829 54 - 1.940 1.963 0.078
ENSG00000139219 E024 0.6775699 0.0187056864 0.026595500   12 47981945 47982106 162 - 0.000 0.374 12.778
ENSG00000139219 E025 95.1135208 0.0004895997 0.930826416 0.98343516 12 47982107 47982160 54 - 1.979 1.976 -0.011
ENSG00000139219 E026 115.0648787 0.0025501072 0.669112396 0.90384226 12 47982502 47982609 108 - 2.065 2.052 -0.042
ENSG00000139219 E027 106.6316354 0.0003130824 0.481224218 0.81988144 12 47982848 47982946 99 - 2.039 2.015 -0.081
ENSG00000139219 E028 63.5571584 0.0009974746 0.272176817 0.67610290 12 47983093 47983137 45 - 1.835 1.784 -0.173
ENSG00000139219 E029 61.2970048 0.0008048464 0.186388310 0.58716818 12 47983385 47983438 54 - 1.822 1.761 -0.204
ENSG00000139219 E030 70.5344334 0.0004864695 0.213463492 0.61799982 12 47983683 47983736 54 - 1.876 1.823 -0.179
ENSG00000139219 E031 0.1812101 0.0428457567 0.560761291   12 47983737 47983855 119 - 0.112 0.000 -10.525
ENSG00000139219 E032 82.4209768 0.0003775462 0.393617667 0.76916827 12 47984087 47984140 54 - 1.896 1.929 0.110
ENSG00000139219 E033 98.6052187 0.0003675385 0.949799447 0.98828936 12 47984546 47984599 54 - 1.992 1.989 -0.009
ENSG00000139219 E034 124.0637580 0.0002337719 0.645837552 0.89466583 12 47984995 47985093 99 - 2.083 2.098 0.048
ENSG00000139219 E035 100.7420397 0.0002979364 0.336478911 0.72924425 12 47985534 47985587 54 - 2.017 1.983 -0.115
ENSG00000139219 E036 109.3866112 0.0002948485 0.167075370 0.56333854 12 47985728 47985826 99 - 2.057 2.010 -0.158
ENSG00000139219 E037 68.0493413 0.0005021143 0.446556072 0.80163941 12 47985912 47985965 54 - 1.845 1.812 -0.112
ENSG00000139219 E038 93.0230527 0.0003286575 0.054197717 0.35638774 12 47986336 47986443 108 - 1.999 1.928 -0.239
ENSG00000139219 E039 86.1024169 0.0003664747 0.477169453 0.81784050 12 47986835 47986888 54 - 1.948 1.920 -0.093
ENSG00000139219 E040 95.8846622 0.0003366267 0.441014771 0.79829037 12 47987078 47987176 99 - 1.991 1.963 -0.095
ENSG00000139219 E041 75.5664077 0.0004091655 0.233226098 0.63814309 12 47987269 47987313 45 - 1.900 1.851 -0.163
ENSG00000139219 E042 81.5354405 0.0008664621 0.036243137 0.30134541 12 47987611 47987709 99 - 1.953 1.868 -0.285
ENSG00000139219 E043 0.0000000       12 47988426 47988471 46 -      
ENSG00000139219 E044 44.5578918 0.0018922662 0.003083821 0.09989402 12 47989228 47989281 54 - 1.732 1.567 -0.562
ENSG00000139219 E045 43.5776503 0.0180281216 0.026766985 0.26604669 12 47989761 47989805 45 - 1.731 1.550 -0.615
ENSG00000139219 E046 53.6232767 0.0033756900 0.030051977 0.27977627 12 47992878 47992931 54 - 1.786 1.668 -0.402
ENSG00000139219 E047 63.7462490 0.0040716826 0.888300535 0.97332209 12 47993458 47993502 45 - 1.812 1.804 -0.025
ENSG00000139219 E048 67.7513614 0.0054251303 0.891825910 0.97406155 12 47993809 47993862 54 - 1.840 1.830 -0.036
ENSG00000139219 E049 63.2279503 0.0005102989 0.788113272 0.94461294 12 47993994 47994047 54 - 1.798 1.810 0.038
ENSG00000139219 E050 85.8544599 0.0003838561 0.962970409 0.99149305 12 47994424 47994477 54 - 1.935 1.933 -0.007
ENSG00000139219 E051 76.8760541 0.0004911870 0.866043448 0.96724737 12 47995255 47995308 54 - 1.893 1.885 -0.025
ENSG00000139219 E052 67.1867200 0.0024051204 0.758401269 0.93536640 12 47995710 47995763 54 - 1.832 1.817 -0.048
ENSG00000139219 E053 61.7541852 0.0033656607 0.759700583 0.93579846 12 47995875 47995919 45 - 1.782 1.797 0.050
ENSG00000139219 E054 81.8498276 0.0004222437 0.903665506 0.97720710 12 47996548 47996625 78 - 1.911 1.915 0.016
ENSG00000139219 E055 51.5531601 0.0009150603 0.720499752 0.92240390 12 47997606 47997614 9 - 1.706 1.724 0.061
ENSG00000139219 E056 83.7283397 0.0046014223 0.310408592 0.70845668 12 47997615 47997707 93 - 1.904 1.950 0.153
ENSG00000139219 E057 76.1423758 0.0017624463 0.251671969 0.65762036 12 47997871 47997924 54 - 1.860 1.908 0.162
ENSG00000139219 E058 76.3945213 0.0004140963 0.388680066 0.76616175 12 47998032 47998064 33 - 1.864 1.899 0.115
ENSG00000139219 E059 79.0170320 0.0012162815 0.328142529 0.72309434 12 47998169 47998201 33 - 1.876 1.915 0.134
ENSG00000139219 E060 73.6822912 0.0075067374 0.373546325 0.75554976 12 47998415 47998431 17 - 1.845 1.891 0.152
ENSG00000139219 E061 4.0182853 0.0058216538 0.001266536 0.06211198 12 47998432 47998859 428 - 0.393 0.874 2.140
ENSG00000139219 E062 5.8860901 0.0062960141 0.367468891 0.75179207 12 47999697 47999918 222 - 0.758 0.874 0.456
ENSG00000139219 E063 121.5320391 0.0011270462 0.638487207 0.89161161 12 47999919 48000125 207 - 2.073 2.089 0.053
ENSG00000139219 E064 1.5026826 0.0886237006 0.878594164   12 48000985 48001094 110 - 0.397 0.374 -0.132
ENSG00000139219 E065 0.1795728 0.0329888748 0.424037334   12 48002622 48003041 420 - 0.000 0.128 10.779
ENSG00000139219 E066 77.0531625 0.0009594778 0.963648494 0.99169035 12 48004237 48004554 318 - 1.882 1.886 0.013