ENSG00000138640

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000264344 ENSG00000138640 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM13A protein_coding protein_coding 7.251212 2.667896 2.757096 0.8785381 0.4500971 0.04727265 1.86994806 1.20654946 1.01055967 0.40671012 0.29783373 -0.25343444 0.27978750 0.450000000 0.35656667 -0.093433333 0.74415291 0.01499257 FALSE TRUE
ENST00000395002 ENSG00000138640 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM13A protein_coding protein_coding 7.251212 2.667896 2.757096 0.8785381 0.4500971 0.04727265 0.26380029 0.00000000 0.47460758 0.00000000 0.28283755 5.59874507 0.07412083 0.000000000 0.15333333 0.153333333 0.01499257 0.01499257 FALSE TRUE
ENST00000502914 ENSG00000138640 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM13A protein_coding retained_intron 7.251212 2.667896 2.757096 0.8785381 0.4500971 0.04727265 0.12819558 0.37234196 0.03532685 0.08174118 0.03532685 -3.07642565 0.02880833 0.148733333 0.01900000 -0.129733333 0.10417208 0.01499257   FALSE
ENST00000509094 ENSG00000138640 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM13A protein_coding protein_coding 7.251212 2.667896 2.757096 0.8785381 0.4500971 0.04727265 0.67220238 0.12121684 0.20406505 0.01722723 0.06651566 0.70609635 0.08685000 0.050800000 0.07206667 0.021266667 0.76752217 0.01499257 FALSE TRUE
ENST00000511573 ENSG00000138640 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM13A protein_coding retained_intron 7.251212 2.667896 2.757096 0.8785381 0.4500971 0.04727265 0.09524786 0.37136971 0.11238585 0.22281201 0.06373137 -1.63975350 0.02418750 0.118833333 0.05150000 -0.067333333 0.63976076 0.01499257 FALSE TRUE
ENST00000515600 ENSG00000138640 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM13A protein_coding protein_coding 7.251212 2.667896 2.757096 0.8785381 0.4500971 0.04727265 1.12644656 0.24677789 0.25307381 0.08161388 0.08724448 0.03494665 0.15120417 0.093000000 0.08613333 -0.006866667 0.98870210 0.01499257 FALSE TRUE
MSTRG.25177.26 ENSG00000138640 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM13A protein_coding   7.251212 2.667896 2.757096 0.8785381 0.4500971 0.04727265 1.39232284 0.03647063 0.14835255 0.03647063 0.14835255 1.76874894 0.15475417 0.008266667 0.04700000 0.038733333 0.93882929 0.01499257 FALSE TRUE
MSTRG.25177.3 ENSG00000138640 HEK293_DMSO_6hA HEK293_OSMI2_6hA FAM13A protein_coding   7.251212 2.667896 2.757096 0.8785381 0.4500971 0.04727265 0.93392152 0.04637876 0.16448243 0.04637876 0.09072965 1.62985801 0.09648750 0.028933333 0.07460000 0.045666667 0.74803424 0.01499257 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000138640 E001 0.0000000       4 88725955 88725959 5 -      
ENSG00000138640 E002 43.1440576 0.0026042447 0.0721564450 0.40018747 4 88725960 88727068 1109 - 1.597 1.693 0.327
ENSG00000138640 E003 38.9546722 0.0053268778 0.2707466950 0.67493816 4 88727069 88727425 357 - 1.563 1.636 0.248
ENSG00000138640 E004 10.4069621 0.0025403364 0.9141007163 0.97942057 4 88727426 88727428 3 - 1.053 1.064 0.039
ENSG00000138640 E005 31.3914432 0.0011430849 0.4560762747 0.80671160 4 88727429 88727654 226 - 1.492 1.537 0.156
ENSG00000138640 E006 50.6319516 0.0008865159 0.1437055158 0.53059932 4 88727655 88728178 524 - 1.681 1.750 0.234
ENSG00000138640 E007 16.4364782 0.0420886458 0.9426779528 0.98659984 4 88728179 88728305 127 - 1.235 1.254 0.066
ENSG00000138640 E008 15.3111800 0.0303762415 0.9905316909 0.99765637 4 88728306 88728481 176 - 1.210 1.239 0.103
ENSG00000138640 E009 18.9424230 0.0016354306 0.7554875473 0.93448836 4 88728482 88728659 178 - 1.322 1.298 -0.083
ENSG00000138640 E010 6.5104314 0.0036739136 0.2218909995 0.62650086 4 88731327 88731328 2 - 0.948 0.799 -0.572
ENSG00000138640 E011 10.3460760 0.0024901527 0.4820928470 0.82044848 4 88731329 88731361 33 - 1.097 1.026 -0.261
ENSG00000138640 E012 11.6780117 0.0052928162 0.3187177311 0.71560507 4 88731362 88731397 36 - 1.164 1.064 -0.359
ENSG00000138640 E013 11.1151076 0.0187541136 0.8102279222 0.95154437 4 88731398 88731428 31 - 1.113 1.076 -0.135
ENSG00000138640 E014 0.1795728 0.0462142362 0.4483374486   4 88731429 88731832 404 - 0.000 0.124 10.323
ENSG00000138640 E015 0.1767706 0.0703534083 0.5365978358   4 88731833 88732001 169 - 0.115 0.000 -10.842
ENSG00000138640 E016 16.2286977 0.0039406317 0.5026071359 0.83107480 4 88732002 88732121 120 - 1.275 1.219 -0.199
ENSG00000138640 E017 13.5382822 0.0021238596 0.1408983038 0.52658195 4 88732122 88732198 77 - 1.232 1.100 -0.470
ENSG00000138640 E018 1.6628351 0.0130053772 0.1702348737 0.56730746 4 88732199 88732559 361 - 0.281 0.521 1.345
ENSG00000138640 E019 0.0000000       4 88736361 88736634 274 -      
ENSG00000138640 E020 7.0507097 0.0452799366 0.7218937851 0.92275223 4 88737472 88737555 84 - 0.951 0.898 -0.200
ENSG00000138640 E021 0.1544607 0.0309979230 0.4508537302   4 88737556 88737639 84 - 0.000 0.124 10.383
ENSG00000138640 E022 11.0426204 0.0038364165 0.2833721042 0.68620235 4 88739030 88739125 96 - 1.146 1.039 -0.388
ENSG00000138640 E023 10.0732856 0.0088735665 0.2206576616 0.62529859 4 88746932 88747015 84 - 1.116 0.983 -0.488
ENSG00000138640 E024 15.2187641 0.2007062279 0.7940855356 0.94620100 4 88747631 88747851 221 - 1.216 1.211 -0.020
ENSG00000138640 E025 11.5784527 0.0384094810 0.9426588460 0.98659984 4 88748952 88749033 82 - 1.104 1.109 0.019
ENSG00000138640 E026 14.2197624 0.0024432370 0.1505259601 0.54011100 4 88749771 88749909 139 - 1.118 1.244 0.449
ENSG00000138640 E027 7.7862727 0.0060561911 0.2251030282 0.63014873 4 88750424 88750445 22 - 0.868 1.011 0.539
ENSG00000138640 E028 15.9140789 0.0086011883 0.5151833750 0.83777082 4 88750446 88750608 163 - 1.193 1.259 0.233
ENSG00000138640 E029 7.7539684 0.0447341537 0.8925832534 0.97424383 4 88750609 88750637 29 - 0.940 0.934 -0.020
ENSG00000138640 E030 9.3327888 0.0473044870 0.3940844871 0.76942330 4 88758754 88758789 36 - 1.061 0.951 -0.407
ENSG00000138640 E031 16.3360777 0.0591864401 0.4269884652 0.79038550 4 88758790 88758901 112 - 1.288 1.171 -0.412
ENSG00000138640 E032 1.5686645 0.2339790398 0.6984126386   4 88758902 88759164 263 - 0.357 0.426 0.387
ENSG00000138640 E033 0.6875747 0.2805582035 0.9661126522   4 88759165 88759469 305 - 0.211 0.221 0.080
ENSG00000138640 E034 10.2033076 0.0220282606 0.5808396272 0.86729013 4 88767553 88767595 43 - 1.071 1.010 -0.222
ENSG00000138640 E035 11.7857131 0.0027972242 0.4480220723 0.80254780 4 88767983 88768059 77 - 1.138 1.064 -0.266
ENSG00000138640 E036 2.1826699 0.0094789795 0.0006576734 0.04277175 4 88768060 88768414 355 - 0.115 0.697 3.712
ENSG00000138640 E037 13.5909875 0.0020740533 0.2665435009 0.67120711 4 88781165 88781351 187 - 1.224 1.122 -0.361
ENSG00000138640 E038 9.4799452 0.0147953525 0.1967092120 0.59995639 4 88787753 88787932 180 - 1.112 0.951 -0.590
ENSG00000138640 E039 5.1889034 0.2111444396 0.7599174811 0.93582218 4 88790586 88790627 42 - 0.757 0.826 0.274
ENSG00000138640 E040 4.7441714 0.2134583589 0.8619278918 0.96633731 4 88805011 88805052 42 - 0.794 0.730 -0.258
ENSG00000138640 E041 0.8080470 0.0172671820 0.0116872889   4 88822976 88823361 386 - 0.449 0.000 -13.402
ENSG00000138640 E042 8.0957220 0.0058389454 0.1056059652 0.46779838 4 88851020 88851183 164 - 1.052 0.863 -0.707
ENSG00000138640 E043 0.1544607 0.0309979230 0.4508537302   4 88855367 88855509 143 - 0.000 0.124 10.383
ENSG00000138640 E044 0.6026480 0.0199959563 0.9340800753   4 88855510 88856026 517 - 0.206 0.221 0.127
ENSG00000138640 E045 0.0000000       4 88905686 88905718 33 -      
ENSG00000138640 E046 7.3320068 0.0048256007 0.8503666165 0.96311929 4 88906379 88906462 84 - 0.917 0.935 0.068
ENSG00000138640 E047 0.8073330 0.0193709252 0.5829154141   4 88936283 88936313 31 - 0.206 0.300 0.714
ENSG00000138640 E048 8.7662805 0.0254019559 0.3941999129 0.76949516 4 88936314 88938087 1774 - 1.035 0.918 -0.433
ENSG00000138640 E049 9.0797760 0.0030445302 0.5143426651 0.83729763 4 88938088 88938241 154 - 1.053 0.983 -0.257
ENSG00000138640 E050 0.6183183 0.0197549044 0.2713381071   4 88949326 88949438 113 - 0.115 0.300 1.716
ENSG00000138640 E051 1.9022252 0.0127337793 0.6907177681 0.91202719 4 88987149 88987217 69 - 0.495 0.424 -0.357
ENSG00000138640 E052 11.1224293 0.0066477114 0.3035398310 0.70280822 4 88989624 88990972 1349 - 1.030 1.133 0.375
ENSG00000138640 E053 14.5749839 0.0021725847 0.8969763667 0.97547436 4 88990973 88991150 178 - 1.215 1.201 -0.049
ENSG00000138640 E054 0.5029995 0.0223052784 0.5227788940   4 89008951 89009078 128 - 0.115 0.221 1.126
ENSG00000138640 E055 11.3306254 0.0030135989 0.2854364414 0.68781054 4 89020460 89020529 70 - 1.147 1.039 -0.390
ENSG00000138640 E056 16.9278729 0.0377875663 0.9081045278 0.97812808 4 89020530 89020669 140 - 1.275 1.252 -0.081
ENSG00000138640 E057 18.2051672 0.0115050368 0.5844192534 0.86877265 4 89029460 89029649 190 - 1.277 1.312 0.123
ENSG00000138640 E058 0.0000000       4 89029650 89029900 251 -      
ENSG00000138640 E059 12.1836954 0.0651549692 0.9698621948 0.99299148 4 89056938 89056988 51 - 1.138 1.121 -0.061
ENSG00000138640 E060 13.6836122 0.0159270635 0.3572500615 0.74498057 4 89056989 89057117 129 - 1.132 1.219 0.308
ENSG00000138640 E061 8.6794697 0.0748321207 0.4676575004 0.81274823 4 89057118 89057345 228 - 0.957 1.038 0.301
ENSG00000138640 E062 1.0169297 0.2933230112 0.2580241327   4 89111042 89111398 357 - 0.412 0.125 -2.244