ENSG00000138434

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000320370 ENSG00000138434 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITPRID2 protein_coding protein_coding 10.59982 2.959372 3.262239 1.117261 0.5284846 0.1401203 1.3129677 0.0000000 0.1798066 0.00000000 0.08997630 4.2464586 0.07712083 0.00000000 0.06426667 0.06426667 2.914781e-01 5.740483e-05 FALSE TRUE
ENST00000409001 ENSG00000138434 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITPRID2 protein_coding protein_coding 10.59982 2.959372 3.262239 1.117261 0.5284846 0.1401203 3.6151167 0.8578944 1.0481635 0.50870480 0.34545613 0.2859712 0.29764583 0.24963333 0.30020000 0.05056667 8.364444e-01 5.740483e-05 FALSE TRUE
ENST00000431877 ENSG00000138434 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITPRID2 protein_coding protein_coding 10.59982 2.959372 3.262239 1.117261 0.5284846 0.1401203 1.9682571 0.1537669 0.5747317 0.15376689 0.17485103 1.8361310 0.15141250 0.08040000 0.16846667 0.08806667 4.275568e-01 5.740483e-05 FALSE TRUE
ENST00000451836 ENSG00000138434 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITPRID2 protein_coding protein_coding 10.59982 2.959372 3.262239 1.117261 0.5284846 0.1401203 0.2277458 0.3951078 0.0000000 0.10008573 0.00000000 -5.3402340 0.05338750 0.14620000 0.00000000 -0.14620000 5.740483e-05 5.740483e-05 FALSE TRUE
ENST00000467172 ENSG00000138434 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITPRID2 protein_coding processed_transcript 10.59982 2.959372 3.262239 1.117261 0.5284846 0.1401203 0.1396878 0.0000000 0.2588910 0.00000000 0.25889099 4.7489495 0.04004167 0.00000000 0.06776667 0.06776667 7.633675e-01 5.740483e-05 FALSE TRUE
ENST00000480753 ENSG00000138434 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITPRID2 protein_coding retained_intron 10.59982 2.959372 3.262239 1.117261 0.5284846 0.1401203 1.0249873 0.1749034 0.3044607 0.05943421 0.04500567 0.7661079 0.09981667 0.06123333 0.09443333 0.03320000 7.481173e-01 5.740483e-05 FALSE FALSE
ENST00000491720 ENSG00000138434 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITPRID2 protein_coding retained_intron 10.59982 2.959372 3.262239 1.117261 0.5284846 0.1401203 0.9824824 0.5603917 0.3073305 0.22498855 0.04009723 -0.8459668 0.09192500 0.18676667 0.10556667 -0.08120000 5.594939e-01 5.740483e-05 TRUE TRUE
MSTRG.19607.14 ENSG00000138434 HEK293_DMSO_6hA HEK293_OSMI2_6hA ITPRID2 protein_coding   10.59982 2.959372 3.262239 1.117261 0.5284846 0.1401203 0.6089594 0.5332239 0.4953381 0.30426632 0.27586261 -0.1042980 0.10986250 0.16280000 0.16500000 0.00220000 1.000000e+00 5.740483e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000138434 E001 0.1125166 0.0326988466 0.553325778   2 181891730 181891832 103 + 0.113 0.000 -9.679
ENSG00000138434 E002 1.4564798 0.0501814075 0.106963634   2 181891833 181891954 122 + 0.528 0.223 -1.817
ENSG00000138434 E003 2.8484638 0.0087342033 0.020421600 0.23788625 2 181891955 181891984 30 + 0.739 0.370 -1.740
ENSG00000138434 E004 11.2724359 0.0025417124 0.220491792 0.62504233 2 181891985 181892195 211 + 1.142 1.030 -0.406
ENSG00000138434 E005 11.6593225 0.0021713789 0.106070746 0.46832957 2 181892196 181892277 82 + 1.178 1.030 -0.532
ENSG00000138434 E006 0.0000000       2 181892353 181892378 26 +      
ENSG00000138434 E007 8.7849088 0.0030997701 0.112388400 0.47989511 2 181892615 181892631 17 + 1.071 0.905 -0.614
ENSG00000138434 E008 9.7941245 0.0030182527 0.144260180 0.53113247 2 181892632 181892660 29 + 1.103 0.957 -0.536
ENSG00000138434 E009 5.1959516 0.0955281178 0.721949153 0.92277506 2 181892661 181893392 732 + 0.816 0.754 -0.247
ENSG00000138434 E010 2.4865524 0.0077311879 0.845001999 0.96158212 2 181893393 181893610 218 + 0.531 0.566 0.164
ENSG00000138434 E011 3.1345096 0.0069450258 0.523385308 0.84179191 2 181893611 181893745 135 + 0.568 0.671 0.453
ENSG00000138434 E012 7.8859458 0.0034730734 0.520454319 0.84032662 2 181893746 181894695 950 + 0.986 0.923 -0.236
ENSG00000138434 E013 10.6873147 0.0204752496 0.115364989 0.48522400 2 181896030 181896079 50 + 1.158 0.972 -0.677
ENSG00000138434 E014 10.9508977 0.0053137162 0.429083244 0.79136056 2 181896908 181896964 57 + 1.122 1.044 -0.284
ENSG00000138434 E015 0.0000000       2 181898859 181898879 21 +      
ENSG00000138434 E016 8.2280603 0.0326878898 0.753876247 0.93378946 2 181898880 181898919 40 + 0.965 0.987 0.081
ENSG00000138434 E017 13.5210138 0.0032692623 0.569685940 0.86222188 2 181899014 181899112 99 + 1.194 1.148 -0.164
ENSG00000138434 E018 11.1158799 0.0024617045 0.883447121 0.97198290 2 181900696 181900860 165 + 1.102 1.093 -0.032
ENSG00000138434 E019 7.4104713 0.0034197684 0.821728289 0.95498698 2 181900861 181900904 44 + 0.943 0.923 -0.076
ENSG00000138434 E020 47.0696882 0.0040755441 0.799408202 0.94812422 2 181901766 181902466 701 + 1.688 1.679 -0.028
ENSG00000138434 E021 14.5724888 0.0241082711 0.686484581 0.91053241 2 181909899 181909971 73 + 1.201 1.184 -0.059
ENSG00000138434 E022 0.1544607 0.0326491905 0.441733797   2 181910505 181910629 125 + 0.000 0.126 11.843
ENSG00000138434 E023 0.3312313 0.0266079599 0.952071311   2 181911200 181911233 34 + 0.114 0.126 0.160
ENSG00000138434 E024 17.4658010 0.0053184263 0.715664395 0.92060263 2 181913845 181913933 89 + 1.250 1.295 0.158
ENSG00000138434 E025 30.0680274 0.0112568069 0.770673276 0.93969416 2 181915216 181915414 199 + 1.496 1.499 0.011
ENSG00000138434 E026 46.8901689 0.0006666482 0.780946803 0.94249354 2 181915415 181915921 507 + 1.678 1.698 0.069
ENSG00000138434 E027 44.5266231 0.0271083824 0.712304380 0.91932729 2 181915922 181916427 506 + 1.671 1.651 -0.071
ENSG00000138434 E028 6.1373150 0.1102969538 0.217264140 0.62181800 2 181916428 181916721 294 + 0.742 0.941 0.774
ENSG00000138434 E029 7.0389669 0.0442643011 0.054322576 0.35671983 2 181916722 181917005 284 + 0.741 1.028 1.102
ENSG00000138434 E030 18.9306643 0.0161625184 0.001880119 0.07713607 2 181917006 181918322 1317 + 1.107 1.435 1.155
ENSG00000138434 E031 5.2643914 0.0987090357 0.609256545 0.87969689 2 181918323 181918470 148 + 0.716 0.878 0.644
ENSG00000138434 E032 3.3799274 0.0069199591 0.005472222 0.13198831 2 181918471 181918597 127 + 0.397 0.826 1.931
ENSG00000138434 E033 14.1528339 0.0023365372 0.446695412 0.80174106 2 181918598 181918675 78 + 1.160 1.233 0.259
ENSG00000138434 E034 17.4917212 0.0015979192 0.548579686 0.85336206 2 181918755 181918860 106 + 1.249 1.303 0.190
ENSG00000138434 E035 11.3473115 0.0022873696 0.594970077 0.87355827 2 181918861 181918882 22 + 1.071 1.127 0.204
ENSG00000138434 E036 22.7835811 0.0014201190 0.161482028 0.55621219 2 181919296 181919446 151 + 1.423 1.331 -0.316
ENSG00000138434 E037 9.8395577 0.0043443771 0.721232213 0.92264615 2 181920597 181920605 9 + 1.059 1.030 -0.107
ENSG00000138434 E038 13.1259629 0.0030513178 0.813954305 0.95266148 2 181920606 181920650 45 + 1.142 1.169 0.095
ENSG00000138434 E039 7.6664549 0.0077594578 0.990141834 0.99756474 2 181920651 181920662 12 + 0.943 0.940 -0.010
ENSG00000138434 E040 61.9290508 0.0005636732 0.105544361 0.46769605 2 181921948 181922412 465 + 1.838 1.776 -0.211
ENSG00000138434 E041 21.9751813 0.0210912257 0.425854210 0.78963648 2 181928161 181928199 39 + 1.404 1.341 -0.219
ENSG00000138434 E042 25.8354864 0.0012386244 0.867630734 0.96742933 2 181928200 181928278 79 + 1.432 1.449 0.061
ENSG00000138434 E043 96.4996415 0.0061994893 0.063375231 0.38043336 2 181929561 181930738 1178 + 1.950 2.033 0.278