ENSG00000138246

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000260818 ENSG00000138246 HEK293_DMSO_6hA HEK293_OSMI2_6hA DNAJC13 protein_coding protein_coding 7.867658 3.194803 3.711898 0.9975207 0.9149284 0.2158029 6.0105626 0.9672062 3.02521305 0.42673851 0.73875332 1.6350629 0.67891667 0.3286333 0.8165667 0.48793333 0.02251754 0.02251754 FALSE TRUE
ENST00000463038 ENSG00000138246 HEK293_DMSO_6hA HEK293_OSMI2_6hA DNAJC13 protein_coding retained_intron 7.867658 3.194803 3.711898 0.9975207 0.9149284 0.2158029 0.2199671 0.2062712 0.03334359 0.07606568 0.03334359 -2.3189509 0.02705417 0.0682000 0.0072000 -0.06100000 0.23766189 0.02251754 FALSE TRUE
ENST00000509279 ENSG00000138246 HEK293_DMSO_6hA HEK293_OSMI2_6hA DNAJC13 protein_coding nonsense_mediated_decay 7.867658 3.194803 3.711898 0.9975207 0.9149284 0.2158029 0.6674534 0.6536264 0.50933302 0.21039802 0.25669146 -0.3537112 0.14892917 0.2036000 0.1100667 -0.09353333 0.72761757 0.02251754   FALSE
MSTRG.23696.2 ENSG00000138246 HEK293_DMSO_6hA HEK293_OSMI2_6hA DNAJC13 protein_coding   7.867658 3.194803 3.711898 0.9975207 0.9149284 0.2158029 0.6440352 1.2981174 0.00000000 0.85749547 0.00000000 -7.0313482 0.10707500 0.3754333 0.0000000 -0.37543333 0.20938136 0.02251754 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000138246 E001 3.8870584 0.1231235710 0.58177659 0.86755131 3 132417502 132417699 198 + 0.752 0.625 -0.532
ENSG00000138246 E002 3.4203985 0.0362094049 0.12056659 0.49472489 3 132417700 132417707 8 + 0.762 0.495 -1.169
ENSG00000138246 E003 3.4203985 0.0362094049 0.12056659 0.49472489 3 132417708 132417708 1 + 0.762 0.495 -1.169
ENSG00000138246 E004 5.2362082 0.0045433867 0.39322545 0.76893926 3 132417709 132417760 52 + 0.860 0.747 -0.444
ENSG00000138246 E005 6.2527205 0.0053217476 0.73782255 0.92830407 3 132434538 132434618 81 + 0.843 0.887 0.166
ENSG00000138246 E006 5.8965579 0.0054814084 0.88924644 0.97349445 3 132446475 132446550 76 + 0.860 0.845 -0.058
ENSG00000138246 E007 10.8912659 0.0122165282 0.73069037 0.92595799 3 132447321 132447470 150 + 1.108 1.076 -0.116
ENSG00000138246 E008 6.4561902 0.0087577285 0.18797533 0.58919253 3 132447898 132447939 42 + 0.963 0.799 -0.631
ENSG00000138246 E009 12.2311056 0.0021093457 0.08685927 0.43159803 3 132450647 132450847 201 + 1.198 1.037 -0.581
ENSG00000138246 E010 13.1244341 0.0329758409 0.76238065 0.93665343 3 132453298 132453504 207 + 1.153 1.145 -0.031
ENSG00000138246 E011 11.3234073 0.0108525117 0.71624004 0.92072148 3 132453599 132453694 96 + 1.104 1.076 -0.100
ENSG00000138246 E012 10.7948839 0.0028293569 0.43799235 0.79651534 3 132454066 132454157 92 + 1.112 1.037 -0.274
ENSG00000138246 E013 7.4805709 0.0034318954 0.36701401 0.75152047 3 132456235 132456293 59 + 0.991 0.887 -0.391
ENSG00000138246 E014 11.5831847 0.0021512415 0.74535843 0.93127973 3 132456294 132456401 108 + 1.121 1.090 -0.114
ENSG00000138246 E015 10.7409592 0.0025791922 0.35910415 0.74625950 3 132456501 132456580 80 + 1.112 1.022 -0.326
ENSG00000138246 E016 16.7204164 0.0029280058 0.45802958 0.80752871 3 132456663 132456832 170 + 1.277 1.218 -0.207
ENSG00000138246 E017 12.2581550 0.0023353522 0.29994747 0.69984927 3 132457269 132457368 100 + 1.174 1.077 -0.348
ENSG00000138246 E018 0.1544607 0.0311262147 0.40213831   3 132457369 132458349 981 + 0.000 0.131 10.623
ENSG00000138246 E019 11.6351952 0.0023789590 0.36376165 0.74950051 3 132460250 132460357 108 + 1.061 1.148 0.312
ENSG00000138246 E020 10.8834480 0.0202183796 0.03611355 0.30100514 3 132461050 132461205 156 + 1.192 0.926 -0.970
ENSG00000138246 E021 7.4865760 0.1134965058 0.19328450 0.59555632 3 132462467 132462523 57 + 1.038 0.776 -0.996
ENSG00000138246 E022 10.1859385 0.0041940701 0.00172573 0.07377941 3 132463696 132463817 122 + 1.182 0.845 -1.243
ENSG00000138246 E023 0.1544607 0.0311262147 0.40213831   3 132465951 132465994 44 + 0.000 0.131 10.623
ENSG00000138246 E024 8.4376442 0.0133967562 0.14354222 0.53030748 3 132465995 132466070 76 + 1.051 0.886 -0.614
ENSG00000138246 E025 10.1714532 0.0439311079 0.66309109 0.90152163 3 132466299 132466394 96 + 1.003 1.108 0.382
ENSG00000138246 E026 12.2298486 0.0125474740 0.17872521 0.57762048 3 132467170 132467313 144 + 1.067 1.207 0.503
ENSG00000138246 E027 0.1544607 0.0311262147 0.40213831   3 132467314 132467346 33 + 0.000 0.131 10.623
ENSG00000138246 E028 8.7505144 0.0361168653 0.88660115 0.97281731 3 132473145 132473227 83 + 1.004 1.007 0.008
ENSG00000138246 E029 0.3607829 0.0345044566 0.87128337   3 132474256 132474383 128 + 0.109 0.131 0.310
ENSG00000138246 E030 13.7792075 0.0217710252 0.95871336 0.99049253 3 132474932 132475085 154 + 1.183 1.186 0.013
ENSG00000138246 E031 15.9857801 0.0027882645 0.50321959 0.83143942 3 132477789 132477892 104 + 1.263 1.209 -0.193
ENSG00000138246 E032 16.3393883 0.0022922897 0.39298038 0.76884409 3 132477981 132478140 160 + 1.283 1.209 -0.259
ENSG00000138246 E033 8.7837008 0.0047446958 0.73385703 0.92701971 3 132479227 132479289 63 + 0.990 1.022 0.118
ENSG00000138246 E034 11.4909342 0.0025574221 0.79433218 0.94626958 3 132480369 132480470 102 + 1.102 1.126 0.086
ENSG00000138246 E035 14.2499121 0.0169245330 0.96837896 0.99270045 3 132482226 132482330 105 + 1.201 1.188 -0.044
ENSG00000138246 E036 22.4495399 0.0049767357 0.83034573 0.95691287 3 132483375 132483577 203 + 1.385 1.372 -0.046
ENSG00000138246 E037 0.6797700 0.3493626682 0.87095942   3 132484363 132484488 126 + 0.202 0.231 0.249
ENSG00000138246 E038 0.0000000       3 132484489 132484493 5 +      
ENSG00000138246 E039 14.0301164 0.0102917599 0.69279142 0.91269344 3 132484588 132484672 85 + 1.198 1.168 -0.108
ENSG00000138246 E040 22.7286035 0.0022989923 0.39980391 0.77319184 3 132488298 132488452 155 + 1.410 1.352 -0.200
ENSG00000138246 E041 14.3306839 0.0018150288 0.29799307 0.69826355 3 132488976 132489021 46 + 1.229 1.137 -0.326
ENSG00000138246 E042 21.7230536 0.0019015819 0.69567804 0.91363731 3 132490897 132491051 155 + 1.375 1.346 -0.102
ENSG00000138246 E043 23.4253471 0.0141286298 0.91366210 0.97936627 3 132492414 132492615 202 + 1.379 1.391 0.041
ENSG00000138246 E044 16.6749078 0.0017557048 0.73520174 0.92756390 3 132494144 132494259 116 + 1.236 1.262 0.094
ENSG00000138246 E045 15.9053014 0.0018839908 0.01434649 0.20469629 3 132495088 132495166 79 + 1.314 1.102 -0.752
ENSG00000138246 E046 22.2018048 0.0041618871 0.28665077 0.68890286 3 132496528 132496663 136 + 1.413 1.325 -0.308
ENSG00000138246 E047 35.0187284 0.0189169121 0.96575086 0.99213655 3 132499126 132499310 185 + 1.571 1.543 -0.096
ENSG00000138246 E048 23.7465037 0.0436679920 0.32527278 0.72109172 3 132499734 132499808 75 + 1.357 1.432 0.261
ENSG00000138246 E049 28.0654280 0.0012392351 0.19213633 0.59421868 3 132500794 132500913 120 + 1.429 1.511 0.281
ENSG00000138246 E050 31.7906330 0.0011140582 0.18996072 0.59143522 3 132502289 132502468 180 + 1.481 1.560 0.269
ENSG00000138246 E051 28.2419508 0.0012051179 0.14145989 0.52730510 3 132503214 132503381 168 + 1.420 1.515 0.327
ENSG00000138246 E052 22.4804685 0.0014841809 0.58029506 0.86701031 3 132505302 132505415 114 + 1.359 1.398 0.133
ENSG00000138246 E053 27.1927303 0.0010812977 0.91774329 0.98030932 3 132507237 132507353 117 + 1.456 1.461 0.017
ENSG00000138246 E054 36.9812073 0.0010800001 0.76183826 0.93642690 3 132511067 132511244 178 + 1.582 1.596 0.049
ENSG00000138246 E055 28.9912753 0.0010171170 0.43496559 0.79438931 3 132513008 132513099 92 + 1.505 1.455 -0.171
ENSG00000138246 E056 27.5490146 0.0010581959 0.86832633 0.96760304 3 132514571 132514670 100 + 1.460 1.471 0.038
ENSG00000138246 E057 0.3312313 0.0299033966 0.88160588   3 132514671 132514816 146 + 0.109 0.131 0.308
ENSG00000138246 E058 29.9250519 0.0010392856 0.07820986 0.41409172 3 132516422 132516496 75 + 1.443 1.551 0.373
ENSG00000138246 E059 36.7958710 0.0008454409 0.80344967 0.94933717 3 132516704 132516816 113 + 1.576 1.589 0.043
ENSG00000138246 E060 40.0404015 0.0008200426 0.23149529 0.63655879 3 132522828 132522972 145 + 1.589 1.654 0.223
ENSG00000138246 E061 23.5126178 0.0435900113 0.65696019 0.89946149 3 132522973 132522997 25 + 1.396 1.392 -0.014
ENSG00000138246 E062 27.0906561 0.0015068959 0.35649399 0.74436852 3 132523157 132523199 43 + 1.481 1.422 -0.205
ENSG00000138246 E063 49.5192557 0.0007076272 0.70199330 0.91574936 3 132523540 132523713 174 + 1.698 1.717 0.065
ENSG00000138246 E064 1.0990078 0.0144032716 0.02577192   3 132523714 132524017 304 + 0.109 0.494 2.898
ENSG00000138246 E065 62.9091962 0.0013213495 0.93776219 0.98543140 3 132525610 132525789 180 + 1.807 1.805 -0.009
ENSG00000138246 E066 53.4876145 0.0007535046 0.44195197 0.79874596 3 132526141 132526281 141 + 1.754 1.718 -0.124
ENSG00000138246 E067 28.0765228 0.0011391089 0.68288379 0.90928075 3 132528189 132528201 13 + 1.456 1.481 0.088
ENSG00000138246 E068 52.8867827 0.0022003931 0.81681169 0.95357973 3 132528202 132528332 131 + 1.745 1.732 -0.046
ENSG00000138246 E069 47.9258727 0.0033347783 0.02932700 0.27694836 3 132530998 132531097 100 + 1.642 1.756 0.387
ENSG00000138246 E070 0.7649743 0.0247710647 0.11098093   3 132537158 132537266 109 + 0.108 0.382 2.314
ENSG00000138246 E071 118.7760892 0.0004475653 0.01033499 0.17615195 3 132538176 132539032 857 + 2.044 2.124 0.267