ENSG00000138162

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000334433 ENSG00000138162 HEK293_DMSO_6hA HEK293_OSMI2_6hA TACC2 protein_coding protein_coding 1.983539 2.277931 2.706596 0.1329559 0.1587779 0.2477568 0.04637119 0.0000000 0.17508979 0.00000000 0.07916344 4.2101534 0.02377917 0.00000000 0.06350000 0.06350000 0.121682848 0.008850676 FALSE TRUE
ENST00000465600 ENSG00000138162 HEK293_DMSO_6hA HEK293_OSMI2_6hA TACC2 protein_coding retained_intron 1.983539 2.277931 2.706596 0.1329559 0.1587779 0.2477568 0.04761296 0.1623596 0.04301318 0.01755954 0.02236485 -1.7009989 0.02253333 0.07246667 0.01693333 -0.05553333 0.316022922 0.008850676 FALSE FALSE
ENST00000503769 ENSG00000138162 HEK293_DMSO_6hA HEK293_OSMI2_6hA TACC2 protein_coding retained_intron 1.983539 2.277931 2.706596 0.1329559 0.1587779 0.2477568 0.12568521 0.3674341 0.13897592 0.13531858 0.04160829 -1.3411458 0.05780833 0.15976667 0.05313333 -0.10663333 0.525255554 0.008850676 FALSE FALSE
MSTRG.4752.13 ENSG00000138162 HEK293_DMSO_6hA HEK293_OSMI2_6hA TACC2 protein_coding   1.983539 2.277931 2.706596 0.1329559 0.1587779 0.2477568 0.34176968 0.4004178 0.68058218 0.10974384 0.17570448 0.7507198 0.18769167 0.17443333 0.24560000 0.07116667 0.750991080 0.008850676 FALSE TRUE
MSTRG.4752.16 ENSG00000138162 HEK293_DMSO_6hA HEK293_OSMI2_6hA TACC2 protein_coding   1.983539 2.277931 2.706596 0.1329559 0.1587779 0.2477568 0.26853121 0.0000000 0.54644615 0.00000000 0.29797710 5.7981702 0.13687083 0.00000000 0.20160000 0.20160000 0.008850676 0.008850676 FALSE TRUE
MSTRG.4752.23 ENSG00000138162 HEK293_DMSO_6hA HEK293_OSMI2_6hA TACC2 protein_coding   1.983539 2.277931 2.706596 0.1329559 0.1587779 0.2477568 0.72054063 0.8878541 0.71854462 0.09418296 0.36011481 -0.3014637 0.35653750 0.39636667 0.27040000 -0.12596667 0.751798333 0.008850676 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000138162 E001 0.0000000       10 121989163 121989173 11 +      
ENSG00000138162 E002 0.0000000       10 121989174 121989193 20 +      
ENSG00000138162 E003 0.0000000       10 121989194 121989205 12 +      
ENSG00000138162 E004 0.0000000       10 121989206 121989262 57 +      
ENSG00000138162 E005 0.1812101 0.0376314809 6.419846e-01   10 121989263 121989488 226 + 0.104 0.000 -11.964
ENSG00000138162 E006 0.0000000       10 121994632 121994710 79 +      
ENSG00000138162 E007 0.8732242 0.0479405426 9.118985e-01   10 122019748 122019881 134 + 0.260 0.241 -0.139
ENSG00000138162 E008 0.0000000       10 122021936 122021936 1 +      
ENSG00000138162 E009 0.1544607 0.0440428218 3.642865e-01   10 122021937 122021992 56 + 0.000 0.137 12.712
ENSG00000138162 E010 0.1544607 0.0440428218 3.642865e-01   10 122021993 122022014 22 + 0.000 0.137 12.712
ENSG00000138162 E011 0.1717682 0.0324640421 3.653052e-01   10 122022015 122023790 1776 + 0.000 0.137 12.714
ENSG00000138162 E012 0.0000000       10 122033094 122033153 60 +      
ENSG00000138162 E013 1.9927782 0.0588412104 5.464617e-01 0.852483614 10 122050438 122050550 113 + 0.503 0.397 -0.551
ENSG00000138162 E014 0.1717682 0.0324640421 3.653052e-01   10 122050551 122052697 2147 + 0.000 0.137 12.714
ENSG00000138162 E015 0.0000000       10 122078977 122079145 169 +      
ENSG00000138162 E016 1.0064135 0.0188236711 6.527416e-01   10 122082647 122082655 9 + 0.319 0.242 -0.541
ENSG00000138162 E017 37.3063929 0.0008438685 6.367314e-03 0.141021272 10 122082656 122087959 5304 + 1.643 1.493 -0.511
ENSG00000138162 E018 2.4357320 0.0669471044 1.887959e-01 0.590149368 10 122088478 122088591 114 + 0.645 0.397 -1.196
ENSG00000138162 E019 0.0000000       10 122088592 122088738 147 +      
ENSG00000138162 E020 1.2268264 0.4454672707 8.828545e-01   10 122113011 122113029 19 + 0.336 0.327 -0.053
ENSG00000138162 E021 1.2268264 0.4454672707 8.828545e-01   10 122113030 122113038 9 + 0.336 0.327 -0.053
ENSG00000138162 E022 2.3329494 0.1186576877 9.095889e-01 0.978364644 10 122113039 122113055 17 + 0.506 0.511 0.024
ENSG00000138162 E023 5.4230399 0.0043957900 6.301951e-01 0.888217715 10 122113056 122113229 174 + 0.824 0.766 -0.230
ENSG00000138162 E024 1.5511259 0.1537524811 4.907667e-01   10 122113230 122113233 4 + 0.488 0.326 -0.891
ENSG00000138162 E025 0.1125166 0.0327096250 6.445162e-01   10 122126714 122127142 429 + 0.104 0.000 -11.955
ENSG00000138162 E026 5.2911057 0.0067531536 4.196189e-01 0.785826281 10 122132609 122132734 126 + 0.841 0.738 -0.411
ENSG00000138162 E027 1.4236457 0.1228467381 7.666979e-01   10 122143572 122143706 135 + 0.380 0.327 -0.320
ENSG00000138162 E028 0.3485388 0.0286379973 8.233425e-01   10 122163426 122163589 164 + 0.104 0.137 0.459
ENSG00000138162 E029 0.4610554 0.0217681645 7.626154e-01   10 122163590 122163773 184 + 0.188 0.137 -0.538
ENSG00000138162 E030 0.5143203 0.0301616342 7.732482e-02   10 122163774 122163843 70 + 0.317 0.000 -13.950
ENSG00000138162 E031 1.4558268 0.0128676633 1.492131e-01   10 122163844 122163931 88 + 0.257 0.510 1.465
ENSG00000138162 E032 2.1557066 0.0303575979 6.927950e-02 0.394017689 10 122163932 122163992 61 + 0.318 0.639 1.638
ENSG00000138162 E033 0.0000000       10 122192448 122192797 350 +      
ENSG00000138162 E034 11.5802554 0.0067825692 8.693479e-01 0.967930188 10 122195040 122195176 137 + 1.090 1.111 0.074
ENSG00000138162 E035 0.0000000       10 122209874 122209969 96 +      
ENSG00000138162 E036 0.0000000       10 122210042 122210396 355 +      
ENSG00000138162 E037 33.4034490 0.0009166450 8.848222e-01 0.972483599 10 122210397 122210885 489 + 1.537 1.533 -0.016
ENSG00000138162 E038 7.3404518 0.0509696713 9.680342e-01 0.992629997 10 122210886 122210902 17 + 0.901 0.908 0.028
ENSG00000138162 E039 18.7480144 0.0390668573 3.692453e-01 0.753101877 10 122210903 122211157 255 + 1.229 1.342 0.399
ENSG00000138162 E040 10.4194341 0.0102075203 2.405509e-01 0.645607206 10 122211158 122211208 51 + 0.974 1.112 0.503
ENSG00000138162 E041 16.9722249 0.0016776046 4.245525e-01 0.789002100 10 122211209 122211422 214 + 1.215 1.284 0.243
ENSG00000138162 E042 9.5732208 0.0564928640 8.459379e-01 0.961833324 10 122211423 122211496 74 + 1.031 0.995 -0.133
ENSG00000138162 E043 19.3102463 0.0021202190 8.652991e-01 0.967138766 10 122211497 122211685 189 + 1.311 1.300 -0.037
ENSG00000138162 E044 9.0271872 0.0037345895 2.003777e-01 0.603906107 10 122211686 122211708 23 + 1.061 0.926 -0.499
ENSG00000138162 E045 0.0000000       10 122213342 122213377 36 +      
ENSG00000138162 E046 7.2077541 0.0051562755 9.592708e-01 0.990643924 10 122215391 122215402 12 + 0.917 0.926 0.034
ENSG00000138162 E047 11.6348940 0.0021476175 6.910616e-01 0.912198543 10 122215403 122215451 49 + 1.082 1.123 0.149
ENSG00000138162 E048 22.6331970 0.0015866635 8.884841e-01 0.973367055 10 122216627 122216828 202 + 1.374 1.368 -0.024
ENSG00000138162 E049 0.0000000       10 122216829 122216921 93 +      
ENSG00000138162 E050 11.7780708 0.0235575235 8.220660e-01 0.955002906 10 122224726 122224787 62 + 1.104 1.123 0.069
ENSG00000138162 E051 18.2396940 0.0017055403 8.497262e-01 0.963005551 10 122226366 122226481 116 + 1.287 1.275 -0.041
ENSG00000138162 E052 20.7221372 0.0136245022 7.434171e-01 0.930472959 10 122227837 122228008 172 + 1.335 1.309 -0.089
ENSG00000138162 E053 0.6422654 0.0190803332 4.771309e-01   10 122229346 122229486 141 + 0.258 0.137 -1.125
ENSG00000138162 E054 0.8045307 0.0169562943 9.184734e-01   10 122230351 122230440 90 + 0.258 0.241 -0.125
ENSG00000138162 E055 24.6352390 0.0011967206 8.471742e-01 0.962188762 10 122237395 122237538 144 + 1.404 1.395 -0.031
ENSG00000138162 E056 0.0000000       10 122237959 122237960 2 +      
ENSG00000138162 E057 17.5415673 0.0016208155 6.571843e-01 0.899557733 10 122237961 122238018 58 + 1.281 1.249 -0.112
ENSG00000138162 E058 15.1300235 0.0016632113 1.499793e-01 0.539372231 10 122238019 122238037 19 + 1.256 1.135 -0.428
ENSG00000138162 E059 2.6470607 0.0753847153 2.745533e-02 0.268911319 10 122241634 122241957 324 + 0.320 0.737 2.032
ENSG00000138162 E060 16.4081240 0.0015941710 9.083056e-01 0.978137714 10 122241958 122242001 44 + 1.236 1.230 -0.020
ENSG00000138162 E061 0.3563434 0.0289627940 8.230277e-01   10 122245065 122245073 9 + 0.104 0.137 0.459
ENSG00000138162 E062 7.2618860 0.0285602403 4.929085e-05 0.008858934 10 122246473 122248642 2170 + 0.569 1.136 2.227
ENSG00000138162 E063 27.2160045 0.0010469001 5.521073e-01 0.854956487 10 122248643 122248803 161 + 1.430 1.472 0.144
ENSG00000138162 E064 19.1484068 0.0019984194 8.133865e-01 0.952530795 10 122249050 122249094 45 + 1.316 1.300 -0.053
ENSG00000138162 E065 20.4275458 0.0014908978 5.934869e-01 0.872771721 10 122249095 122249156 62 + 1.310 1.354 0.151
ENSG00000138162 E066 18.6530781 0.0019237800 8.638008e-01 0.966829129 10 122249544 122249664 121 + 1.293 1.284 -0.031
ENSG00000138162 E067 20.6609358 0.0014992841 4.380833e-01 0.796628248 10 122253991 122254126 136 + 1.299 1.361 0.214
ENSG00000138162 E068 26.6520298 0.0015582543 8.423004e-01 0.960939958 10 122254127 122254545 419 + 1.435 1.426 -0.032