ENSG00000138138

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000308448 ENSG00000138138 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATAD1 protein_coding protein_coding 35.94016 8.285608 8.123787 3.392222 1.324563 -0.02842057 4.694437 1.3539400 1.163142 0.1849383 0.2033384 -0.2174024 0.15741250 0.19910000 0.1438000 -0.055300000 0.75096259 0.03719837 FALSE TRUE
ENST00000328142 ENSG00000138138 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATAD1 protein_coding protein_coding 35.94016 8.285608 8.123787 3.392222 1.324563 -0.02842057 12.224591 3.5455553 3.147021 1.4109823 0.5015944 -0.1715109 0.38791250 0.43140000 0.3885333 -0.042866667 0.74899234 0.03719837 FALSE TRUE
MSTRG.4320.2 ENSG00000138138 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATAD1 protein_coding   35.94016 8.285608 8.123787 3.392222 1.324563 -0.02842057 2.256091 0.2281313 1.331844 0.1972024 0.4267946 2.4943875 0.05721667 0.01823333 0.1549667 0.136733333 0.03719837 0.03719837 TRUE TRUE
MSTRG.4320.7 ENSG00000138138 HEK293_DMSO_6hA HEK293_OSMI2_6hA ATAD1 protein_coding   35.94016 8.285608 8.123787 3.392222 1.324563 -0.02842057 14.961646 2.1234567 2.049240 0.9842684 0.5426513 -0.0510808 0.33377500 0.24550000 0.2532333 0.007733333 0.99590087 0.03719837 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000138138 E001 1.9769133 0.0159216897 0.426647518 0.79016352 10 87746196 87746532 337 - 0.414 0.545 0.656
ENSG00000138138 E002 1.8424689 0.0231794919 0.039196961 0.31151888 10 87746686 87746806 121 - 0.215 0.582 2.135
ENSG00000138138 E003 7.7455745 0.0415556607 0.774323115 0.94068539 10 87751512 87751877 366 - 0.925 0.947 0.084
ENSG00000138138 E004 54.2259295 0.0273317023 0.008348847 0.15936864 10 87751878 87753116 1239 - 1.596 1.837 0.816
ENSG00000138138 E005 64.3891036 0.0005393975 0.007063381 0.14813931 10 87753117 87753451 335 - 1.756 1.875 0.403
ENSG00000138138 E006 186.3322921 0.0009554011 0.104184318 0.46516198 10 87753452 87754379 928 - 2.252 2.299 0.157
ENSG00000138138 E007 107.5397788 0.0003238912 0.001423930 0.06618737 10 87754380 87754661 282 - 1.981 2.091 0.368
ENSG00000138138 E008 68.4308500 0.0054471652 0.543256217 0.85147852 10 87754662 87754807 146 - 1.857 1.834 -0.076
ENSG00000138138 E009 74.0577719 0.0005038269 0.125927217 0.50394218 10 87756789 87756922 134 - 1.915 1.860 -0.184
ENSG00000138138 E010 2.1485881 0.1674734734 0.183425743 0.58365973 10 87759701 87759813 113 - 0.299 0.612 1.644
ENSG00000138138 E011 2.4039993 0.4831855314 0.615707460 0.88242953 10 87766220 87766405 186 - 0.439 0.583 0.692
ENSG00000138138 E012 58.1390335 0.0006134255 0.092111632 0.44234869 10 87767673 87767723 51 - 1.819 1.749 -0.234
ENSG00000138138 E013 65.5067584 0.0005386991 0.465050218 0.81119808 10 87770952 87771041 90 - 1.846 1.821 -0.083
ENSG00000138138 E014 74.6890585 0.0015492566 0.265637890 0.67049503 10 87776321 87776427 107 - 1.908 1.869 -0.131
ENSG00000138138 E015 0.5982085 0.0199589055 0.966479371   10 87778521 87778731 211 - 0.215 0.211 -0.029
ENSG00000138138 E016 62.8496473 0.0023871605 0.050851611 0.34634482 10 87784470 87784551 82 - 1.861 1.770 -0.307
ENSG00000138138 E017 69.6734708 0.0004460384 0.029157643 0.27625408 10 87784552 87784670 119 - 1.901 1.817 -0.284
ENSG00000138138 E018 2.0930255 0.0270772510 0.367352502 0.75168932 10 87789040 87789129 90 - 0.554 0.409 -0.720
ENSG00000138138 E019 70.1424647 0.0004374074 0.891035421 0.97388650 10 87790310 87790430 121 - 1.859 1.858 -0.003
ENSG00000138138 E020 72.5057916 0.0003931097 0.586936080 0.86999053 10 87792657 87792755 99 - 1.861 1.888 0.089
ENSG00000138138 E021 79.8828421 0.0004210196 0.059151913 0.36938515 10 87814438 87814612 175 - 1.951 1.884 -0.224
ENSG00000138138 E022 0.6472678 0.0202787100 0.036701998   10 87814613 87814882 270 - 0.359 0.000 -10.650
ENSG00000138138 E023 33.7638301 0.0116171661 0.001768335 0.07469514 10 87817795 87818160 366 - 1.666 1.410 -0.877
ENSG00000138138 E024 13.1835886 0.0377017379 0.451457379 0.80434379 10 87818167 87818226 60 - 1.104 1.202 0.349
ENSG00000138138 E025 0.0000000       10 87841187 87841361 175 -