ENSG00000137497

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000393695 ENSG00000137497 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUMA1 protein_coding protein_coding 50.73834 54.81558 77.32556 3.052288 9.138172 0.4962828 7.826567 9.055547 14.4732995 0.58643470 2.4667652 0.6759243 0.15036667 0.16650000 0.18506667 0.01856667 0.75138001 0.03512931 FALSE TRUE
ENST00000540626 ENSG00000137497 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUMA1 protein_coding retained_intron 50.73834 54.81558 77.32556 3.052288 9.138172 0.4962828 7.379770 13.354340 10.7243063 1.15290856 0.4678568 -0.3161596 0.13040417 0.24333333 0.14346667 -0.09986667 0.03512931 0.03512931 FALSE TRUE
ENST00000541584 ENSG00000137497 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUMA1 protein_coding protein_coding 50.73834 54.81558 77.32556 3.052288 9.138172 0.4962828 4.725058 1.495059 9.7568411 0.94846195 4.4600396 2.6980722 0.06964167 0.02570000 0.11510000 0.08940000 0.72718818 0.03512931 FALSE TRUE
ENST00000545721 ENSG00000137497 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUMA1 protein_coding nonsense_mediated_decay 50.73834 54.81558 77.32556 3.052288 9.138172 0.4962828 3.497194 6.878273 4.4167506 0.45148662 1.3529412 -0.6378942 0.07560833 0.12726667 0.06330000 -0.06396667 0.27538780 0.03512931 TRUE TRUE
ENST00000620566 ENSG00000137497 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUMA1 protein_coding protein_coding 50.73834 54.81558 77.32556 3.052288 9.138172 0.4962828 14.738972 16.345524 25.2537777 1.84162387 3.9771193 0.6272924 0.28418750 0.29623333 0.32363333 0.02740000 0.75090116 0.03512931 FALSE TRUE
MSTRG.5914.1 ENSG00000137497 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUMA1 protein_coding   50.73834 54.81558 77.32556 3.052288 9.138172 0.4962828 2.551086 1.809512 3.3133315 0.05805853 0.3406087 0.8690785 0.05293750 0.03323333 0.04403333 0.01080000 0.71473196 0.03512931 FALSE TRUE
MSTRG.5914.7 ENSG00000137497 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUMA1 protein_coding   50.73834 54.81558 77.32556 3.052288 9.138172 0.4962828 3.263005 0.000000 0.6898375 0.00000000 0.6898375 6.1289481 0.08999583 0.00000000 0.01153333 0.01153333 0.78363487 0.03512931 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000137497 E001 1.7327182 0.0100563871 0.321190591 0.71763573 11 72002864 72002864 1 - 0.498 0.327 -0.931
ENSG00000137497 E002 721.0939766 0.0072339828 0.602450362 0.87669881 11 72002865 72003263 399 - 2.861 2.849 -0.038
ENSG00000137497 E003 1026.1250399 0.0034615591 0.482002226 0.82040541 11 72003264 72003538 275 - 3.014 3.003 -0.039
ENSG00000137497 E004 848.1956741 0.0030749698 0.340162923 0.73206221 11 72003887 72004099 213 - 2.934 2.918 -0.054
ENSG00000137497 E005 565.0148063 0.0006478692 0.638771179 0.89180512 11 72004225 72004341 117 - 2.751 2.748 -0.009
ENSG00000137497 E006 630.0473355 0.0002749063 0.551416654 0.85459818 11 72004640 72004816 177 - 2.791 2.805 0.047
ENSG00000137497 E007 245.6209129 0.0005957307 0.437047586 0.79582056 11 72005233 72005242 10 - 2.399 2.383 -0.055
ENSG00000137497 E008 348.9358452 0.0008778328 0.913646312 0.97936498 11 72005243 72005285 43 - 2.542 2.543 0.005
ENSG00000137497 E009 410.3807989 0.0005171952 0.685406811 0.91008718 11 72005286 72005369 84 - 2.607 2.619 0.042
ENSG00000137497 E010 730.9646916 0.0006094729 0.215408408 0.62002478 11 72006035 72006263 229 - 2.848 2.877 0.095
ENSG00000137497 E011 761.0741808 0.0019170525 0.448288413 0.80272745 11 72007189 72007435 247 - 2.865 2.895 0.100
ENSG00000137497 E012 216.9621073 0.0747019599 0.010808927 0.17992330 11 72007436 72007925 490 - 2.169 2.480 1.037
ENSG00000137497 E013 103.2109855 0.0579156916 0.002004189 0.07973880 11 72007926 72008091 166 - 1.816 2.178 1.216
ENSG00000137497 E014 52.9892046 0.0770384762 0.029149028 0.27623563 11 72008092 72008145 54 - 1.579 1.861 0.955
ENSG00000137497 E015 109.2621541 0.0770459709 0.003547380 0.10728506 11 72008146 72008437 292 - 1.830 2.208 1.271
ENSG00000137497 E016 85.4978548 0.1123165109 0.016071277 0.21532627 11 72008438 72008687 250 - 1.739 2.095 1.196
ENSG00000137497 E017 518.3372335 0.0009107728 0.496262740 0.82741285 11 72008688 72008845 158 - 2.716 2.708 -0.026
ENSG00000137497 E018 576.1059962 0.0001778418 0.107035524 0.47002105 11 72008967 72009185 219 - 2.767 2.746 -0.069
ENSG00000137497 E019 388.2069144 0.0018457655 0.418228032 0.78530460 11 72009268 72009387 120 - 2.592 2.581 -0.039
ENSG00000137497 E020 363.6918986 0.0028417388 0.945461496 0.98732106 11 72010786 72010854 69 - 2.551 2.567 0.055
ENSG00000137497 E021 9.6827120 0.0255161737 0.009586616 0.17017553 11 72012259 72012400 142 - 0.842 1.173 1.223
ENSG00000137497 E022 81.6352682 0.0038169473 0.804344671 0.94964302 11 72012401 72012442 42 - 1.910 1.926 0.053
ENSG00000137497 E023 3092.0117028 0.0005785989 0.298141592 0.69844457 11 72012895 72014947 2053 - 3.488 3.487 -0.004
ENSG00000137497 E024 774.4180623 0.0001956542 0.958946449 0.99056160 11 72014948 72015428 481 - 2.884 2.890 0.019
ENSG00000137497 E025 1113.7680881 0.0008583592 0.256505531 0.66227194 11 72015429 72016260 832 - 3.048 3.038 -0.035
ENSG00000137497 E026 305.9703161 0.0001439167 0.696958839 0.91394738 11 72016408 72016530 123 - 2.477 2.489 0.041
ENSG00000137497 E027 11.4077015 0.0427363520 0.316706435 0.71382428 11 72016976 72017279 304 - 1.015 1.151 0.494
ENSG00000137497 E028 16.7864162 0.2476639279 0.108325731 0.47250720 11 72017280 72017686 407 - 1.106 1.372 0.938
ENSG00000137497 E029 328.9316718 0.0003117504 0.310906131 0.70877304 11 72017687 72017827 141 - 2.522 2.505 -0.055
ENSG00000137497 E030 313.8460860 0.0016474998 0.582326895 0.86776707 11 72018183 72018300 118 - 2.497 2.492 -0.019
ENSG00000137497 E031 295.8691054 0.0029190614 0.765785104 0.93795177 11 72018396 72018513 118 - 2.469 2.469 -0.001
ENSG00000137497 E032 239.4029491 0.0041791651 0.615178238 0.88225871 11 72018823 72018902 80 - 2.366 2.392 0.086
ENSG00000137497 E033 228.8308934 0.0012577522 0.737918273 0.92835249 11 72018903 72018961 59 - 2.352 2.366 0.047
ENSG00000137497 E034 167.1251221 0.0002521207 0.268810713 0.67336064 11 72018962 72018980 19 - 2.234 2.207 -0.090
ENSG00000137497 E035 214.4283961 0.0001852195 0.487092744 0.82294664 11 72019494 72019555 62 - 2.337 2.324 -0.045
ENSG00000137497 E036 183.9481252 0.0012864832 0.614822814 0.88221173 11 72019556 72019598 43 - 2.272 2.259 -0.044
ENSG00000137497 E037 133.5371852 0.0023606111 0.812016147 0.95216539 11 72019599 72019600 2 - 2.132 2.125 -0.024
ENSG00000137497 E038 148.8096922 0.0018590714 0.751822988 0.93315055 11 72019601 72019617 17 - 2.179 2.170 -0.030
ENSG00000137497 E039 136.1558075 0.0003147213 0.923114119 0.98162423 11 72021204 72021225 22 - 2.136 2.136 0.001
ENSG00000137497 E040 214.4128189 0.0104173954 0.337569747 0.73014658 11 72021226 72021291 66 - 2.352 2.302 -0.169
ENSG00000137497 E041 3.0829726 0.2490963930 0.154282136 0.54541158 11 72022202 72022338 137 - 0.420 0.766 1.568
ENSG00000137497 E042 166.3324543 0.0108594603 0.299157845 0.69924192 11 72022339 72022382 44 - 2.245 2.187 -0.195
ENSG00000137497 E043 149.8771920 0.0095194306 0.382266795 0.76166086 11 72022383 72022419 37 - 2.197 2.150 -0.159
ENSG00000137497 E044 139.5730702 0.0045228428 0.500787519 0.82997933 11 72023065 72023081 17 - 2.158 2.130 -0.093
ENSG00000137497 E045 142.1360689 0.0040654461 0.428530209 0.79113306 11 72023082 72023107 26 - 2.166 2.135 -0.103
ENSG00000137497 E046 130.0163137 0.0006127261 0.775213207 0.94098718 11 72023108 72023129 22 - 2.109 2.122 0.043
ENSG00000137497 E047 116.2579725 0.0012780694 0.524672997 0.84243000 11 72023130 72023137 8 - 2.055 2.082 0.088
ENSG00000137497 E048 120.6947344 0.0031937841 0.822294927 0.95500315 11 72023138 72023147 10 - 2.078 2.090 0.040
ENSG00000137497 E049 0.5297488 0.0240571773 0.766994999   11 72024071 72024273 203 - 0.187 0.138 -0.519
ENSG00000137497 E050 121.5778391 0.0022583687 0.927541404 0.98282151 11 72024274 72024298 25 - 2.082 2.090 0.025
ENSG00000137497 E051 101.6262136 0.0036685681 0.776687305 0.94122758 11 72024299 72024304 6 - 1.999 2.018 0.063
ENSG00000137497 E052 99.2003502 0.0018522628 0.919861871 0.98078516 11 72024305 72024312 8 - 1.997 1.999 0.006
ENSG00000137497 E053 165.0728817 0.0059509426 0.348318818 0.73810183 11 72024313 72024353 41 - 2.234 2.198 -0.121
ENSG00000137497 E054 0.4979971 0.0269305701 0.046247534   11 72024354 72024850 497 - 0.000 0.327 12.335
ENSG00000137497 E055 194.3516961 0.0054749300 0.388790699 0.76624783 11 72029205 72029290 86 - 2.304 2.271 -0.109
ENSG00000137497 E056 185.8483013 0.0033358513 0.163427653 0.55835495 11 72035902 72035975 74 - 2.290 2.243 -0.156
ENSG00000137497 E057 0.3513410 0.0244411696 0.128121484   11 72035976 72035987 12 - 0.000 0.243 11.804
ENSG00000137497 E058 0.0000000       11 72039735 72039825 91 -      
ENSG00000137497 E059 0.2842848 0.0268223256 0.810009869   11 72040605 72040958 354 - 0.103 0.138 0.489
ENSG00000137497 E060 13.3001319 0.0024792279 0.739660171 0.92903372 11 72040959 72041146 188 - 1.166 1.138 -0.099
ENSG00000137497 E061 0.2250332 0.0838966409 0.328170957   11 72041428 72041525 98 - 0.184 0.000 -11.267
ENSG00000137497 E062 0.0000000       11 72041722 72041822 101 -      
ENSG00000137497 E063 0.5029995 0.0221552434 0.396631375   11 72041823 72042142 320 - 0.103 0.243 1.483
ENSG00000137497 E064 21.4292709 0.0013147459 0.027744298 0.27012220 11 72049419 72049539 121 - 1.271 1.436 0.573
ENSG00000137497 E065 1.4329148 0.0157343049 0.880145374   11 72050662 72050833 172 - 0.369 0.398 0.163
ENSG00000137497 E066 0.5391907 0.1305930055 0.160357798   11 72062589 72062686 98 - 0.261 0.000 -11.698
ENSG00000137497 E067 1.0810109 0.0144063012 0.957379112   11 72065199 72068078 2880 - 0.316 0.327 0.071
ENSG00000137497 E068 0.8499911 0.0160030802 0.194459397   11 72068079 72068104 26 - 0.369 0.138 -1.834
ENSG00000137497 E069 9.8008834 0.0143489314 0.819030140 0.95429413 11 72068105 72068231 127 - 1.017 1.046 0.105
ENSG00000137497 E070 2.9568112 0.0072456248 0.255389044 0.66122803 11 72068496 72068617 122 - 0.497 0.677 0.808
ENSG00000137497 E071 135.2771689 0.0005713991 0.376760913 0.75780684 11 72069842 72069911 70 - 2.144 2.119 -0.083
ENSG00000137497 E072 0.5419930 0.3726269607 0.821836737   11 72069912 72070093 182 - 0.193 0.139 -0.569
ENSG00000137497 E073 0.2669773 0.0284501013 0.807234040   11 72076568 72076757 190 - 0.103 0.138 0.488
ENSG00000137497 E074 18.5020216 0.0019420477 0.002882949 0.09629725 11 72080320 72080457 138 - 1.372 1.126 -0.864
ENSG00000137497 E075 101.7627268 0.0010815725 0.338972370 0.73113326 11 72080458 72080693 236 - 2.025 1.992 -0.109