ENSG00000136937

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000375130 ENSG00000136937 HEK293_DMSO_6hA HEK293_OSMI2_6hA NCBP1 protein_coding protein_coding 29.9536 11.01633 10.61989 2.483826 1.590326 -0.05282561 0.6415778 0.9064629 0.4060078 0.1666578 0.02959739 -1.1394660 0.02900417 0.09176667 0.03936667 -0.05240000 0.43126243 0.02087903 FALSE TRUE
ENST00000375147 ENSG00000136937 HEK293_DMSO_6hA HEK293_OSMI2_6hA NCBP1 protein_coding protein_coding 29.9536 11.01633 10.61989 2.483826 1.590326 -0.05282561 9.6736874 5.2108930 4.0591632 1.2514245 0.82004734 -0.3595645 0.36287083 0.47010000 0.37553333 -0.09456667 0.31617973 0.02087903 FALSE TRUE
MSTRG.33113.2 ENSG00000136937 HEK293_DMSO_6hA HEK293_OSMI2_6hA NCBP1 protein_coding   29.9536 11.01633 10.61989 2.483826 1.590326 -0.05282561 19.0134147 4.6697470 6.0084666 1.1780219 0.82530061 0.3629654 0.57612500 0.41916667 0.56866667 0.14950000 0.02087903 0.02087903 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000136937 E001 7.0765842 0.0100827739 1.924030e-01 0.59446759 9 97633526 97633628 103 + 0.987 0.826 -0.609
ENSG00000136937 E002 7.6866686 0.0091758450 2.284581e-02 0.24941835 9 97633629 97633667 39 + 1.058 0.785 -1.030
ENSG00000136937 E003 13.7278080 0.0206112798 6.748640e-03 0.14478942 9 97633668 97633776 109 + 1.296 0.999 -1.067
ENSG00000136937 E004 16.4528245 0.0109332398 2.287007e-03 0.08514437 9 97633777 97633820 44 + 1.368 1.082 -1.011
ENSG00000136937 E005 29.0036783 0.0018985148 4.847835e-02 0.34023451 9 97633821 97633881 61 + 1.538 1.413 -0.430
ENSG00000136937 E006 28.0908201 0.0011746233 3.939951e-01 0.76939680 9 97633882 97633915 34 + 1.493 1.442 -0.175
ENSG00000136937 E007 45.2410674 0.0059577995 3.038043e-01 0.70297780 9 97640794 97640882 89 + 1.697 1.643 -0.182
ENSG00000136937 E008 56.2192230 0.0023292290 7.776822e-02 0.41314038 9 97641562 97641662 101 + 1.800 1.717 -0.278
ENSG00000136937 E009 87.9887226 0.0033741728 4.502989e-01 0.80375046 9 97643204 97643360 157 + 1.967 1.937 -0.100
ENSG00000136937 E010 76.7234268 0.0005501828 7.428169e-01 0.93028822 9 97645117 97645224 108 + 1.897 1.887 -0.033
ENSG00000136937 E011 89.6268096 0.0003404579 7.576091e-01 0.93507583 9 97645611 97645732 122 + 1.950 1.965 0.051
ENSG00000136937 E012 72.6069069 0.0004124585 3.021566e-01 0.70157728 9 97647492 97647561 70 + 1.887 1.849 -0.128
ENSG00000136937 E013 105.6304569 0.0002857469 9.509402e-02 0.44836213 9 97648008 97648223 216 + 2.057 2.005 -0.176
ENSG00000136937 E014 75.2366706 0.0003618943 5.172021e-01 0.83875711 9 97650503 97650600 98 + 1.894 1.872 -0.074
ENSG00000136937 E015 67.0513327 0.0004222083 6.959205e-01 0.91372186 9 97651310 97651373 64 + 1.839 1.826 -0.043
ENSG00000136937 E016 85.1567345 0.0005339678 5.146147e-01 0.83744766 9 97653798 97653908 111 + 1.945 1.925 -0.068
ENSG00000136937 E017 74.1875532 0.0011538691 9.607253e-01 0.99097935 9 97654880 97654944 65 + 1.873 1.875 0.007
ENSG00000136937 E018 61.9418252 0.0004597377 9.659583e-01 0.99217974 9 97655702 97655764 63 + 1.794 1.800 0.019
ENSG00000136937 E019 76.6877276 0.0004592984 6.461386e-01 0.89488545 9 97656011 97656085 75 + 1.898 1.882 -0.051
ENSG00000136937 E020 90.7972788 0.0003572705 2.288966e-01 0.63407341 9 97658640 97658743 104 + 1.933 1.981 0.161
ENSG00000136937 E021 110.2224870 0.0036371038 4.595035e-01 0.80833837 9 97660946 97661068 123 + 2.022 2.059 0.122
ENSG00000136937 E022 110.5253470 0.0037243449 8.761099e-01 0.97028601 9 97662042 97662144 103 + 2.046 2.042 -0.012
ENSG00000136937 E023 111.7984795 0.0011375715 8.988793e-01 0.97586665 9 97662954 97663047 94 + 2.053 2.051 -0.008
ENSG00000136937 E024 113.2904504 0.0003279592 3.221143e-01 0.71849335 9 97664340 97664443 104 + 2.074 2.044 -0.098
ENSG00000136937 E025 126.3641465 0.0003043389 2.148498e-01 0.61944926 9 97666763 97666877 115 + 2.083 2.126 0.142
ENSG00000136937 E026 163.5481712 0.0002681578 3.211766e-01 0.71763349 9 97668846 97668974 129 + 2.230 2.207 -0.078
ENSG00000136937 E027 126.9565045 0.0003862106 8.089169e-01 0.95110285 9 97669593 97669706 114 + 2.111 2.108 -0.012
ENSG00000136937 E028 7.6694983 0.0579032885 2.844958e-02 0.27337499 9 97669707 97670076 370 + 0.704 1.051 1.338
ENSG00000136937 E029 105.2399573 0.0013872516 3.329534e-01 0.72689029 9 97671086 97671201 116 + 2.046 2.012 -0.113
ENSG00000136937 E030 47.1045142 0.0010536674 7.753440e-02 0.41254536 9 97671202 97671223 22 + 1.729 1.642 -0.293
ENSG00000136937 E031 128.7349799 0.0002442063 1.842891e-01 0.58470856 9 97671224 97671495 272 + 2.087 2.131 0.149
ENSG00000136937 E032 207.7785667 0.0022862811 7.266069e-05 0.01122137 9 97671496 97672667 1172 + 2.241 2.373 0.438
ENSG00000136937 E033 35.3457268 0.0012592699 8.633801e-01 0.96670606 9 97672668 97672710 43 + 1.558 1.571 0.047
ENSG00000136937 E034 34.0789319 0.0008373016 8.486017e-01 0.96265902 9 97672711 97672781 71 + 1.550 1.543 -0.025
ENSG00000136937 E035 135.6190000 0.0036499495 3.654080e-02 0.30224514 9 97672782 97673511 730 + 2.085 2.169 0.279
ENSG00000136937 E036 77.6733345 0.0003871133 7.305636e-02 0.40222469 9 97673512 97674750 1239 + 1.849 1.925 0.254
ENSG00000136937 E037 2.5172657 0.0100411458 8.037023e-01 0.94945866 9 97675508 97675538 31 + 0.566 0.531 -0.161
ENSG00000136937 E038 0.1544607 0.0317643305 5.452930e-01   9 97683283 97683483 201 + 0.000 0.114 9.198