ENSG00000136895

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373386 ENSG00000136895 HEK293_DMSO_6hA HEK293_OSMI2_6hA GARNL3 protein_coding nonsense_mediated_decay 5.693422 7.273409 4.252726 1.945964 0.09926604 -0.7728378 0.3544350 0.3505021 0.3974669 0.1723950 0.21548044 0.1766753 0.06324167 0.04393333 0.09206667 0.04813333 9.088015e-01 4.208291e-05 TRUE TRUE
ENST00000446764 ENSG00000136895 HEK293_DMSO_6hA HEK293_OSMI2_6hA GARNL3 protein_coding protein_coding 5.693422 7.273409 4.252726 1.945964 0.09926604 -0.7728378 0.3700914 0.6711657 0.1006697 0.4885691 0.10066974 -2.6217450 0.06039583 0.07176667 0.02366667 -0.04810000 7.340881e-01 4.208291e-05 FALSE FALSE
ENST00000460176 ENSG00000136895 HEK293_DMSO_6hA HEK293_OSMI2_6hA GARNL3 protein_coding nonsense_mediated_decay 5.693422 7.273409 4.252726 1.945964 0.09926604 -0.7728378 0.1796242 0.6488662 0.0000000 0.1096287 0.00000000 -6.0419137 0.02863333 0.09473333 0.00000000 -0.09473333 4.208291e-05 4.208291e-05 FALSE FALSE
ENST00000478696 ENSG00000136895 HEK293_DMSO_6hA HEK293_OSMI2_6hA GARNL3 protein_coding processed_transcript 5.693422 7.273409 4.252726 1.945964 0.09926604 -0.7728378 0.2421037 0.7383657 0.1316771 0.4793163 0.07615027 -2.4011368 0.03298750 0.08330000 0.03060000 -0.05270000 8.025031e-01 4.208291e-05 FALSE FALSE
ENST00000481242 ENSG00000136895 HEK293_DMSO_6hA HEK293_OSMI2_6hA GARNL3 protein_coding retained_intron 5.693422 7.273409 4.252726 1.945964 0.09926604 -0.7728378 0.3553899 1.0226855 0.5039012 0.2034743 0.16595396 -1.0068378 0.06535833 0.14576667 0.11710000 -0.02866667 7.812823e-01 4.208291e-05 FALSE TRUE
ENST00000497703 ENSG00000136895 HEK293_DMSO_6hA HEK293_OSMI2_6hA GARNL3 protein_coding retained_intron 5.693422 7.273409 4.252726 1.945964 0.09926604 -0.7728378 0.3291990 0.4673220 0.3218012 0.4673220 0.32180120 -0.5246439 0.05645833 0.04190000 0.07276667 0.03086667 9.737927e-01 4.208291e-05   FALSE
MSTRG.33408.11 ENSG00000136895 HEK293_DMSO_6hA HEK293_OSMI2_6hA GARNL3 protein_coding   5.693422 7.273409 4.252726 1.945964 0.09926604 -0.7728378 0.3867948 0.1787998 0.3365006 0.1787998 0.22419340 0.8760004 0.07605000 0.03533333 0.08093333 0.04560000 7.046384e-01 4.208291e-05 FALSE TRUE
MSTRG.33408.6 ENSG00000136895 HEK293_DMSO_6hA HEK293_OSMI2_6hA GARNL3 protein_coding   5.693422 7.273409 4.252726 1.945964 0.09926604 -0.7728378 2.0306842 1.6856500 1.2150536 0.2565156 0.60929101 -0.4689936 0.35021667 0.26226667 0.29196667 0.02970000 9.812940e-01 4.208291e-05   FALSE
MSTRG.33408.7 ENSG00000136895 HEK293_DMSO_6hA HEK293_OSMI2_6hA GARNL3 protein_coding   5.693422 7.273409 4.252726 1.945964 0.09926604 -0.7728378 0.3510983 0.5095256 0.2671771 0.1141914 0.16201183 -0.9063868 0.06454583 0.07210000 0.06113333 -0.01096667 8.050645e-01 4.208291e-05 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000136895 E001 0.0000000       9 127224265 127224338 74 +      
ENSG00000136895 E002 0.1544607 0.032474967 0.6894975567   9 127224471 127224538 68 + 0.000 0.103 10.409
ENSG00000136895 E003 0.4481873 0.022796928 0.3676532975   9 127224539 127224625 87 + 0.243 0.103 -1.485
ENSG00000136895 E004 0.6293974 0.077436961 0.1759380744   9 127224626 127224631 6 + 0.328 0.103 -2.079
ENSG00000136895 E005 0.6293974 0.077436961 0.1759380744   9 127224632 127224638 7 + 0.328 0.103 -2.079
ENSG00000136895 E006 1.6721505 0.031899688 0.0145428082 0.20595455 9 127224639 127224691 53 + 0.606 0.186 -2.505
ENSG00000136895 E007 1.3064917 0.487498725 0.6784392173   9 127225239 127225337 99 + 0.254 0.408 0.974
ENSG00000136895 E008 1.4609524 0.541190709 0.6353794574   9 127225338 127225354 17 + 0.254 0.448 1.183
ENSG00000136895 E009 2.6523671 0.253964346 0.8401707431 0.96035174 9 127225355 127225403 49 + 0.460 0.614 0.722
ENSG00000136895 E010 4.5184043 0.069245603 0.2403641989 0.64547801 9 127235794 127235891 98 + 0.595 0.820 0.934
ENSG00000136895 E011 5.8760104 0.214452623 0.6364724075 0.89088970 9 127237153 127237272 120 + 0.756 0.873 0.462
ENSG00000136895 E012 10.7031056 0.016927633 0.4202299104 0.78625084 9 127243079 127243249 171 + 0.986 1.096 0.402
ENSG00000136895 E013 0.6775699 0.019233957 0.0841029263   9 127243250 127243253 4 + 0.000 0.316 12.417
ENSG00000136895 E014 0.8938969 0.211509296 0.4648609792   9 127245337 127245420 84 + 0.336 0.188 -1.111
ENSG00000136895 E015 0.1812101 0.042138381 0.3382590216   9 127263662 127263999 338 + 0.139 0.000 -11.558
ENSG00000136895 E016 0.0000000       9 127264236 127264330 95 +      
ENSG00000136895 E017 0.1125166 0.033928678 0.3392551143   9 127264513 127264773 261 + 0.138 0.000 -11.549
ENSG00000136895 E018 0.1125166 0.033928678 0.3392551143   9 127264774 127264880 107 + 0.138 0.000 -11.549
ENSG00000136895 E019 0.1125166 0.033928678 0.3392551143   9 127264881 127264922 42 + 0.138 0.000 -11.549
ENSG00000136895 E020 0.0000000       9 127264923 127264951 29 +      
ENSG00000136895 E021 6.3173382 0.003922917 0.7881308178 0.94461711 9 127264952 127265001 50 + 0.821 0.871 0.193
ENSG00000136895 E022 4.5774684 0.006166681 0.9337738794 0.98444134 9 127265002 127265021 20 + 0.740 0.745 0.018
ENSG00000136895 E023 8.1490538 0.006512813 0.4627094490 0.81009107 9 127291168 127291242 75 + 0.890 0.992 0.386
ENSG00000136895 E024 10.6456282 0.005624649 0.7072135135 0.91780507 9 127311636 127311735 100 + 1.062 1.038 -0.090
ENSG00000136895 E025 0.0000000       9 127313353 127313440 88 +      
ENSG00000136895 E026 10.4976223 0.002386271 0.0019690780 0.07895320 9 127313441 127313559 119 + 1.194 0.901 -1.073
ENSG00000136895 E027 0.1767706 0.032002451 0.3395226563   9 127313560 127313560 1 + 0.139 0.000 -11.557
ENSG00000136895 E028 9.2039125 0.004537845 0.0003347972 0.02835877 9 127318063 127318127 65 + 1.174 0.803 -1.378
ENSG00000136895 E029 7.0818468 0.003722156 0.0025151271 0.08975231 9 127320715 127320778 64 + 1.061 0.723 -1.295
ENSG00000136895 E030 5.9894323 0.004840440 0.0060699694 0.13831424 9 127325069 127325095 27 + 1.000 0.677 -1.265
ENSG00000136895 E031 6.1374872 0.005380468 0.0356831006 0.29946877 9 127332274 127332349 76 + 0.967 0.723 -0.948
ENSG00000136895 E032 9.7199675 0.002620034 0.0270534034 0.26708325 9 127333023 127333121 99 + 1.127 0.916 -0.777
ENSG00000136895 E033 11.7908739 0.002339478 0.4309531072 0.79244819 9 127335230 127335333 104 + 1.127 1.069 -0.209
ENSG00000136895 E034 12.4178056 0.002114543 0.1702708976 0.56731176 9 127336128 127336236 109 + 1.016 1.166 0.542
ENSG00000136895 E035 7.7585743 0.003924410 0.2568885015 0.66274345 9 127338116 127338161 46 + 0.845 0.993 0.561
ENSG00000136895 E036 10.0509174 0.002792680 0.7546986564 0.93405556 9 127339645 127339751 107 + 1.000 1.049 0.178
ENSG00000136895 E037 9.6556706 0.002963225 0.7600754762 0.93589318 9 127342219 127342314 96 + 1.031 1.016 -0.055
ENSG00000136895 E038 6.2891636 0.021705505 0.7097198033 0.91856252 9 127342315 127342334 20 + 0.818 0.886 0.263
ENSG00000136895 E039 12.6569646 0.005953886 0.9161893594 0.97989378 9 127344235 127344339 105 + 1.125 1.133 0.029
ENSG00000136895 E040 13.0582318 0.006850794 0.6274847746 0.88686061 9 127345403 127345477 75 + 1.160 1.133 -0.098
ENSG00000136895 E041 6.4627027 0.003681162 0.1364535540 0.52005754 9 127348924 127349035 112 + 0.949 0.785 -0.631
ENSG00000136895 E042 3.3879003 0.006764721 0.8148030096 0.95293348 9 127353518 127353845 328 + 0.602 0.651 0.215
ENSG00000136895 E043 14.6276103 0.002305236 0.2002796796 0.60379408 9 127353846 127353944 99 + 1.243 1.150 -0.329
ENSG00000136895 E044 20.4752924 0.003735982 0.6708240494 0.90450640 9 127354294 127354410 117 + 1.295 1.346 0.177
ENSG00000136895 E045 11.1330026 0.002664184 0.9923716893 0.99818153 9 127355297 127355307 11 + 1.061 1.079 0.066
ENSG00000136895 E046 12.9144561 0.002272731 0.7428530871 0.93028822 9 127355308 127355355 48 + 1.138 1.125 -0.049
ENSG00000136895 E047 18.6797329 0.001440474 0.3682930533 0.75235656 9 127355356 127355472 117 + 1.224 1.313 0.312
ENSG00000136895 E048 0.0000000       9 127356429 127356505 77 +      
ENSG00000136895 E049 20.2723816 0.001739360 0.6768278258 0.90695980 9 127357219 127357377 159 + 1.327 1.313 -0.050
ENSG00000136895 E050 49.1118825 0.043456174 0.2199133481 0.62448759 9 127361716 127363948 2233 + 1.626 1.719 0.314
ENSG00000136895 E051 7.4413289 0.003939486 0.4871302496 0.82297871 9 127363949 127364033 85 + 0.846 0.943 0.371
ENSG00000136895 E052 24.7349202 0.079047266 0.0725047172 0.40121165 9 127364034 127364588 555 + 1.249 1.471 0.773
ENSG00000136895 E053 18.5558664 0.079483262 0.2793472708 0.68274473 9 127364589 127364776 188 + 1.189 1.329 0.493
ENSG00000136895 E054 20.9197430 0.001957625 0.0098869584 0.17280592 9 127364777 127365299 523 + 1.173 1.395 0.777
ENSG00000136895 E055 14.3130917 0.001972002 0.1089510009 0.47363936 9 127365300 127365366 67 + 1.061 1.225 0.589
ENSG00000136895 E056 10.6226024 0.025130462 0.7377221901 0.92822480 9 127365495 127365655 161 + 1.009 1.059 0.186
ENSG00000136895 E057 2.0853725 0.010083490 0.8723349346 0.96887190 9 127369022 127369118 97 + 0.459 0.497 0.193
ENSG00000136895 E058 12.5759844 0.002406982 0.5933568746 0.87276477 9 127383438 127383545 108 + 1.139 1.107 -0.115
ENSG00000136895 E059 11.6218226 0.002349149 0.7494432421 0.93246761 9 127385027 127385145 119 + 1.101 1.088 -0.048
ENSG00000136895 E060 4.6560469 0.005145644 0.8916878515 0.97406155 9 127387130 127387192 63 + 0.710 0.745 0.140
ENSG00000136895 E061 11.4432882 0.002249880 0.3794556992 0.75973207 9 127387193 127387331 139 + 1.126 1.059 -0.244
ENSG00000136895 E062 2.0269568 0.108853273 0.3515719782 0.74072312 9 127388412 127388903 492 + 0.329 0.535 1.102
ENSG00000136895 E063 24.6071895 0.001294122 0.3581184358 0.74552085 9 127388904 127389119 216 + 1.418 1.371 -0.161
ENSG00000136895 E064 19.4249973 0.001718769 0.5060265732 0.83273573 9 127390641 127390767 127 + 1.312 1.278 -0.121
ENSG00000136895 E065 26.9897803 0.001310688 0.7965965871 0.94712557 9 127393083 127393660 578 + 1.405 1.440 0.119