ENSG00000136574

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335135 ENSG00000136574 HEK293_DMSO_6hA HEK293_OSMI2_6hA GATA4 protein_coding protein_coding 15.42395 13.7321 24.60468 1.683515 4.218936 0.8409168 3.2499893 2.6430661 6.339131 0.3324620 1.7085327 1.25889863 0.20701667 0.19383333 0.2464333 0.052600000 6.930121e-01 3.458525e-24 FALSE TRUE
ENST00000532059 ENSG00000136574 HEK293_DMSO_6hA HEK293_OSMI2_6hA GATA4 protein_coding protein_coding 15.42395 13.7321 24.60468 1.683515 4.218936 0.8409168 2.3771493 2.1724472 4.047788 0.3873790 0.7532720 0.89474672 0.16079167 0.16050000 0.1655667 0.005066667 9.660746e-01 3.458525e-24 FALSE TRUE
MSTRG.31143.10 ENSG00000136574 HEK293_DMSO_6hA HEK293_OSMI2_6hA GATA4 protein_coding   15.42395 13.7321 24.60468 1.683515 4.218936 0.8409168 0.9187549 0.0000000 3.350355 0.0000000 0.3922978 8.39246979 0.05162083 0.00000000 0.1398000 0.139800000 3.458525e-24 3.458525e-24 FALSE TRUE
MSTRG.31143.3 ENSG00000136574 HEK293_DMSO_6hA HEK293_OSMI2_6hA GATA4 protein_coding   15.42395 13.7321 24.60468 1.683515 4.218936 0.8409168 1.0092352 0.9861333 1.850078 0.1314039 0.5724749 0.90095235 0.06285000 0.07603333 0.0730000 -0.003033333 9.998632e-01 3.458525e-24 FALSE TRUE
MSTRG.31143.5 ENSG00000136574 HEK293_DMSO_6hA HEK293_OSMI2_6hA GATA4 protein_coding   15.42395 13.7321 24.60468 1.683515 4.218936 0.8409168 0.9163954 1.1796065 2.056626 0.3576438 0.4017431 0.79679317 0.06185833 0.08826667 0.0872000 -0.001066667 9.939040e-01 3.458525e-24 FALSE TRUE
MSTRG.31143.7 ENSG00000136574 HEK293_DMSO_6hA HEK293_OSMI2_6hA GATA4 protein_coding   15.42395 13.7321 24.60468 1.683515 4.218936 0.8409168 5.5963377 5.4355825 5.089200 1.5834329 1.4348104 -0.09481546 0.36080833 0.38693333 0.1975667 -0.189366667 2.225150e-01 3.458525e-24 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000136574 E001 0.0000000       8 11676959 11676959 1 +      
ENSG00000136574 E002 0.2892872 0.0256657006 0.387285383   8 11676960 11677063 104 + 0.170 0.000 -8.977
ENSG00000136574 E003 2.8414096 0.0072799027 0.653333172 0.89787160 8 11692610 11692625 16 + 0.560 0.638 0.348
ENSG00000136574 E004 7.2278388 0.0537815907 0.718947118 0.92183349 8 11692626 11692660 35 + 0.900 0.952 0.197
ENSG00000136574 E005 6.0497398 0.0128018591 0.491582800 0.82529153 8 11700508 11700510 3 + 0.811 0.909 0.378
ENSG00000136574 E006 13.2835120 0.0111092695 0.995444161 0.99876175 8 11700511 11700778 268 + 1.143 1.159 0.057
ENSG00000136574 E007 0.8827271 0.1874338536 0.985106433   8 11704151 11704167 17 + 0.242 0.265 0.172
ENSG00000136574 E008 4.3969380 0.0284071835 0.184452284 0.58489549 8 11704168 11704201 34 + 0.616 0.837 0.909
ENSG00000136574 E009 4.9093793 0.0221342644 0.212842757 0.61745429 8 11704202 11704203 2 + 0.665 0.863 0.797
ENSG00000136574 E010 9.3847453 0.0163692121 0.770065441 0.93944775 8 11704204 11704215 12 + 1.007 0.991 -0.056
ENSG00000136574 E011 15.0652406 0.0268559507 0.453127644 0.80515109 8 11704216 11704221 6 + 1.221 1.160 -0.216
ENSG00000136574 E012 54.7636881 0.0006039853 0.003363343 0.10451234 8 11704222 11704304 83 + 1.788 1.657 -0.444
ENSG00000136574 E013 6.1296467 0.0216315423 0.928789452 0.98302831 8 11705914 11706033 120 + 0.833 0.837 0.016
ENSG00000136574 E014 101.0153058 0.0003557341 0.002701898 0.09318989 8 11707856 11708014 159 + 2.035 1.941 -0.315
ENSG00000136574 E015 162.0635505 0.0039925632 0.185109675 0.58567876 8 11708015 11708381 367 + 2.216 2.183 -0.111
ENSG00000136574 E016 101.0427123 0.0107513679 0.411957881 0.78173637 8 11708382 11708928 547 + 2.013 1.979 -0.115
ENSG00000136574 E017 12.6689577 0.0022541510 0.896064329 0.97515531 8 11748916 11748918 3 + 1.121 1.146 0.087
ENSG00000136574 E018 116.0087161 0.0014444886 0.529756430 0.84478494 8 11748919 11749085 167 + 2.066 2.056 -0.031
ENSG00000136574 E019 136.2529985 0.0003466604 0.382215654 0.76163222 8 11750111 11750236 126 + 2.135 2.122 -0.043
ENSG00000136574 E020 128.7904623 0.0003391890 0.848542935 0.96265902 8 11755046 11755133 88 + 2.102 2.110 0.025
ENSG00000136574 E021 5.5444300 0.2246783888 0.163376574 0.55827304 8 11756493 11756934 442 + 0.662 0.952 1.146
ENSG00000136574 E022 155.6673330 0.0002202347 0.875471527 0.97010441 8 11756935 11757083 149 + 2.178 2.197 0.061
ENSG00000136574 E023 995.6617223 0.0026280844 0.029224248 0.27648992 8 11758293 11760002 1710 + 2.964 3.021 0.187