ENSG00000134644

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000257075 ENSG00000134644 HEK293_DMSO_6hA HEK293_OSMI2_6hA PUM1 protein_coding protein_coding 38.2536 14.4959 25.20956 3.492753 5.77866 0.7979035 13.477405 3.733642 11.1331087 1.3427435 2.3351821 1.5736374 0.33631667 0.2462667 0.44593333 0.19966667 0.01735815 0.01735815 FALSE TRUE
ENST00000373747 ENSG00000134644 HEK293_DMSO_6hA HEK293_OSMI2_6hA PUM1 protein_coding protein_coding 38.2536 14.4959 25.20956 3.492753 5.77866 0.7979035 6.310087 5.878268 7.8939542 1.3917970 2.0125011 0.4247313 0.22393333 0.4088667 0.30896667 -0.09990000 0.41994389 0.01735815 FALSE TRUE
ENST00000424085 ENSG00000134644 HEK293_DMSO_6hA HEK293_OSMI2_6hA PUM1 protein_coding protein_coding 38.2536 14.4959 25.20956 3.492753 5.77866 0.7979035 2.153622 2.378288 1.1070421 0.6861754 0.6337343 -1.0962936 0.09377917 0.1726000 0.03683333 -0.13576667 0.12682078 0.01735815 FALSE TRUE
ENST00000440538 ENSG00000134644 HEK293_DMSO_6hA HEK293_OSMI2_6hA PUM1 protein_coding protein_coding 38.2536 14.4959 25.20956 3.492753 5.77866 0.7979035 6.100549 0.000000 0.5109079 0.0000000 0.5109079 5.7029565 0.11142083 0.0000000 0.03546667 0.03546667 0.84745979 0.01735815 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000134644 E001 369.0157338 0.0047065027 4.233823e-04 0.032646936 1 30931506 30931813 308 - 2.505 2.636 0.439
ENSG00000134644 E002 345.0793802 0.0083892447 2.073554e-01 0.611286562 1 30931814 30932058 245 - 2.506 2.567 0.202
ENSG00000134644 E003 527.4119051 0.0055360875 1.137160e-01 0.481962195 1 30932059 30932834 776 - 2.688 2.752 0.212
ENSG00000134644 E004 74.8935468 0.0004162098 1.226547e-01 0.498187168 1 30932835 30932843 9 - 1.851 1.920 0.234
ENSG00000134644 E005 67.5144829 0.0004626894 1.841374e-01 0.584527450 1 30932844 30932849 6 - 1.811 1.874 0.215
ENSG00000134644 E006 155.7016509 0.0020637790 1.218867e-01 0.497046173 1 30932850 30932954 105 - 2.163 2.227 0.214
ENSG00000134644 E007 190.2796185 0.0001947149 3.084642e-02 0.282725796 1 30932955 30933079 125 - 2.254 2.316 0.208
ENSG00000134644 E008 294.0100303 0.0001435567 8.023893e-02 0.418091287 1 30933080 30933304 225 - 2.452 2.495 0.144
ENSG00000134644 E009 155.1286965 0.0002152811 9.508178e-01 0.988512832 1 30933305 30933342 38 - 2.192 2.196 0.016
ENSG00000134644 E010 170.9691097 0.0004170764 4.332740e-01 0.793669305 1 30936643 30936721 79 - 2.242 2.225 -0.056
ENSG00000134644 E011 87.0240879 0.0034748802 2.034440e-01 0.607278540 1 30936722 30936723 2 - 1.915 1.977 0.209
ENSG00000134644 E012 176.3484142 0.0004876705 1.022612e-01 0.461443769 1 30936724 30936835 112 - 2.224 2.277 0.177
ENSG00000134644 E013 188.8033244 0.0025233328 7.561710e-02 0.408181103 1 30941151 30941272 122 - 2.243 2.320 0.258
ENSG00000134644 E014 3.4200667 0.0453004978 6.478124e-01 0.895646922 1 30941922 30941997 76 - 0.592 0.678 0.373
ENSG00000134644 E015 186.8747215 0.0041831265 5.940223e-01 0.873090441 1 30941998 30942123 126 - 2.254 2.294 0.135
ENSG00000134644 E016 149.1912609 0.0003247120 1.579926e-01 0.551215066 1 30945346 30945400 55 - 2.157 2.206 0.165
ENSG00000134644 E017 175.7503741 0.0001938488 6.321901e-01 0.888866775 1 30945401 30945483 83 - 2.240 2.259 0.066
ENSG00000134644 E018 40.3462484 0.0009177291 7.230020e-01 0.923180816 1 30950127 30950132 6 - 1.599 1.627 0.094
ENSG00000134644 E019 190.7090317 0.0002261443 1.179285e-01 0.489832033 1 30950133 30950261 129 - 2.298 2.263 -0.115
ENSG00000134644 E020 153.3405268 0.0002399559 1.804489e-01 0.579788251 1 30952234 30952363 130 - 2.204 2.171 -0.109
ENSG00000134644 E021 122.4301223 0.0015615372 2.162025e-01 0.620902725 1 30953714 30953818 105 - 2.103 2.069 -0.113
ENSG00000134644 E022 150.4228867 0.0039320208 2.344599e-01 0.639457379 1 30953819 30953981 163 - 2.187 2.158 -0.099
ENSG00000134644 E023 169.4090311 0.0019412621 8.726614e-03 0.162901716 1 30964674 30964887 214 - 2.261 2.181 -0.269
ENSG00000134644 E024 67.9010081 0.0106841203 4.193196e-02 0.320277211 1 30964888 30964910 23 - 1.881 1.759 -0.410
ENSG00000134644 E025 75.2634879 0.0047023804 1.173379e-03 0.059316501 1 30965982 30966015 34 - 1.943 1.776 -0.562
ENSG00000134644 E026 109.1797544 0.0039576325 4.592874e-05 0.008382559 1 30966016 30966146 131 - 2.105 1.923 -0.608
ENSG00000134644 E027 68.8047900 0.0091109269 3.264526e-01 0.721917047 1 30966147 30966197 51 - 1.860 1.810 -0.166
ENSG00000134644 E028 48.3917656 0.0105833336 8.892854e-01 0.973494451 1 30966198 30966278 81 - 1.693 1.692 0.000
ENSG00000134644 E029 1.2402355 0.2272716495 1.486886e-01   1 30966279 30966380 102 - 0.175 0.494 2.097
ENSG00000134644 E030 3.6724094 0.4758602645 4.577011e-01 0.807431753 1 30967099 30967166 68 - 0.614 0.714 0.424
ENSG00000134644 E031 60.8727805 0.0005785412 6.592881e-01 0.900384594 1 30967167 30967224 58 - 1.793 1.780 -0.043
ENSG00000134644 E032 73.1986869 0.0004453794 6.817228e-01 0.908811795 1 30967225 30967310 86 - 1.878 1.867 -0.035
ENSG00000134644 E033 1.0166058 0.0141762911 2.141645e-02   1 30968297 30968353 57 - 0.094 0.490 3.116
ENSG00000134644 E034 89.0976387 0.0006654009 4.790669e-01 0.818702021 1 30968354 30968492 139 - 1.967 1.946 -0.073
ENSG00000134644 E035 1.4484334 0.0129040302 3.447905e-01   1 30969211 30969276 66 - 0.429 0.264 -1.015
ENSG00000134644 E036 0.3579807 0.0411757603 3.883006e-01   1 30974649 30974650 2 - 0.171 0.000 -10.573
ENSG00000134644 E037 93.6435162 0.0047892976 3.649940e-01 0.750212598 1 30974651 30974802 152 - 1.991 1.949 -0.141
ENSG00000134644 E038 0.1795728 0.0457272248 2.955540e-01   1 30974803 30974859 57 - 0.000 0.152 10.986
ENSG00000134644 E039 74.8124056 0.0011155961 2.532839e-01 0.659067815 1 30980062 30980163 102 - 1.897 1.852 -0.150
ENSG00000134644 E040 19.3511844 0.0081753308 6.913710e-01 0.912261997 1 30980164 30980166 3 - 1.288 1.331 0.150
ENSG00000134644 E041 1.8399985 0.0162212002 8.963980e-01 0.975264082 1 30980167 30980178 12 - 0.464 0.489 0.125
ENSG00000134644 E042 46.3892607 0.0038213976 4.793104e-01 0.818805367 1 30981312 30981337 26 - 1.689 1.652 -0.129
ENSG00000134644 E043 64.4533725 0.0033488144 9.320757e-01 0.983841871 1 30981338 30981405 68 - 1.817 1.817 0.000
ENSG00000134644 E044 1.3020522 0.1537744167 1.101493e-01   1 30981917 30982145 229 - 0.173 0.540 2.329
ENSG00000134644 E045 76.8349928 0.0007172038 3.478981e-01 0.737762121 1 30992390 30992440 51 - 1.876 1.920 0.150
ENSG00000134644 E046 142.9854720 0.0002705665 7.469961e-01 0.931732296 1 30992441 30992660 220 - 2.159 2.156 -0.010
ENSG00000134644 E047 144.4497573 0.0025995312 7.140173e-02 0.398501549 1 30995054 30995181 128 - 2.178 2.125 -0.179
ENSG00000134644 E048 100.1460751 0.0016547692 1.750260e-01 0.572873632 1 30995182 30995220 39 - 2.015 1.971 -0.148
ENSG00000134644 E049 156.2170781 0.0008720986 1.706483e-02 0.220938726 1 31005853 31006031 179 - 2.216 2.151 -0.219
ENSG00000134644 E050 111.2473636 0.0059127493 1.276586e-02 0.194700227 1 31006994 31007099 106 - 2.082 1.978 -0.348
ENSG00000134644 E051 46.4105703 0.0030614709 1.289487e-01 0.508603531 1 31007100 31007102 3 - 1.700 1.626 -0.254
ENSG00000134644 E052 0.0000000       1 31028758 31028795 38 -      
ENSG00000134644 E053 95.3007080 0.0003850758 8.093878e-03 0.157052505 1 31028796 31028864 69 - 2.022 1.929 -0.312
ENSG00000134644 E054 1.9590647 0.1005366405 5.908189e-01 0.871789716 1 31055313 31055380 68 - 0.425 0.543 0.585
ENSG00000134644 E055 94.4621782 0.0050701238 2.301306e-01 0.635038830 1 31059204 31059278 75 - 1.998 1.943 -0.186
ENSG00000134644 E056 61.0435879 0.0004641825 6.281788e-01 0.887150888 1 31059279 31059298 20 - 1.799 1.783 -0.054
ENSG00000134644 E057 154.9011322 0.0002862368 3.175694e-01 0.714786981 1 31059299 31059577 279 - 2.199 2.176 -0.076
ENSG00000134644 E058 0.6948774 0.3071549125 3.093115e-02   1 31061667 31061916 250 - 0.000 0.429 12.986
ENSG00000134644 E059 60.5241015 0.0028971351 3.791316e-01 0.759459316 1 31065616 31065688 73 - 1.798 1.761 -0.126
ENSG00000134644 E060 18.3057648 0.0029492723 1.487640e-01 0.537491842 1 31065689 31065991 303 - 1.321 1.205 -0.409