ENSG00000134262

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000256658 ENSG00000134262 HEK293_DMSO_6hA HEK293_OSMI2_6hA AP4B1 protein_coding protein_coding 17.85892 23.05526 15.64143 2.106588 0.3147875 -0.5594266 4.505081 3.810270 3.6433825 0.9390054 0.41924313 -0.06444186 0.25789583 0.16063333 0.23283333 0.07220000 0.463799224 0.001198302 FALSE TRUE
ENST00000369567 ENSG00000134262 HEK293_DMSO_6hA HEK293_OSMI2_6hA AP4B1 protein_coding protein_coding 17.85892 23.05526 15.64143 2.106588 0.3147875 -0.5594266 1.772426 2.203961 1.9780231 0.4163872 0.10539454 -0.15529554 0.10340000 0.09393333 0.12663333 0.03270000 0.574815802 0.001198302 FALSE TRUE
ENST00000460653 ENSG00000134262 HEK293_DMSO_6hA HEK293_OSMI2_6hA AP4B1 protein_coding processed_transcript 17.85892 23.05526 15.64143 2.106588 0.3147875 -0.5594266 1.169179 2.277731 0.4092337 0.3565415 0.07355136 -2.44809118 0.06112083 0.09770000 0.02636667 -0.07133333 0.001198302 0.001198302   FALSE
ENST00000472122 ENSG00000134262 HEK293_DMSO_6hA HEK293_OSMI2_6hA AP4B1 protein_coding processed_transcript 17.85892 23.05526 15.64143 2.106588 0.3147875 -0.5594266 1.478108 2.665655 0.9474064 0.8256782 0.51040332 -1.48268892 0.07835417 0.11220000 0.06083333 -0.05136667 0.616745384 0.001198302 FALSE FALSE
ENST00000479285 ENSG00000134262 HEK293_DMSO_6hA HEK293_OSMI2_6hA AP4B1 protein_coding processed_transcript 17.85892 23.05526 15.64143 2.106588 0.3147875 -0.5594266 1.004757 2.455643 0.4655944 0.3699911 0.18743165 -2.37416001 0.05272083 0.10560000 0.02973333 -0.07586667 0.031580979 0.001198302 FALSE TRUE
ENST00000489499 ENSG00000134262 HEK293_DMSO_6hA HEK293_OSMI2_6hA AP4B1 protein_coding processed_transcript 17.85892 23.05526 15.64143 2.106588 0.3147875 -0.5594266 2.548062 2.505529 2.1063179 0.1187050 0.28893719 -0.24930535 0.14221667 0.11126667 0.13410000 0.02283333 0.752177603 0.001198302 FALSE TRUE
MSTRG.1852.6 ENSG00000134262 HEK293_DMSO_6hA HEK293_OSMI2_6hA AP4B1 protein_coding   17.85892 23.05526 15.64143 2.106588 0.3147875 -0.5594266 3.175046 4.444517 3.8037670 0.5588944 0.32273715 -0.22405237 0.17934583 0.19793333 0.24396667 0.04603333 0.741099240 0.001198302 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000134262 E001 4.580393 0.0123017593 2.684601e-01 0.673009761 1 113894194 113894747 554 - 0.639 0.804 0.677
ENSG00000134262 E002 7.079510 0.0034322803 7.192372e-01 0.921895218 1 113894748 113895055 308 - 0.867 0.916 0.185
ENSG00000134262 E003 2.089751 0.0090447878 7.294680e-01 0.925413936 1 113895056 113895059 4 - 0.512 0.459 -0.261
ENSG00000134262 E004 31.000429 0.0011817178 4.913027e-01 0.825173372 1 113895060 113895130 71 - 1.464 1.514 0.172
ENSG00000134262 E005 77.041198 0.0003838746 2.992171e-01 0.699315774 1 113895131 113895184 54 - 1.849 1.898 0.164
ENSG00000134262 E006 102.789218 0.0003133103 1.993307e-01 0.602511531 1 113895185 113895242 58 - 1.971 2.023 0.174
ENSG00000134262 E007 203.413978 0.0008335594 8.208717e-02 0.422125833 1 113895243 113895492 250 - 2.265 2.319 0.180
ENSG00000134262 E008 16.863701 0.0247854637 1.115601e-03 0.057630050 1 113895493 113895756 264 - 0.969 1.351 1.368
ENSG00000134262 E009 215.774595 0.0026315141 6.627810e-01 0.901402300 1 113895757 113896038 282 - 2.312 2.332 0.066
ENSG00000134262 E010 7.953612 0.0033458471 1.714929e-05 0.004454218 1 113896039 113896044 6 - 0.512 1.089 2.325
ENSG00000134262 E011 20.786299 0.0375601534 1.878155e-03 0.077124638 1 113896045 113896257 213 - 1.056 1.435 1.337
ENSG00000134262 E012 123.036948 0.0002817467 5.696567e-01 0.862221884 1 113896258 113896348 91 - 2.085 2.074 -0.038
ENSG00000134262 E013 151.503033 0.0002715951 7.645172e-01 0.937487570 1 113896349 113896465 117 - 2.167 2.165 -0.007
ENSG00000134262 E014 51.265473 0.0482800810 3.242086e-02 0.288809147 1 113896466 113897839 1374 - 1.554 1.778 0.761
ENSG00000134262 E015 132.869630 0.0007305347 9.654088e-01 0.992070676 1 113897840 113897943 104 - 2.106 2.111 0.017
ENSG00000134262 E016 7.817695 0.0056431596 3.226264e-01 0.718912434 1 113897944 113897975 32 - 0.845 0.970 0.472
ENSG00000134262 E017 96.400516 0.0014626758 7.175772e-01 0.921304694 1 113898718 113898763 46 - 1.975 1.966 -0.028
ENSG00000134262 E018 84.190710 0.0003875368 7.711972e-01 0.939788509 1 113898764 113898801 38 - 1.902 1.920 0.061
ENSG00000134262 E019 13.334060 0.0043837601 3.814075e-05 0.007365929 1 113899128 113899352 225 - 0.821 1.266 1.633
ENSG00000134262 E020 84.611220 0.0004540669 3.528730e-01 0.741701270 1 113899904 113899941 38 - 1.935 1.905 -0.099
ENSG00000134262 E021 91.990454 0.0054525182 8.270328e-01 0.956108972 1 113899942 113899987 46 - 1.959 1.953 -0.021
ENSG00000134262 E022 90.041748 0.0069495757 9.668188e-01 0.992408541 1 113899988 113900024 37 - 1.947 1.949 0.006
ENSG00000134262 E023 81.175714 0.0038928050 6.002128e-01 0.875527396 1 113900025 113900061 37 - 1.916 1.896 -0.069
ENSG00000134262 E024 148.654602 0.0003427317 3.660162e-02 0.302406149 1 113900062 113900230 169 - 2.194 2.140 -0.181
ENSG00000134262 E025 81.084092 0.0007425873 2.588515e-01 0.664380824 1 113900231 113900269 39 - 1.923 1.885 -0.130
ENSG00000134262 E026 96.079577 0.0003228842 1.031027e-01 0.462913378 1 113900270 113900330 61 - 2.001 1.949 -0.174
ENSG00000134262 E027 97.434540 0.0006300011 9.267561e-02 0.443336670 1 113900331 113900400 70 - 2.010 1.955 -0.184
ENSG00000134262 E028 107.709779 0.0003333720 4.356430e-01 0.794740982 1 113901236 113901383 148 - 2.033 2.013 -0.067
ENSG00000134262 E029 87.000191 0.0005368366 3.519042e-01 0.740952474 1 113901755 113901885 131 - 1.945 1.915 -0.099
ENSG00000134262 E030 21.659722 0.0830742195 1.004070e-01 0.458081944 1 113901886 113902119 234 - 1.192 1.415 0.779
ENSG00000134262 E031 82.413767 0.0003744627 4.264672e-01 0.790061814 1 113902638 113902734 97 - 1.919 1.895 -0.082
ENSG00000134262 E032 84.664266 0.0004138877 3.529992e-01 0.741837456 1 113902735 113902862 128 - 1.933 1.904 -0.099
ENSG00000134262 E033 116.329908 0.0002510349 1.860933e-02 0.229035442 1 113904605 113904793 189 - 2.096 2.026 -0.234
ENSG00000134262 E034 29.034830 0.0010357044 8.204349e-01 0.954594571 1 113904794 113904920 127 - 1.469 1.461 -0.029
ENSG00000134262 E035 1.876100 0.0100131688 5.560991e-01 0.856457604 1 113904921 113904941 21 - 0.511 0.417 -0.481
ENSG00000134262 E036 29.408782 0.0038851710 3.894293e-02 0.310428782 1 113904942 113905201 260 - 1.554 1.418 -0.465