ENSG00000132780

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000350030 ENSG00000132780 HEK293_DMSO_6hA HEK293_OSMI2_6hA NASP protein_coding protein_coding 299.5766 218.9229 225.2151 29.61444 22.48198 0.04087881 41.88517 22.623637 52.20889 2.558352 13.0231441 1.20610343 0.14662917 0.10433333 0.2243000 0.1199666667 0.01803698 0.01803698 FALSE TRUE
ENST00000351223 ENSG00000132780 HEK293_DMSO_6hA HEK293_OSMI2_6hA NASP protein_coding protein_coding 299.5766 218.9229 225.2151 29.61444 22.48198 0.04087881 66.13975 49.665084 44.73289 6.379777 4.7248419 -0.15086394 0.23339167 0.22890000 0.1987000 -0.0302000000 0.71224305 0.01803698 FALSE TRUE
ENST00000453748 ENSG00000132780 HEK293_DMSO_6hA HEK293_OSMI2_6hA NASP protein_coding nonsense_mediated_decay 299.5766 218.9229 225.2151 29.61444 22.48198 0.04087881 18.74531 15.516476 15.08015 3.554215 0.5631394 -0.04112307 0.06346250 0.06926667 0.0690000 -0.0002666667 0.99144344 0.01803698 FALSE TRUE
ENST00000464190 ENSG00000132780 HEK293_DMSO_6hA HEK293_OSMI2_6hA NASP protein_coding retained_intron 299.5766 218.9229 225.2151 29.61444 22.48198 0.04087881 66.64404 46.505146 36.87849 7.666585 3.8422500 -0.33452974 0.20700833 0.21170000 0.1671000 -0.0446000000 0.52754090 0.01803698 FALSE TRUE
ENST00000525515 ENSG00000132780 HEK293_DMSO_6hA HEK293_OSMI2_6hA NASP protein_coding protein_coding 299.5766 218.9229 225.2151 29.61444 22.48198 0.04087881 17.71228 7.498404 11.22642 2.605378 1.1772189 0.58160391 0.05517917 0.03256667 0.0506000 0.0180333333 0.39883843 0.01803698 FALSE FALSE
ENST00000528238 ENSG00000132780 HEK293_DMSO_6hA HEK293_OSMI2_6hA NASP protein_coding protein_coding 299.5766 218.9229 225.2151 29.61444 22.48198 0.04087881 44.39269 30.132743 32.39385 6.890622 4.1248412 0.10435473 0.14830833 0.13450000 0.1435333 0.0090333333 0.81752464 0.01803698 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000132780 E001 0.8715870 2.064080e-02 6.703067e-01   1 45581985 45583319 1335 + 0.211 0.293 0.620
ENSG00000132780 E002 2.0079729 2.046886e-01 9.135935e-01 9.793581e-01 1 45583320 45583845 526 + 0.469 0.467 -0.011
ENSG00000132780 E003 1.6213274 1.958423e-01 3.212958e-02   1 45583846 45583912 67 + 0.593 0.120 -3.190
ENSG00000132780 E004 0.9293524 2.135499e-02 9.988736e-01   1 45583913 45583987 75 + 0.287 0.293 0.044
ENSG00000132780 E005 0.6356258 3.577345e-02 3.181568e-01   1 45583988 45583988 1 + 0.118 0.293 1.630
ENSG00000132780 E006 1.5167156 1.028825e-01 3.939166e-01   1 45583989 45584040 52 + 0.288 0.468 1.042
ENSG00000132780 E007 1.4994081 1.153691e-02 3.254755e-01   1 45584041 45584041 1 + 0.287 0.467 1.039
ENSG00000132780 E008 1.7663854 1.012023e-02 3.762454e-01 7.574871e-01 1 45584042 45584044 3 + 0.352 0.512 0.847
ENSG00000132780 E009 39.2384725 7.516363e-04 6.835047e-02 3.921541e-01 1 45584045 45584057 13 + 1.651 1.564 -0.295
ENSG00000132780 E010 63.5231077 4.595387e-04 1.703851e-01 5.674706e-01 1 45584058 45584059 2 + 1.834 1.788 -0.154
ENSG00000132780 E011 68.9558717 4.952433e-04 7.002666e-02 3.957589e-01 1 45584060 45584060 1 + 1.879 1.817 -0.210
ENSG00000132780 E012 120.6531730 1.361476e-03 1.008200e-02 1.741560e-01 1 45584061 45584062 2 + 2.127 2.048 -0.264
ENSG00000132780 E013 231.5610692 1.906815e-04 7.371497e-07 4.574994e-04 1 45584063 45584064 2 + 2.418 2.316 -0.340
ENSG00000132780 E014 637.8385651 8.470076e-04 1.142728e-02 1.849403e-01 1 45584065 45584107 43 + 2.825 2.789 -0.120
ENSG00000132780 E015 950.0735202 1.563295e-03 4.721585e-02 3.366359e-01 1 45584108 45584205 98 + 2.995 2.963 -0.104
ENSG00000132780 E016 2.2907025 2.161239e-01 3.255322e-01 7.212418e-01 1 45588651 45588948 298 + 0.608 0.359 -1.248
ENSG00000132780 E017 839.1444548 1.434575e-03 1.031065e-01 4.629134e-01 1 45591223 45591270 48 + 2.937 2.913 -0.078
ENSG00000132780 E018 3.9285242 1.993677e-01 7.340065e-01 9.270616e-01 1 45594694 45594773 80 + 0.646 0.737 0.380
ENSG00000132780 E019 30.8218281 9.565726e-04 5.186175e-01 8.394122e-01 1 45600385 45600457 73 + 1.474 1.528 0.188
ENSG00000132780 E020 1158.4823444 1.529564e-03 2.106675e-01 6.150044e-01 1 45602255 45602365 111 + 3.072 3.058 -0.048
ENSG00000132780 E021 0.7592215 1.885815e-02 1.708740e-01   1 45604917 45604935 19 + 0.352 0.121 -1.959
ENSG00000132780 E022 815.9804867 6.281495e-04 3.289651e-01 7.235934e-01 1 45604936 45604965 30 + 2.914 2.911 -0.010
ENSG00000132780 E023 1029.4135345 9.313618e-05 1.255538e-02 1.933407e-01 1 45604966 45605016 51 + 3.021 3.007 -0.047
ENSG00000132780 E024 965.0518400 8.230228e-05 6.935894e-04 4.425645e-02 1 45606482 45606516 35 + 2.999 2.974 -0.084
ENSG00000132780 E025 1158.7640701 2.124671e-04 5.088173e-06 1.889727e-03 1 45606517 45606591 75 + 3.086 3.045 -0.136
ENSG00000132780 E026 53.9543713 1.244438e-01 3.290597e-02 2.905379e-01 1 45606592 45606680 89 + 1.524 1.872 1.181
ENSG00000132780 E027 1387.8224886 3.274438e-03 2.066075e-10 7.962030e-07 1 45607321 45607972 652 + 3.224 3.052 -0.570
ENSG00000132780 E028 838.1871598 3.647428e-03 5.824740e-10 1.930424e-06 1 45607973 45608337 365 + 3.011 2.825 -0.618
ENSG00000132780 E029 382.6182558 1.026490e-01 2.316214e-03 8.585333e-02 1 45609300 45610553 1254 + 2.303 2.740 1.456
ENSG00000132780 E030 198.8558820 1.118270e-01 1.918731e-03 7.787219e-02 1 45610554 45610995 442 + 1.998 2.464 1.555
ENSG00000132780 E031 981.1276161 7.286002e-02 4.523257e-04 3.393139e-02 1 45610996 45613168 2173 + 2.714 3.148 1.443
ENSG00000132780 E032 1236.7751529 8.298778e-05 6.195628e-02 3.768257e-01 1 45613169 45613248 80 + 3.096 3.091 -0.016
ENSG00000132780 E033 1222.6483136 1.770934e-04 6.798952e-01 9.081437e-01 1 45614096 45614181 86 + 3.077 3.097 0.066
ENSG00000132780 E034 1313.4570127 5.254566e-05 3.724938e-01 7.550586e-01 1 45614293 45614366 74 + 3.106 3.130 0.079
ENSG00000132780 E035 6.2283542 4.482076e-03 1.197103e-01 4.930237e-01 1 45614963 45615012 50 + 0.731 0.940 0.814
ENSG00000132780 E036 1122.6893726 1.970288e-04 2.686092e-01 6.732179e-01 1 45615013 45615058 46 + 3.036 3.064 0.093
ENSG00000132780 E037 1762.2093720 1.235904e-04 6.431005e-01 8.936726e-01 1 45615059 45615201 143 + 3.236 3.255 0.063
ENSG00000132780 E038 2098.3133675 9.271826e-05 9.302296e-01 9.833698e-01 1 45615305 45615471 167 + 3.313 3.329 0.052
ENSG00000132780 E039 21.1193826 7.225761e-02 1.864077e-01 5.872066e-01 1 45615472 45615715 244 + 1.212 1.430 0.759
ENSG00000132780 E040 1173.4866095 1.053101e-03 9.169863e-01 9.801519e-01 1 45616337 45616393 57 + 3.062 3.075 0.043
ENSG00000132780 E041 1474.9242151 1.036029e-03 7.608493e-01 9.362183e-01 1 45616626 45616700 75 + 3.157 3.178 0.068
ENSG00000132780 E042 980.2776212 9.674367e-04 2.012738e-01 6.048693e-01 1 45616701 45616703 3 + 2.970 3.009 0.130
ENSG00000132780 E043 37.8326478 4.100442e-02 1.463551e-03 6.734013e-02 1 45617237 45617462 226 + 1.352 1.724 1.276
ENSG00000132780 E044 1007.8787567 4.022278e-03 8.497353e-01 9.630056e-01 1 45617463 45617464 2 + 2.990 3.014 0.081
ENSG00000132780 E045 1859.5454943 9.387526e-04 1.931960e-01 5.953605e-01 1 45617465 45617591 127 + 3.249 3.286 0.122
ENSG00000132780 E046 1262.7402240 4.905881e-04 3.967764e-01 7.709824e-01 1 45618061 45618904 844 + 3.087 3.114 0.090