ENSG00000132153

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000445061 ENSG00000132153 HEK293_DMSO_6hA HEK293_OSMI2_6hA DHX30 protein_coding protein_coding 177.748 163.815 254.6596 14.46228 35.12327 0.6364714 20.12529 18.64263 32.48281 0.4366164 5.612722 0.80074106 0.1159958 0.1154000 0.12606667 0.01066667 0.7508059035 0.0001319213 FALSE TRUE
ENST00000457607 ENSG00000132153 HEK293_DMSO_6hA HEK293_OSMI2_6hA DHX30 protein_coding protein_coding 177.748 163.815 254.6596 14.46228 35.12327 0.6364714 101.02859 80.22544 159.11386 6.6979977 25.631204 0.98783874 0.5659292 0.4907667 0.62020000 0.12943333 0.0001319213 0.0001319213 FALSE TRUE
ENST00000474183 ENSG00000132153 HEK293_DMSO_6hA HEK293_OSMI2_6hA DHX30 protein_coding retained_intron 177.748 163.815 254.6596 14.46228 35.12327 0.6364714 19.73690 25.00811 23.78989 0.8581437 2.552004 -0.07201814 0.1197375 0.1544000 0.10083333 -0.05356667 0.3196722860 0.0001319213 FALSE FALSE
ENST00000619982 ENSG00000132153 HEK293_DMSO_6hA HEK293_OSMI2_6hA DHX30 protein_coding protein_coding 177.748 163.815 254.6596 14.46228 35.12327 0.6364714 15.13369 20.47719 17.35686 7.0417308 3.698291 -0.23838539 0.0689125 0.1192333 0.06656667 -0.05266667 0.4922144974 0.0001319213 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000132153 E001 12.9401431 2.522085e-03 4.461369e-02 0.3287766911 3 47802737 47802849 113 + 1.206 1.012 -0.701
ENSG00000132153 E002 10.5538387 3.186945e-03 2.582351e-01 0.6639080892 3 47802850 47802908 59 + 1.095 0.978 -0.428
ENSG00000132153 E003 6.8934010 3.505833e-03 2.606067e-01 0.6660175819 3 47802909 47802928 20 + 0.944 0.807 -0.525
ENSG00000132153 E004 4.4681031 5.092050e-03 5.155583e-01 0.8379695011 3 47802929 47802933 5 + 0.690 0.780 0.368
ENSG00000132153 E005 5.5519162 4.149217e-03 3.272390e-01 0.7225697763 3 47802934 47802949 16 + 0.754 0.879 0.492
ENSG00000132153 E006 10.4157377 2.501645e-03 7.729412e-01 0.9402892673 3 47802950 47802995 46 + 1.057 1.028 -0.106
ENSG00000132153 E007 4.6658776 1.836259e-02 5.932736e-03 0.1369551439 3 47802996 47803046 51 + 0.900 0.468 -1.843
ENSG00000132153 E008 8.7605418 2.060002e-02 8.649341e-02 0.4308505360 3 47803047 47803106 60 + 1.079 0.858 -0.823
ENSG00000132153 E009 7.8898781 2.809849e-02 1.582117e-01 0.5514977312 3 47803107 47803124 18 + 1.029 0.834 -0.733
ENSG00000132153 E010 7.8209428 8.374487e-03 1.176741e-01 0.4894001509 3 47803125 47803133 9 + 1.024 0.833 -0.721
ENSG00000132153 E011 7.6660066 4.229566e-03 1.274356e-01 0.5063341607 3 47803134 47803137 4 + 1.014 0.832 -0.686
ENSG00000132153 E012 65.5858026 4.805240e-04 3.036007e-01 0.7028676547 3 47803138 47803164 27 + 1.797 1.842 0.152
ENSG00000132153 E013 131.2917367 5.937221e-03 1.527177e-01 0.5430271154 3 47803165 47803212 48 + 2.088 2.155 0.225
ENSG00000132153 E014 5.4260196 4.320927e-03 2.975180e-01 0.6977865531 3 47803610 47803730 121 + 0.859 0.720 -0.552
ENSG00000132153 E015 247.7207522 2.568125e-03 4.794214e-03 0.1243184335 3 47805326 47805420 95 + 2.348 2.442 0.313
ENSG00000132153 E016 1.3242138 1.906289e-01 6.268007e-01   3 47806156 47806286 131 + 0.314 0.405 0.541
ENSG00000132153 E017 200.7259541 2.789979e-03 2.597871e-03 0.0913604708 3 47810657 47810683 27 + 2.252 2.358 0.355
ENSG00000132153 E018 186.3610449 1.270179e-03 3.819536e-03 0.1106149089 3 47810684 47810711 28 + 2.228 2.317 0.297
ENSG00000132153 E019 68.4656727 3.355263e-02 1.692882e-04 0.0184504836 3 47815963 47816128 166 + 1.640 2.005 1.230
ENSG00000132153 E020 10.9345671 1.944866e-02 3.986559e-02 0.3137241121 3 47816129 47816972 844 + 0.948 1.185 0.862
ENSG00000132153 E021 0.5325511 2.065539e-02 3.657197e-01   3 47818005 47818021 17 + 0.100 0.249 1.571
ENSG00000132153 E022 206.4610390 3.711797e-03 9.668045e-01 0.9924085407 3 47818022 47818117 96 + 2.314 2.313 -0.002
ENSG00000132153 E023 0.5203070 1.992985e-01 4.438476e-01   3 47818118 47818128 11 + 0.102 0.249 1.558
ENSG00000132153 E024 1.4776611 1.155883e-02 1.155311e-01   3 47819218 47819226 9 + 0.250 0.521 1.572
ENSG00000132153 E025 3.0066255 1.499263e-01 2.832183e-01 0.6860874891 3 47819227 47819235 9 + 0.513 0.717 0.898
ENSG00000132153 E026 42.7062282 9.277905e-03 4.872339e-02 0.3407396076 3 47819236 47819264 29 + 1.571 1.711 0.474
ENSG00000132153 E027 3.0212162 6.901531e-03 8.694945e-01 0.9679748933 3 47822097 47822231 135 + 0.586 0.612 0.114
ENSG00000132153 E028 1.7777063 9.988772e-03 9.087003e-01 0.9781520691 3 47822232 47822310 79 + 0.449 0.467 0.092
ENSG00000132153 E029 50.9045357 1.775175e-02 4.741888e-01 0.8162292270 3 47824767 47825027 261 + 1.728 1.690 -0.131
ENSG00000132153 E030 703.8686346 8.473551e-05 5.796910e-07 0.0003796838 3 47825028 47825247 220 + 2.874 2.804 -0.233
ENSG00000132153 E031 2.8740556 3.162149e-02 2.264851e-02 0.2483168840 3 47825912 47826132 221 + 0.363 0.752 1.830
ENSG00000132153 E032 569.0581320 2.327950e-03 3.427573e-01 0.7340718723 3 47827347 47827372 26 + 2.762 2.738 -0.081
ENSG00000132153 E033 1143.1374873 3.105353e-03 7.553855e-01 0.9344099511 3 47827373 47827477 105 + 3.048 3.062 0.043
ENSG00000132153 E034 692.0688887 2.897174e-03 2.266783e-01 0.6316466510 3 47829024 47829027 4 + 2.818 2.859 0.136
ENSG00000132153 E035 1127.6697208 2.168988e-03 6.742501e-01 0.9056954918 3 47829028 47829134 107 + 3.042 3.057 0.049
ENSG00000132153 E036 3.5355948 1.790440e-01 3.669235e-01 0.7514740777 3 47829135 47829135 1 + 0.558 0.752 0.832
ENSG00000132153 E037 4.0385360 5.264696e-03 8.624975e-01 0.9665094965 3 47830780 47831128 349 + 0.712 0.687 -0.104
ENSG00000132153 E038 2431.2032702 3.533737e-04 9.976593e-01 0.9993327909 3 47840877 47841178 302 + 3.380 3.384 0.013
ENSG00000132153 E039 1699.7676876 9.147230e-04 6.520728e-01 0.8973767261 3 47841617 47841737 121 + 3.227 3.224 -0.008
ENSG00000132153 E040 120.3073428 1.302355e-01 2.206912e-02 0.2457440445 3 47841738 47842679 942 + 1.887 2.247 1.209
ENSG00000132153 E041 1733.9284438 7.195537e-05 7.252319e-03 0.1497996217 3 47843106 47843255 150 + 3.245 3.221 -0.081
ENSG00000132153 E042 12.9452304 7.519364e-03 2.397132e-03 0.0875526455 3 47845502 47845699 198 + 0.982 1.283 1.081
ENSG00000132153 E043 1791.7362715 5.368206e-04 4.595780e-01 0.8083836109 3 47845700 47845852 153 + 3.251 3.247 -0.014
ENSG00000132153 E044 4688.1897615 2.967054e-04 5.105428e-01 0.8350923575 3 47846165 47847001 837 + 3.665 3.668 0.009
ENSG00000132153 E045 1329.2301517 9.636638e-04 1.860645e-01 0.5868065857 3 47847273 47847348 76 + 3.103 3.138 0.116
ENSG00000132153 E046 1452.8885901 6.762601e-05 3.235154e-03 0.1023471122 3 47847432 47847536 105 + 3.144 3.175 0.100
ENSG00000132153 E047 21.4787387 2.259684e-02 2.876149e-04 0.0257206587 3 47847777 47847780 4 + 1.135 1.517 1.334
ENSG00000132153 E048 2069.5698489 4.686362e-05 2.973602e-01 0.6975941408 3 47847781 47847956 176 + 3.307 3.317 0.031
ENSG00000132153 E049 270.6826847 5.239971e-02 2.294970e-02 0.2498211028 3 47847957 47848179 223 + 2.306 2.552 0.820
ENSG00000132153 E050 2326.4065359 2.648822e-04 3.600213e-01 0.7469110925 3 47848180 47848386 207 + 3.365 3.359 -0.018
ENSG00000132153 E051 1735.1930425 5.317398e-05 4.858146e-03 0.1250059777 3 47848469 47848550 82 + 3.247 3.221 -0.083
ENSG00000132153 E052 2545.2996833 1.855615e-04 1.011245e-01 0.4593472665 3 47848624 47848817 194 + 3.407 3.396 -0.037
ENSG00000132153 E053 1951.2447913 2.964293e-04 1.317715e-01 0.5130274891 3 47848920 47849079 160 + 3.293 3.279 -0.046
ENSG00000132153 E054 2109.0883304 2.531413e-04 4.513858e-01 0.8043162345 3 47849192 47849349 158 + 3.323 3.318 -0.015
ENSG00000132153 E055 1982.6178707 1.177453e-03 9.200925e-01 0.9808251092 3 47849451 47849554 104 + 3.288 3.299 0.036
ENSG00000132153 E056 2144.5935221 2.111202e-03 5.807218e-01 0.8672100926 3 47849630 47849769 140 + 3.326 3.329 0.010
ENSG00000132153 E057 1711.9740446 2.528648e-03 6.719882e-01 0.9048860849 3 47849867 47850195 329 + 3.228 3.232 0.013