ENSG00000131941

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000254260 ENSG00000131941 HEK293_DMSO_6hA HEK293_OSMI2_6hA RHPN2 protein_coding protein_coding 9.639625 4.24763 5.322976 0.6269815 0.9814158 0.3248904 8.71891 3.694939 5.322976 0.6643313 0.9814158 0.5254909 0.9199792 0.8705333 1 0.1294667 8.860365e-05 8.860365e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000131941 E001 0.2920894 0.0277276858 0.8476624129   19 32978592 32978592 1 - 0.106 0.134 0.377
ENSG00000131941 E002 124.6487192 0.0002483467 0.0153109031 0.21044995 19 32978593 32979638 1046 - 2.066 2.136 0.237
ENSG00000131941 E003 39.2667982 0.0009853399 0.9026257743 0.97689950 19 32979639 32979790 152 - 1.602 1.609 0.024
ENSG00000131941 E004 45.0867466 0.0011496060 0.8338857643 0.95820245 19 32979791 32979953 163 - 1.664 1.653 -0.038
ENSG00000131941 E005 75.2262863 0.0015132816 0.1891174608 0.59048962 19 32979954 32980256 303 - 1.857 1.911 0.181
ENSG00000131941 E006 0.1544607 0.0322961747 0.3879195736   19 32990453 32990513 61 - 0.000 0.134 9.355
ENSG00000131941 E007 50.6027860 0.0007180440 0.5677932749 0.86135560 19 32990514 32990669 156 - 1.721 1.693 -0.094
ENSG00000131941 E008 0.0000000       19 32990670 32990772 103 -      
ENSG00000131941 E009 0.0000000       19 32991334 32991417 84 -      
ENSG00000131941 E010 49.7051014 0.0020692322 0.7372706110 0.92810971 19 32991823 32991969 147 - 1.708 1.690 -0.061
ENSG00000131941 E011 0.9696593 0.0149597029 0.0469508120   19 32991970 32992145 176 - 0.107 0.448 2.697
ENSG00000131941 E012 28.6037563 0.0010455224 0.9550588117 0.98966214 19 32993977 32994021 45 - 1.473 1.470 -0.011
ENSG00000131941 E013 27.0164372 0.0014148212 0.7734406904 0.94046707 19 32994022 32994053 32 - 1.435 1.453 0.065
ENSG00000131941 E014 54.3858982 0.0019993033 0.5797851075 0.86677201 19 32996026 32996220 195 - 1.731 1.758 0.090
ENSG00000131941 E015 2.0360138 0.0107516389 0.0005182821 0.03687203 19 32996221 32996461 241 - 0.107 0.696 3.831
ENSG00000131941 E016 41.2742823 0.0081330817 0.2890696589 0.69066042 19 32999586 32999705 120 - 1.666 1.593 -0.248
ENSG00000131941 E017 42.4091005 0.0016360117 0.0004310998 0.03301160 19 33002247 33002403 157 - 1.724 1.529 -0.663
ENSG00000131941 E018 38.8938042 0.0014447020 0.1035256495 0.46365340 19 33002813 33003000 188 - 1.647 1.556 -0.312
ENSG00000131941 E019 32.5539260 0.0036846973 0.2097634386 0.61395264 19 33008014 33008180 167 - 1.559 1.479 -0.271
ENSG00000131941 E020 30.1859081 0.0123599291 0.3274247612 0.72272628 19 33011679 33011803 125 - 1.453 1.540 0.299
ENSG00000131941 E021 27.6227344 0.0012037018 0.2845128839 0.68724131 19 33012647 33012724 78 - 1.425 1.495 0.241
ENSG00000131941 E022 31.2622200 0.0010834231 0.8459918437 0.96184715 19 33021571 33021646 76 - 1.512 1.500 -0.039
ENSG00000131941 E023 38.9871077 0.0013571654 0.8530606812 0.96356327 19 33026504 33026632 129 - 1.590 1.601 0.037
ENSG00000131941 E024 0.8699498 0.2094429954 0.1712133465   19 33026633 33027271 639 - 0.108 0.390 2.363
ENSG00000131941 E025 32.2933322 0.0008999021 0.7377612450 0.92825280 19 33044249 33044364 116 - 1.530 1.510 -0.068
ENSG00000131941 E026 18.8611510 0.0049310819 0.3378987859 0.73037671 19 33064784 33064888 105 - 1.343 1.263 -0.282