ENSG00000131652

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000326266 ENSG00000131652 HEK293_DMSO_6hA HEK293_OSMI2_6hA THOC6 protein_coding protein_coding 82.85724 74.70361 117.4021 8.660824 20.62019 0.6521379 52.249416 44.224810 89.910774 6.7093933 16.577453 1.0234723 0.62605417 0.58633333 0.76480000 0.17846667 7.309314e-06 7.309314e-06 FALSE TRUE
ENST00000574957 ENSG00000131652 HEK293_DMSO_6hA HEK293_OSMI2_6hA THOC6 protein_coding retained_intron 82.85724 74.70361 117.4021 8.660824 20.62019 0.6521379 3.346625 5.155761 3.691575 0.2281241 1.101767 -0.4808418 0.05285833 0.07096667 0.03760000 -0.03336667 3.445877e-01 7.309314e-06   FALSE
MSTRG.11906.7 ENSG00000131652 HEK293_DMSO_6hA HEK293_OSMI2_6hA THOC6 protein_coding   82.85724 74.70361 117.4021 8.660824 20.62019 0.6521379 17.760724 14.230260 11.539244 1.2456216 5.209014 -0.3021771 0.19548333 0.19253333 0.09026667 -0.10226667 2.535834e-01 7.309314e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000131652 E001 3.433775 6.283034e-03 0.6408477909 0.89262866 16 3024027 3024030 4 + 0.615 0.687 0.308
ENSG00000131652 E002 3.259205 7.035719e-03 0.8300136044 0.95688932 16 3024031 3024034 4 + 0.642 0.612 -0.130
ENSG00000131652 E003 8.881242 3.173434e-03 0.2405253283 0.64560721 16 3024035 3024040 6 + 1.047 0.921 -0.465
ENSG00000131652 E004 9.925312 4.561138e-03 0.1223698240 0.49784639 16 3024041 3024042 2 + 1.103 0.941 -0.596
ENSG00000131652 E005 22.176219 3.282861e-03 0.0001328306 0.01599653 16 3024043 3024053 11 + 1.477 1.173 -1.060
ENSG00000131652 E006 26.399842 1.391754e-03 0.0003062872 0.02682587 16 3024054 3024059 6 + 1.534 1.282 -0.872
ENSG00000131652 E007 27.898266 1.179728e-03 0.0002354338 0.02258264 16 3024060 3024060 1 + 1.557 1.308 -0.860
ENSG00000131652 E008 32.991785 1.328177e-02 0.0089477221 0.16469156 16 3024061 3024063 3 + 1.617 1.398 -0.750
ENSG00000131652 E009 67.483275 1.691263e-02 0.0958290863 0.44973971 16 3024064 3024086 23 + 1.887 1.757 -0.438
ENSG00000131652 E010 119.094912 1.081348e-02 0.0429667301 0.32357634 16 3024087 3024137 51 + 2.125 2.006 -0.398
ENSG00000131652 E011 297.169334 1.612958e-04 0.2297582002 0.63475103 16 3024138 3024192 55 + 2.481 2.461 -0.068
ENSG00000131652 E012 650.404637 2.232079e-04 0.1618331858 0.55662908 16 3024193 3024365 173 + 2.818 2.803 -0.049
ENSG00000131652 E013 256.200233 2.672497e-04 0.7878410893 0.94450451 16 3025708 3025711 4 + 2.405 2.416 0.036
ENSG00000131652 E014 680.870673 1.620436e-03 0.8187521904 0.95414007 16 3025712 3025823 112 + 2.820 2.842 0.073
ENSG00000131652 E015 31.422318 2.195433e-02 0.0030959521 0.10008854 16 3025824 3025923 100 + 1.353 1.645 1.003
ENSG00000131652 E016 549.378338 2.025473e-03 0.5691696963 0.86202692 16 3025924 3025988 65 + 2.722 2.754 0.107
ENSG00000131652 E017 77.496750 6.110656e-02 0.0261287387 0.26288811 16 3025989 3026062 74 + 1.746 2.026 0.945
ENSG00000131652 E018 734.785423 1.003421e-03 0.7552256056 0.93432738 16 3026063 3026166 104 + 2.854 2.872 0.062
ENSG00000131652 E019 82.881998 8.810501e-02 0.0285848885 0.27396536 16 3026167 3026250 84 + 1.759 2.067 1.036
ENSG00000131652 E020 562.359258 2.447148e-04 0.6037567508 0.87722437 16 3026251 3026288 38 + 2.740 2.755 0.048
ENSG00000131652 E021 61.777726 1.209909e-01 0.0579980862 0.36622773 16 3026289 3026364 76 + 1.641 1.936 0.996
ENSG00000131652 E022 667.607705 6.851427e-04 0.8959809503 0.97510299 16 3026365 3026413 49 + 2.816 2.827 0.037
ENSG00000131652 E023 38.395700 9.423727e-02 0.0544679219 0.35699228 16 3026414 3026515 102 + 1.445 1.728 0.965
ENSG00000131652 E024 830.121425 1.334753e-04 0.2042486112 0.60817928 16 3026516 3026587 72 + 2.907 2.929 0.072
ENSG00000131652 E025 886.840765 3.390076e-04 0.6440054944 0.89394320 16 3026679 3026781 103 + 2.947 2.946 -0.002
ENSG00000131652 E026 716.100590 3.296401e-04 0.3575108119 0.74512683 16 3026867 3026916 50 + 2.857 2.849 -0.026
ENSG00000131652 E027 675.366889 2.806787e-04 0.0197629907 0.23442415 16 3027011 3027073 63 + 2.840 2.811 -0.097
ENSG00000131652 E028 868.473874 9.864519e-05 0.1807294332 0.58027850 16 3027170 3027280 111 + 2.942 2.931 -0.038
ENSG00000131652 E029 766.021703 1.353438e-04 0.6339334247 0.88955529 16 3027366 3027500 135 + 2.877 2.889 0.040
ENSG00000131652 E030 485.350651 2.644238e-04 0.9106410804 0.97861488 16 3027577 3027814 238 + 2.684 2.687 0.013