ENSG00000130985

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000335972 ENSG00000130985 HEK293_DMSO_6hA HEK293_OSMI2_6hA UBA1 protein_coding protein_coding 403.3792 383.0017 596.8657 37.96807 79.63929 0.6400421 117.08061 99.08344 189.193359 11.2995003 32.340148 0.9330763 0.30195417 0.25796667 0.3132333 0.05526667 0.12956754 0.00053362 FALSE TRUE
ENST00000377351 ENSG00000130985 HEK293_DMSO_6hA HEK293_OSMI2_6hA UBA1 protein_coding protein_coding 403.3792 383.0017 596.8657 37.96807 79.63929 0.6400421 190.56409 183.39555 323.589628 23.8626605 47.885453 0.8191727 0.47792500 0.47586667 0.5399000 0.06403333 0.28059622 0.00053362 FALSE TRUE
MSTRG.34178.2 ENSG00000130985 HEK293_DMSO_6hA HEK293_OSMI2_6hA UBA1 protein_coding   403.3792 383.0017 596.8657 37.96807 79.63929 0.6400421 20.60766 15.81392 31.246280 0.1242376 4.494036 0.9820389 0.05605000 0.04226667 0.0523000 0.01003333 0.46571527 0.00053362 FALSE TRUE
MSTRG.34178.22 ENSG00000130985 HEK293_DMSO_6hA HEK293_OSMI2_6hA UBA1 protein_coding   403.3792 383.0017 596.8657 37.96807 79.63929 0.6400421 43.15791 34.44160 6.336819 11.4565289 4.861581 -2.4404652 0.07519167 0.08870000 0.0095000 -0.07920000 0.00053362 0.00053362 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000130985 E001 3.117763 1.353970e-01 9.963503e-01 9.990734e-01 X 47190748 47190794 47 + 0.595 0.612 0.079
ENSG00000130985 E002 2.978497 9.223659e-02 5.616332e-01 8.586767e-01 X 47190795 47190798 4 + 0.531 0.650 0.533
ENSG00000130985 E003 12.197261 5.580156e-03 9.540641e-01 9.893374e-01 X 47190799 47190810 12 + 1.116 1.122 0.019
ENSG00000130985 E004 137.962636 6.420915e-04 4.052602e-02 3.159168e-01 X 47190811 47190860 50 + 2.167 2.102 -0.217
ENSG00000130985 E005 1191.450906 5.283901e-04 8.207985e-05 1.210545e-02 X 47190861 47190950 90 + 3.095 3.039 -0.184
ENSG00000130985 E006 9.103460 1.498386e-01 9.051594e-01 9.775819e-01 X 47191399 47191422 24 + 1.003 0.989 -0.051
ENSG00000130985 E007 12.768255 1.084919e-01 7.028801e-01 9.161215e-01 X 47191423 47191567 145 + 1.112 1.157 0.163
ENSG00000130985 E008 15.517738 1.056820e-01 7.923716e-01 9.457451e-01 X 47191568 47191734 167 + 1.203 1.231 0.099
ENSG00000130985 E009 7.727188 2.225316e-02 4.330178e-01 7.935563e-01 X 47193809 47193810 2 + 0.880 0.992 0.421
ENSG00000130985 E010 10.600259 2.992359e-02 3.701028e-01 7.535338e-01 X 47193811 47193811 1 + 0.998 1.123 0.456
ENSG00000130985 E011 12.326338 2.291210e-02 3.508979e-01 7.402068e-01 X 47193812 47193813 2 + 1.062 1.182 0.432
ENSG00000130985 E012 24.610050 4.431821e-03 4.280851e-01 7.908890e-01 X 47193814 47193828 15 + 1.372 1.438 0.228
ENSG00000130985 E013 39.719080 1.998117e-03 4.834636e-01 8.211439e-01 X 47193829 47193836 8 + 1.586 1.631 0.154
ENSG00000130985 E014 1058.464554 9.642368e-04 9.244415e-05 1.294914e-02 X 47193837 47194024 188 + 3.050 2.982 -0.227
ENSG00000130985 E015 125.189674 1.057244e-01 4.262852e-02 3.223495e-01 X 47196356 47196469 114 + 1.945 2.238 0.983
ENSG00000130985 E016 104.937198 7.540067e-02 2.321742e-01 6.372009e-01 X 47196947 47197024 78 + 1.953 2.095 0.477
ENSG00000130985 E017 423.910855 9.104675e-02 4.645261e-02 3.343011e-01 X 47197199 47198017 819 + 2.491 2.753 0.871
ENSG00000130985 E018 127.069010 8.752646e-02 2.941991e-02 2.771452e-01 X 47198018 47198166 149 + 1.951 2.245 0.986
ENSG00000130985 E019 137.246677 8.329072e-02 4.279983e-02 3.229935e-01 X 47198167 47198308 142 + 2.004 2.264 0.873
ENSG00000130985 E020 122.725894 5.037856e-02 4.993243e-02 3.440152e-01 X 47198309 47198355 47 + 1.986 2.193 0.694
ENSG00000130985 E021 183.168147 7.111021e-02 2.351449e-02 2.524661e-01 X 47198527 47198802 276 + 2.122 2.393 0.907
ENSG00000130985 E022 3438.220165 5.440077e-05 2.826717e-09 6.505729e-06 X 47198803 47198919 117 + 3.547 3.510 -0.125
ENSG00000130985 E023 3029.766319 3.085427e-05 2.403527e-06 1.101719e-03 X 47199048 47199106 59 + 3.488 3.459 -0.097
ENSG00000130985 E024 4178.860407 2.965570e-04 1.410820e-05 3.896427e-03 X 47199209 47199377 169 + 3.632 3.596 -0.119
ENSG00000130985 E025 3456.798489 8.358812e-04 5.797647e-02 3.661289e-01 X 47199480 47199614 135 + 3.542 3.524 -0.063
ENSG00000130985 E026 2.079469 1.489368e-01 3.359317e-01 7.287937e-01 X 47200500 47200517 18 + 0.375 0.567 0.970
ENSG00000130985 E027 2.569600 1.602128e-01 2.650366e-01 6.699336e-01 X 47200518 47200544 27 + 0.425 0.647 1.048
ENSG00000130985 E028 2374.063709 5.481050e-04 1.909554e-02 2.312411e-01 X 47200894 47201000 107 + 3.381 3.356 -0.081
ENSG00000130985 E029 2680.139171 7.132421e-04 8.707075e-03 1.627203e-01 X 47201276 47201366 91 + 3.438 3.405 -0.111
ENSG00000130985 E030 3920.483078 7.605299e-04 9.757594e-02 4.529194e-01 X 47201478 47201610 133 + 3.597 3.579 -0.061
ENSG00000130985 E031 5.162919 5.287587e-03 3.889228e-01 7.663200e-01 X 47201611 47201611 1 + 0.831 0.717 -0.458
ENSG00000130985 E032 3713.252032 4.806023e-04 6.649186e-01 9.022715e-01 X 47202156 47202253 98 + 3.565 3.566 0.003
ENSG00000130985 E033 4395.201226 3.171351e-05 8.362784e-01 9.590130e-01 X 47202358 47202504 147 + 3.635 3.640 0.017
ENSG00000130985 E034 1748.881743 9.332096e-04 7.115056e-01 9.192317e-01 X 47202638 47202640 3 + 3.230 3.248 0.062
ENSG00000130985 E035 2793.030596 1.429655e-04 6.353459e-01 8.903837e-01 X 47202641 47202692 52 + 3.441 3.442 0.003
ENSG00000130985 E036 3877.310878 4.422582e-05 1.264388e-01 5.048632e-01 X 47202693 47202814 122 + 3.585 3.579 -0.020
ENSG00000130985 E037 3905.442066 2.456885e-04 6.214260e-01 8.846155e-01 X 47202943 47203047 105 + 3.586 3.588 0.007
ENSG00000130985 E038 3574.068761 4.642195e-04 2.337613e-01 6.386786e-01 X 47203134 47203214 81 + 3.550 3.545 -0.018
ENSG00000130985 E039 4493.012672 1.115713e-04 5.866202e-01 8.698330e-01 X 47203541 47203696 156 + 3.647 3.648 0.005
ENSG00000130985 E040 3407.722685 2.543408e-04 3.553078e-01 7.435727e-01 X 47205948 47206077 130 + 3.530 3.526 -0.014
ENSG00000130985 E041 2639.635574 4.882588e-05 1.800455e-02 2.258852e-01 X 47206078 47206113 36 + 3.423 3.408 -0.048
ENSG00000130985 E042 5669.851171 2.353055e-05 7.671975e-01 9.386216e-01 X 47206248 47206444 197 + 3.747 3.749 0.007
ENSG00000130985 E043 35.808152 1.248076e-01 5.285347e-02 3.523693e-01 X 47206445 47206664 220 + 1.407 1.702 1.009
ENSG00000130985 E044 149.017858 1.302428e-01 4.054419e-03 1.139315e-01 X 47208562 47209622 1061 + 1.920 2.368 1.500
ENSG00000130985 E045 3445.151912 8.456828e-05 2.880929e-01 6.899567e-01 X 47209623 47209687 65 + 3.526 3.539 0.043
ENSG00000130985 E046 4908.414343 3.685931e-04 3.382709e-01 7.307002e-01 X 47209928 47210123 196 + 3.686 3.687 0.001
ENSG00000130985 E047 3428.886959 1.029803e-03 6.836074e-01 9.095694e-01 X 47210842 47210916 75 + 3.522 3.542 0.067
ENSG00000130985 E048 5906.252529 4.164812e-04 2.403529e-01 6.454780e-01 X 47211036 47211225 190 + 3.757 3.780 0.076
ENSG00000130985 E049 4486.464981 4.281087e-04 1.517390e-02 2.094457e-01 X 47212424 47212512 89 + 3.631 3.668 0.124
ENSG00000130985 E050 4710.381610 1.483795e-04 6.774021e-02 3.907122e-01 X 47212771 47212863 93 + 3.658 3.679 0.070
ENSG00000130985 E051 7195.391280 2.311145e-04 5.591303e-03 1.331603e-01 X 47212990 47213181 192 + 3.839 3.870 0.103
ENSG00000130985 E052 9.750807 6.760702e-02 4.071834e-02 3.165562e-01 X 47213182 47213265 84 + 0.855 1.172 1.166
ENSG00000130985 E053 5668.936629 3.534388e-04 1.701333e-03 7.321969e-02 X 47214327 47214428 102 + 3.732 3.771 0.130
ENSG00000130985 E054 2745.186279 6.656307e-04 5.038071e-01 8.316949e-01 X 47214537 47214540 4 + 3.428 3.443 0.048
ENSG00000130985 E055 4801.004338 4.306030e-04 7.244042e-01 9.237209e-01 X 47214541 47214637 97 + 3.672 3.684 0.037
ENSG00000130985 E056 5387.673955 2.015912e-03 4.099036e-01 7.803224e-01 X 47214794 47215252 459 + 3.714 3.745 0.105