ENSG00000130827

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369682 ENSG00000130827 HEK293_DMSO_6hA HEK293_OSMI2_6hA PLXNA3 protein_coding protein_coding 18.73435 32.05162 28.00642 1.894889 5.529653 -0.1945748 1.463010 2.927355 2.109619 0.3667327 0.3839120 -0.4707131 0.07592083 0.09066667 0.07600000 -0.01466667 0.74796145 0.00139582 FALSE TRUE
ENST00000467463 ENSG00000130827 HEK293_DMSO_6hA HEK293_OSMI2_6hA PLXNA3 protein_coding processed_transcript 18.73435 32.05162 28.00642 1.894889 5.529653 -0.1945748 2.080671 2.693544 3.412004 0.5810795 1.7655866 0.3399900 0.10937917 0.08293333 0.11486667 0.03193333 0.98371731 0.00139582 FALSE FALSE
ENST00000478236 ENSG00000130827 HEK293_DMSO_6hA HEK293_OSMI2_6hA PLXNA3 protein_coding retained_intron 18.73435 32.05162 28.00642 1.894889 5.529653 -0.1945748 1.028031 1.376318 0.746862 0.7612518 0.7468620 -0.8731565 0.06034167 0.04313333 0.03310000 -0.01003333 0.74287534 0.00139582 FALSE FALSE
ENST00000480645 ENSG00000130827 HEK293_DMSO_6hA HEK293_OSMI2_6hA PLXNA3 protein_coding processed_transcript 18.73435 32.05162 28.00642 1.894889 5.529653 -0.1945748 1.010811 2.165435 2.220958 0.8161450 0.6488988 0.0363596 0.05218333 0.06823333 0.08476667 0.01653333 0.85133552 0.00139582   FALSE
ENST00000482598 ENSG00000130827 HEK293_DMSO_6hA HEK293_OSMI2_6hA PLXNA3 protein_coding retained_intron 18.73435 32.05162 28.00642 1.894889 5.529653 -0.1945748 1.823894 3.545796 2.351852 0.5016572 1.2615338 -0.5902540 0.09875000 0.10990000 0.07473333 -0.03516667 0.71322943 0.00139582   FALSE
ENST00000493546 ENSG00000130827 HEK293_DMSO_6hA HEK293_OSMI2_6hA PLXNA3 protein_coding processed_transcript 18.73435 32.05162 28.00642 1.894889 5.529653 -0.1945748 3.293243 5.831325 4.323017 0.2723110 1.1232633 -0.4309236 0.18030417 0.18230000 0.15156667 -0.03073333 0.70820355 0.00139582 FALSE TRUE
ENST00000497802 ENSG00000130827 HEK293_DMSO_6hA HEK293_OSMI2_6hA PLXNA3 protein_coding retained_intron 18.73435 32.05162 28.00642 1.894889 5.529653 -0.1945748 2.792988 5.722767 4.255123 0.4975083 1.1746109 -0.4266442 0.14220000 0.17803333 0.14843333 -0.02960000 0.71693649 0.00139582 FALSE TRUE
MSTRG.35113.4 ENSG00000130827 HEK293_DMSO_6hA HEK293_OSMI2_6hA PLXNA3 protein_coding   18.73435 32.05162 28.00642 1.894889 5.529653 -0.1945748 1.552821 3.432787 1.409887 0.6126772 0.9281101 -1.2778009 0.07792917 0.10806667 0.05583333 -0.05223333 0.56017931 0.00139582 TRUE TRUE
MSTRG.35113.6 ENSG00000130827 HEK293_DMSO_6hA HEK293_OSMI2_6hA PLXNA3 protein_coding   18.73435 32.05162 28.00642 1.894889 5.529653 -0.1945748 2.616859 2.205633 5.723477 0.4263865 0.9823534 1.3716914 0.14828333 0.07096667 0.20656667 0.13560000 0.00139582 0.00139582 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000130827 E001 0.000000       X 154458281 154458283 3 +      
ENSG00000130827 E002 0.468860 0.0217681645 0.5231445623   X 154458284 154458340 57 + 0.218 0.117 -1.081
ENSG00000130827 E003 0.937720 0.0330996403 0.3787511783   X 154458341 154458347 7 + 0.362 0.209 -1.080
ENSG00000130827 E004 1.452964 0.0135214779 0.6571148184   X 154458348 154458367 20 + 0.420 0.349 -0.406
ENSG00000130827 E005 17.161776 0.0142849046 0.1382452604 0.52270253 X 154458368 154458428 61 + 1.326 1.190 -0.480
ENSG00000130827 E006 58.844704 0.0012374090 0.0906641711 0.43979859 X 154460157 154460428 272 + 1.805 1.732 -0.248
ENSG00000130827 E007 105.597017 0.0035548760 0.6140511663 0.88182756 X 154460429 154460777 349 + 2.035 2.010 -0.083
ENSG00000130827 E008 150.315230 0.0172021943 0.3805797137 0.76042678 X 154461099 154461638 540 + 2.156 2.194 0.125
ENSG00000130827 E009 86.039223 0.0008225172 0.4411336841 0.79835068 X 154462128 154462310 183 + 1.909 1.948 0.133
ENSG00000130827 E010 65.922399 0.0044084082 0.8236291220 0.95539169 X 154463391 154463519 129 + 1.811 1.834 0.077
ENSG00000130827 E011 51.587776 0.0005726014 0.4080688618 0.77895039 X 154463590 154463690 101 + 1.729 1.699 -0.103
ENSG00000130827 E012 55.559562 0.0057121862 0.3183229596 0.71533518 X 154463951 154464074 124 + 1.773 1.727 -0.156
ENSG00000130827 E013 61.581952 0.0067269961 0.3223481442 0.71872966 X 154464157 154464313 157 + 1.821 1.765 -0.188
ENSG00000130827 E014 35.525272 0.0107688055 0.2255524412 0.63057496 X 154464402 154464448 47 + 1.606 1.507 -0.337
ENSG00000130827 E015 39.003762 0.0144906373 0.8817425208 0.97167257 X 154464449 154464501 53 + 1.596 1.591 -0.017
ENSG00000130827 E016 60.357075 0.0004783431 0.6044924820 0.87740991 X 154464754 154464868 115 + 1.788 1.775 -0.046
ENSG00000130827 E017 22.694383 0.0546587477 0.1886403222 0.58996156 X 154464869 154464980 112 + 1.297 1.421 0.431
ENSG00000130827 E018 88.775678 0.0003270841 0.8414186499 0.96076622 X 154465018 154465218 201 + 1.936 1.953 0.057
ENSG00000130827 E019 63.869858 0.0010797894 0.1861555230 0.58690027 X 154465424 154465520 97 + 1.831 1.779 -0.176
ENSG00000130827 E020 91.293852 0.0003907553 0.3429020374 0.73412341 X 154465657 154465847 191 + 1.971 1.945 -0.086
ENSG00000130827 E021 87.599106 0.0003816293 0.4283614405 0.79104780 X 154465935 154466080 146 + 1.916 1.956 0.134
ENSG00000130827 E022 5.818754 0.0159380863 0.0774241188 0.41222981 X 154466091 154466149 59 + 0.690 0.939 0.979
ENSG00000130827 E023 84.456242 0.0003438926 0.7230538050 0.92318527 X 154466150 154466270 121 + 1.924 1.920 -0.014
ENSG00000130827 E024 58.637955 0.0005252626 0.9426365615 0.98659948 X 154466376 154466418 43 + 1.757 1.770 0.043
ENSG00000130827 E025 74.386568 0.0004257434 0.6003807600 0.87558523 X 154466419 154466512 94 + 1.849 1.880 0.104
ENSG00000130827 E026 56.342572 0.0007193898 0.3243554803 0.72033642 X 154466623 154466680 58 + 1.772 1.734 -0.127
ENSG00000130827 E027 63.494089 0.0022664702 0.3068493560 0.70525909 X 154466681 154466721 41 + 1.824 1.781 -0.145
ENSG00000130827 E028 83.040848 0.0004674816 0.2672662112 0.67183060 X 154466722 154466793 72 + 1.931 1.897 -0.115
ENSG00000130827 E029 86.634767 0.0003429646 0.0432365171 0.32428171 X 154467057 154467150 94 + 1.968 1.900 -0.226
ENSG00000130827 E030 3.666844 0.0070274459 0.8078581924 0.95073758 X 154467151 154467175 25 + 0.631 0.672 0.175
ENSG00000130827 E031 141.967524 0.0002941045 0.1817964893 0.58169169 X 154467232 154467471 240 + 2.161 2.130 -0.102
ENSG00000130827 E032 118.012425 0.0087732020 0.2010872890 0.60461673 X 154467545 154467688 144 + 2.107 2.034 -0.246
ENSG00000130827 E033 144.975333 0.0004578194 0.9752030279 0.99423260 X 154467767 154468001 235 + 2.152 2.162 0.034
ENSG00000130827 E034 111.433228 0.0002801757 0.8777249619 0.97069229 X 154468082 154468224 143 + 2.036 2.051 0.049
ENSG00000130827 E035 142.661858 0.0002221128 0.8405810402 0.96053279 X 154468303 154468559 257 + 2.140 2.156 0.052
ENSG00000130827 E036 11.540030 0.0324083359 0.5495810857 0.85380758 X 154468617 154468660 44 + 1.054 1.114 0.217
ENSG00000130827 E037 6.017435 0.0880687568 0.8206789083 0.95465854 X 154468661 154468662 2 + 0.824 0.853 0.113
ENSG00000130827 E038 88.794590 0.0003103970 0.7283458328 0.92518731 X 154468663 154468729 67 + 1.947 1.944 -0.012
ENSG00000130827 E039 3.075856 0.0937917104 0.8143489102 0.95274737 X 154468730 154468822 93 + 0.587 0.643 0.246
ENSG00000130827 E040 149.195737 0.0002249680 0.4513302181 0.80431623 X 154468823 154468969 147 + 2.175 2.163 -0.041
ENSG00000130827 E041 95.131129 0.0003139943 0.4703717766 0.81403679 X 154469056 154469081 26 + 1.984 1.967 -0.056
ENSG00000130827 E042 167.932232 0.0001890604 0.5873350568 0.87018303 X 154469082 154469215 134 + 2.206 2.231 0.082
ENSG00000130827 E043 5.157412 0.0045663614 0.0353171540 0.29827435 X 154469216 154469350 135 + 0.595 0.891 1.205
ENSG00000130827 E044 136.628885 0.0003419582 0.6254537698 0.88620748 X 154469379 154469482 104 + 2.135 2.130 -0.017
ENSG00000130827 E045 132.411238 0.0012812409 0.7020320795 0.91577016 X 154469688 154469784 97 + 2.124 2.119 -0.016
ENSG00000130827 E046 202.815737 0.0005511418 0.5328048904 0.84661824 X 154469977 154470167 191 + 2.290 2.316 0.088
ENSG00000130827 E047 177.056352 0.0004755360 0.9173945310 0.98026127 X 154470442 154470611 170 + 2.236 2.249 0.043
ENSG00000130827 E048 12.947358 0.1322068162 0.1021299028 0.46120883 X 154470612 154470708 97 + 0.990 1.228 0.855
ENSG00000130827 E049 25.272323 0.0125722987 0.0052270245 0.12938030 X 154470847 154471104 258 + 1.258 1.511 0.879
ENSG00000130827 E050 229.504868 0.0043054431 0.2516761748 0.65762098 X 154471105 154471317 213 + 2.373 2.344 -0.099
ENSG00000130827 E051 230.640032 0.0018885166 0.3996449692 0.77318742 X 154471488 154471638 151 + 2.367 2.348 -0.061
ENSG00000130827 E052 177.902847 0.0008112641 0.7049816574 0.91696586 X 154472590 154472698 109 + 2.244 2.242 -0.006
ENSG00000130827 E053 482.218246 0.0033282401 0.7475569783 0.93191479 X 154472699 154473859 1161 + 2.669 2.689 0.069
ENSG00000130827 E054 277.704422 0.0105612535 0.0009017644 0.05094343 X 154473860 154477779 3920 + 2.344 2.510 0.554