ENSG00000130733

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000253031 ENSG00000130733 HEK293_DMSO_6hA HEK293_OSMI2_6hA YIPF2 protein_coding protein_coding 50.92034 46.05848 75.2398 4.484961 8.985539 0.7079078 11.579416 9.482757 16.838335 1.5067314 3.7549621 0.8277070 0.22410417 0.20310000 0.21846667 0.01536667 8.512765e-01 1.497153e-29 FALSE  
ENST00000586748 ENSG00000130733 HEK293_DMSO_6hA HEK293_OSMI2_6hA YIPF2 protein_coding protein_coding 50.92034 46.05848 75.2398 4.484961 8.985539 0.7079078 18.956756 20.627848 29.074207 1.7504213 3.3155645 0.4949434 0.36549167 0.44910000 0.38826667 -0.06083333 3.667143e-01 1.497153e-29 FALSE  
ENST00000588962 ENSG00000130733 HEK293_DMSO_6hA HEK293_OSMI2_6hA YIPF2 protein_coding retained_intron 50.92034 46.05848 75.2398 4.484961 8.985539 0.7079078 2.697223 4.189997 2.891066 0.2383835 0.2104458 -0.5338055 0.05787083 0.09176667 0.03903333 -0.05273333 3.221518e-05 1.497153e-29 FALSE  
MSTRG.16434.11 ENSG00000130733 HEK293_DMSO_6hA HEK293_OSMI2_6hA YIPF2 protein_coding   50.92034 46.05848 75.2398 4.484961 8.985539 0.7079078 1.370762 0.000000 4.130569 0.0000000 1.6479321 8.6936852 0.02575417 0.00000000 0.05166667 0.05166667 2.147365e-15 1.497153e-29 FALSE  
MSTRG.16434.3 ENSG00000130733 HEK293_DMSO_6hA HEK293_OSMI2_6hA YIPF2 protein_coding   50.92034 46.05848 75.2398 4.484961 8.985539 0.7079078 5.283801 6.496302 7.361960 0.8274686 1.1995465 0.1802106 0.10840000 0.14300000 0.09706667 -0.04593333 3.405130e-01 1.497153e-29 FALSE  
MSTRG.16434.6 ENSG00000130733 HEK293_DMSO_6hA HEK293_OSMI2_6hA YIPF2 protein_coding   50.92034 46.05848 75.2398 4.484961 8.985539 0.7079078 3.670938 0.000000 5.950575 0.0000000 1.4721000 9.2193077 0.07019583 0.00000000 0.07640000 0.07640000 1.497153e-29 1.497153e-29 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000130733 E001 1.673233 2.980510e-01 4.588125e-01 0.807898572 19 10922185 10922192 8 - 0.515 0.325 -1.030
ENSG00000130733 E002 555.328681 1.846893e-03 8.990691e-02 0.438445661 19 10922193 10922769 577 - 2.723 2.766 0.140
ENSG00000130733 E003 270.938718 3.003202e-03 8.285083e-01 0.956515748 19 10922770 10922834 65 - 2.432 2.428 -0.013
ENSG00000130733 E004 592.796321 5.461185e-04 3.666280e-01 0.751324002 19 10922835 10923100 266 - 2.761 2.779 0.059
ENSG00000130733 E005 347.822852 1.890393e-03 3.032593e-02 0.280842109 19 10923101 10923124 24 - 2.510 2.572 0.205
ENSG00000130733 E006 320.132588 5.432769e-04 1.139091e-02 0.184574096 19 10923125 10923133 9 - 2.475 2.533 0.191
ENSG00000130733 E007 384.093275 1.200166e-04 1.210983e-02 0.190128636 19 10923134 10923174 41 - 2.561 2.606 0.152
ENSG00000130733 E008 47.401251 6.936137e-04 2.122912e-02 0.241561283 19 10923175 10923191 17 - 1.628 1.744 0.395
ENSG00000130733 E009 11.433856 2.504098e-02 3.252719e-04 0.028000249 19 10923192 10923271 80 - 0.851 1.282 1.575
ENSG00000130733 E010 449.834800 1.270201e-04 5.213436e-01 0.840706342 19 10923272 10923351 80 - 2.645 2.656 0.038
ENSG00000130733 E011 348.171636 2.585025e-04 8.849192e-01 0.972517287 19 10923352 10923407 56 - 2.540 2.538 -0.006
ENSG00000130733 E012 179.143592 2.154449e-04 7.134485e-01 0.919781460 19 10923495 10923495 1 - 2.247 2.257 0.034
ENSG00000130733 E013 494.333287 7.585876e-04 8.317497e-01 0.957460851 19 10923496 10923677 182 - 2.694 2.691 -0.009
ENSG00000130733 E014 206.935229 5.907144e-04 9.456180e-01 0.987336936 19 10923833 10923836 4 - 2.318 2.316 -0.005
ENSG00000130733 E015 209.395793 2.539453e-04 8.644657e-01 0.966961584 19 10923837 10923841 5 - 2.324 2.320 -0.014
ENSG00000130733 E016 451.032691 9.454633e-05 4.029887e-01 0.775527782 19 10923842 10923980 139 - 2.658 2.644 -0.046
ENSG00000130733 E017 255.081585 1.640012e-04 1.842319e-01 0.584676592 19 10923981 10923999 19 - 2.417 2.387 -0.098
ENSG00000130733 E018 27.931453 2.064753e-02 3.357774e-03 0.104490773 19 10924000 10924075 76 - 1.320 1.589 0.927
ENSG00000130733 E019 473.076582 1.839999e-04 3.895419e-01 0.766654525 19 10924076 10924192 117 - 2.678 2.664 -0.045
ENSG00000130733 E020 414.822432 1.369351e-04 6.459073e-01 0.894715694 19 10925686 10925773 88 - 2.617 2.610 -0.025
ENSG00000130733 E021 4.933465 1.724828e-01 8.439048e-01 0.961270883 19 10927598 10927629 32 - 0.801 0.710 -0.365
ENSG00000130733 E022 353.235501 1.077954e-03 4.407582e-01 0.798131899 19 10927630 10927716 87 - 2.552 2.539 -0.043
ENSG00000130733 E023 21.462483 1.705570e-03 9.153543e-01 0.979813480 19 10927717 10927769 53 - 1.337 1.346 0.030
ENSG00000130733 E024 12.309749 2.230323e-03 3.907012e-01 0.767511024 19 10927770 10927798 29 - 1.085 1.165 0.287
ENSG00000130733 E025 640.468578 6.826802e-04 9.502650e-02 0.448203862 19 10927799 10927959 161 - 2.814 2.789 -0.081
ENSG00000130733 E026 402.204118 1.351846e-03 6.268742e-02 0.378939560 19 10928380 10928440 61 - 2.619 2.579 -0.134
ENSG00000130733 E027 9.733380 2.646155e-02 5.848068e-01 0.868926826 19 10928441 10928510 70 - 1.000 1.065 0.237
ENSG00000130733 E028 225.953395 1.791510e-04 1.764319e-03 0.074620587 19 10928511 10928584 74 - 2.385 2.310 -0.250
ENSG00000130733 E029 238.922074 2.613670e-04 4.512471e-05 0.008280809 19 10928585 10928692 108 - 2.416 2.320 -0.323