ENSG00000128641

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000304164 ENSG00000128641 HEK293_DMSO_6hA HEK293_OSMI2_6hA MYO1B protein_coding protein_coding 7.335574 2.45318 2.824361 0.8949674 0.5528969 0.2025015 0.7961359 0.9634833 0.44354418 0.50605111 0.44354418 -1.1019131 0.14624167 0.35996667 0.13790000 -0.22206667 0.62445588 0.02386414 FALSE TRUE
ENST00000339514 ENSG00000128641 HEK293_DMSO_6hA HEK293_OSMI2_6hA MYO1B protein_coding protein_coding 7.335574 2.45318 2.824361 0.8949674 0.5528969 0.2025015 0.7600450 0.0000000 0.51101994 0.00000000 0.24509187 5.7032667 0.08807917 0.00000000 0.15680000 0.15680000 0.02703011 0.02386414 FALSE TRUE
ENST00000392316 ENSG00000128641 HEK293_DMSO_6hA HEK293_OSMI2_6hA MYO1B protein_coding protein_coding 7.335574 2.45318 2.824361 0.8949674 0.5528969 0.2025015 1.2290145 0.1397535 0.48875499 0.13975350 0.05772125 1.7357416 0.17132083 0.03303333 0.19490000 0.16186667 0.29736105 0.02386414 FALSE TRUE
ENST00000392318 ENSG00000128641 HEK293_DMSO_6hA HEK293_OSMI2_6hA MYO1B protein_coding protein_coding 7.335574 2.45318 2.824361 0.8949674 0.5528969 0.2025015 2.6157738 0.2751644 0.83305008 0.27516438 0.45981342 1.5638246 0.33580417 0.19870000 0.32556667 0.12686667 0.67630765 0.02386414 FALSE TRUE
ENST00000427152 ENSG00000128641 HEK293_DMSO_6hA HEK293_OSMI2_6hA MYO1B protein_coding protein_coding 7.335574 2.45318 2.824361 0.8949674 0.5528969 0.2025015 0.2749809 0.1977338 0.39024859 0.19773383 0.24267001 0.9461601 0.03973333 0.04673333 0.11376667 0.06703333 0.74796145 0.02386414 FALSE FALSE
ENST00000490069 ENSG00000128641 HEK293_DMSO_6hA HEK293_OSMI2_6hA MYO1B protein_coding retained_intron 7.335574 2.45318 2.824361 0.8949674 0.5528969 0.2025015 0.2495542 0.3502529 0.09203849 0.09725019 0.01929740 -1.8198964 0.04772917 0.15630000 0.03736667 -0.11893333 0.21963652 0.02386414 FALSE TRUE
MSTRG.19685.5 ENSG00000128641 HEK293_DMSO_6hA HEK293_OSMI2_6hA MYO1B protein_coding   7.335574 2.45318 2.824361 0.8949674 0.5528969 0.2025015 0.8403695 0.3818335 0.00000000 0.21258383 0.00000000 -5.2921689 0.11476250 0.14720000 0.00000000 -0.14720000 0.02386414 0.02386414 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000128641 E001 0.0000000       2 191245185 191245257 73 +      
ENSG00000128641 E002 0.1767706 0.0474527589 0.563293579   2 191245276 191245403 128 + 0.113 0.000 -8.787
ENSG00000128641 E003 0.1767706 0.0474527589 0.563293579   2 191245404 191245408 5 + 0.113 0.000 -11.409
ENSG00000128641 E004 2.1358380 0.3418690964 0.229348794 0.63446619 2 191245409 191245527 119 + 0.639 0.306 -1.710
ENSG00000128641 E005 4.3865165 0.1012225395 0.489451315 0.82432567 2 191245528 191245611 84 + 0.808 0.672 -0.556
ENSG00000128641 E006 3.7552401 0.0884179825 0.852750833 0.96353547 2 191245612 191245626 15 + 0.705 0.672 -0.138
ENSG00000128641 E007 0.0000000       2 191246283 191246367 85 +      
ENSG00000128641 E008 0.0000000       2 191262999 191263353 355 +      
ENSG00000128641 E009 0.0000000       2 191263354 191263388 35 +      
ENSG00000128641 E010 0.0000000       2 191263573 191263686 114 +      
ENSG00000128641 E011 0.1767706 0.0474527589 0.563293579   2 191276885 191276886 2 + 0.113 0.000 -11.409
ENSG00000128641 E012 9.9679531 0.0027459490 0.970766191 0.99319380 2 191276887 191277030 144 + 1.044 1.048 0.013
ENSG00000128641 E013 10.0644206 0.0030200997 0.934768159 0.98466554 2 191296111 191296226 116 + 1.055 1.061 0.023
ENSG00000128641 E014 9.7766395 0.0076597374 0.705554613 0.91713355 2 191329935 191330029 95 + 1.055 1.007 -0.178
ENSG00000128641 E015 10.7969675 0.0073812594 0.671741920 0.90483260 2 191341461 191341565 105 + 1.046 1.086 0.146
ENSG00000128641 E016 7.7637489 0.0030772355 0.541923641 0.85072643 2 191346236 191346282 47 + 0.909 0.977 0.253
ENSG00000128641 E017 9.4534845 0.0028518102 0.791050918 0.94539870 2 191350162 191350225 64 + 1.008 1.035 0.098
ENSG00000128641 E018 0.0000000       2 191350226 191350389 164 +      
ENSG00000128641 E019 11.2188201 0.0023936642 0.418527542 0.78542213 2 191360631 191360729 99 + 1.128 1.048 -0.290
ENSG00000128641 E020 13.7284619 0.0018801593 0.353461950 0.74221411 2 191362268 191362371 104 + 1.215 1.132 -0.296
ENSG00000128641 E021 19.0083467 0.0110262025 0.243936830 0.64921187 2 191363728 191363875 148 + 1.361 1.260 -0.352
ENSG00000128641 E022 17.4378157 0.0014992423 0.251985982 0.65776568 2 191364158 191364276 119 + 1.313 1.220 -0.326
ENSG00000128641 E023 10.0652312 0.0032826104 0.280225238 0.68327194 2 191369542 191369563 22 + 1.089 0.977 -0.412
ENSG00000128641 E024 13.2750522 0.0041334473 0.236321728 0.64133360 2 191369564 191369628 65 + 1.207 1.097 -0.393
ENSG00000128641 E025 13.0245174 0.0061080197 0.979053237 0.99496422 2 191370227 191370292 66 + 1.140 1.142 0.008
ENSG00000128641 E026 0.0000000       2 191377522 191377917 396 +      
ENSG00000128641 E027 0.0000000       2 191379267 191379272 6 +      
ENSG00000128641 E028 0.2842848 0.0305345780 0.910007337   2 191381004 191381461 458 + 0.112 0.127 0.200
ENSG00000128641 E029 14.3172675 0.0048600730 0.480813962 0.81964575 2 191381462 191381566 105 + 1.209 1.142 -0.236
ENSG00000128641 E030 12.9730949 0.0138510968 0.503322133 0.83145815 2 191383280 191383342 63 + 1.170 1.097 -0.260
ENSG00000128641 E031 14.8956324 0.0077648156 0.160086754 0.55451566 2 191385884 191385973 90 + 1.255 1.121 -0.477
ENSG00000128641 E032 13.1175502 0.0127774347 0.021994317 0.24533227 2 191385974 191386084 111 + 1.258 1.007 -0.900
ENSG00000128641 E033 21.3518759 0.0033877323 0.233021236 0.63795370 2 191387224 191387450 227 + 1.402 1.308 -0.327
ENSG00000128641 E034 0.1795728 0.0408389208 0.424770272   2 191387451 191388276 826 + 0.000 0.127 10.810
ENSG00000128641 E035 20.7824136 0.0015144841 0.801950935 0.94889590 2 191390292 191390492 201 + 1.354 1.336 -0.064
ENSG00000128641 E036 12.2428456 0.0021496917 0.709127293 0.91837452 2 191392108 191392201 94 + 1.109 1.142 0.121
ENSG00000128641 E037 18.9283556 0.0017179961 0.808574538 0.95096473 2 191393073 191393222 150 + 1.313 1.293 -0.069
ENSG00000128641 E038 15.0964988 0.0017685733 0.357802486 0.74531112 2 191396429 191396497 69 + 1.252 1.173 -0.280
ENSG00000128641 E039 16.7875330 0.0016617497 0.074115195 0.40446809 2 191400382 191400468 87 + 1.319 1.173 -0.514
ENSG00000128641 E040 11.8954686 0.0023136826 0.730684044 0.92595799 2 191400749 191400835 87 + 1.099 1.132 0.118
ENSG00000128641 E041 6.0117575 0.0252148280 0.000692931 0.04425645 2 191401540 191402631 1092 + 0.529 1.021 1.995
ENSG00000128641 E042 15.2430228 0.0122635867 0.729060883 0.92537915 2 191402632 191402718 87 + 1.186 1.227 0.147
ENSG00000128641 E043 0.9914936 0.0151723281 0.067133820   2 191407658 191408114 457 + 0.113 0.430 2.515
ENSG00000128641 E044 19.5868906 0.0014953489 0.350957678 0.74023430 2 191408115 191408189 75 + 1.280 1.349 0.241
ENSG00000128641 E045 24.8708830 0.0013466743 0.122776772 0.49835189 2 191409044 191409178 135 + 1.360 1.464 0.359
ENSG00000128641 E046 0.0000000       2 191411065 191411065 1 +      
ENSG00000128641 E047 25.7424997 0.0103693720 0.167078498 0.56333854 2 191411066 191411172 107 + 1.367 1.483 0.399
ENSG00000128641 E048 32.2826398 0.0016013971 0.151963151 0.54210366 2 191414048 191414180 133 + 1.485 1.571 0.293
ENSG00000128641 E049 39.4951227 0.0064842834 0.912321092 0.97904957 2 191414517 191414669 153 + 1.619 1.611 -0.026
ENSG00000128641 E050 37.7290389 0.0009604736 0.614806915 0.88221173 2 191416115 191416242 128 + 1.583 1.609 0.089
ENSG00000128641 E051 0.8106075 0.1009194460 0.251482941   2 191416243 191416511 269 + 0.342 0.127 -1.826
ENSG00000128641 E052 97.7387026 0.0004211365 0.014398039 0.20493769 2 191423837 191425389 1553 + 1.956 2.035 0.264