ENSG00000127483

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000312239 ENSG00000127483 HEK293_DMSO_6hA HEK293_OSMI2_6hA HP1BP3 protein_coding protein_coding 59.61643 47.04106 45.46406 13.39762 0.6604046 -0.04918351 17.015770 7.016030 15.688397 0.4130533 4.39354582 1.1598355 0.32775000 0.16996667 0.34253333 0.17256667 0.34554335 0.01578411 FALSE TRUE
ENST00000375003 ENSG00000127483 HEK293_DMSO_6hA HEK293_OSMI2_6hA HP1BP3 protein_coding protein_coding 59.61643 47.04106 45.46406 13.39762 0.6604046 -0.04918351 7.527612 14.783142 6.435506 4.2500347 1.70354276 -1.1985631 0.13160417 0.31366667 0.14260000 -0.17106667 0.01578411 0.01578411 FALSE TRUE
ENST00000424732 ENSG00000127483 HEK293_DMSO_6hA HEK293_OSMI2_6hA HP1BP3 protein_coding protein_coding 59.61643 47.04106 45.46406 13.39762 0.6604046 -0.04918351 8.621472 1.891510 3.598397 1.2089728 0.06195901 0.9242127 0.12358750 0.03293333 0.07916667 0.04623333 0.58635942 0.01578411 FALSE TRUE
ENST00000487117 ENSG00000127483 HEK293_DMSO_6hA HEK293_OSMI2_6hA HP1BP3 protein_coding processed_transcript 59.61643 47.04106 45.46406 13.39762 0.6604046 -0.04918351 4.592981 6.851393 3.496564 2.5119299 1.03797838 -0.9684435 0.07425000 0.13930000 0.07760000 -0.06170000 0.29719988 0.01578411 FALSE TRUE
ENST00000488722 ENSG00000127483 HEK293_DMSO_6hA HEK293_OSMI2_6hA HP1BP3 protein_coding processed_transcript 59.61643 47.04106 45.46406 13.39762 0.6604046 -0.04918351 4.932211 1.378393 2.275468 1.3783930 1.16130793 0.7190738 0.06569167 0.01870000 0.05066667 0.03196667 0.72700176 0.01578411 TRUE TRUE
MSTRG.478.3 ENSG00000127483 HEK293_DMSO_6hA HEK293_OSMI2_6hA HP1BP3 protein_coding   59.61643 47.04106 45.46406 13.39762 0.6604046 -0.04918351 4.849980 6.498838 5.127874 2.3039839 0.49635815 -0.3412286 0.08409167 0.13316667 0.11270000 -0.02046667 0.73214420 0.01578411 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000127483 E001 12.3579295 2.233843e-03 3.284808e-01 0.7233782180 1 20740266 20742678 2413 - 1.054 1.177 0.444
ENSG00000127483 E002 5.9289648 4.113077e-03 6.296914e-01 0.8879262090 1 20742679 20742681 3 - 0.853 0.820 -0.126
ENSG00000127483 E003 36.3355667 9.809718e-04 4.003577e-01 0.7735319601 1 20742682 20742730 49 - 1.529 1.609 0.271
ENSG00000127483 E004 266.6584032 4.522877e-03 3.776812e-02 0.3063604410 1 20742731 20742941 211 - 2.368 2.473 0.349
ENSG00000127483 E005 137.0452388 5.313844e-03 2.576821e-01 0.6633896214 1 20742942 20742943 2 - 2.098 2.175 0.259
ENSG00000127483 E006 207.9210749 9.352248e-03 1.659205e-01 0.5617168286 1 20742944 20742988 45 - 2.267 2.361 0.315
ENSG00000127483 E007 143.2446081 1.087974e-02 4.522208e-01 0.8046815371 1 20742989 20742989 1 - 2.123 2.187 0.213
ENSG00000127483 E008 306.2014641 7.278166e-03 5.292186e-01 0.8446381040 1 20742990 20743134 145 - 2.459 2.509 0.166
ENSG00000127483 E009 154.7666285 1.626870e-03 4.445630e-01 0.8003225255 1 20743135 20743174 40 - 2.162 2.217 0.184
ENSG00000127483 E010 1461.2606502 1.942970e-03 5.643572e-01 0.8596319242 1 20743175 20744625 1451 - 3.145 3.180 0.118
ENSG00000127483 E011 233.2972572 2.726659e-03 5.567206e-01 0.8567121010 1 20744626 20744743 118 - 2.363 2.374 0.038
ENSG00000127483 E012 499.5359232 9.738834e-05 2.020025e-01 0.6057165315 1 20744744 20745091 348 - 2.693 2.705 0.041
ENSG00000127483 E013 208.3370402 2.118477e-04 5.888444e-02 0.3686734920 1 20745543 20745591 49 - 2.328 2.315 -0.046
ENSG00000127483 E014 237.5550094 2.837593e-04 5.345370e-01 0.8473917335 1 20745592 20745656 65 - 2.368 2.386 0.061
ENSG00000127483 E015 222.0934831 1.788336e-04 2.354739e-01 0.6403782830 1 20747544 20747614 71 - 2.346 2.351 0.014
ENSG00000127483 E016 171.7256861 2.288321e-04 1.736508e-02 0.2229275932 1 20747615 20747655 41 - 2.256 2.224 -0.107
ENSG00000127483 E017 291.6565483 7.010194e-04 1.018158e-02 0.1749097509 1 20749723 20749882 160 - 2.485 2.454 -0.103
ENSG00000127483 E018 29.3007634 2.338107e-02 1.314992e-01 0.5126202838 1 20749883 20749975 93 - 1.382 1.550 0.578
ENSG00000127483 E019 6.5469565 3.695536e-02 6.850175e-02 0.3924274480 1 20749976 20750251 276 - 0.691 0.986 1.153
ENSG00000127483 E020 25.7792528 2.894468e-02 6.215858e-02 0.3774065089 1 20755045 20755238 194 - 1.287 1.509 0.767
ENSG00000127483 E021 21.5152730 4.151306e-03 1.423477e-02 0.2042277188 1 20755239 20755404 166 - 1.209 1.439 0.800
ENSG00000127483 E022 187.3784711 2.171953e-04 2.284022e-01 0.6336458953 1 20757166 20757198 33 - 2.277 2.278 0.002
ENSG00000127483 E023 226.5201449 1.682009e-04 5.307147e-01 0.8453409534 1 20757199 20757256 58 - 2.350 2.367 0.058
ENSG00000127483 E024 317.0654515 1.169808e-04 8.437344e-01 0.9612272667 1 20765377 20765526 150 - 2.483 2.519 0.121
ENSG00000127483 E025 120.2358632 1.709303e-03 4.645090e-01 0.8108928491 1 20765527 20765531 5 - 2.083 2.083 0.000
ENSG00000127483 E026 220.0660401 1.707820e-04 5.841633e-01 0.8686232516 1 20767584 20767664 81 - 2.334 2.353 0.063
ENSG00000127483 E027 294.9366494 8.780565e-04 3.904100e-01 0.7672511348 1 20770930 20771073 144 - 2.463 2.475 0.038
ENSG00000127483 E028 287.4060991 5.028127e-04 6.958384e-02 0.3947507239 1 20773451 20773586 136 - 2.465 2.457 -0.028
ENSG00000127483 E029 130.6711615 9.149348e-04 9.517584e-02 0.4485250681 1 20773587 20773610 24 - 2.136 2.113 -0.078
ENSG00000127483 E030 396.4027272 7.043985e-02 7.059803e-03 0.1481393148 1 20773611 20775005 1395 - 2.401 2.717 1.052
ENSG00000127483 E031 53.4839392 1.118878e-01 3.814687e-02 0.3074701624 1 20775450 20775654 205 - 1.512 1.863 1.192
ENSG00000127483 E032 32.0667424 8.810248e-02 1.899739e-01 0.5914475039 1 20775655 20775723 69 - 1.380 1.608 0.782
ENSG00000127483 E033 92.4967680 2.745988e-02 5.432447e-02 0.3567198325 1 20775724 20776005 282 - 1.855 2.049 0.653
ENSG00000127483 E034 115.7953128 5.283673e-02 2.342033e-02 0.2520267172 1 20776006 20776596 591 - 1.903 2.169 0.894
ENSG00000127483 E035 229.5469218 7.026891e-04 1.746859e-06 0.0008745323 1 20776597 20776697 101 - 2.412 2.320 -0.304
ENSG00000127483 E036 143.4784156 2.652389e-03 3.624250e-04 0.0295411107 1 20776698 20776712 15 - 2.213 2.111 -0.342
ENSG00000127483 E037 121.8405933 1.584596e-03 4.222687e-04 0.0326104644 1 20776713 20776719 7 - 2.139 2.043 -0.321
ENSG00000127483 E038 159.4669412 1.347251e-03 2.317417e-04 0.0224177918 1 20776720 20776750 31 - 2.251 2.165 -0.288
ENSG00000127483 E039 139.6783285 1.753363e-03 1.246552e-02 0.1926372732 1 20779812 20779835 24 - 2.181 2.123 -0.194
ENSG00000127483 E040 186.7107445 4.943727e-04 3.291993e-04 0.0281627674 1 20779836 20779911 76 - 2.310 2.244 -0.221
ENSG00000127483 E041 64.6775194 4.749832e-04 7.477182e-05 0.0114685801 1 20780345 20780349 5 - 1.888 1.747 -0.475
ENSG00000127483 E042 149.7571903 2.663161e-04 1.452199e-03 0.0670313048 1 20780350 20780540 191 - 2.211 2.151 -0.201
ENSG00000127483 E043 0.6775699 1.859845e-02 4.736260e-02   1 20780541 20780541 1 - 0.000 0.352 10.758
ENSG00000127483 E044 35.2543591 2.057167e-03 7.459115e-01 0.9314389337 1 20786186 20786252 67 - 1.554 1.566 0.042
ENSG00000127483 E045 66.1622483 5.770122e-04 6.626180e-03 0.1433817733 1 20786253 20786513 261 - 1.870 1.784 -0.289
ENSG00000127483 E046 24.2545490 3.161788e-03 2.434985e-03 0.0883553079 1 20786514 20786648 135 - 1.488 1.295 -0.668
ENSG00000127483 E047 13.4722625 2.748917e-02 1.500263e-02 0.2085916136 1 20786649 20786802 154 - 1.285 1.015 -0.965
ENSG00000127483 E048 32.1441508 9.443765e-04 6.792730e-03 0.1452408479 1 20787195 20787323 129 - 1.591 1.459 -0.453