ENSG00000126883

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000359428 ENSG00000126883 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUP214 protein_coding protein_coding 27.28923 28.40022 36.64529 1.553073 3.911404 0.3676112 10.584808 8.619686 17.233501 1.113120 2.8667458 0.9986727 0.4165042 0.3010333 0.4634333 0.16240000 0.01598346 0.01598346 FALSE TRUE
ENST00000411637 ENSG00000126883 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUP214 protein_coding protein_coding 27.28923 28.40022 36.64529 1.553073 3.911404 0.3676112 3.450607 3.016723 4.693255 0.627598 0.3528145 0.6359029 0.1385958 0.1074333 0.1293667 0.02193333 0.74957775 0.01598346 FALSE TRUE
ENST00000695500 ENSG00000126883 HEK293_DMSO_6hA HEK293_OSMI2_6hA NUP214 protein_coding retained_intron 27.28923 28.40022 36.64529 1.553073 3.911404 0.3676112 4.549676 5.679127 6.944131 1.116977 1.5518716 0.2896628 0.1347042 0.1980333 0.1844000 -0.01363333 0.93077826 0.01598346 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000126883 E001 2.6318950 0.0157416575 0.5555056699 0.85625491 9 131125573 131125585 13 + 0.601 0.507 -0.432
ENSG00000126883 E002 3.4542962 0.0060480264 0.3049736979 0.70382695 9 131125586 131125593 8 + 0.706 0.555 -0.658
ENSG00000126883 E003 4.2738951 0.0053846186 0.0756634518 0.40828796 9 131125594 131125595 2 + 0.809 0.555 -1.074
ENSG00000126883 E004 87.4746448 0.0098510828 0.0419231689 0.32027721 9 131125596 131125738 143 + 1.994 1.873 -0.407
ENSG00000126883 E005 63.6655749 0.0055533469 0.0535899228 0.35450429 9 131125739 131125749 11 + 1.851 1.746 -0.353
ENSG00000126883 E006 0.1125166 0.0325950023 0.6306360994   9 131125973 131126079 107 + 0.104 0.000 -10.957
ENSG00000126883 E007 0.1125166 0.0325950023 0.6306360994   9 131126080 131126093 14 + 0.104 0.000 -10.957
ENSG00000126883 E008 0.0000000       9 131126094 131126194 101 +      
ENSG00000126883 E009 0.0000000       9 131126412 131126460 49 +      
ENSG00000126883 E010 80.7618831 0.0052987905 0.0406685342 0.31642556 9 131127524 131127576 53 + 1.954 1.851 -0.347
ENSG00000126883 E011 115.1044868 0.0002783919 0.0738079138 0.40374461 9 131127577 131127719 143 + 2.085 2.031 -0.181
ENSG00000126883 E012 143.1911838 0.0002387007 0.9362011724 0.98507788 9 131128332 131128483 152 + 2.149 2.157 0.027
ENSG00000126883 E013 0.0000000       9 131128528 131128808 281 +      
ENSG00000126883 E014 173.6274473 0.0002237095 0.6890010238 0.91141021 9 131129279 131129477 199 + 2.237 2.232 -0.017
ENSG00000126883 E015 118.7108455 0.0024897523 0.3922202425 0.76835275 9 131130766 131130836 71 + 2.084 2.056 -0.092
ENSG00000126883 E016 108.4688566 0.0007550893 0.5643986886 0.85963192 9 131132596 131132659 64 + 2.043 2.028 -0.051
ENSG00000126883 E017 118.8170203 0.0032737689 0.7841912511 0.94341952 9 131133106 131133196 91 + 2.080 2.074 -0.018
ENSG00000126883 E018 82.7917002 0.0037106347 0.8449206917 0.96156866 9 131133197 131133209 13 + 1.917 1.931 0.047
ENSG00000126883 E019 138.3317300 0.0002566956 0.7834944355 0.94316902 9 131134898 131135004 107 + 2.143 2.140 -0.010
ENSG00000126883 E020 0.8045307 0.0168830406 0.9040798903   9 131135005 131135725 721 + 0.259 0.240 -0.143
ENSG00000126883 E021 0.1125166 0.0325950023 0.6306360994   9 131135726 131135881 156 + 0.104 0.000 -10.957
ENSG00000126883 E022 0.0000000       9 131135882 131135939 58 +      
ENSG00000126883 E023 93.5116336 0.0004538444 0.5777944151 0.86581298 9 131135940 131135987 48 + 1.980 1.965 -0.051
ENSG00000126883 E024 78.1880434 0.0030931832 0.7666337041 0.93831925 9 131135988 131136006 19 + 1.902 1.894 -0.026
ENSG00000126883 E025 143.8248702 0.0002853096 0.0293853611 0.27712815 9 131139281 131139407 127 + 2.184 2.124 -0.201
ENSG00000126883 E026 140.8895331 0.0003621753 0.0153827477 0.21082290 9 131140549 131140710 162 + 2.177 2.108 -0.232
ENSG00000126883 E027 3.4102102 0.0244848818 0.2248886112 0.62997057 9 131140711 131142981 2271 + 0.538 0.735 0.853
ENSG00000126883 E028 171.0309089 0.0051410644 0.7742512781 0.94068223 9 131144280 131144567 288 + 2.238 2.228 -0.035
ENSG00000126883 E029 48.2210353 0.0156357520 0.9445174442 0.98707812 9 131144568 131144576 9 + 1.685 1.694 0.031
ENSG00000126883 E030 118.5705189 0.0005836418 0.8279011471 0.95636762 9 131144577 131144701 125 + 2.076 2.074 -0.008
ENSG00000126883 E031 94.0724802 0.0004382409 0.1614917630 0.55622184 9 131144702 131144754 53 + 1.994 1.947 -0.157
ENSG00000126883 E032 10.5175930 0.1805477665 0.1246235844 0.50157262 9 131144755 131145340 586 + 0.911 1.185 0.999
ENSG00000126883 E033 56.5715178 0.0005358614 0.0608582614 0.37377900 9 131146129 131146161 33 + 1.790 1.707 -0.281
ENSG00000126883 E034 60.8015058 0.0089968083 0.5770451951 0.86537804 9 131146162 131146164 3 + 1.799 1.769 -0.102
ENSG00000126883 E035 189.5906144 0.0044125980 0.7074365355 0.91786064 9 131146165 131146304 140 + 2.278 2.270 -0.028
ENSG00000126883 E036 19.6223990 0.0024271237 0.8869924211 0.97292453 9 131147487 131147489 3 + 1.297 1.314 0.060
ENSG00000126883 E037 180.2368517 0.0001980884 0.7008311103 0.91536369 9 131147490 131147584 95 + 2.255 2.251 -0.015
ENSG00000126883 E038 0.0000000       9 131149951 131150100 150 +      
ENSG00000126883 E039 177.7248466 0.0002157531 0.0521169695 0.35021293 9 131150324 131150410 87 + 2.269 2.222 -0.157
ENSG00000126883 E040 239.2368293 0.0001491161 0.5823082851 0.86775763 9 131150616 131150765 150 + 2.380 2.373 -0.023
ENSG00000126883 E041 255.8572763 0.0004570452 0.6377207295 0.89127906 9 131151736 131151894 159 + 2.397 2.415 0.058
ENSG00000126883 E042 216.2363026 0.0014544078 0.9106128504 0.97861488 9 131159383 131159486 104 + 2.329 2.337 0.029
ENSG00000126883 E043 214.5194586 0.0017832358 0.3578703325 0.74533193 9 131162991 131163099 109 + 2.339 2.316 -0.078
ENSG00000126883 E044 174.0302190 0.0002427649 0.0135178717 0.20015901 9 131163100 131163173 74 + 2.264 2.202 -0.208
ENSG00000126883 E045 192.0962419 0.0001663470 0.0276474394 0.26963495 9 131163870 131163955 86 + 2.304 2.253 -0.171
ENSG00000126883 E046 194.4748727 0.0009201964 0.1093771067 0.47456502 9 131164061 131164144 84 + 2.308 2.267 -0.137
ENSG00000126883 E047 0.0000000       9 131164145 131164549 405 +      
ENSG00000126883 E048 204.8516544 0.0029773719 0.9686343593 0.99270704 9 131174055 131174167 113 + 2.310 2.317 0.024
ENSG00000126883 E049 218.2630400 0.0005489704 0.9630941908 0.99151557 9 131174168 131174318 151 + 2.337 2.342 0.016
ENSG00000126883 E050 204.6649604 0.0001946577 0.4131748557 0.78241661 9 131175460 131175621 162 + 2.318 2.303 -0.050
ENSG00000126883 E051 0.4749367 0.0372968655 0.1419448787   9 131175622 131175719 98 + 0.259 0.000 -12.527
ENSG00000126883 E052 0.1717682 0.0325217122 0.3727402050   9 131175720 131175795 76 + 0.000 0.137 11.078
ENSG00000126883 E053 0.7358373 0.0172671820 0.9089144952   9 131175796 131177572 1777 + 0.259 0.240 -0.139
ENSG00000126883 E054 119.8751118 0.0003470606 0.1284116364 0.50785277 9 131178311 131178348 38 + 2.096 2.052 -0.148
ENSG00000126883 E055 160.5888771 0.0002082053 0.1089511445 0.47363936 9 131178349 131178410 62 + 2.221 2.181 -0.133
ENSG00000126883 E056 4.9964863 0.0802879004 0.2240684088 0.62888166 9 131184373 131187288 2916 + 0.662 0.880 0.876
ENSG00000126883 E057 122.6760565 0.0002728967 0.2690231677 0.67358841 9 131187289 131187311 23 + 2.100 2.070 -0.100
ENSG00000126883 E058 160.2953970 0.0002249130 0.2012355150 0.60483483 9 131187312 131187357 46 + 2.216 2.185 -0.102
ENSG00000126883 E059 108.8711939 0.0003191282 0.2117622236 0.61633796 9 131187358 131187364 7 + 2.053 2.016 -0.124
ENSG00000126883 E060 198.1183848 0.0002071550 0.3929713177 0.76884409 9 131189053 131189131 79 + 2.299 2.284 -0.053
ENSG00000126883 E061 0.5074389 0.0220323560 0.4124763886   9 131190121 131190125 5 + 0.105 0.240 1.440
ENSG00000126883 E062 0.5074389 0.0220323560 0.4124763886   9 131190126 131190138 13 + 0.105 0.240 1.440
ENSG00000126883 E063 0.5074389 0.0220323560 0.4124763886   9 131190139 131190142 4 + 0.105 0.240 1.440
ENSG00000126883 E064 0.5074389 0.0220323560 0.4124763886   9 131190143 131190172 30 + 0.105 0.240 1.440
ENSG00000126883 E065 1.1508694 0.0134225792 0.1303279163   9 131190173 131190480 308 + 0.189 0.455 1.766
ENSG00000126883 E066 0.5813766 0.0197981759 0.4714463363   9 131192124 131192207 84 + 0.259 0.137 -1.138
ENSG00000126883 E067 169.4988567 0.0002266098 0.2005471157 0.60404754 9 131192208 131192292 85 + 2.240 2.210 -0.100
ENSG00000126883 E068 1.3997596 0.2592236389 0.1874055202   9 131192293 131192767 475 + 0.193 0.512 2.004
ENSG00000126883 E069 162.4368332 0.0003052632 0.1611043972 0.55580176 9 131195233 131195294 62 + 2.188 2.233 0.151
ENSG00000126883 E070 9.6990936 0.2767398755 0.0967484525 0.45136657 9 131195295 131195658 364 + 0.842 1.177 1.238
ENSG00000126883 E071 10.2776678 0.1117658258 0.0263915593 0.26400959 9 131196885 131197215 331 + 0.830 1.209 1.401
ENSG00000126883 E072 253.5030421 0.0002150407 0.5006937167 0.82996821 9 131197216 131197337 122 + 2.392 2.413 0.069
ENSG00000126883 E073 197.5947216 0.0001657999 0.8430275720 0.96103429 9 131197338 131197416 79 + 2.293 2.293 0.002
ENSG00000126883 E074 545.2927225 0.0010502549 0.3852310067 0.76385642 9 131197417 131197886 470 + 2.720 2.747 0.092
ENSG00000126883 E075 166.8097458 0.0020710603 0.0794615501 0.41658489 9 131197887 131197918 32 + 2.190 2.257 0.226
ENSG00000126883 E076 608.4474384 0.0013052816 0.2610968454 0.66634298 9 131197919 131198451 533 + 2.766 2.800 0.114
ENSG00000126883 E077 834.0342570 0.0011563652 0.9016934922 0.97669926 9 131198452 131199015 564 + 2.913 2.925 0.042
ENSG00000126883 E078 359.8562630 0.0016732313 0.6230917550 0.88536595 9 131201647 131201717 71 + 2.555 2.551 -0.015
ENSG00000126883 E079 19.4764597 0.1022999388 0.0099032594 0.17283404 9 131212657 131215211 2555 + 1.054 1.491 1.538
ENSG00000126883 E080 513.7177760 0.0043237228 0.9518749031 0.98876138 9 131215212 131215368 157 + 2.706 2.712 0.020
ENSG00000126883 E081 2.9481164 0.1024115469 0.0543329845 0.35672826 9 131222498 131222777 280 + 0.377 0.760 1.784
ENSG00000126883 E082 448.8543732 0.0028722416 0.5718307358 0.86300012 9 131222778 131222930 153 + 2.640 2.664 0.078
ENSG00000126883 E083 143.8833949 0.0086023573 0.9331688061 0.98418843 9 131228160 131228174 15 + 2.158 2.161 0.008
ENSG00000126883 E084 210.8864187 0.0032559963 0.2366850078 0.64161818 9 131228175 131228223 49 + 2.302 2.351 0.163
ENSG00000126883 E085 275.7648799 0.0045737892 0.1808725814 0.58049687 9 131228224 131228293 70 + 2.411 2.472 0.201
ENSG00000126883 E086 246.5210171 0.0036217106 0.5093332505 0.83438995 9 131228294 131228331 38 + 2.376 2.409 0.110
ENSG00000126883 E087 21.7194739 0.0921316542 0.0102853720 0.17567292 9 131228518 131229662 1145 + 1.130 1.523 1.375
ENSG00000126883 E088 7.1203834 0.0043452160 0.0009318663 0.05194034 9 131229663 131229825 163 + 0.682 1.082 1.544
ENSG00000126883 E089 22.5283823 0.1040465245 0.2008770149 0.60435246 9 131229826 131230629 804 + 1.284 1.449 0.572
ENSG00000126883 E090 362.1580585 0.0035215869 0.5975864331 0.87464405 9 131230630 131230769 140 + 2.545 2.573 0.091
ENSG00000126883 E091 10.2359649 0.0026208127 0.0463852293 0.33403591 9 131232162 131232283 122 + 0.935 1.144 0.764
ENSG00000126883 E092 211.8878515 0.0002461113 0.4350083225 0.79442765 9 131232284 131232308 25 + 2.332 2.318 -0.046
ENSG00000126883 E093 14.2666096 0.0485359686 0.0536404503 0.35464034 9 131232309 131233008 700 + 1.032 1.304 0.971
ENSG00000126883 E094 227.7918294 0.0002321919 0.7910873667 0.94541707 9 131233454 131233501 48 + 2.356 2.355 -0.002
ENSG00000126883 E095 223.3395921 0.0001527412 0.3094786519 0.70765003 9 131233502 131233562 61 + 2.333 2.363 0.100
ENSG00000126883 E096 749.1703068 0.0013902157 0.0029528794 0.09761205 9 131233563 131234663 1101 + 2.838 2.909 0.235