ENSG00000125388

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000398051 ENSG00000125388 HEK293_DMSO_6hA HEK293_OSMI2_6hA GRK4 protein_coding protein_coding 5.21982 4.731211 4.769009 0.4276367 0.43607 0.01145581 0.3200645 0.0000000 0.4647039 0.00000000 0.10374176 5.5689560 0.05990417 0.00000000 0.09736667 0.097366667 5.303806e-05 5.303806e-05 FALSE  
ENST00000398052 ENSG00000125388 HEK293_DMSO_6hA HEK293_OSMI2_6hA GRK4 protein_coding protein_coding 5.21982 4.731211 4.769009 0.4276367 0.43607 0.01145581 0.3860462 0.2995726 0.3954885 0.05681498 0.04760325 0.3893832 0.07372917 0.06500000 0.08510000 0.020100000 7.804237e-01 5.303806e-05 FALSE  
ENST00000503518 ENSG00000125388 HEK293_DMSO_6hA HEK293_OSMI2_6hA GRK4 protein_coding protein_coding 5.21982 4.731211 4.769009 0.4276367 0.43607 0.01145581 2.4124866 1.7362250 2.1078768 0.17456099 0.22716196 0.2783792 0.46417917 0.36650000 0.44223333 0.075733333 6.937263e-01 5.303806e-05 FALSE  
ENST00000507230 ENSG00000125388 HEK293_DMSO_6hA HEK293_OSMI2_6hA GRK4 protein_coding retained_intron 5.21982 4.731211 4.769009 0.4276367 0.43607 0.01145581 0.8136499 1.2013559 0.6018672 0.17491377 0.19322260 -0.9853324 0.15686667 0.25156667 0.12650000 -0.125066667 3.616951e-01 5.303806e-05    
ENST00000509545 ENSG00000125388 HEK293_DMSO_6hA HEK293_OSMI2_6hA GRK4 protein_coding processed_transcript 5.21982 4.731211 4.769009 0.4276367 0.43607 0.01145581 0.3062207 0.2601321 0.3699589 0.06859150 0.11349048 0.4921786 0.05949583 0.05723333 0.08186667 0.024633333 8.277073e-01 5.303806e-05 FALSE  
MSTRG.24497.5 ENSG00000125388 HEK293_DMSO_6hA HEK293_OSMI2_6hA GRK4 protein_coding   5.21982 4.731211 4.769009 0.4276367 0.43607 0.01145581 0.3917702 0.3762119 0.4045139 0.05082349 0.20704802 0.1020278 0.07369583 0.07893333 0.08386667 0.004933333 9.453663e-01 5.303806e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000125388 E001 3.3799082 0.0284552383 0.491232870 0.82514765 4 2963571 2963607 37 + 0.686 0.572 -0.496
ENSG00000125388 E002 5.9391458 0.0042720544 0.144665307 0.53170260 4 2963608 2963633 26 + 0.922 0.736 -0.728
ENSG00000125388 E003 6.4827760 0.0039171639 0.064187289 0.38204129 4 2963634 2963637 4 + 0.966 0.736 -0.893
ENSG00000125388 E004 9.4760169 0.0029192207 0.024243905 0.25531829 4 2963638 2963662 25 + 1.116 0.874 -0.896
ENSG00000125388 E005 16.5235183 0.0017989594 0.000419435 0.03247988 4 2963663 2963820 158 + 1.363 1.064 -1.059
ENSG00000125388 E006 30.5176752 0.0101153323 0.001351115 0.06430062 4 2963821 2964122 302 + 1.604 1.360 -0.837
ENSG00000125388 E007 35.6183866 0.0166088378 0.853253138 0.96360524 4 2965243 2965406 164 + 1.571 1.556 -0.053
ENSG00000125388 E008 91.5073250 0.0006241367 0.004066421 0.11412412 4 2965407 2966889 1483 + 1.917 2.007 0.304
ENSG00000125388 E009 7.4242632 0.0053618101 0.024623818 0.25699174 4 2969169 2969317 149 + 0.778 1.037 0.985
ENSG00000125388 E010 4.0952026 0.0055138420 0.118898608 0.49153202 4 2970948 2971192 245 + 0.595 0.811 0.895
ENSG00000125388 E011 4.4543449 0.0053154059 0.252230243 0.65805523 4 2984513 2984608 96 + 0.656 0.810 0.629
ENSG00000125388 E012 6.7582691 0.0525990776 0.571006690 0.86269083 4 2988727 2988839 113 + 0.917 0.833 -0.322
ENSG00000125388 E013 9.3579699 0.0041774973 0.680362687 0.90830016 4 2992215 2992292 78 + 1.041 0.995 -0.171
ENSG00000125388 E014 10.9823772 0.0031473307 0.527167047 0.84349852 4 3004231 3004334 104 + 1.116 1.051 -0.235
ENSG00000125388 E015 9.8825184 0.0058409951 0.715844028 0.92061217 4 3007736 3007828 93 + 1.029 1.063 0.126
ENSG00000125388 E016 8.2775254 0.0541989607 0.756219610 0.93460404 4 3009648 3009711 64 + 0.942 0.991 0.181
ENSG00000125388 E017 12.2554256 0.0145963650 0.120593432 0.49476939 4 3013688 3013828 141 + 1.041 1.203 0.584
ENSG00000125388 E018 14.6923352 0.0019727714 0.143417050 0.53012483 4 3019641 3019831 191 + 1.126 1.249 0.437
ENSG00000125388 E019 0.1795728 0.0336183013 0.426712174   4 3022412 3022413 2 + 0.000 0.128 9.510
ENSG00000125388 E020 9.1262674 0.0027573572 0.944214279 0.98701912 4 3022414 3022451 38 + 1.005 1.009 0.016
ENSG00000125388 E021 0.2669773 0.0287018387 0.909346375   4 3027911 3027911 1 + 0.112 0.127 0.217
ENSG00000125388 E022 11.5638068 0.0021982654 0.533505075 0.84693416 4 3027912 3028001 90 + 1.126 1.064 -0.224
ENSG00000125388 E023 11.6548573 0.0022956769 0.914617634 0.97959004 4 3029201 3029322 122 + 1.106 1.112 0.024
ENSG00000125388 E024 10.1573208 0.0028153845 0.533315595 0.84689916 4 3029323 3029409 87 + 1.017 1.077 0.216
ENSG00000125388 E025 2.9682804 0.0070090117 0.909443049 0.97832956 4 3035386 3035523 138 + 0.595 0.610 0.064
ENSG00000125388 E026 8.5222206 0.0041830026 0.727049535 0.92472166 4 3037374 3037511 138 + 1.005 0.963 -0.153
ENSG00000125388 E027 4.3582518 0.0156301405 0.065447796 0.38552803 4 3038376 3038513 138 + 0.594 0.854 1.072
ENSG00000125388 E028 2.2162099 0.0089865776 0.776910442 0.94132352 4 3038514 3038578 65 + 0.486 0.530 0.214
ENSG00000125388 E029 6.0663769 0.0062203400 0.975478071 0.99424417 4 3038624 3038878 255 + 0.839 0.833 -0.023
ENSG00000125388 E030 8.2773227 0.0359159975 0.372511728 0.75505863 4 3040572 3040760 189 + 0.904 1.025 0.453