ENSG00000124784

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000379834 ENSG00000124784 HEK293_DMSO_6hA HEK293_OSMI2_6hA RIOK1 protein_coding protein_coding 38.06613 17.36328 20.39403 4.616947 3.324522 0.2319837 32.8097157 13.793666 18.6508073 3.9655141 3.1052489 0.4349599 0.8685542 0.7866000 0.91346667 0.1268667 0.0001181009 0.0001181009 FALSE TRUE
ENST00000493691 ENSG00000124784 HEK293_DMSO_6hA HEK293_OSMI2_6hA RIOK1 protein_coding retained_intron 38.06613 17.36328 20.39403 4.616947 3.324522 0.2319837 0.8008639 1.710161 0.2920731 0.2351356 0.1824506 -2.5095741 0.0262125 0.1084667 0.01856667 -0.0899000 0.1898800291 0.0001181009   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000124784 E001 0.6517073 0.0192619354 0.055903916   6 7389791 7389791 1 + 0.336 0.000 -12.275
ENSG00000124784 E002 0.6517073 0.0192619354 0.055903916   6 7389792 7389792 1 + 0.336 0.000 -12.275
ENSG00000124784 E003 2.4421299 0.0087253911 0.005076909 0.12779728 6 7389793 7389807 15 + 0.705 0.228 -2.562
ENSG00000124784 E004 127.7389757 0.0028766428 0.001043394 0.05563053 6 7389808 7390073 266 + 2.176 2.040 -0.455
ENSG00000124784 E005 58.6022415 0.0016130864 0.489011679 0.82403401 6 7393099 7393107 9 + 1.800 1.763 -0.125
ENSG00000124784 E006 166.5630994 0.0010700188 0.137493641 0.52146694 6 7393108 7393303 196 + 2.253 2.210 -0.146
ENSG00000124784 E007 4.6236348 0.0050261293 0.639349670 0.89201905 6 7395021 7395052 32 + 0.775 0.711 -0.258
ENSG00000124784 E008 121.9511303 0.0003033648 0.205822791 0.60966857 6 7395053 7395143 91 + 2.118 2.078 -0.134
ENSG00000124784 E009 90.3642910 0.0003446842 0.384525372 0.76335240 6 7396703 7396751 49 + 1.984 1.951 -0.110
ENSG00000124784 E010 87.3465514 0.0003517033 0.771851414 0.93992905 6 7396752 7396772 21 + 1.950 1.959 0.032
ENSG00000124784 E011 101.2673443 0.0003401179 0.735462541 0.92759994 6 7398698 7398740 43 + 2.014 2.025 0.036
ENSG00000124784 E012 135.7089597 0.0002529078 0.452773917 0.80497729 6 7400958 7401050 93 + 2.155 2.132 -0.076
ENSG00000124784 E013 138.6850885 0.0002262748 0.250263097 0.65610125 6 7402603 7402715 113 + 2.167 2.133 -0.114
ENSG00000124784 E014 3.7189633 0.0437362568 0.015144865 0.20925877 6 7402716 7402816 101 + 0.436 0.855 1.833
ENSG00000124784 E015 130.2990704 0.0002933108 0.257714145 0.66340785 6 7402817 7402897 81 + 2.139 2.105 -0.115
ENSG00000124784 E016 0.6842095 0.0189868620 0.871555122   6 7403934 7403940 7 + 0.200 0.228 0.242
ENSG00000124784 E017 147.5936987 0.0009624595 0.721504290 0.92268801 6 7403941 7404027 87 + 2.180 2.169 -0.034
ENSG00000124784 E018 190.2541612 0.0003542311 0.878526624 0.97086836 6 7404418 7404555 138 + 2.287 2.283 -0.016
ENSG00000124784 E019 152.6258600 0.0002241016 0.703181092 0.91626644 6 7404918 7405021 104 + 2.188 2.198 0.032
ENSG00000124784 E020 1.5851143 0.0147260589 0.375530096   6 7405022 7405184 163 + 0.335 0.487 0.832
ENSG00000124784 E021 172.9804444 0.0002059093 0.244522534 0.64996567 6 7405249 7405355 107 + 2.233 2.263 0.099
ENSG00000124784 E022 1.7195263 0.0101508394 0.243515174 0.64865224 6 7410378 7410385 8 + 0.335 0.533 1.053
ENSG00000124784 E023 157.7118227 0.0027415336 0.465286915 0.81132246 6 7410386 7410451 66 + 2.191 2.222 0.102
ENSG00000124784 E024 192.9119011 0.0001909331 0.057840363 0.36575009 6 7411332 7411451 120 + 2.270 2.317 0.155
ENSG00000124784 E025 4.4866697 0.0395774728 0.002900772 0.09666988 6 7411452 7411567 116 + 0.440 0.917 2.051
ENSG00000124784 E026 133.4891716 0.0002394775 0.236164647 0.64109131 6 7412889 7412942 54 + 2.119 2.154 0.116
ENSG00000124784 E027 72.5833827 0.0003881184 0.022678510 0.24853074 6 7414238 7414253 16 + 1.828 1.920 0.309
ENSG00000124784 E028 174.1972553 0.0002024413 0.428069672 0.79088898 6 7414254 7414390 137 + 2.240 2.260 0.068
ENSG00000124784 E029 294.9114462 0.0019714306 0.258131234 0.66382154 6 7417331 7418037 707 + 2.461 2.488 0.091