ENSG00000123992

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000373963 ENSG00000123992 HEK293_DMSO_6hA HEK293_OSMI2_6hA DNPEP protein_coding nonsense_mediated_decay 57.37407 53.57064 72.99911 4.575332 8.305649 0.4463646 15.367951 12.431573 20.814195 2.2497550 3.6219395 0.7430918 0.25792083 0.22796667 0.28066667 0.05270000 0.54646177 0.01620014 FALSE TRUE
ENST00000460963 ENSG00000123992 HEK293_DMSO_6hA HEK293_OSMI2_6hA DNPEP protein_coding retained_intron 57.37407 53.57064 72.99911 4.575332 8.305649 0.4463646 2.659890 3.713359 2.070015 0.1186238 0.4305196 -0.8400104 0.05658333 0.07073333 0.03066667 -0.04006667 0.17945827 0.01620014 FALSE TRUE
ENST00000521459 ENSG00000123992 HEK293_DMSO_6hA HEK293_OSMI2_6hA DNPEP protein_coding protein_coding 57.37407 53.57064 72.99911 4.575332 8.305649 0.4463646 6.607129 4.578196 12.420876 0.7832881 1.8238967 1.4379290 0.11420417 0.08583333 0.16976667 0.08393333 0.01620014 0.01620014 FALSE FALSE
ENST00000523282 ENSG00000123992 HEK293_DMSO_6hA HEK293_OSMI2_6hA DNPEP protein_coding protein_coding 57.37407 53.57064 72.99911 4.575332 8.305649 0.4463646 18.745896 17.157387 25.279695 1.4714509 4.2705700 0.5588791 0.30715000 0.32030000 0.34133333 0.02103333 0.76120754 0.01620014 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000123992 E001 45.592904 6.619811e-02 0.2907545134 0.69211338 2 219372043 219373526 1484 - 1.591 1.742 0.510
ENSG00000123992 E002 75.022668 4.276075e-04 0.5143361697 0.83729763 2 219373527 219374193 667 - 1.860 1.893 0.110
ENSG00000123992 E003 41.002443 9.986930e-03 0.5171959682 0.83875540 2 219374194 219374195 2 - 1.634 1.599 -0.121
ENSG00000123992 E004 41.741083 6.733048e-03 0.5625190382 0.85900192 2 219374196 219374196 1 - 1.639 1.610 -0.098
ENSG00000123992 E005 320.249334 3.823737e-03 0.3767396840 0.75778928 2 219374197 219374342 146 - 2.483 2.529 0.152
ENSG00000123992 E006 285.348958 1.311233e-03 0.1311950567 0.51204781 2 219374855 219374879 25 - 2.430 2.482 0.174
ENSG00000123992 E007 344.714348 7.368640e-04 0.4418906668 0.79874097 2 219374880 219374923 44 - 2.523 2.550 0.091
ENSG00000123992 E008 437.959469 8.718823e-04 0.8968390013 0.97547436 2 219374924 219375022 99 - 2.637 2.644 0.024
ENSG00000123992 E009 435.496863 6.254485e-04 0.9587212245 0.99049253 2 219381335 219381436 102 - 2.633 2.643 0.032
ENSG00000123992 E010 4.362106 1.037461e-01 0.8254670123 0.95572386 2 219381437 219381486 50 - 0.676 0.757 0.336
ENSG00000123992 E011 335.249355 1.607716e-04 0.2480575721 0.65353470 2 219381545 219381584 40 - 2.511 2.540 0.095
ENSG00000123992 E012 22.905474 1.481833e-01 0.0814530544 0.42079467 2 219381585 219381779 195 - 1.220 1.503 0.984
ENSG00000123992 E013 9.992412 9.386313e-02 0.0705560396 0.39682546 2 219381792 219381802 11 - 0.867 1.180 1.154
ENSG00000123992 E014 21.318917 1.312768e-01 0.0683416954 0.39214772 2 219381803 219381978 176 - 1.181 1.482 1.049
ENSG00000123992 E015 285.442343 1.877106e-04 0.2892818753 0.69086862 2 219381979 219381997 19 - 2.440 2.469 0.097
ENSG00000123992 E016 489.064109 3.619530e-04 0.3030560001 0.70244641 2 219381998 219382139 142 - 2.676 2.701 0.085
ENSG00000123992 E017 317.944830 1.469680e-04 0.8422604396 0.96093996 2 219383131 219383204 74 - 2.497 2.507 0.034
ENSG00000123992 E018 183.255093 6.545016e-04 0.3532701348 0.74203130 2 219383205 219383208 4 - 2.247 2.281 0.114
ENSG00000123992 E019 191.219586 3.393907e-04 0.6286699789 0.88734667 2 219383209 219383214 6 - 2.273 2.292 0.065
ENSG00000123992 E020 325.004791 1.694713e-04 0.3073390149 0.70562016 2 219384366 219384443 78 - 2.517 2.503 -0.046
ENSG00000123992 E021 24.273342 1.057594e-01 0.1673507271 0.56364172 2 219384444 219384573 130 - 1.293 1.499 0.713
ENSG00000123992 E022 61.168540 1.219110e-01 0.0065608728 0.14274790 2 219384586 219385153 568 - 1.536 1.971 1.470
ENSG00000123992 E023 45.454204 3.046108e-02 0.0004401908 0.03343061 2 219385154 219385423 270 - 1.460 1.818 1.217
ENSG00000123992 E024 177.169509 2.269455e-04 0.5954645669 0.87374896 2 219385424 219385430 7 - 2.237 2.258 0.069
ENSG00000123992 E025 345.247471 1.338725e-03 0.6894888618 0.91157055 2 219385431 219385531 101 - 2.539 2.538 -0.001
ENSG00000123992 E026 245.003011 1.012836e-03 0.4968856471 0.82774184 2 219385631 219385658 28 - 2.398 2.385 -0.044
ENSG00000123992 E027 294.173776 1.474559e-04 0.1459220281 0.53348345 2 219385659 219385706 48 - 2.481 2.456 -0.081
ENSG00000123992 E028 10.276330 1.699311e-01 0.0665267185 0.38783029 2 219385707 219385751 45 - 0.854 1.197 1.264
ENSG00000123992 E029 10.389409 2.374466e-01 0.1166780856 0.48754984 2 219385752 219385834 83 - 0.888 1.187 1.095
ENSG00000123992 E030 223.586762 2.013898e-04 0.0146534037 0.20657730 2 219385968 219385981 14 - 2.374 2.321 -0.175
ENSG00000123992 E031 462.010207 9.900547e-05 0.0068020613 0.14534659 2 219385982 219386098 117 - 2.681 2.642 -0.128
ENSG00000123992 E032 2.741108 1.423339e-02 0.0334955835 0.29236165 2 219386204 219386285 82 - 0.379 0.726 1.636
ENSG00000123992 E033 499.697139 1.564954e-04 0.0128086153 0.19497546 2 219386286 219386411 126 - 2.711 2.677 -0.114
ENSG00000123992 E034 265.735203 2.454066e-03 0.0685043243 0.39242863 2 219386665 219386681 17 - 2.447 2.394 -0.176
ENSG00000123992 E035 256.806651 1.851343e-03 0.0376119949 0.30598685 2 219386682 219386686 5 - 2.433 2.377 -0.188
ENSG00000123992 E036 380.760090 6.508332e-04 0.1573772773 0.55029791 2 219386687 219386778 92 - 2.590 2.566 -0.080
ENSG00000123992 E037 308.262721 2.265977e-04 0.6518187743 0.89735479 2 219386892 219386948 57 - 2.481 2.496 0.050
ENSG00000123992 E038 211.350467 2.032403e-04 0.4432868488 0.79951914 2 219386949 219386980 32 - 2.330 2.317 -0.044
ENSG00000123992 E039 270.385654 1.360352e-04 0.0616213035 0.37590268 2 219387070 219387163 94 - 2.447 2.412 -0.115
ENSG00000123992 E040 1.313607 7.398871e-02 0.7361646819   2 219387278 219387575 298 - 0.383 0.317 -0.393
ENSG00000123992 E041 17.508801 1.607704e-03 0.6043752788 0.87739134 2 219387576 219387758 183 - 1.282 1.245 -0.129
ENSG00000123992 E042 140.913836 2.133570e-04 0.1528804302 0.54332518 2 219387759 219387932 174 - 2.166 2.129 -0.123
ENSG00000123992 E043 0.000000       2 219388702 219388748 47 -      
ENSG00000123992 E044 0.000000       2 219388834 219388876 43 -      
ENSG00000123992 E045 0.000000       2 219393611 219393748 138 -      
ENSG00000123992 E046 0.000000       2 219399440 219399500 61 -      
ENSG00000123992 E047 0.000000       2 219399866 219399939 74 -      
ENSG00000123992 E048 0.000000       2 219399940 219400022 83 -