ENSG00000123143

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000242783 ENSG00000123143 HEK293_DMSO_6hA HEK293_OSMI2_6hA PKN1 protein_coding protein_coding 97.5233 73.37846 156.1833 11.31741 37.69114 1.089707 28.64582 16.23409 47.50379 2.970269 12.21270 1.548432 0.3064792 0.2187667 0.3022333 0.08346667 0.001176826 0.001176826 FALSE TRUE
ENST00000342216 ENSG00000123143 HEK293_DMSO_6hA HEK293_OSMI2_6hA PKN1 protein_coding protein_coding 97.5233 73.37846 156.1833 11.31741 37.69114 1.089707 63.66126 51.45569 104.88247 7.541532 26.15494 1.027228 0.6416917 0.7033000 0.6668333 -0.03646667 0.516563229 0.001176826 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000123143 E001 1.5233553 3.963757e-02 0.569009891   19 14433053 14433170 118 + 0.331 0.443 0.630
ENSG00000123143 E002 0.7393535 1.437099e-01 0.098912011   19 14433306 14433322 17 + 0.363 0.000 -11.009
ENSG00000123143 E003 3.3318291 6.677602e-03 0.109539768 0.47486528 19 14433323 14433399 77 + 0.706 0.442 -1.207
ENSG00000123143 E004 6.0222863 4.006085e-03 0.072540277 0.40131462 19 14433400 14433418 19 + 0.905 0.657 -0.993
ENSG00000123143 E005 55.8849912 5.596324e-04 0.078306447 0.41419195 19 14433419 14433483 65 + 1.779 1.688 -0.309
ENSG00000123143 E006 62.1848763 5.555731e-04 0.174321138 0.57211347 19 14433484 14433492 9 + 1.818 1.750 -0.230
ENSG00000123143 E007 150.3207710 2.971181e-04 0.003300734 0.10339534 19 14433493 14433542 50 + 2.205 2.110 -0.317
ENSG00000123143 E008 1.3759025 1.208263e-02 0.185016916   19 14434590 14434654 65 + 0.280 0.507 1.286
ENSG00000123143 E009 0.5325511 2.050743e-02 0.255127992   19 14440260 14440329 70 + 0.089 0.275 1.959
ENSG00000123143 E010 0.1767706 1.113347e-01 0.907833736   19 14440373 14440402 30 + 0.090 0.000 -8.495
ENSG00000123143 E011 676.2800448 1.921931e-03 0.029645842 0.27812845 19 14441143 14441443 301 + 2.830 2.791 -0.129
ENSG00000123143 E012 746.9985910 8.888047e-05 0.840442297 0.96046160 19 14443470 14443621 152 + 2.864 2.859 -0.019
ENSG00000123143 E013 2.0701168 1.015295e-02 0.730875741 0.92596050 19 14446409 14446425 17 + 0.450 0.507 0.281
ENSG00000123143 E014 770.9917050 8.784510e-05 0.736642229 0.92795925 19 14446426 14446561 136 + 2.876 2.878 0.004
ENSG00000123143 E015 748.5680402 1.280606e-03 0.805518630 0.94983384 19 14450318 14450463 146 + 2.859 2.865 0.022
ENSG00000123143 E016 4.8478381 4.923443e-03 0.448869916 0.80295552 19 14450806 14450895 90 + 0.809 0.697 -0.450
ENSG00000123143 E017 941.8495521 2.698818e-04 0.099983057 0.45739300 19 14450896 14451109 214 + 2.971 2.948 -0.078
ENSG00000123143 E018 1158.6247102 5.999473e-05 0.005742003 0.13513264 19 14451829 14452023 195 + 3.065 3.032 -0.111
ENSG00000123143 E019 1008.0183088 6.128474e-05 0.002027635 0.08028613 19 14458031 14458140 110 + 3.006 2.967 -0.132
ENSG00000123143 E020 1136.3240899 5.477580e-05 0.001193085 0.05974763 19 14458232 14458375 144 + 3.059 3.019 -0.131
ENSG00000123143 E021 4.2840908 2.220957e-02 0.316000429 0.71306754 19 14463543 14463666 124 + 0.644 0.801 0.644
ENSG00000123143 E022 725.7245935 3.112378e-04 0.785091818 0.94372352 19 14463667 14463742 76 + 2.850 2.847 -0.010
ENSG00000123143 E023 708.8672107 9.008340e-05 0.895798554 0.97506459 19 14463828 14463874 47 + 2.840 2.839 -0.003
ENSG00000123143 E024 906.8035925 2.392975e-04 0.838372746 0.95965912 19 14463875 14463969 95 + 2.945 2.944 -0.006
ENSG00000123143 E025 908.4757812 3.353715e-04 0.579869747 0.86681880 19 14464060 14464153 94 + 2.947 2.941 -0.021
ENSG00000123143 E026 3.5712529 6.907226e-02 0.121255175 0.49593876 19 14467486 14467564 79 + 0.516 0.801 1.225
ENSG00000123143 E027 849.3658328 9.861010e-05 0.723992442 0.92350848 19 14467565 14467621 57 + 2.919 2.913 -0.023
ENSG00000123143 E028 625.0525776 4.500055e-04 0.978918608 0.99489490 19 14467622 14467641 20 + 2.781 2.783 0.006
ENSG00000123143 E029 16.9675483 6.031458e-02 0.201533423 0.60514074 19 14467642 14467717 76 + 1.160 1.347 0.659
ENSG00000123143 E030 924.5650887 2.375946e-04 0.100229970 0.45775547 19 14467718 14467793 76 + 2.943 2.967 0.080
ENSG00000123143 E031 12.7011048 1.145687e-02 0.054167279 0.35631969 19 14467794 14467875 82 + 1.048 1.240 0.688
ENSG00000123143 E032 1118.3590187 5.999118e-04 0.081839030 0.42159921 19 14467876 14467967 92 + 3.021 3.055 0.110
ENSG00000123143 E033 1498.5478428 1.193095e-04 0.037619936 0.30599630 19 14469341 14469517 177 + 3.155 3.176 0.070
ENSG00000123143 E034 17.5439937 3.165704e-01 0.156210944 0.54826025 19 14469518 14469751 234 + 1.120 1.414 1.034
ENSG00000123143 E035 1036.8672560 5.628201e-05 0.069695609 0.39492631 19 14469752 14469814 63 + 2.998 3.016 0.059
ENSG00000123143 E036 12.3589381 2.207869e-03 0.001977189 0.07908231 19 14469815 14469911 97 + 0.984 1.272 1.036
ENSG00000123143 E037 1245.0029000 1.008535e-04 0.014154701 0.20375187 19 14469912 14469988 77 + 3.075 3.100 0.085
ENSG00000123143 E038 837.0476291 5.633576e-04 0.281244479 0.68432471 19 14470163 14470174 12 + 2.901 2.925 0.082
ENSG00000123143 E039 1028.4709602 5.102207e-04 0.644958632 0.89435523 19 14470175 14470208 34 + 2.994 3.007 0.045
ENSG00000123143 E040 1390.8552184 1.738722e-04 0.742458703 0.93017450 19 14470209 14470305 97 + 3.129 3.133 0.014
ENSG00000123143 E041 1163.4914180 2.693854e-04 0.248635956 0.65425977 19 14470575 14470631 57 + 3.047 3.063 0.053
ENSG00000123143 E042 1054.7662982 9.238747e-05 0.252797214 0.65853385 19 14470632 14470682 51 + 3.008 3.019 0.036
ENSG00000123143 E043 15.3442960 8.207770e-02 0.573158200 0.86354833 19 14470683 14470770 88 + 1.162 1.251 0.315
ENSG00000123143 E044 737.9927443 8.318898e-05 0.062716031 0.37901571 19 14470771 14470781 11 + 2.849 2.872 0.074
ENSG00000123143 E045 962.8911497 4.775744e-04 0.754514098 0.93397942 19 14470782 14470851 70 + 2.970 2.975 0.016
ENSG00000123143 E046 3.8310243 7.742489e-02 0.052313345 0.35080701 19 14471102 14471426 325 + 0.516 0.855 1.432
ENSG00000123143 E047 504.3850500 1.239140e-03 0.213519475 0.61806205 19 14471581 14471596 16 + 2.702 2.672 -0.102
ENSG00000123143 E048 751.4849424 2.046582e-03 0.367965567 0.75211126 19 14471597 14471867 271 + 2.871 2.847 -0.079