ENSG00000121749

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000468049 ENSG00000121749 HEK293_DMSO_6hA HEK293_OSMI2_6hA TBC1D15 protein_coding nonsense_mediated_decay 21.65845 3.69586 3.742494 1.368592 0.5615205 0.01804123 1.4913090 0.2029711 0.0000000 0.20297114 0.00000000 -4.4125860 0.05175833 0.03186667 0.00000000 -0.03186667 0.74469894 0.01387998 FALSE FALSE
ENST00000479971 ENSG00000121749 HEK293_DMSO_6hA HEK293_OSMI2_6hA TBC1D15 protein_coding retained_intron 21.65845 3.69586 3.742494 1.368592 0.5615205 0.01804123 0.2334151 0.1939053 0.0000000 0.05757479 0.00000000 -4.3498270 0.01282500 0.05490000 0.00000000 -0.05490000 0.01387998 0.01387998 FALSE FALSE
ENST00000483828 ENSG00000121749 HEK293_DMSO_6hA HEK293_OSMI2_6hA TBC1D15 protein_coding retained_intron 21.65845 3.69586 3.742494 1.368592 0.5615205 0.01804123 4.3013923 0.5927346 0.7073818 0.30390217 0.36396212 0.2512182 0.17194583 0.15686667 0.19436667 0.03750000 0.96130126 0.01387998 FALSE FALSE
ENST00000485960 ENSG00000121749 HEK293_DMSO_6hA HEK293_OSMI2_6hA TBC1D15 protein_coding protein_coding 21.65845 3.69586 3.742494 1.368592 0.5615205 0.01804123 3.1378242 0.5811483 0.8676017 0.34160405 0.30143307 0.5700462 0.23361667 0.16343333 0.23100000 0.06756667 0.76741256 0.01387998 FALSE TRUE
ENST00000491063 ENSG00000121749 HEK293_DMSO_6hA HEK293_OSMI2_6hA TBC1D15 protein_coding protein_coding 21.65845 3.69586 3.742494 1.368592 0.5615205 0.01804123 8.3067716 1.1724124 1.7235274 0.65928882 0.36475403 0.5519773 0.32253333 0.27986667 0.45296667 0.17310000 0.41720616 0.01387998 FALSE TRUE
ENST00000546450 ENSG00000121749 HEK293_DMSO_6hA HEK293_OSMI2_6hA TBC1D15 protein_coding retained_intron 21.65845 3.69586 3.742494 1.368592 0.5615205 0.01804123 0.2209253 0.3845159 0.1448603 0.07151407 0.03392523 -1.3491160 0.02616250 0.11886667 0.04136667 -0.07750000 0.34041026 0.01387998 FALSE TRUE
ENST00000548679 ENSG00000121749 HEK293_DMSO_6hA HEK293_OSMI2_6hA TBC1D15 protein_coding processed_transcript 21.65845 3.69586 3.742494 1.368592 0.5615205 0.01804123 1.2736567 0.2878134 0.1287145 0.14393424 0.12871449 -1.1022902 0.06098750 0.10136667 0.02720000 -0.07416667 0.73895469 0.01387998 TRUE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000121749 E001 0.0000000       12 71839707 71839717 11 +      
ENSG00000121749 E002 0.3485388 0.032005155 0.9647385234   12 71839718 71839758 41 + 0.116 0.123 0.098
ENSG00000121749 E003 0.3485388 0.032005155 0.9647385234   12 71839759 71839762 4 + 0.116 0.123 0.098
ENSG00000121749 E004 4.8766844 0.006717521 0.1214724253 0.49624224 12 71839763 71839777 15 + 0.669 0.878 0.840
ENSG00000121749 E005 8.7395585 0.007407227 0.7091240073 0.91837452 12 71839778 71839811 34 + 0.991 1.034 0.158
ENSG00000121749 E006 0.5253094 0.602718444 0.7484499564   12 71841101 71841231 131 + 0.217 0.124 -0.977
ENSG00000121749 E007 0.1812101 0.045483823 0.5231481487   12 71854563 71854602 40 + 0.116 0.000 -11.475
ENSG00000121749 E008 0.2892872 0.027442404 0.2274971994   12 71854785 71854853 69 + 0.207 0.000 -12.469
ENSG00000121749 E009 0.2937266 0.027442404 0.2282088855   12 71861405 71861496 92 + 0.207 0.000 -12.470
ENSG00000121749 E010 0.0000000       12 71868802 71868921 120 +      
ENSG00000121749 E011 16.8895919 0.001736070 0.6653843411 0.90249258 12 71872070 71872168 99 + 1.286 1.256 -0.104
ENSG00000121749 E012 18.5218038 0.001644896 0.5139478902 0.83710347 12 71872929 71873003 75 + 1.332 1.287 -0.156
ENSG00000121749 E013 24.1990397 0.001365332 0.0462979262 0.33372409 12 71880469 71880607 139 + 1.477 1.349 -0.446
ENSG00000121749 E014 13.7911191 0.006333543 0.2788594186 0.68220512 12 71884811 71884859 49 + 1.227 1.138 -0.314
ENSG00000121749 E015 22.8351641 0.010053358 0.0055229839 0.13227134 12 71884860 71885021 162 + 1.484 1.270 -0.744
ENSG00000121749 E016 17.2721972 0.002170820 0.0225430629 0.24791286 12 71893222 71893324 103 + 1.356 1.179 -0.622
ENSG00000121749 E017 0.4481873 0.021768165 0.6110636368   12 71894325 71894375 51 + 0.207 0.123 -0.900
ENSG00000121749 E018 0.0000000       12 71894376 71894379 4 +      
ENSG00000121749 E019 30.9205320 0.001658328 0.4854728507 0.82226120 12 71894686 71894883 198 + 1.532 1.498 -0.116
ENSG00000121749 E020 25.2217002 0.002492265 0.8279212040 0.95636762 12 71895947 71896075 129 + 1.421 1.445 0.084
ENSG00000121749 E021 0.1717682 0.063289687 0.4631315242   12 71896388 71896676 289 + 0.000 0.123 11.505
ENSG00000121749 E022 20.7693442 0.001456106 0.0908775015 0.44008355 12 71896677 71896780 104 + 1.411 1.294 -0.405
ENSG00000121749 E023 0.0000000       12 71897217 71897286 70 +      
ENSG00000121749 E024 26.6240720 0.001131363 0.0981595907 0.45389770 12 71897847 71897941 95 + 1.503 1.403 -0.347
ENSG00000121749 E025 28.7922036 0.007314925 0.1081452962 0.47224225 12 71907022 71907138 117 + 1.542 1.428 -0.391
ENSG00000121749 E026 2.1793047 0.009930571 0.0007989688 0.04751983 12 71907139 71907762 624 + 0.116 0.693 3.684
ENSG00000121749 E027 1.7114222 0.070187372 0.0647848045 0.38386246 12 71907863 71907989 127 + 0.209 0.560 2.088
ENSG00000121749 E028 12.7851208 0.025043562 0.0030940270 0.10007966 12 71913360 71913825 466 + 0.923 1.278 1.283
ENSG00000121749 E029 29.4734870 0.018250081 0.9446046946 0.98707812 12 71913826 71913926 101 + 1.488 1.488 0.000
ENSG00000121749 E030 31.2963064 0.001040001 0.2935171498 0.69428925 12 71917698 71917797 100 + 1.482 1.549 0.230
ENSG00000121749 E031 32.9979383 0.001096294 0.5292285253 0.84463810 12 71918451 71918548 98 + 1.524 1.565 0.142
ENSG00000121749 E032 33.2026956 0.001043663 0.0462278140 0.33343627 12 71920731 71920847 117 + 1.482 1.602 0.412
ENSG00000121749 E033 30.9112328 0.001141911 0.2832913494 0.68613639 12 71921368 71921454 87 + 1.482 1.549 0.232
ENSG00000121749 E034 75.1822077 0.008951123 0.0268796778 0.26651137 12 71922983 71927248 4266 + 1.823 1.940 0.394