ENSG00000118600

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000261234 ENSG00000118600 HEK293_DMSO_6hA HEK293_OSMI2_6hA RXYLT1 protein_coding protein_coding 12.88323 5.476163 5.658602 1.409581 0.9472857 0.04719562 4.8148684 2.56841062 1.2390324 0.75657568 0.7157043 -1.04567108 0.37732083 0.46286667 0.21763333 -0.24523333 6.010029e-01 1.455598e-10 FALSE TRUE
ENST00000537373 ENSG00000118600 HEK293_DMSO_6hA HEK293_OSMI2_6hA RXYLT1 protein_coding nonsense_mediated_decay 12.88323 5.476163 5.658602 1.409581 0.9472857 0.04719562 2.2005768 0.00000000 1.6316849 0.00000000 0.4807102 7.35903340 0.16652500 0.00000000 0.28576667 0.28576667 1.455598e-10 1.455598e-10 FALSE TRUE
ENST00000537982 ENSG00000118600 HEK293_DMSO_6hA HEK293_OSMI2_6hA RXYLT1 protein_coding nonsense_mediated_decay 12.88323 5.476163 5.658602 1.409581 0.9472857 0.04719562 1.1656813 0.84732917 0.3037149 0.30194070 0.3037149 -1.45039515 0.07929583 0.15140000 0.04186667 -0.10953333 3.334322e-01 1.455598e-10 FALSE FALSE
ENST00000543342 ENSG00000118600 HEK293_DMSO_6hA HEK293_OSMI2_6hA RXYLT1 protein_coding nonsense_mediated_decay 12.88323 5.476163 5.658602 1.409581 0.9472857 0.04719562 0.9806715 0.08659979 0.8453227 0.08659979 0.2258446 3.14637692 0.08731250 0.02136667 0.14823333 0.12686667 2.148271e-01 1.455598e-10 FALSE TRUE
ENST00000690060 ENSG00000118600 HEK293_DMSO_6hA HEK293_OSMI2_6hA RXYLT1 protein_coding nonsense_mediated_decay 12.88323 5.476163 5.658602 1.409581 0.9472857 0.04719562 2.5604545 1.17128932 1.2507937 0.26651388 0.2295554 0.09396985 0.20227083 0.21813333 0.23066667 0.01253333 9.860343e-01 1.455598e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000118600 E001 0.1812101 0.0373151757 5.217706e-01   12 63779833 63779841 9 + 0.116 0.000 -9.193
ENSG00000118600 E002 0.4749367 0.0514113322 1.024701e-01   12 63779842 63779848 7 + 0.283 0.000 -12.923
ENSG00000118600 E003 1.7902715 0.0121969559 4.417530e-01 0.79864765 12 63779849 63779865 17 + 0.497 0.365 -0.704
ENSG00000118600 E004 1.9670421 0.0142059055 3.105531e-01 0.70859074 12 63779866 63779869 4 + 0.538 0.365 -0.899
ENSG00000118600 E005 13.8514123 0.0093959585 1.187308e-01 0.49135325 12 63779870 63779908 39 + 1.238 1.085 -0.544
ENSG00000118600 E006 35.7401134 0.0008178284 3.338475e-01 0.72751210 12 63779909 63780111 203 + 1.600 1.542 -0.195
ENSG00000118600 E007 16.6554567 0.0155658298 4.947345e-01 0.82661198 12 63780112 63780113 2 + 1.289 1.216 -0.257
ENSG00000118600 E008 16.3696248 0.0044947481 1.964973e-01 0.59964732 12 63780114 63780116 3 + 1.305 1.189 -0.406
ENSG00000118600 E009 17.0118902 0.0062940718 1.673877e-01 0.56364172 12 63780117 63780125 9 + 1.323 1.198 -0.439
ENSG00000118600 E010 14.5288295 0.0039278869 3.929238e-01 0.76884409 12 63780126 63780129 4 + 1.241 1.161 -0.286
ENSG00000118600 E011 2.9912871 0.2478137770 4.274875e-01 0.79059212 12 63780130 63780160 31 + 0.714 0.512 -0.891
ENSG00000118600 E012 17.1287831 0.0333440976 7.268456e-02 0.40151309 12 63780161 63780462 302 + 1.360 1.149 -0.740
ENSG00000118600 E013 7.2191881 0.0075402828 9.223398e-02 0.44259116 12 63780463 63781018 556 + 0.793 0.995 0.769
ENSG00000118600 E014 61.3000126 0.0005310451 9.939074e-01 0.99849972 12 63781019 63781174 156 + 1.803 1.800 -0.010
ENSG00000118600 E015 7.5514137 0.0035692551 8.792250e-01 0.97097318 12 63782541 63782704 164 + 0.936 0.949 0.049
ENSG00000118600 E016 59.9212208 0.0008644815 9.713476e-01 0.99327255 12 63784970 63785072 103 + 1.789 1.784 -0.016
ENSG00000118600 E017 5.3434533 0.0315889116 3.906122e-02 0.31084837 12 63785073 63786802 1730 + 0.610 0.930 1.290
ENSG00000118600 E018 1.1632618 0.0136679757 3.987869e-02   12 63786803 63787059 257 + 0.116 0.473 2.689
ENSG00000118600 E019 0.6010108 0.0194858862 2.786159e-01   12 63789814 63789887 74 + 0.116 0.298 1.693
ENSG00000118600 E020 4.6026415 0.0051170102 1.321485e-01 0.51362740 12 63789888 63789931 44 + 0.639 0.840 0.818
ENSG00000118600 E021 0.6105136 0.0221959089 2.777690e-01   12 63790319 63790553 235 + 0.116 0.298 1.694
ENSG00000118600 E022 104.1926389 0.0004495376 3.082469e-01 0.70654950 12 63802091 63802405 315 + 2.010 2.039 0.097
ENSG00000118600 E023 2.5630214 0.2054380598 6.329501e-02 0.38026800 12 63803705 63804950 1246 + 0.290 0.696 2.062
ENSG00000118600 E024 1.0793736 0.0146131141 6.262630e-01   12 63804951 63805233 283 + 0.282 0.365 0.524
ENSG00000118600 E025 78.0097848 0.0004739361 8.290678e-01 0.95663549 12 63805234 63805404 171 + 1.907 1.895 -0.039
ENSG00000118600 E026 7.0731455 0.0033870277 9.390743e-05 0.01308103 12 63805405 63808674 3270 + 0.608 1.085 1.871
ENSG00000118600 E027 120.5736959 0.0004446675 3.775672e-01 0.75845550 12 63808675 63809792 1118 + 2.079 2.102 0.077