ENSG00000118197

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000331314 ENSG00000118197 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX59 protein_coding protein_coding 10.51911 6.157148 5.095501 1.626261 0.2547299 -0.2725511 4.2826632 1.6109351 2.6727575 1.12826704 0.711364780 0.7268904 0.40470000 0.20960000 0.51413333 0.30453333 0.51677163 0.01029839 FALSE TRUE
ENST00000413408 ENSG00000118197 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX59 protein_coding protein_coding 10.51911 6.157148 5.095501 1.626261 0.2547299 -0.2725511 0.7094514 0.6445253 0.4156158 0.16314669 0.121965234 -0.6208973 0.07117917 0.10560000 0.08206667 -0.02353333 0.77449943 0.01029839 FALSE TRUE
ENST00000429498 ENSG00000118197 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX59 protein_coding protein_coding 10.51911 6.157148 5.095501 1.626261 0.2547299 -0.2725511 0.1771459 0.4692588 0.0000000 0.23645393 0.000000000 -5.5827331 0.02769167 0.10343333 0.00000000 -0.10343333 0.31789640 0.01029839 FALSE TRUE
ENST00000433235 ENSG00000118197 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX59 protein_coding protein_coding 10.51911 6.157148 5.095501 1.626261 0.2547299 -0.2725511 0.2683467 0.6532538 0.1576418 0.41181650 0.008138925 -1.9841794 0.03156667 0.09106667 0.03120000 -0.05986667 0.79815491 0.01029839 FALSE FALSE
ENST00000436897 ENSG00000118197 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX59 protein_coding protein_coding 10.51911 6.157148 5.095501 1.626261 0.2547299 -0.2725511 0.3002872 0.1065485 0.5075362 0.06295403 0.295228969 2.1507299 0.03025417 0.01930000 0.09743333 0.07813333 0.74103302 0.01029839 FALSE FALSE
ENST00000452560 ENSG00000118197 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX59 protein_coding protein_coding 10.51911 6.157148 5.095501 1.626261 0.2547299 -0.2725511 0.0862801 0.2791836 0.0000000 0.27918363 0.000000000 -4.8539140 0.01665000 0.06293333 0.00000000 -0.06293333 0.81414787 0.01029839 FALSE FALSE
MSTRG.2811.2 ENSG00000118197 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX59 protein_coding   10.51911 6.157148 5.095501 1.626261 0.2547299 -0.2725511 1.0702953 0.1970415 0.3013856 0.15036322 0.172164940 0.5887824 0.09070417 0.02456667 0.05780000 0.03323333 0.81237534 0.01029839 FALSE TRUE
MSTRG.2811.8 ENSG00000118197 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX59 protein_coding   10.51911 6.157148 5.095501 1.626261 0.2547299 -0.2725511 1.0989552 0.8687747 0.0000000 0.46505908 0.000000000 -6.4574215 0.09850000 0.18236667 0.00000000 -0.18236667 0.01029839 0.01029839 FALSE TRUE
MSTRG.2811.9 ENSG00000118197 HEK293_DMSO_6hA HEK293_OSMI2_6hA DDX59 protein_coding   10.51911 6.157148 5.095501 1.626261 0.2547299 -0.2725511 2.3447326 0.8232623 0.7663300 0.52255277 0.403855011 -0.1021007 0.20240417 0.11230000 0.15893333 0.04663333 0.97023819 0.01029839 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000118197 E001 0.3356707 0.0268313172 0.9504993168   1 200623896 200625047 1152 - 0.124 0.116 -0.116
ENSG00000118197 E002 0.0000000       1 200640811 200640821 11 -      
ENSG00000118197 E003 6.8665370 0.1094816621 0.6032392167 0.87705572 1 200640822 200641029 208 - 0.844 0.924 0.303
ENSG00000118197 E004 9.2412623 0.0603247068 0.2815720783 0.68457155 1 200641030 200641185 156 - 0.918 1.068 0.554
ENSG00000118197 E005 3.4960430 0.0061732176 0.0551976332 0.35893227 1 200641186 200641256 71 - 0.474 0.769 1.303
ENSG00000118197 E006 0.7896109 0.0208562640 0.0242092590   1 200644037 200644120 84 - 0.000 0.402 11.852
ENSG00000118197 E007 0.7896109 0.0208562640 0.0242092590   1 200644121 200644174 54 - 0.000 0.402 11.852
ENSG00000118197 E008 2.1928257 0.0085830920 0.7194924429 0.92199835 1 200644175 200644182 8 - 0.474 0.536 0.304
ENSG00000118197 E009 33.8486281 0.0010906084 0.1639679831 0.55906007 1 200644183 200644368 186 - 1.496 1.582 0.295
ENSG00000118197 E010 49.2070827 0.0025659303 0.0003500052 0.02896805 1 200644369 200644517 149 - 1.596 1.783 0.634
ENSG00000118197 E011 55.3105265 0.0006599453 0.0536909145 0.35482587 1 200648439 200648567 129 - 1.708 1.800 0.313
ENSG00000118197 E012 47.5629624 0.0019566229 0.7664032252 0.93823119 1 200649074 200649226 153 - 1.681 1.706 0.084
ENSG00000118197 E013 14.7617069 0.0068906778 0.8470952241 0.96217595 1 200650425 200650442 18 - 1.215 1.209 -0.021
ENSG00000118197 E014 22.1792438 0.0130478063 0.5708571602 0.86269083 1 200650443 200650490 48 - 1.394 1.363 -0.108
ENSG00000118197 E015 35.7099484 0.0007976934 0.6017160896 0.87626323 1 200650491 200650676 186 - 1.582 1.560 -0.075
ENSG00000118197 E016 3.9188406 0.0626315796 0.4348372659 0.79435644 1 200654441 200654550 110 - 0.603 0.744 0.593
ENSG00000118197 E017 1.8784264 0.0097122399 0.3271055251 0.72246431 1 200654551 200654582 32 - 0.365 0.536 0.888
ENSG00000118197 E018 9.4908672 0.1143673129 0.0992783538 0.45593489 1 200654806 200655104 299 - 0.841 1.116 1.022
ENSG00000118197 E019 25.0999272 0.0010933668 0.2530500375 0.65882229 1 200659027 200659116 90 - 1.457 1.388 -0.238
ENSG00000118197 E020 36.4143437 0.0008110595 0.3233897790 0.71946454 1 200663919 200664086 168 - 1.601 1.553 -0.163
ENSG00000118197 E021 57.2359500 0.0007507426 0.0092772444 0.16762871 1 200665937 200666258 322 - 1.823 1.717 -0.358
ENSG00000118197 E022 64.2825986 0.0005637307 0.0004225199 0.03261046 1 200666259 200666751 493 - 1.889 1.752 -0.462
ENSG00000118197 E023 2.2148966 0.2502236844 0.3075599005 0.70586324 1 200669567 200669766 200 - 0.637 0.347 -1.448
ENSG00000118197 E024 14.0466276 0.0164145778 0.0826586690 0.42325213 1 200669767 200669955 189 - 1.262 1.087 -0.621