ENSG00000117448

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351829 ENSG00000117448 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKR1A1 protein_coding protein_coding 98.03468 85.33232 129.0674 7.630555 22.43276 0.596903 29.502452 21.241408 45.588027 1.4981744 10.1231230 1.1014129 0.28336667 0.24996667 0.34570000 0.09573333 0.05034882 0.0025222 FALSE TRUE
ENST00000434299 ENSG00000117448 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKR1A1 protein_coding protein_coding 98.03468 85.33232 129.0674 7.630555 22.43276 0.596903 9.536114 6.009056 15.909869 0.2786066 3.0190441 1.4032194 0.09575417 0.07126667 0.12330000 0.05203333 0.00252220 0.0025222 FALSE FALSE
ENST00000471651 ENSG00000117448 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKR1A1 protein_coding protein_coding 98.03468 85.33232 129.0674 7.630555 22.43276 0.596903 5.251153 5.790944 7.125678 0.4323266 1.0072503 0.2987628 0.06369583 0.06933333 0.05840000 -0.01093333 0.75686106 0.0025222 FALSE TRUE
ENST00000473038 ENSG00000117448 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKR1A1 protein_coding processed_transcript 98.03468 85.33232 129.0674 7.630555 22.43276 0.596903 5.610296 8.282605 6.540621 0.2061622 0.3237992 -0.3401937 0.06650417 0.09910000 0.05546667 -0.04363333 0.24365011 0.0025222 FALSE TRUE
ENST00000621846 ENSG00000117448 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKR1A1 protein_coding protein_coding 98.03468 85.33232 129.0674 7.630555 22.43276 0.596903 21.093363 16.944483 24.223758 3.8404910 6.5654479 0.5153514 0.20675833 0.19350000 0.17953333 -0.01396667 0.91069064 0.0025222 FALSE TRUE
MSTRG.1084.8 ENSG00000117448 HEK293_DMSO_6hA HEK293_OSMI2_6hA AKR1A1 protein_coding   98.03468 85.33232 129.0674 7.630555 22.43276 0.596903 11.688245 9.092896 11.799159 1.7878283 2.7977825 0.3755088 0.11974167 0.10456667 0.08890000 -0.01566667 0.75054192 0.0025222 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000117448 E001 0.1125166 3.207998e-02 0.6713882172   1 45550503 45550536 34 + 0.101 0.000 -10.025
ENSG00000117448 E002 0.1125166 3.207998e-02 0.6713882172   1 45550537 45550538 2 + 0.101 0.000 -10.021
ENSG00000117448 E003 0.1125166 3.207998e-02 0.6713882172   1 45550539 45550542 4 + 0.101 0.000 -10.021
ENSG00000117448 E004 1.1515833 1.697902e-02 0.3620966965   1 45550543 45550782 240 + 0.409 0.248 -1.022
ENSG00000117448 E005 1.8877418 4.375567e-02 0.2781118810 0.68134718 1 45550783 45550803 21 + 0.527 0.333 -1.039
ENSG00000117448 E006 4.2116467 6.762771e-03 0.6050331215 0.87763140 1 45550804 45550813 10 + 0.755 0.685 -0.288
ENSG00000117448 E007 24.9440937 1.492372e-03 0.1465697958 0.53438799 1 45550814 45550825 12 + 1.457 1.360 -0.333
ENSG00000117448 E008 63.0312381 9.900549e-04 0.2547427435 0.66047968 1 45550826 45550845 20 + 1.826 1.780 -0.153
ENSG00000117448 E009 81.7376476 1.686455e-03 0.3395586543 0.73154082 1 45550846 45550853 8 + 1.930 1.897 -0.111
ENSG00000117448 E010 172.3276121 3.593255e-04 0.0108713392 0.18034626 1 45550854 45550876 23 + 2.266 2.202 -0.216
ENSG00000117448 E011 239.4690850 8.003014e-04 0.0993651351 0.45606296 1 45550877 45550965 89 + 2.395 2.360 -0.118
ENSG00000117448 E012 483.3141818 1.982583e-04 0.1005690695 0.45831227 1 45550966 45551066 101 + 2.692 2.672 -0.065
ENSG00000117448 E013 289.9535760 2.484319e-04 0.7121890815 0.91930885 1 45551067 45551067 1 + 2.460 2.460 0.002
ENSG00000117448 E014 599.7705102 9.183619e-05 0.0744346104 0.40527304 1 45551068 45551155 88 + 2.785 2.766 -0.062
ENSG00000117448 E015 0.9417449 3.273722e-02 0.2145355814   1 45552416 45552435 20 + 0.182 0.404 1.557
ENSG00000117448 E016 191.1827408 1.928099e-04 0.2274976984 0.63251858 1 45552436 45552563 128 + 2.293 2.269 -0.082
ENSG00000117448 E017 0.3312313 6.718574e-02 0.7936551821   1 45557082 45557119 38 + 0.101 0.141 0.548
ENSG00000117448 E018 591.7231934 4.354652e-04 0.2334706029 0.63844103 1 45561789 45561878 90 + 2.776 2.764 -0.038
ENSG00000117448 E019 784.9825867 3.173236e-04 0.0312871993 0.28459918 1 45566569 45566688 120 + 2.903 2.881 -0.074
ENSG00000117448 E020 815.1274948 1.166263e-04 0.0005768539 0.03944852 1 45566869 45567020 152 + 2.924 2.888 -0.118
ENSG00000117448 E021 187.5494245 6.846340e-02 0.0720938730 0.40013345 1 45567021 45567548 528 + 2.155 2.388 0.776
ENSG00000117448 E022 55.4566910 1.355010e-02 0.0206662134 0.23885115 1 45567549 45567756 208 + 1.658 1.841 0.619
ENSG00000117448 E023 80.2634571 4.113235e-02 0.0170880114 0.22101446 1 45567757 45567960 204 + 1.771 2.035 0.891
ENSG00000117448 E024 47.3111232 6.620812e-02 0.0376043327 0.30595455 1 45567961 45567981 21 + 1.533 1.817 0.964
ENSG00000117448 E025 748.9430513 1.006135e-04 0.0411279834 0.31777926 1 45567982 45568090 109 + 2.881 2.861 -0.064
ENSG00000117448 E026 524.1571084 1.093873e-04 0.9554612665 0.98974954 1 45568091 45568146 56 + 2.714 2.722 0.027
ENSG00000117448 E027 446.8444336 4.910857e-04 0.6766675704 0.90690665 1 45568147 45568177 31 + 2.640 2.657 0.057
ENSG00000117448 E028 480.7628645 6.887855e-03 0.6835957694 0.90956943 1 45568485 45568613 129 + 2.681 2.676 -0.017
ENSG00000117448 E029 360.2535452 4.129239e-03 0.5386241344 0.84918907 1 45568614 45568684 71 + 2.559 2.547 -0.038
ENSG00000117448 E030 33.0072474 1.423976e-01 0.0339711208 0.29379109 1 45568685 45568926 242 + 1.317 1.702 1.321
ENSG00000117448 E031 356.2666288 1.345586e-04 0.0504578733 0.34543747 1 45568927 45568933 7 + 2.532 2.575 0.145
ENSG00000117448 E032 574.4425358 4.678116e-04 0.0306879268 0.28210195 1 45568934 45568999 66 + 2.735 2.782 0.155
ENSG00000117448 E033 5.7773680 4.309430e-03 0.0012774218 0.06238735 1 45569000 45569006 7 + 0.588 1.010 1.683
ENSG00000117448 E034 14.8059849 5.431382e-02 0.0012431855 0.06131162 1 45569050 45569142 93 + 0.919 1.391 1.694
ENSG00000117448 E035 568.5983670 4.481745e-04 0.0065237024 0.14224161 1 45569143 45569229 87 + 2.725 2.783 0.190
ENSG00000117448 E036 407.2259734 4.232519e-04 0.2052333842 0.60892258 1 45569891 45570049 159 + 2.590 2.625 0.117