ENSG00000116984

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000366576 ENSG00000116984 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTR protein_coding protein_coding 16.17194 12.02462 15.90134 1.986894 4.091984 0.4028649 2.4506361 3.1976066 4.1138201 0.5718984 1.81087093 0.3624842 0.18163750 0.271533333 0.22060000 -0.050933333 0.76417815 0.01137627 FALSE TRUE
ENST00000366577 ENSG00000116984 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTR protein_coding protein_coding 16.17194 12.02462 15.90134 1.986894 4.091984 0.4028649 7.6793927 4.9794722 9.0995336 0.7311406 2.57129313 0.8684900 0.47128750 0.416433333 0.56126667 0.144833333 0.01137627 0.01137627 FALSE TRUE
ENST00000535889 ENSG00000116984 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTR protein_coding protein_coding 16.17194 12.02462 15.90134 1.986894 4.091984 0.4028649 1.1441987 0.1188385 0.2476081 0.1043102 0.04334138 0.9996143 0.05985833 0.007866667 0.01783333 0.009966667 0.65131017 0.01137627 FALSE TRUE
ENST00000674797 ENSG00000116984 HEK293_DMSO_6hA HEK293_OSMI2_6hA MTR protein_coding protein_coding 16.17194 12.02462 15.90134 1.986894 4.091984 0.4028649 0.9223289 0.7322349 0.3494939 0.4624240 0.23570660 -1.0459085 0.05441667 0.054333333 0.02480000 -0.029533333 0.86724223 0.01137627 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000116984 E001 1.6965269 0.0167828209 0.9301035487 0.98336984 1 236795260 236795291 32 + 0.421 0.453 0.166
ENSG00000116984 E002 4.0052371 0.0064675598 0.4905560033 0.82477594 1 236795292 236795311 20 + 0.750 0.670 -0.332
ENSG00000116984 E003 7.7431942 0.0031100857 0.2242270041 0.62910598 1 236795312 236795325 14 + 1.000 0.882 -0.444
ENSG00000116984 E004 25.0395128 0.0048406038 0.0018965215 0.07750202 1 236795326 236795386 61 + 1.511 1.295 -0.746
ENSG00000116984 E005 22.6169727 0.0017892047 0.0002256828 0.02197336 1 236795387 236795394 8 + 1.479 1.225 -0.884
ENSG00000116984 E006 28.9255493 0.0060784415 0.0002612379 0.02418406 1 236795395 236795438 44 + 1.581 1.327 -0.875
ENSG00000116984 E007 49.2133681 0.0044223264 0.0034344234 0.10537213 1 236795439 236795614 176 + 1.771 1.618 -0.521
ENSG00000116984 E008 31.6148334 0.0039982801 0.0237826667 0.25366989 1 236795615 236795681 67 + 1.578 1.445 -0.457
ENSG00000116984 E009 27.4084368 0.0013385534 0.7027264983 0.91608402 1 236795682 236795703 22 + 1.464 1.461 -0.007
ENSG00000116984 E010 34.4733365 0.0010593683 0.3927892516 0.76872500 1 236795704 236795737 34 + 1.568 1.542 -0.091
ENSG00000116984 E011 21.8431651 0.0013288134 0.9923297072 0.99818153 1 236803428 236803430 3 + 1.353 1.376 0.080
ENSG00000116984 E012 77.5155441 0.0009898999 0.0019140355 0.07780307 1 236803431 236803642 212 + 1.948 1.841 -0.358
ENSG00000116984 E013 51.7365554 0.0041317359 0.0110166840 0.18169456 1 236806144 236806233 90 + 1.779 1.660 -0.400
ENSG00000116984 E014 49.3203165 0.0013535594 0.2325594608 0.63756859 1 236808704 236808773 70 + 1.725 1.688 -0.124
ENSG00000116984 E015 12.5126611 0.1634711612 0.0588707108 0.36861169 1 236809462 236810502 1041 + 0.870 1.315 1.614
ENSG00000116984 E016 56.6894935 0.0004803125 0.4651978836 0.81129282 1 236810503 236810595 93 + 1.768 1.758 -0.035
ENSG00000116984 E017 1.2466414 0.0483151664 0.7686310971   1 236811645 236811701 57 + 0.320 0.393 0.431
ENSG00000116984 E018 56.0999776 0.0005012515 0.8773142035 0.97055956 1 236812738 236812844 107 + 1.749 1.766 0.056
ENSG00000116984 E019 48.8746385 0.0011186035 0.4729682857 0.81550685 1 236815604 236815663 60 + 1.703 1.692 -0.038
ENSG00000116984 E020 63.6622756 0.0004560538 0.0336064996 0.29279177 1 236816449 236816543 95 + 1.844 1.774 -0.235
ENSG00000116984 E021 51.9725848 0.0006030790 0.2295528112 0.63458650 1 236824119 236824219 101 + 1.745 1.711 -0.116
ENSG00000116984 E022 48.2283093 0.0006833310 0.4185694322 0.78542213 1 236825338 236825399 62 + 1.705 1.688 -0.056
ENSG00000116984 E023 53.2186308 0.0006528005 0.4355954670 0.79473437 1 236826829 236826896 68 + 1.745 1.732 -0.044
ENSG00000116984 E024 63.6858385 0.0006710492 0.3681404373 0.75221279 1 236829189 236829268 80 + 1.818 1.803 -0.051
ENSG00000116984 E025 73.4125365 0.0004845363 0.0838159315 0.42540311 1 236831966 236832078 113 + 1.891 1.844 -0.159
ENSG00000116984 E026 63.4064948 0.0005636441 0.1778414147 0.57662825 1 236835547 236835615 69 + 1.823 1.787 -0.121
ENSG00000116984 E027 62.2774665 0.0035807302 0.3933127810 0.76901214 1 236835616 236835687 72 + 1.808 1.789 -0.062
ENSG00000116984 E028 68.0822097 0.0049991364 0.1520678811 0.54219418 1 236838414 236838518 105 + 1.861 1.814 -0.158
ENSG00000116984 E029 64.4230339 0.0051956197 0.3691902216 0.75310188 1 236838519 236838599 81 + 1.827 1.806 -0.071
ENSG00000116984 E030 84.7808259 0.0009931126 0.9153518346 0.97981348 1 236850344 236850523 180 + 1.921 1.950 0.097
ENSG00000116984 E031 71.5254920 0.0068095561 0.7557206320 0.93455032 1 236852521 236852637 117 + 1.863 1.859 -0.015
ENSG00000116984 E032 86.0649608 0.0046636993 0.6893415338 0.91150797 1 236852948 236853088 141 + 1.944 1.939 -0.016
ENSG00000116984 E033 79.5716857 0.0010232750 0.4497308362 0.80343498 1 236859833 236859922 90 + 1.915 1.907 -0.027
ENSG00000116984 E034 77.7717919 0.0004111437 0.0510103886 0.34687022 1 236861125 236861277 153 + 1.924 1.870 -0.182
ENSG00000116984 E035 73.4839832 0.0004529887 0.0034074807 0.10508811 1 236862236 236862343 108 + 1.917 1.820 -0.327
ENSG00000116984 E036 68.9478090 0.0040838948 0.0072273239 0.14963208 1 236863454 236863554 101 + 1.890 1.780 -0.374
ENSG00000116984 E037 52.3061614 0.0005566914 0.2971717862 0.69744837 1 236873773 236873840 68 + 1.741 1.714 -0.091
ENSG00000116984 E038 79.3716918 0.0003689453 0.2783318182 0.68164330 1 236874726 236874846 121 + 1.918 1.899 -0.064
ENSG00000116984 E039 84.8515365 0.0061720958 0.1822055365 0.58211456 1 236880755 236880836 82 + 1.958 1.906 -0.173
ENSG00000116984 E040 90.6689417 0.0016606422 0.5208596100 0.84052862 1 236885121 236885219 99 + 1.965 1.961 -0.012
ENSG00000116984 E041 80.5118634 0.0003935339 0.6197237581 0.88392442 1 236886292 236886367 76 + 1.911 1.915 0.013
ENSG00000116984 E042 30.4286886 0.1154282400 0.0846843525 0.42716135 1 236886368 236889180 2813 + 1.309 1.645 1.157
ENSG00000116984 E043 110.1982876 0.0005071176 0.3364878057 0.72924425 1 236889181 236889336 156 + 2.054 2.045 -0.031
ENSG00000116984 E044 83.1105880 0.0004264434 0.4833768494 0.82113589 1 236891133 236891222 90 + 1.932 1.929 -0.013
ENSG00000116984 E045 90.3681085 0.0037709126 0.9459025288 0.98738631 1 236891223 236891329 107 + 1.950 1.977 0.091
ENSG00000116984 E046 77.0690679 0.1708917814 0.1091194580 0.47415960 1 236891330 236894356 3027 + 1.706 2.041 1.127
ENSG00000116984 E047 137.5485791 0.0008265078 0.8891174200 0.97349445 1 236894357 236894557 201 + 2.129 2.158 0.098
ENSG00000116984 E048 28.2959145 0.1471082799 0.0844766242 0.42676947 1 236894558 236895357 800 + 1.263 1.622 1.237
ENSG00000116984 E049 122.4113727 0.0002506953 0.6382495506 0.89145103 1 236895358 236895550 193 + 2.075 2.114 0.130
ENSG00000116984 E050 107.3122271 0.0005936135 0.5156491369 0.83803231 1 236897006 236897118 113 + 2.010 2.058 0.159
ENSG00000116984 E051 252.5134770 0.0001624756 0.4295355653 0.79165731 1 236897558 236898003 446 + 2.388 2.429 0.138
ENSG00000116984 E052 258.2458093 0.0010712939 0.6941146501 0.91324958 1 236898004 236898522 519 + 2.413 2.425 0.040
ENSG00000116984 E053 333.1233475 0.0001542213 0.0275564064 0.26924201 1 236898523 236899109 587 + 2.494 2.560 0.222
ENSG00000116984 E054 1936.5737449 0.0030919717 0.0263361212 0.26375431 1 236899110 236903778 4669 + 3.256 3.320 0.213
ENSG00000116984 E055 70.4895824 0.0008388176 0.1073138059 0.47050969 1 236903779 236903981 203 + 1.809 1.901 0.312
ENSG00000116984 E056 1.5650656 0.0122012323 0.3241545552   1 236907045 236907206 162 + 0.321 0.506 1.014
ENSG00000116984 E057 2.9810115 0.3936599850 0.3259144619 0.72149800 1 236913298 236913424 127 + 0.438 0.756 1.435
ENSG00000116984 E058 0.8069184 0.0277546626 0.0097092912   1 236913425 236913430 6 + 0.000 0.453 12.001
ENSG00000116984 E059 3.6304549 0.1059174903 0.0458885894 0.33253194 1 236916741 236916920 180 + 0.420 0.856 1.922
ENSG00000116984 E060 6.6861005 0.1926670259 0.4266938981 0.79017127 1 236920811 236921278 468 + 0.746 1.002 0.987