ENSG00000116754

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000370949 ENSG00000116754 HEK293_DMSO_6hA HEK293_OSMI2_6hA SRSF11 protein_coding protein_coding 110.8548 57.25033 46.96802 16.65593 3.849382 -0.2855501 22.629726 7.033529 9.990283 1.986964 1.8035378 0.5056705 0.20801667 0.12370000 0.21983333 0.09613333 0.32269472 0.01433364 FALSE  
ENST00000370951 ENSG00000116754 HEK293_DMSO_6hA HEK293_OSMI2_6hA SRSF11 protein_coding protein_coding 110.8548 57.25033 46.96802 16.65593 3.849382 -0.2855501 19.601432 4.438097 7.312223 1.137416 0.3803957 0.7190935 0.16040000 0.08010000 0.15906667 0.07896667 0.03858823 0.01433364 FALSE  
ENST00000463116 ENSG00000116754 HEK293_DMSO_6hA HEK293_OSMI2_6hA SRSF11 protein_coding processed_transcript 110.8548 57.25033 46.96802 16.65593 3.849382 -0.2855501 7.220752 5.484786 2.838636 1.756259 0.9212216 -0.9477920 0.06274583 0.09533333 0.05833333 -0.03700000 0.34068777 0.01433364    
ENST00000463877 ENSG00000116754 HEK293_DMSO_6hA HEK293_OSMI2_6hA SRSF11 protein_coding processed_transcript 110.8548 57.25033 46.96802 16.65593 3.849382 -0.2855501 25.035519 15.310525 11.747941 3.060128 2.1685206 -0.3818303 0.23311667 0.28183333 0.24736667 -0.03446667 0.76442248 0.01433364 FALSE  
ENST00000484162 ENSG00000116754 HEK293_DMSO_6hA HEK293_OSMI2_6hA SRSF11 protein_coding retained_intron 110.8548 57.25033 46.96802 16.65593 3.849382 -0.2855501 10.196064 9.140757 4.577741 3.321979 1.3554855 -0.9961072 0.09022917 0.15316667 0.09413333 -0.05903333 0.28336179 0.01433364 FALSE  
ENST00000690370 ENSG00000116754 HEK293_DMSO_6hA HEK293_OSMI2_6hA SRSF11 protein_coding retained_intron 110.8548 57.25033 46.96802 16.65593 3.849382 -0.2855501 8.376686 6.047105 3.559662 2.092709 0.4250473 -0.7628409 0.07297500 0.10213333 0.07563333 -0.02650000 0.38246237 0.01433364 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000116754 E001 0.9625077 0.0181973309 2.748083e-02   1 70205682 70205687 6 + 0.483 0.112 -2.795
ENSG00000116754 E002 3.1572044 0.0109255856 7.874894e-02 4.149676e-01 1 70205688 70205697 10 + 0.736 0.485 -1.111
ENSG00000116754 E003 9.1863448 0.0028312388 1.028243e-02 1.756712e-01 1 70205698 70205716 19 + 1.124 0.873 -0.927
ENSG00000116754 E004 9.8818752 0.0026693632 1.667439e-03 7.248416e-02 1 70205717 70205723 7 + 1.176 0.873 -1.114
ENSG00000116754 E005 38.4812197 0.0013706369 3.666236e-03 1.089203e-01 1 70205724 70205780 57 + 1.667 1.523 -0.490
ENSG00000116754 E006 2.0562355 0.0101633901 5.340367e-01 8.471143e-01 1 70221370 70221379 10 + 0.530 0.442 -0.437
ENSG00000116754 E007 5.9990339 0.0365816376 2.480562e-01 6.535347e-01 1 70221380 70221395 16 + 0.940 0.778 -0.627
ENSG00000116754 E008 6.9866536 0.0515429461 1.376069e-01 5.215682e-01 1 70221396 70221400 5 + 1.026 0.799 -0.863
ENSG00000116754 E009 20.3992280 0.0067380219 9.832283e-02 4.542264e-01 1 70221401 70221468 68 + 1.399 1.283 -0.404
ENSG00000116754 E010 20.5120439 0.0041913042 1.378580e-01 5.220848e-01 1 70221469 70221479 11 + 1.389 1.297 -0.321
ENSG00000116754 E011 80.2774724 0.0026484167 2.818077e-05 6.070849e-03 1 70221480 70221611 132 + 1.999 1.828 -0.574
ENSG00000116754 E012 64.2409553 0.0011417527 1.570076e-03 6.986458e-02 1 70221612 70221614 3 + 1.876 1.755 -0.408
ENSG00000116754 E013 145.1677493 0.0091170921 5.666693e-03 1.341460e-01 1 70221615 70221723 109 + 2.235 2.093 -0.476
ENSG00000116754 E014 236.8816514 0.0063106205 2.980354e-03 9.818517e-02 1 70221724 70221839 116 + 2.436 2.316 -0.399
ENSG00000116754 E015 3.2443677 0.0622405030 5.206007e-01 8.403939e-01 1 70222766 70222798 33 + 0.539 0.656 0.521
ENSG00000116754 E016 209.0735570 0.0023559119 1.398681e-02 2.027129e-01 1 70228422 70228464 43 + 2.353 2.289 -0.211
ENSG00000116754 E017 305.6180423 0.0040313643 2.974646e-02 2.785133e-01 1 70228465 70228555 91 + 2.517 2.455 -0.207
ENSG00000116754 E018 118.6030682 0.0358912904 1.768421e-01 5.752321e-01 1 70228556 70228735 180 + 2.004 2.118 0.380
ENSG00000116754 E019 71.1483628 0.0468874153 4.153145e-02 3.190309e-01 1 70230064 70230277 214 + 1.731 1.927 0.662
ENSG00000116754 E020 122.5789713 0.0294185797 2.087852e-02 2.399709e-01 1 70230278 70230556 279 + 1.972 2.158 0.625
ENSG00000116754 E021 66.9447830 0.0109802038 2.009934e-01 6.044282e-01 1 70230557 70230618 62 + 1.770 1.865 0.321
ENSG00000116754 E022 160.7261307 0.0438290393 1.073284e-02 1.793052e-01 1 70230619 70231094 476 + 2.053 2.293 0.804
ENSG00000116754 E023 88.7681776 0.0220361115 1.683496e-01 5.650477e-01 1 70231095 70231159 65 + 1.885 1.990 0.352
ENSG00000116754 E024 75.6402964 0.0143461750 5.447759e-02 3.569923e-01 1 70231160 70231203 44 + 1.795 1.932 0.461
ENSG00000116754 E025 67.3734435 0.0195432745 9.572830e-04 5.264866e-02 1 70231204 70231257 54 + 1.650 1.929 0.939
ENSG00000116754 E026 135.9985437 0.0357397426 2.781416e-02 2.703734e-01 1 70231258 70231547 290 + 2.000 2.212 0.711
ENSG00000116754 E027 150.8654582 0.0126805643 5.040194e-03 1.272985e-01 1 70231548 70231858 311 + 2.064 2.247 0.613
ENSG00000116754 E028 140.9517637 0.0160231414 1.062968e-01 4.687158e-01 1 70231859 70231975 117 + 2.085 2.191 0.355
ENSG00000116754 E029 85.2746224 0.0144889642 6.066135e-02 3.732555e-01 1 70231976 70232267 292 + 1.838 1.990 0.511
ENSG00000116754 E030 290.9833189 0.0066390737 1.136837e-01 4.819240e-01 1 70232268 70232377 110 + 2.491 2.442 -0.164
ENSG00000116754 E031 280.2426954 0.0030849661 4.927340e-01 8.257736e-01 1 70234696 70234788 93 + 2.452 2.445 -0.023
ENSG00000116754 E032 169.3755350 0.0017339121 3.070140e-01 7.053362e-01 1 70235501 70235550 50 + 2.238 2.225 -0.044
ENSG00000116754 E033 323.5038209 0.0001379970 4.493041e-02 3.297794e-01 1 70237425 70237552 128 + 2.518 2.504 -0.046
ENSG00000116754 E034 292.8933897 0.0001394958 3.900235e-02 3.106036e-01 1 70239439 70239520 82 + 2.476 2.460 -0.056
ENSG00000116754 E035 393.7955533 0.0022335128 1.665263e-01 5.625758e-01 1 70244684 70244815 132 + 2.605 2.588 -0.059
ENSG00000116754 E036 3.5842441 0.0061790792 4.392186e-01 7.971937e-01 1 70246730 70246817 88 + 0.572 0.709 0.589
ENSG00000116754 E037 319.2582480 0.0035507323 3.014479e-01 7.010535e-01 1 70246818 70246907 90 + 2.512 2.499 -0.042
ENSG00000116754 E038 16.0035697 0.0626514928 8.221005e-01 9.550029e-01 1 70247117 70247149 33 + 1.205 1.250 0.158
ENSG00000116754 E039 78.5590023 0.0095386956 5.839700e-12 3.584040e-08 1 70248394 70249741 1348 + 1.577 2.042 1.568
ENSG00000116754 E040 20.9076757 0.0025626881 5.456593e-07 3.661348e-04 1 70249742 70249930 189 + 1.038 1.482 1.567
ENSG00000116754 E041 13.7411200 0.0096922851 1.680225e-02 2.193731e-01 1 70249931 70249951 21 + 1.007 1.276 0.963
ENSG00000116754 E042 387.0652371 0.0033270527 3.973441e-01 7.714351e-01 1 70249952 70250047 96 + 2.591 2.585 -0.021
ENSG00000116754 E043 5.0968886 0.0050742460 2.261611e-02 2.482409e-01 1 70250048 70250364 317 + 0.571 0.906 1.371
ENSG00000116754 E044 461.7325246 0.0024960649 6.657313e-01 9.025804e-01 1 70250365 70250503 139 + 2.658 2.667 0.029
ENSG00000116754 E045 156.9699312 0.0060040317 8.788254e-01 9.709330e-01 1 70250608 70250610 3 + 2.180 2.206 0.088
ENSG00000116754 E046 2072.2852826 0.0062329762 9.101611e-01 9.785535e-01 1 70250611 70253052 2442 + 3.302 3.321 0.063