ENSG00000116337

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000342115 ENSG00000116337 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMPD2 protein_coding protein_coding 44.05619 51.99147 63.47878 1.236377 6.574203 0.2879492 11.008420 5.412994 20.3042452 1.3564450 5.5043357 1.905330364 0.24410417 0.10303333 0.309733333 0.20670000 0.01989502 0.01852924 FALSE TRUE
ENST00000474459 ENSG00000116337 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMPD2 protein_coding retained_intron 44.05619 51.99147 63.47878 1.236377 6.574203 0.2879492 2.554624 4.688971 2.5669545 0.9872409 1.1027076 -0.866677955 0.06380833 0.09000000 0.042800000 -0.04720000 0.41882299 0.01852924 FALSE TRUE
ENST00000479919 ENSG00000116337 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMPD2 protein_coding retained_intron 44.05619 51.99147 63.47878 1.236377 6.574203 0.2879492 2.635061 2.632041 4.3701502 0.6033549 0.7042735 0.729327714 0.05484167 0.05016667 0.068333333 0.01816667 0.69159220 0.01852924 TRUE TRUE
ENST00000528958 ENSG00000116337 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMPD2 protein_coding retained_intron 44.05619 51.99147 63.47878 1.236377 6.574203 0.2879492 7.880246 9.829821 9.7724143 0.4132046 2.4267392 -0.008441511 0.13643333 0.18966667 0.149266667 -0.04040000 0.64719015 0.01852924 FALSE TRUE
ENST00000529299 ENSG00000116337 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMPD2 protein_coding retained_intron 44.05619 51.99147 63.47878 1.236377 6.574203 0.2879492 1.052491 3.339262 0.2714897 0.5683499 0.2714897 -3.572688983 0.02770000 0.06470000 0.004333333 -0.06036667 0.03940097 0.01852924 FALSE TRUE
MSTRG.1762.12 ENSG00000116337 HEK293_DMSO_6hA HEK293_OSMI2_6hA AMPD2 protein_coding   44.05619 51.99147 63.47878 1.236377 6.574203 0.2879492 2.370429 2.858025 4.4299447 1.4324239 0.4749894 0.630484202 0.06347917 0.05566667 0.071000000 0.01533333 0.82664163 0.01852924 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000116337 E001 10.1547086 0.0600804750 8.860452e-01 0.972777858 1 109616104 109616235 132 + 1.034 1.034 0.001
ENSG00000116337 E002 62.9752244 0.0358232074 1.423432e-02 0.204227719 1 109616236 109618324 2089 + 1.663 1.919 0.865
ENSG00000116337 E003 0.1767706 0.0348460275 5.882531e-01   1 109619483 109619503 21 + 0.107 0.000 -8.314
ENSG00000116337 E004 0.6205184 0.0261048399 4.325728e-01   1 109619504 109619656 153 + 0.265 0.133 -1.224
ENSG00000116337 E005 2.5162260 0.1741388254 3.887462e-01 0.766209761 1 109619831 109619836 6 + 0.420 0.665 1.150
ENSG00000116337 E006 15.3406767 0.0108248686 3.906659e-01 0.767478965 1 109619837 109619845 9 + 1.246 1.178 -0.242
ENSG00000116337 E007 17.3295268 0.0180773490 4.036495e-01 0.775945284 1 109619846 109619846 1 + 1.291 1.228 -0.221
ENSG00000116337 E008 41.6808944 0.0084073500 9.245739e-03 0.167419389 1 109619847 109619864 18 + 1.697 1.534 -0.554
ENSG00000116337 E009 95.6416893 0.0027353690 1.553851e-04 0.017524552 1 109619865 109619904 40 + 2.049 1.897 -0.511
ENSG00000116337 E010 105.3614508 0.0010835817 1.993915e-05 0.004887718 1 109619905 109619915 11 + 2.089 1.941 -0.494
ENSG00000116337 E011 289.8949062 0.0050259820 2.132877e-02 0.242030342 1 109619916 109620139 224 + 2.494 2.424 -0.235
ENSG00000116337 E012 263.4983001 0.0005767028 2.875605e-03 0.096090654 1 109620140 109620278 139 + 2.448 2.389 -0.195
ENSG00000116337 E013 14.4668952 0.0489939903 2.982570e-01 0.698506718 1 109620608 109620651 44 + 1.110 1.246 0.486
ENSG00000116337 E014 25.2610512 0.1294103422 2.043048e-01 0.608179283 1 109620654 109620913 260 + 1.332 1.495 0.561
ENSG00000116337 E015 14.8175642 0.0129768653 1.433290e-01 0.529964758 1 109620914 109620917 4 + 1.107 1.271 0.585
ENSG00000116337 E016 16.0203825 0.0084823406 9.955970e-02 0.456509804 1 109620918 109620927 10 + 1.135 1.303 0.596
ENSG00000116337 E017 18.5232581 0.0015503555 2.122910e-01 0.616902450 1 109620928 109620950 23 + 1.229 1.340 0.388
ENSG00000116337 E018 16.1930421 0.0025441378 5.537305e-01 0.855364923 1 109620951 109620957 7 + 1.199 1.261 0.220
ENSG00000116337 E019 18.7760758 0.0020148711 8.648460e-01 0.967061902 1 109620958 109620967 10 + 1.276 1.302 0.090
ENSG00000116337 E020 24.9869993 0.0033335733 3.734396e-01 0.755549758 1 109620968 109621031 64 + 1.369 1.447 0.269
ENSG00000116337 E021 22.2545397 0.0012880839 4.862846e-01 0.822629857 1 109621032 109621073 42 + 1.330 1.393 0.218
ENSG00000116337 E022 16.1503263 0.0019038926 2.041279e-01 0.608050192 1 109621074 109621081 8 + 1.167 1.287 0.421
ENSG00000116337 E023 15.6927872 0.0017469577 3.814968e-01 0.761170045 1 109621082 109621083 2 + 1.175 1.262 0.305
ENSG00000116337 E024 19.3865318 0.0015509849 5.709416e-01 0.862690828 1 109621084 109621102 19 + 1.276 1.332 0.197
ENSG00000116337 E025 17.4758780 0.0018507956 5.101662e-01 0.834835628 1 109621103 109621117 15 + 1.229 1.295 0.231
ENSG00000116337 E026 21.3752388 0.0054768806 3.911841e-01 0.767760490 1 109621118 109621140 23 + 1.307 1.388 0.281
ENSG00000116337 E027 19.7620371 0.0018913704 1.467961e-01 0.534824908 1 109621141 109621151 11 + 1.250 1.374 0.435
ENSG00000116337 E028 23.6323185 0.0042189160 2.718981e-01 0.675836029 1 109621152 109621175 24 + 1.342 1.436 0.327
ENSG00000116337 E029 28.0091983 0.0149958545 4.525986e-01 0.804897551 1 109621176 109621231 56 + 1.423 1.496 0.250
ENSG00000116337 E030 24.0588628 0.0074816781 9.642063e-01 0.991804135 1 109621232 109621266 35 + 1.385 1.400 0.050
ENSG00000116337 E031 15.0678377 0.1448013598 2.433852e-01 0.648519787 1 109621269 109621345 77 + 1.123 1.273 0.531
ENSG00000116337 E032 12.2933798 0.1425807851 1.158143e-01 0.485900209 1 109621346 109621422 77 + 0.985 1.229 0.879
ENSG00000116337 E033 33.7907674 0.0632162851 1.948814e-02 0.233116272 1 109622185 109622353 169 + 1.368 1.672 1.039
ENSG00000116337 E034 17.7571465 0.1250310458 1.298100e-01 0.510004506 1 109623814 109623838 25 + 1.150 1.372 0.781
ENSG00000116337 E035 31.8776530 0.0827582783 1.396709e-02 0.202617002 1 109623839 109623978 140 + 1.327 1.660 1.142
ENSG00000116337 E036 19.2173401 0.0806344297 1.855915e-02 0.228872118 1 109623979 109624038 60 + 1.106 1.453 1.216
ENSG00000116337 E037 17.4398437 0.0482573196 2.230250e-02 0.247023908 1 109624039 109624089 51 + 1.102 1.393 1.024
ENSG00000116337 E038 240.8165969 0.0001507954 1.507066e-02 0.208976594 1 109625303 109625433 131 + 2.402 2.358 -0.144
ENSG00000116337 E039 8.9787172 0.0482238582 2.438278e-02 0.255918838 1 109625598 109625661 64 + 0.807 1.134 1.222
ENSG00000116337 E040 283.2329305 0.0009965707 7.734463e-02 0.412057037 1 109625662 109625792 131 + 2.467 2.436 -0.102
ENSG00000116337 E041 1.9705293 0.2854863454 8.854850e-01 0.972662342 1 109625793 109625805 13 + 0.432 0.503 0.357
ENSG00000116337 E042 3.6378039 0.0173559425 2.011339e-01 0.604693686 1 109626071 109626159 89 + 0.548 0.754 0.885
ENSG00000116337 E043 243.1425308 0.0001625197 1.298911e-01 0.510132327 1 109626160 109626228 69 + 2.396 2.374 -0.073
ENSG00000116337 E044 10.7609669 0.0328704342 4.701991e-01 0.813973545 1 109626229 109626318 90 + 1.007 1.110 0.377
ENSG00000116337 E045 273.5726191 0.0011156782 7.930913e-02 0.416170611 1 109626319 109626427 109 + 2.451 2.420 -0.103
ENSG00000116337 E046 7.5769371 0.1625864310 6.970764e-02 0.394956767 1 109626428 109626725 298 + 0.701 1.096 1.511
ENSG00000116337 E047 293.3595863 0.0021605361 7.860450e-01 0.943943319 1 109626726 109626912 187 + 2.464 2.470 0.021
ENSG00000116337 E048 129.7743514 0.0738508876 7.110098e-02 0.397881705 1 109626913 109627174 262 + 2.011 2.210 0.667
ENSG00000116337 E049 271.8725226 0.0001532250 6.183863e-01 0.883251774 1 109627175 109627316 142 + 2.424 2.447 0.078
ENSG00000116337 E050 19.7539436 0.0709184049 2.095392e-02 0.240116676 1 109627317 109627330 14 + 1.132 1.457 1.138
ENSG00000116337 E051 26.3408334 0.0742212503 6.782334e-02 0.390881458 1 109627331 109627412 82 + 1.309 1.544 0.812
ENSG00000116337 E052 20.7130019 0.1371496445 1.532176e-01 0.543801851 1 109627413 109627428 16 + 1.229 1.428 0.691
ENSG00000116337 E053 262.2357674 0.0005631997 6.270860e-01 0.886793254 1 109627429 109627518 90 + 2.420 2.421 0.003
ENSG00000116337 E054 150.9231086 0.0010994381 4.231750e-01 0.788044765 1 109627774 109627777 4 + 2.188 2.175 -0.043
ENSG00000116337 E055 364.4630204 0.0001748433 1.119081e-01 0.479126086 1 109627778 109627903 126 + 2.571 2.553 -0.059
ENSG00000116337 E056 420.9142753 0.0008665700 7.453487e-01 0.931279733 1 109628083 109628214 132 + 2.622 2.627 0.017
ENSG00000116337 E057 314.1154911 0.0021781609 1.714415e-01 0.568828511 1 109628215 109628277 63 + 2.506 2.482 -0.081
ENSG00000116337 E058 59.1620815 0.0034987862 1.382613e-02 0.201998791 1 109628278 109628363 86 + 1.711 1.850 0.471
ENSG00000116337 E059 184.9009180 0.0008575439 3.719207e-01 0.754629627 1 109628364 109628368 5 + 2.269 2.258 -0.039
ENSG00000116337 E060 206.6931340 0.0006461272 5.080998e-01 0.833842433 1 109628369 109628378 10 + 2.315 2.310 -0.014
ENSG00000116337 E061 415.2080340 0.0017569328 9.191813e-01 0.980644349 1 109628379 109628495 117 + 2.609 2.623 0.048
ENSG00000116337 E062 37.4741030 0.1291843860 1.279894e-02 0.194934590 1 109628496 109628533 38 + 1.364 1.744 1.300
ENSG00000116337 E063 44.0222534 0.1905457631 4.229226e-02 0.321287785 1 109628534 109628626 93 + 1.480 1.789 1.051
ENSG00000116337 E064 19.0896577 0.1590239536 3.156531e-01 0.712710731 1 109628627 109628642 16 + 1.234 1.362 0.447
ENSG00000116337 E065 265.0387327 0.0007275589 2.709576e-01 0.675128663 1 109628643 109628713 71 + 2.426 2.414 -0.042
ENSG00000116337 E066 269.5013270 0.0001484594 4.379291e-02 0.326039485 1 109628714 109628806 93 + 2.444 2.413 -0.104
ENSG00000116337 E067 43.0221173 0.1375346170 4.846110e-02 0.340200848 1 109628807 109629092 286 + 1.490 1.767 0.942
ENSG00000116337 E068 17.7805849 0.0866015870 2.896028e-01 0.691171562 1 109629093 109629108 16 + 1.203 1.332 0.454
ENSG00000116337 E069 354.0062247 0.0002399584 1.311117e-01 0.511914798 1 109629109 109629235 127 + 2.558 2.540 -0.059
ENSG00000116337 E070 7.6222178 0.0032835336 9.100732e-03 0.166197183 1 109629236 109629326 91 + 0.760 1.071 1.183
ENSG00000116337 E071 440.5976120 0.0001343658 1.616309e-01 0.556346990 1 109629327 109629486 160 + 2.650 2.639 -0.039
ENSG00000116337 E072 191.7727524 0.0001899031 6.632483e-01 0.901594795 1 109629487 109629490 4 + 2.283 2.285 0.005
ENSG00000116337 E073 24.6961895 0.1258082128 1.468889e-02 0.206719078 1 109629491 109629795 305 + 1.181 1.574 1.364
ENSG00000116337 E074 208.7330914 0.0001729591 5.635785e-01 0.859458897 1 109629796 109629799 4 + 2.321 2.320 -0.005
ENSG00000116337 E075 419.1437641 0.0001090010 7.246676e-01 0.923857626 1 109629800 109629916 117 + 2.618 2.625 0.022
ENSG00000116337 E076 526.7986769 0.0016355868 8.036269e-01 0.949438207 1 109630233 109630406 174 + 2.714 2.727 0.043
ENSG00000116337 E077 4.6433306 0.0086044016 5.484048e-03 0.132049859 1 109630407 109630439 33 + 0.511 0.913 1.682
ENSG00000116337 E078 3.4211993 0.2658590989 2.285941e-01 0.633828108 1 109630638 109630682 45 + 0.493 0.754 1.144
ENSG00000116337 E079 372.8757919 0.0024013540 7.250318e-01 0.924008570 1 109630683 109630793 111 + 2.568 2.576 0.027
ENSG00000116337 E080 1813.9945239 0.0015956781 4.562502e-01 0.806769146 1 109630943 109632051 1109 + 3.243 3.274 0.104