ENSG00000116288

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000338639 ENSG00000116288 HEK293_DMSO_6hA HEK293_OSMI2_6hA PARK7 protein_coding protein_coding 374.6755 375.679 233.7416 46.32003 33.3563 -0.6845625 60.06228 57.76748 48.04126 5.256628 6.433754 -0.2659332 0.16191250 0.15523333 0.2060000 0.05076667 0.016562679 0.002276339 FALSE  
ENST00000493373 ENSG00000116288 HEK293_DMSO_6hA HEK293_OSMI2_6hA PARK7 protein_coding protein_coding 374.6755 375.679 233.7416 46.32003 33.3563 -0.6845625 206.14542 218.49051 124.83259 30.229810 16.725345 -0.8075265 0.54859167 0.57930000 0.5353333 -0.04396667 0.285038711 0.002276339 FALSE  
ENST00000493678 ENSG00000116288 HEK293_DMSO_6hA HEK293_OSMI2_6hA PARK7 protein_coding protein_coding 374.6755 375.679 233.7416 46.32003 33.3563 -0.6845625 63.45456 60.65206 28.06990 10.857530 7.462257 -1.1112568 0.16652500 0.15940000 0.1165333 -0.04286667 0.254850969 0.002276339 FALSE  
MSTRG.224.4 ENSG00000116288 HEK293_DMSO_6hA HEK293_OSMI2_6hA PARK7 protein_coding   374.6755 375.679 233.7416 46.32003 33.3563 -0.6845625 25.74981 20.04508 24.25677 1.335384 2.756334 0.2750145 0.07252917 0.05503333 0.1047333 0.04970000 0.002276339 0.002276339 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000116288 E001 0.0000000       1 7954291 7954323 33 +      
ENSG00000116288 E002 1.4401565 1.141977e-02 6.534439e-01   1 7961647 7961651 5 + 0.424 0.345 -0.445
ENSG00000116288 E003 2.7845707 2.650006e-02 5.571520e-01 0.856945729 1 7961652 7961662 11 + 0.486 0.594 0.505
ENSG00000116288 E004 2.8970873 4.118487e-02 7.967787e-01 0.947226306 1 7961663 7961665 3 + 0.539 0.594 0.251
ENSG00000116288 E005 170.3715267 4.608502e-03 1.066460e-02 0.178770116 1 7961666 7961691 26 + 2.281 2.165 -0.388
ENSG00000116288 E006 209.3842647 3.890859e-03 2.311117e-02 0.250511229 1 7961692 7961700 9 + 2.357 2.262 -0.315
ENSG00000116288 E007 261.2991793 2.947075e-03 2.110304e-02 0.240920714 1 7961701 7961710 10 + 2.446 2.361 -0.282
ENSG00000116288 E008 515.0204210 1.974447e-03 1.387183e-01 0.523352274 1 7961711 7961735 25 + 2.714 2.671 -0.144
ENSG00000116288 E009 188.0293332 1.725167e-03 3.486396e-05 0.006952193 1 7961736 7961747 12 + 2.337 2.200 -0.459
ENSG00000116288 E010 318.2103767 2.583723e-03 1.016720e-04 0.013708672 1 7961748 7961793 46 + 2.559 2.432 -0.422
ENSG00000116288 E011 2.1388103 9.114720e-03 7.843048e-02 0.414526984 1 7961894 7961968 75 + 0.635 0.345 -1.449
ENSG00000116288 E012 3.3698424 6.861435e-03 6.798200e-02 0.391251257 1 7961969 7962081 113 + 0.776 0.503 -1.185
ENSG00000116288 E013 0.1544607 3.478895e-02 7.894361e-01   1 7962082 7962101 20 + 0.000 0.094 8.491
ENSG00000116288 E014 821.8942135 1.307750e-03 6.692471e-02 0.388879651 1 7962763 7962766 4 + 2.917 2.875 -0.140
ENSG00000116288 E015 1867.0028650 4.457680e-04 5.563924e-01 0.856577968 1 7962767 7962875 109 + 3.251 3.242 -0.029
ENSG00000116288 E016 1376.3935177 6.594647e-05 3.527695e-01 0.741621397 1 7965324 7965350 27 + 3.104 3.114 0.032
ENSG00000116288 E017 2036.3367760 6.803915e-05 1.906728e-01 0.592416746 1 7965351 7965425 75 + 3.273 3.284 0.038
ENSG00000116288 E018 1.8820254 1.183146e-02 9.671594e-01 0.992453460 1 7969085 7969148 64 + 0.425 0.431 0.034
ENSG00000116288 E019 1948.2983252 5.535844e-05 3.164879e-01 0.713612298 1 7969345 7969404 60 + 3.256 3.265 0.029
ENSG00000116288 E020 2208.7665172 5.172270e-04 6.504333e-01 0.896649537 1 7970894 7970963 70 + 3.315 3.321 0.019
ENSG00000116288 E021 22.3528983 2.407553e-02 5.601262e-02 0.361060993 1 7970964 7971521 558 + 1.469 1.263 -0.715
ENSG00000116288 E022 2.1556456 9.173600e-03 9.082325e-01 0.978137714 1 7971629 7971957 329 + 0.487 0.469 -0.089
ENSG00000116288 E023 2257.9891875 2.512946e-04 4.033107e-01 0.775722254 1 7977652 7977738 87 + 3.322 3.330 0.027
ENSG00000116288 E024 21.1887523 3.088307e-02 9.225480e-01 0.981513270 1 7984864 7984893 30 + 1.325 1.320 -0.020
ENSG00000116288 E025 3142.0997579 3.609582e-04 2.652336e-03 0.092456313 1 7984894 7985135 242 + 3.452 3.482 0.099
ENSG00000116288 E026 769.2624731 1.706475e-03 1.632355e-01 0.558018950 1 7985136 7985505 370 + 2.838 2.872 0.112
ENSG00000116288 E027 18.2150296 4.964129e-02 7.237187e-01 0.923432470 1 7985922 7986028 107 + 1.236 1.277 0.142
ENSG00000116288 E028 0.6853745 1.842043e-02 1.122222e-01   1 7990715 7990907 193 + 0.000 0.295 10.812
ENSG00000116288 E029 1.7050210 9.253417e-02 5.439952e-01 0.851683032 1 7990908 7991075 168 + 0.348 0.467 0.652