ENSG00000115484

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394440 ENSG00000115484 HEK293_DMSO_6hA HEK293_OSMI2_6hA CCT4 protein_coding protein_coding 339.7049 182.9148 152.7108 26.38057 20.97779 -0.2603546 30.49900 17.01034 12.80937 1.864874 2.743954 -0.4089349 0.09088333 0.0944000 0.08173333 -0.01266667 7.363829e-01 6.927759e-06 FALSE TRUE
ENST00000461370 ENSG00000115484 HEK293_DMSO_6hA HEK293_OSMI2_6hA CCT4 protein_coding processed_transcript 339.7049 182.9148 152.7108 26.38057 20.97779 -0.2603546 40.04171 28.20919 52.90965 3.259385 11.628334 0.9071270 0.15522500 0.1646333 0.33810000 0.17346667 2.624542e-02 6.927759e-06 FALSE FALSE
MSTRG.18473.3 ENSG00000115484 HEK293_DMSO_6hA HEK293_OSMI2_6hA CCT4 protein_coding   339.7049 182.9148 152.7108 26.38057 20.97779 -0.2603546 100.95768 49.24887 35.61221 9.573380 4.830107 -0.4676064 0.28227500 0.2645333 0.23610000 -0.02843333 7.412635e-01 6.927759e-06 TRUE TRUE
MSTRG.18473.5 ENSG00000115484 HEK293_DMSO_6hA HEK293_OSMI2_6hA CCT4 protein_coding   339.7049 182.9148 152.7108 26.38057 20.97779 -0.2603546 96.90727 67.59680 33.93642 12.600356 3.993537 -0.9939091 0.28812500 0.3641667 0.22440000 -0.13976667 6.927759e-06 6.927759e-06 FALSE TRUE
MSTRG.18473.8 ENSG00000115484 HEK293_DMSO_6hA HEK293_OSMI2_6hA CCT4 protein_coding   339.7049 182.9148 152.7108 26.38057 20.97779 -0.2603546 68.06825 19.35327 16.90913 3.408239 1.562141 -0.1946674 0.17434167 0.1046667 0.11570000 0.01103333 8.743749e-01 6.927759e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000115484 E001 1.175506 1.378136e-02 1.702022e-01   2 61868085 61868124 40 - 0.150 0.393 1.836
ENSG00000115484 E002 34.682402 5.025482e-03 7.460771e-01 0.9315586716 2 61868125 61868419 295 - 1.529 1.535 0.023
ENSG00000115484 E003 16.421023 1.574621e-03 7.016156e-01 0.9156711737 2 61868420 61868429 10 - 1.208 1.229 0.071
ENSG00000115484 E004 1207.746734 2.594997e-03 4.627106e-02 0.3336610562 2 61868430 61868706 277 - 3.039 3.071 0.107
ENSG00000115484 E005 1351.002032 7.481127e-04 1.612511e-03 0.0710754750 2 61869440 61869553 114 - 3.084 3.120 0.117
ENSG00000115484 E006 1897.419450 1.074127e-03 3.820108e-02 0.3076377757 2 61872082 61872316 235 - 3.241 3.264 0.074
ENSG00000115484 E007 1409.470529 1.189915e-04 6.757767e-03 0.1448483734 2 61872458 61872581 124 - 3.116 3.131 0.051
ENSG00000115484 E008 763.226778 4.224181e-04 1.518778e-02 0.2095371950 2 61872582 61872588 7 - 2.843 2.870 0.088
ENSG00000115484 E009 1369.208285 5.559256e-05 1.413887e-03 0.0659610993 2 61873002 61873112 111 - 3.101 3.120 0.062
ENSG00000115484 E010 985.514752 1.722220e-04 7.784862e-01 0.9419451540 2 61873197 61873291 95 - 2.977 2.967 -0.031
ENSG00000115484 E011 441.667987 1.535322e-03 7.584785e-01 0.9354076438 2 61873292 61873293 2 - 2.624 2.621 -0.009
ENSG00000115484 E012 1147.214492 3.172309e-04 4.400621e-02 0.3264410008 2 61876095 61876234 140 - 3.029 3.042 0.045
ENSG00000115484 E013 966.705977 5.756411e-04 1.667738e-01 0.5629412505 2 61876920 61877052 133 - 2.958 2.967 0.030
ENSG00000115484 E014 747.264077 8.913160e-04 3.542009e-01 0.7426508909 2 61877393 61877514 122 - 2.850 2.853 0.011
ENSG00000115484 E015 1025.379505 1.298620e-03 4.732706e-01 0.8155868516 2 61878869 61879011 143 - 2.989 2.989 0.002
ENSG00000115484 E016 818.730237 1.893004e-04 4.135288e-01 0.7825350850 2 61880286 61880394 109 - 2.891 2.889 -0.006
ENSG00000115484 E017 727.604282 1.155877e-04 2.282284e-01 0.6334659037 2 61883459 61883548 90 - 2.858 2.828 -0.101
ENSG00000115484 E018 643.357340 9.000648e-05 1.436672e-05 0.0039471342 2 61885020 61885072 53 - 2.834 2.758 -0.254
ENSG00000115484 E019 1.151432 1.363008e-02 8.002553e-01   2 61886923 61887085 163 - 0.348 0.297 -0.327
ENSG00000115484 E020 330.470805 5.474938e-02 7.708836e-04 0.0465872875 2 61887948 61888257 310 - 2.723 2.306 -1.389
ENSG00000115484 E021 1273.588728 3.734304e-03 4.498451e-07 0.0003185615 2 61888381 61888676 296 - 3.187 3.017 -0.566