ENSG00000114942

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000236957 ENSG00000114942 HEK293_DMSO_6hA HEK293_OSMI2_6hA EEF1B2 protein_coding protein_coding 968.0333 512.3194 349.5862 94.87689 32.43848 -0.5513822 99.90602 45.95332 46.8732 7.889312 7.736718 0.02858796 0.1060667 0.09126667 0.1324667 0.0412 0.10633768 0.02558909 FALSE  
ENST00000392222 ENSG00000114942 HEK293_DMSO_6hA HEK293_OSMI2_6hA EEF1B2 protein_coding protein_coding 968.0333 512.3194 349.5862 94.87689 32.43848 -0.5513822 782.42021 422.37260 258.4355 81.626478 23.378054 -0.70869025 0.8014083 0.82193333 0.7396333 -0.0823 0.02558909 0.02558909 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000114942 E001 2.873244 1.975546e-02 1.117297e-01 4.787108e-01 2 206159585 206159593 9 + 0.700 0.442 -1.182
ENSG00000114942 E002 17.779654 1.566305e-03 3.368558e-03 1.045123e-01 2 206159594 206159606 13 + 1.396 1.157 -0.839
ENSG00000114942 E003 48.423142 5.885974e-03 1.146886e-02 1.851611e-01 2 206159607 206159614 8 + 1.779 1.613 -0.561
ENSG00000114942 E004 49.111791 5.684662e-03 1.012424e-02 1.744674e-01 2 206159615 206159616 2 + 1.785 1.619 -0.563
ENSG00000114942 E005 127.006369 6.877355e-03 1.211713e-02 1.901437e-01 2 206159617 206159635 19 + 2.177 2.038 -0.466
ENSG00000114942 E006 134.945074 6.249593e-03 1.226490e-02 1.913103e-01 2 206159636 206159637 2 + 2.199 2.066 -0.447
ENSG00000114942 E007 285.691474 5.384977e-03 4.880468e-04 3.550208e-02 2 206159638 206159684 47 + 2.535 2.378 -0.523
ENSG00000114942 E008 156.006110 1.076687e-02 3.568321e-01 7.446859e-01 2 206159685 206159872 188 + 2.221 2.156 -0.216
ENSG00000114942 E009 83.347581 2.806397e-03 1.171610e-02 1.871651e-01 2 206159873 206159894 22 + 1.986 1.863 -0.411
ENSG00000114942 E010 122.669221 5.078391e-04 4.586269e-03 1.215394e-01 2 206159895 206159912 18 + 2.135 2.036 -0.329
ENSG00000114942 E011 714.986912 2.026502e-04 1.401947e-02 2.028600e-01 2 206159913 206159926 14 + 2.862 2.822 -0.134
ENSG00000114942 E012 730.462611 2.720646e-04 3.836565e-02 3.083786e-01 2 206159927 206159933 7 + 2.868 2.833 -0.116
ENSG00000114942 E013 983.448819 2.204736e-04 1.348076e-01 5.175633e-01 2 206159934 206159958 25 + 2.989 2.966 -0.078
ENSG00000114942 E014 1791.641465 2.131093e-04 3.079141e-03 9.988090e-02 2 206159959 206160018 60 + 3.258 3.222 -0.118
ENSG00000114942 E015 1733.836547 1.927008e-03 5.008248e-01 8.300114e-01 2 206160019 206160059 41 + 3.233 3.215 -0.060
ENSG00000114942 E016 3.580136 6.326478e-02 2.441243e-01 6.494124e-01 2 206160211 206160268 58 + 0.784 0.575 -0.883
ENSG00000114942 E017 8.803934 1.363744e-01 2.350505e-01 6.399195e-01 2 206160311 206160486 176 + 0.763 1.065 1.146
ENSG00000114942 E018 23.066722 8.692934e-03 7.025050e-01 9.160401e-01 2 206160557 206160587 31 + 1.346 1.370 0.082
ENSG00000114942 E019 3152.776408 2.393059e-04 2.484492e-01 6.540882e-01 2 206160588 206160710 123 + 3.488 3.476 -0.038
ENSG00000114942 E020 36.807524 1.035164e-01 6.412848e-01 8.929522e-01 2 206160711 206160842 132 + 1.631 1.515 -0.397
ENSG00000114942 E021 34.035369 1.104583e-01 5.955679e-01 8.737855e-01 2 206160843 206160886 44 + 1.616 1.467 -0.512
ENSG00000114942 E022 97.529339 6.792893e-02 6.950471e-01 9.133741e-01 2 206160887 206161132 246 + 2.037 1.937 -0.334
ENSG00000114942 E023 43.205947 4.499670e-02 9.333958e-01 9.842635e-01 2 206161133 206161190 58 + 1.637 1.618 -0.067
ENSG00000114942 E024 41.435571 1.069474e-01 7.559081e-01 9.345860e-01 2 206161321 206161345 25 + 1.619 1.604 -0.051
ENSG00000114942 E025 1569.381685 3.713130e-04 9.345028e-01 9.846468e-01 2 206161346 206161353 8 + 3.177 3.177 -0.001
ENSG00000114942 E026 3202.908155 2.116309e-04 4.417792e-02 3.271408e-01 2 206161354 206161472 119 + 3.477 3.493 0.055
ENSG00000114942 E027 2979.172186 1.343782e-04 6.342940e-05 1.046895e-02 2 206162038 206162104 67 + 3.437 3.467 0.100
ENSG00000114942 E028 23.470286 9.173694e-02 6.051346e-01 8.776628e-01 2 206162228 206162488 261 + 1.334 1.391 0.199
ENSG00000114942 E029 3037.865645 3.683366e-05 1.821363e-08 2.536271e-05 2 206162489 206162614 126 + 3.442 3.476 0.112
ENSG00000114942 E030 2198.758575 2.690612e-04 3.425248e-03 1.052855e-01 2 206162729 206162928 200 + 3.306 3.334 0.093