ENSG00000114738

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357955 ENSG00000114738 HEK293_DMSO_6hA HEK293_OSMI2_6hA MAPKAPK3 protein_coding protein_coding 70.25341 59.5367 104.4796 6.927074 20.03403 0.8112661 37.772338 32.2020600 52.778949 4.8396926 6.890477 0.7126350 0.5636958 0.5359000 0.52140000 -0.01450000 0.91842088 0.00128664 FALSE  
ENST00000430409 ENSG00000114738 HEK293_DMSO_6hA HEK293_OSMI2_6hA MAPKAPK3 protein_coding protein_coding 70.25341 59.5367 104.4796 6.927074 20.03403 0.8112661 3.226747 0.3237743 4.084529 0.1627110 1.320845 3.6167528 0.0694250 0.0060000 0.03646667 0.03046667 0.18621056 0.00128664 FALSE  
ENST00000621469 ENSG00000114738 HEK293_DMSO_6hA HEK293_OSMI2_6hA MAPKAPK3 protein_coding protein_coding 70.25341 59.5367 104.4796 6.927074 20.03403 0.8112661 16.452835 17.6899064 26.918530 1.1648975 7.089400 0.6053937 0.2048250 0.3012667 0.24813333 -0.05313333 0.52624546 0.00128664 FALSE  
MSTRG.23008.4 ENSG00000114738 HEK293_DMSO_6hA HEK293_OSMI2_6hA MAPKAPK3 protein_coding   70.25341 59.5367 104.4796 6.927074 20.03403 0.8112661 10.573012 7.1306539 18.671760 0.9026301 4.327673 1.3875022 0.1349625 0.1194333 0.17523333 0.05580000 0.02114386 0.00128664 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000114738 E001 0.0000000       3 50611520 50611737 218 +      
ENSG00000114738 E002 0.8089702 2.065782e-02 0.9719506629   3 50611908 50611993 86 + 0.248 0.251 0.028
ENSG00000114738 E003 1.6330086 1.392885e-02 0.1961476331   3 50611994 50612129 136 + 0.485 0.251 -1.390
ENSG00000114738 E004 1.2967750 1.238815e-02 0.3972978264   3 50612328 50612699 372 + 0.405 0.252 -0.971
ENSG00000114738 E005 2.6600041 4.988513e-02 0.0262444886 0.26334916 3 50612848 50612942 95 + 0.669 0.252 -2.221
ENSG00000114738 E006 5.9023445 2.360622e-01 0.4243232367 0.78889464 3 50613792 50614018 227 + 0.892 0.725 -0.658
ENSG00000114738 E007 2.0762545 1.982059e-02 0.9397239947 0.98586715 3 50614019 50614117 99 + 0.485 0.471 -0.065
ENSG00000114738 E008 2.6322195 7.983064e-03 0.7289480015 0.92533510 3 50617122 50617125 4 + 0.520 0.574 0.252
ENSG00000114738 E009 4.9038946 4.781697e-03 0.6689715097 0.90377998 3 50617126 50617130 5 + 0.787 0.725 -0.248
ENSG00000114738 E010 36.5075740 9.748523e-03 0.0198642456 0.23494878 3 50617131 50617150 20 + 1.645 1.456 -0.647
ENSG00000114738 E011 103.4802984 6.575388e-03 0.0007777294 0.04676263 3 50617151 50617169 19 + 2.087 1.898 -0.632
ENSG00000114738 E012 257.5510491 1.793125e-03 0.0001814746 0.01930322 3 50617170 50617226 57 + 2.454 2.337 -0.390
ENSG00000114738 E013 70.5287303 5.773587e-03 0.5931755530 0.87269741 3 50617227 50617241 15 + 1.869 1.829 -0.133
ENSG00000114738 E014 7.4656961 3.469339e-03 0.8827069991 0.97189597 3 50617390 50617513 124 + 0.912 0.927 0.057
ENSG00000114738 E015 671.2490573 5.628010e-04 0.0001127853 0.01439872 3 50617514 50617784 271 + 2.851 2.782 -0.228
ENSG00000114738 E016 618.6964198 1.388961e-04 0.0408814453 0.31707086 3 50640366 50640505 140 + 2.799 2.766 -0.109
ENSG00000114738 E017 533.7328750 9.722903e-04 0.8019880498 0.94889825 3 50641707 50641771 65 + 2.719 2.725 0.020
ENSG00000114738 E018 606.5158103 8.119447e-05 0.7837239502 0.94326137 3 50642253 50642332 80 + 2.780 2.774 -0.023
ENSG00000114738 E019 437.6795346 9.303970e-05 0.6243357046 0.88578301 3 50644409 50644435 27 + 2.634 2.639 0.018
ENSG00000114738 E020 662.3719525 7.836335e-05 0.5797092647 0.86671160 3 50644436 50644532 97 + 2.821 2.810 -0.036
ENSG00000114738 E021 591.4114484 1.014145e-04 0.6420919800 0.89335544 3 50645710 50645785 76 + 2.767 2.771 0.012
ENSG00000114738 E022 622.1899224 1.311889e-04 0.9948227210 0.99862784 3 50646140 50646211 72 + 2.791 2.788 -0.008
ENSG00000114738 E023 555.5573761 1.182826e-04 0.7728137037 0.94027375 3 50646212 50646264 53 + 2.738 2.740 0.007
ENSG00000114738 E024 704.2552168 1.088652e-04 0.0790590348 0.41559476 3 50646740 50646825 86 + 2.832 2.854 0.073
ENSG00000114738 E025 664.9078407 9.225184e-05 0.0390528393 0.31082091 3 50647123 50647203 81 + 2.807 2.833 0.087
ENSG00000114738 E026 1.8039801 1.257456e-02 0.8561280799 0.96450008 3 50647204 50647204 1 + 0.446 0.471 0.131
ENSG00000114738 E027 351.0752303 9.865758e-04 0.1419530030 0.52796360 3 50647894 50647896 3 + 2.526 2.563 0.124
ENSG00000114738 E028 3248.9783638 3.888930e-05 0.0001011935 0.01367755 3 50647897 50649291 1395 + 3.498 3.518 0.065