ENSG00000113649

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296702 ENSG00000113649 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCERG1 protein_coding protein_coding 45.28259 17.44476 30.32556 4.649177 8.237227 0.7973888 4.1487427 0.811789 4.3859938 0.2852603 1.428795 2.4193495 0.09268750 0.04553333 0.1390667 0.09353333 0.0006561488 0.0006561488 FALSE TRUE
ENST00000394421 ENSG00000113649 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCERG1 protein_coding protein_coding 45.28259 17.44476 30.32556 4.649177 8.237227 0.7973888 20.2261428 3.617328 17.2619790 0.6853075 5.624156 2.2514543 0.41160000 0.22816667 0.5446333 0.31646667 0.0032511966 0.0006561488 FALSE TRUE
ENST00000505285 ENSG00000113649 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCERG1 protein_coding retained_intron 45.28259 17.44476 30.32556 4.649177 8.237227 0.7973888 4.1496222 0.000000 0.0000000 0.0000000 0.000000 0.0000000 0.06149167 0.00000000 0.0000000 0.00000000   0.0006561488 FALSE FALSE
ENST00000511077 ENSG00000113649 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCERG1 protein_coding retained_intron 45.28259 17.44476 30.32556 4.649177 8.237227 0.7973888 0.8596918 1.700234 0.5909534 0.3391688 0.137811 -1.5088688 0.02887917 0.10060000 0.0227000 -0.07790000 0.0023607390 0.0006561488   FALSE
MSTRG.27114.16 ENSG00000113649 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCERG1 protein_coding   45.28259 17.44476 30.32556 4.649177 8.237227 0.7973888 2.7060476 1.992668 3.9104618 0.6100103 1.837896 0.9691002 0.10308333 0.12436667 0.1138000 -0.01056667 0.9628376924 0.0006561488 FALSE TRUE
MSTRG.27114.6 ENSG00000113649 HEK293_DMSO_6hA HEK293_OSMI2_6hA TCERG1 protein_coding   45.28259 17.44476 30.32556 4.649177 8.237227 0.7973888 0.8250701 2.102277 0.0000000 1.1762688 0.000000 -7.7226554 0.03182917 0.10486667 0.0000000 -0.10486667 0.1132321300 0.0006561488 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_OSMI2_6hA HEK293_DMSO_6hA log2fold_HEK293_DMSO_6hA_HEK293_OSMI2_6hA
ENSG00000113649 E001 0.2937266 0.0274424043 4.954068e-01   5 146447217 146447310 94 + 0.156 0.000 -13.488
ENSG00000113649 E002 0.1125166 0.0326491905 1.000000e+00   5 146447311 146447311 1 + 0.085 0.000 -12.472
ENSG00000113649 E003 0.4018037 0.0240115053 2.812123e-01   5 146447312 146447325 14 + 0.216 0.000 -14.057
ENSG00000113649 E004 2.4776370 0.1101961641 1.925640e-02 2.319011e-01 5 146447326 146447330 5 + 0.645 0.166 -2.878
ENSG00000113649 E005 4.2866195 0.0828449594 1.056733e-01 4.678246e-01 5 146447331 146447332 2 + 0.787 0.520 -1.146
ENSG00000113649 E006 13.2949487 0.0025789821 7.288735e-02 4.018796e-01 5 146447333 146447345 13 + 1.194 1.032 -0.583
ENSG00000113649 E007 41.4256025 0.0014030525 1.970723e-02 2.341702e-01 5 146447346 146447408 63 + 1.661 1.538 -0.420
ENSG00000113649 E008 108.2582979 0.0002931999 8.992333e-04 5.089175e-02 5 146455056 146455281 226 + 2.065 1.960 -0.350
ENSG00000113649 E009 101.1571672 0.0003099578 5.343761e-03 1.307376e-01 5 146457183 146457335 153 + 2.031 1.942 -0.296
ENSG00000113649 E010 82.5488962 0.0016055124 8.633808e-02 4.304539e-01 5 146458884 146458991 108 + 1.935 1.877 -0.196
ENSG00000113649 E011 53.5238681 0.0143856086 1.532404e-01 5.438355e-01 5 146458992 146459051 60 + 1.753 1.666 -0.296
ENSG00000113649 E012 23.5457781 0.0085758473 7.698312e-03 1.540261e-01 5 146459052 146459063 12 + 1.456 1.225 -0.804
ENSG00000113649 E013 25.1843588 0.0038329905 1.498739e-02 2.084630e-01 5 146459064 146459075 12 + 1.471 1.292 -0.620
ENSG00000113649 E014 26.1955939 0.0016192704 1.214848e-02 1.904193e-01 5 146459076 146459081 6 + 1.483 1.313 -0.590
ENSG00000113649 E015 43.3290604 0.0022822849 4.057802e-03 1.139878e-01 5 146459082 146459135 54 + 1.693 1.532 -0.548
ENSG00000113649 E016 40.9281600 0.0048253367 1.366913e-02 2.011108e-01 5 146459136 146459153 18 + 1.664 1.513 -0.516
ENSG00000113649 E017 61.1666560 0.0154641139 2.249122e-01 6.299706e-01 5 146459154 146459214 61 + 1.803 1.739 -0.215
ENSG00000113649 E018 98.7843123 0.0109158885 1.414458e-01 5.273026e-01 5 146459215 146459337 123 + 2.008 1.943 -0.219
ENSG00000113649 E019 2.3617307 0.0333096043 3.369809e-01 7.296299e-01 5 146462018 146462056 39 + 0.436 0.628 0.909
ENSG00000113649 E020 2.6411004 0.2959575287 6.162428e-01 8.825810e-01 5 146462057 146462096 40 + 0.439 0.705 1.218
ENSG00000113649 E021 159.2610162 0.0047920236 4.284679e-01 7.910946e-01 5 146463551 146463793 243 + 2.198 2.179 -0.063
ENSG00000113649 E022 11.6375228 0.0027820620 1.519167e-02 2.095595e-01 5 146468341 146468403 63 + 1.175 0.927 -0.906
ENSG00000113649 E023 136.6063763 0.0006187542 3.405477e-01 7.323708e-01 5 146469544 146469744 201 + 2.138 2.123 -0.052
ENSG00000113649 E024 0.0000000       5 146469745 146469809 65 +      
ENSG00000113649 E025 54.9824220 0.0004919821 3.077408e-01 7.060543e-01 5 146470636 146470640 5 + 1.752 1.718 -0.118
ENSG00000113649 E026 109.2894950 0.0002782345 1.687654e-01 5.656429e-01 5 146470641 146470748 108 + 2.048 2.014 -0.111
ENSG00000113649 E027 106.9220029 0.0003220959 9.324656e-01 9.839945e-01 5 146471488 146471576 89 + 2.022 2.039 0.059
ENSG00000113649 E028 0.4633820 0.3082195087 7.071416e-02   5 146478418 146478492 75 + 0.000 0.375 16.085
ENSG00000113649 E029 82.4474333 0.0004095145 9.993173e-01 9.998284e-01 5 146478493 146478524 32 + 1.909 1.924 0.050
ENSG00000113649 E030 144.3197848 0.0003085221 4.901824e-01 8.245512e-01 5 146478525 146478653 129 + 2.158 2.152 -0.019
ENSG00000113649 E031 121.8715813 0.0047491867 3.555211e-01 7.437593e-01 5 146479855 146479911 57 + 2.081 2.068 -0.044
ENSG00000113649 E032 130.8503033 0.0017133457 1.057791e-01 4.680022e-01 5 146480028 146480094 67 + 2.125 2.085 -0.132
ENSG00000113649 E033 8.2919844 0.1831195359 1.057186e-01 4.678466e-01 5 146480095 146480518 424 + 0.757 1.180 1.582
ENSG00000113649 E034 8.1087457 0.0031052542 6.672677e-01 9.031168e-01 5 146481150 146481175 26 + 0.931 0.993 0.231
ENSG00000113649 E035 8.6956333 0.0028199784 2.230804e-01 6.278586e-01 5 146481176 146481200 25 + 0.920 1.068 0.547
ENSG00000113649 E036 22.7732894 0.2855561734 3.767431e-02 3.061659e-01 5 146481201 146482591 1391 + 1.068 1.638 1.988
ENSG00000113649 E037 172.0830701 0.0002341056 1.120986e-02 1.832632e-01 5 146482592 146482727 136 + 2.250 2.194 -0.187
ENSG00000113649 E038 8.4510574 0.0722451802 4.587129e-02 3.324977e-01 5 146482728 146482808 81 + 0.781 1.170 1.451
ENSG00000113649 E039 150.0271197 0.0002548504 3.503471e-02 2.975102e-01 5 146483540 146483629 90 + 2.186 2.138 -0.160
ENSG00000113649 E040 0.3579807 0.0620980281 4.839859e-01   5 146492869 146492919 51 + 0.157 0.000 -13.489
ENSG00000113649 E041 164.5222056 0.0002363824 2.064015e-01 6.103354e-01 5 146492920 146493038 119 + 2.217 2.197 -0.066
ENSG00000113649 E042 195.4943699 0.0001713745 2.616174e-01 6.668877e-01 5 146498536 146498686 151 + 2.289 2.275 -0.046
ENSG00000113649 E043 4.8187268 0.0725627163 7.224291e-02 4.004850e-01 5 146499573 146499971 399 + 0.588 0.927 1.375
ENSG00000113649 E044 8.7493567 0.0042165979 7.820675e-08 8.361008e-05 5 146503032 146503374 343 + 0.668 1.272 2.273
ENSG00000113649 E045 138.9479547 0.0003020815 7.467116e-01 9.316901e-01 5 146503375 146503418 44 + 2.129 2.154 0.083
ENSG00000113649 E046 158.1251534 0.0002160830 6.942463e-01 9.133260e-01 5 146503419 146503470 52 + 2.192 2.196 0.013
ENSG00000113649 E047 176.8974933 0.0001826295 9.391150e-01 9.856549e-01 5 146503471 146503539 69 + 2.236 2.250 0.046
ENSG00000113649 E048 99.7122692 0.0003174227 9.897283e-01 9.974653e-01 5 146503824 146503827 4 + 1.991 2.007 0.051
ENSG00000113649 E049 244.4945775 0.0001430822 2.945793e-01 6.951456e-01 5 146503828 146504006 179 + 2.368 2.408 0.133
ENSG00000113649 E050 1.8862311 0.0100653261 1.818315e-02 2.268739e-01 5 146504007 146504202 196 + 0.270 0.674 2.109
ENSG00000113649 E051 3.7354880 0.4974571946 2.199949e-01 6.245261e-01 5 146504364 146504494 131 + 0.418 0.913 2.149
ENSG00000113649 E052 2.4161019 0.4447705581 1.603864e-01 5.548611e-01 5 146505505 146505621 117 + 0.268 0.786 2.583
ENSG00000113649 E053 252.0556517 0.0021554450 2.243481e-01 6.292773e-01 5 146507028 146507207 180 + 2.363 2.428 0.218
ENSG00000113649 E054 3.7053158 0.0083044320 1.427462e-05 3.929290e-03 5 146507208 146507348 141 + 0.318 0.972 2.956
ENSG00000113649 E055 12.9489161 0.0022608274 1.232278e-13 1.361331e-09 5 146507371 146507744 374 + 0.743 1.461 2.624
ENSG00000113649 E056 5.9009438 0.0041745392 9.607490e-07 5.527943e-04 5 146507745 146507778 34 + 0.499 1.132 2.543
ENSG00000113649 E057 4.5520244 0.1759157618 1.076835e-02 1.796087e-01 5 146507779 146507872 94 + 0.416 1.010 2.522
ENSG00000113649 E058 191.9219001 0.0002026051 1.973877e-01 6.006043e-01 5 146507873 146507956 84 + 2.257 2.307 0.168
ENSG00000113649 E059 208.0971848 0.0013549551 6.366684e-01 8.910092e-01 5 146509145 146509245 101 + 2.293 2.329 0.121
ENSG00000113649 E060 9.2639075 0.0028295788 2.385503e-05 5.471510e-03 5 146510067 146510115 49 + 0.775 1.238 1.715
ENSG00000113649 E061 10.7011107 0.0131942983 2.264328e-05 5.312635e-03 5 146510116 146510160 45 + 0.807 1.302 1.816
ENSG00000113649 E062 1.0899805 0.0925771617 4.598283e-02   5 146510161 146510271 111 + 0.154 0.523 2.460
ENSG00000113649 E063 1000.2291256 0.0072616368 4.321484e-02 3.241607e-01 5 146510441 146511961 1521 + 2.948 3.033 0.282